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The map label for this gene is rsbW

Identifier: 49183949

GI number: 49183949

Start: 985535

End: 986017

Strand: Direct

Name: rsbW

Synonym: BAS0927

Alternate gene names: 49183949

Gene position: 985535-986017 (Clockwise)

Preceding gene: 49183948

Following gene: 49183950

Centisome position: 18.85

GC content: 33.33

Gene sequence:

>483_bases
ATGATGGAGAGATTTGAAAAGATAGAAATGAAAATTCCTGCAAAGGCAGAATATGTGGCTATTATTCGTTTAACAATGGC
TGGTGTTGCAAATCGAATGGGCTTTGCTTATGACGATATAGAAGATATGAAAATTGCTATTAGTGAAGCATGTACAAATA
TTGTACAACATGCATACAAAGAAGACGTTGGAGAAATTGCAATTGTCTTTGGGCTATATGAAAATCGATTAGAAATTATG
GTTGCTGATAATGGGGTTAGCTTTGATTTTAATAACTTAAGAAGTAAAGTTGGTCCGTATGATATTAGTAAACCTGTAGA
ACATTTGCCGGAAAATGGTTTAGGTTTATATTTAATCAATACGTTAATGGATGATATACAAATCATGCATGATGAGGGCA
TGACGGTTTTAATGACAAAATATATACAAAGAGAGCAGGTGGAGAATGATGGAAATCCAATCTCAACCTACGAATCTTAC
TAA

Upstream 100 bases:

>100_bases
TGTATCTAAAAGGTTAAAAAGATTATTTGATATTACAGGGTTAACAGAAATATTAAATTTGAATTCCGATTTTGAAAAAG
TAGAAAGAAGGTGACTAGGG

Downstream 100 bases:

>100_bases
AGAAGACGTTATTAAACTAATTGCAGAATTTCAACAAAACCAATGTGGTGAAGCGCAGGAAAGGTTAGTTGATCATTATA
AAAATCTCGTATATTCCATT

Product: serine-protein kinase RsbW

Products: NA

Alternate protein names: Anti-sigma-B factor; Sigma-B negative effector rsbW

Number of amino acids: Translated: 160; Mature: 160

Protein sequence:

>160_residues
MMERFEKIEMKIPAKAEYVAIIRLTMAGVANRMGFAYDDIEDMKIAISEACTNIVQHAYKEDVGEIAIVFGLYENRLEIM
VADNGVSFDFNNLRSKVGPYDISKPVEHLPENGLGLYLINTLMDDIQIMHDEGMTVLMTKYIQREQVENDGNPISTYESY

Sequences:

>Translated_160_residues
MMERFEKIEMKIPAKAEYVAIIRLTMAGVANRMGFAYDDIEDMKIAISEACTNIVQHAYKEDVGEIAIVFGLYENRLEIM
VADNGVSFDFNNLRSKVGPYDISKPVEHLPENGLGLYLINTLMDDIQIMHDEGMTVLMTKYIQREQVENDGNPISTYESY
>Mature_160_residues
MMERFEKIEMKIPAKAEYVAIIRLTMAGVANRMGFAYDDIEDMKIAISEACTNIVQHAYKEDVGEIAIVFGLYENRLEIM
VADNGVSFDFNNLRSKVGPYDISKPVEHLPENGLGLYLINTLMDDIQIMHDEGMTVLMTKYIQREQVENDGNPISTYESY

Specific function: Negative regulator of sigma-B activity. Phosphorylates and inactivates its specific antagonist protein, rsbV. Upon phosphorylation of rsbV, rsbW is released and binds to sigma-B, thereby blocking its ability to form an RNA polymerase holoenzyme (E-sigma-B

COG id: COG2172

COG function: function code T; Anti-sigma regulatory factor (Ser/Thr protein kinase)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anti-sigma-factor family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RSBW_BACAA (C3P2P9)

Other databases:

- EMBL:   CP001598
- RefSeq:   YP_002865546.1
- ProteinModelPortal:   C3P2P9
- SMR:   C3P2P9
- EnsemblBacteria:   EBBACT00000130426
- GeneID:   7852961
- GenomeReviews:   CP001598_GR
- KEGG:   bai:BAA_1085
- GeneTree:   EBGT00050000001549
- ProtClustDB:   PRK04069
- HAMAP:   MF_00638
- InterPro:   IPR010193
- InterPro:   IPR003594
- Gene3D:   G3DSA:3.30.565.10
- SMART:   SM00387
- TIGRFAMs:   TIGR01924

Pfam domain/function: PF02518 HATPase_c; SSF55874 ATP_bd_ATPase

EC number: =2.7.11.1

Molecular weight: Translated: 18241; Mature: 18241

Theoretical pI: Translated: 4.26; Mature: 4.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
6.9 %Met     (Translated Protein)
7.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
6.9 %Met     (Mature Protein)
7.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMERFEKIEMKIPAKAEYVAIIRLTMAGVANRMGFAYDDIEDMKIAISEACTNIVQHAYK
CCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
EDVGEIAIVFGLYENRLEIMVADNGVSFDFNNLRSKVGPYDISKPVEHLPENGLGLYLIN
HCHHHEEEEEEEECCCEEEEEECCCCCCCHHHHHHHCCCCCCCCHHHHCCCCCCHHHHHH
TLMDDIQIMHDEGMTVLMTKYIQREQVENDGNPISTYESY
HHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MMERFEKIEMKIPAKAEYVAIIRLTMAGVANRMGFAYDDIEDMKIAISEACTNIVQHAYK
CCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
EDVGEIAIVFGLYENRLEIMVADNGVSFDFNNLRSKVGPYDISKPVEHLPENGLGLYLIN
HCHHHEEEEEEEECCCEEEEEECCCCCCCHHHHHHHCCCCCCCCHHHHCCCCCCHHHHHH
TLMDDIQIMHDEGMTVLMTKYIQREQVENDGNPISTYESY
HHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA