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The map label for this gene is kgtP [H]

Identifier: 49183892

GI number: 49183892

Start: 931053

End: 932375

Strand: Reverse

Name: kgtP [H]

Synonym: BAS0868

Alternate gene names: 49183892

Gene position: 932375-931053 (Counterclockwise)

Preceding gene: 49183908

Following gene: 49183871

Centisome position: 17.83

GC content: 43.16

Gene sequence:

>1323_bases
ATGGCTCAAGCAAAATCTAATCGAGTCGCCGGCAATATTTTTAAAGGTTCTGTCGGCAATTTAATTGAATGGTACGACTG
GTACGTTTACTCTGCTTTCGCTGTTTATTTTTCAGCAGAGTTCTTTCCTAAAGGTGATCCAACGAGTCAATTATTGAACA
CAGCGGCTATTTTCGCAGTTGGATTTTTAATGCGCCCTATCGGAAGTTTACTAATGGGACGTTATGCAGATCGGCACGGA
CGCCGAGCAGCATTAACGCTTTCGATTACGGTTATGGCCAGTGGTTCTTTAATTATCGCCTGTACACCTAGTTACGAAAG
CATCGGTATTATGGCACCAATTATTTTAGTTCTTGCCCGTTTACTGCAAGGATTATCACTTGGCGGAGAGTACGGAACTT
CCGCAACGTATTTATCTGAAATGGCTAGTAGTGGTCGCCGCGGTTTTTATTCAAGCTTCCAATATGTAACGCTCGTTGCG
GGGCAAATGGTTGCATTAGGCGTTCAAATTGTTCTTCAGCAATTACTAAGCGAACCAGATATGAAAGCTTGGGGATGGCG
CATTCCGTTCATTATTGGAGCGATGGGTGCAGTAGCTGTATTATGGCTTCGCCGTACGATGGATGAATCGGAGCAATTCG
CAAACATAAAATCACAAAAACGCGAGAGCGCAGGAACCGTTCGCACTCTTATGAAACATCCGAAAGCAGTATTGACAGTA
GTCGGCCTAACATTAGGAGGCACTGTTGCATTCTATACGTACACAACATATTTACAAAAATTCATGGTAAACACAGTCGG
TCTTCCGAAAGAAATTGTAAGCTGGATTAACTTTGTCGCACTACTTATATTCGTCGTACTTCAACCGATTGCAGGGCTAC
TATCTGATAAAATCGGCCGCCGCCCATTATTAATGGCATTCGGTATTCTCGGAACGTTACTAACAGCACCAATCTTCTTC
TTTATGGAAAAAACGACAGAACCAATCGTAGCATTCTTACTCATGATGGTCGGCCTCATTATCGTTACTGGTTACACTTC
CATTAACGCAATTGTAAAAGCCGAACTCTTCCCAACTGAAATTCGCGCACTTGGCGTAGGTTTACCATATGCACTAACCG
TTGCGATATTCGGCGGAACAGCTGAGTTCATCGCATTATGGCTAAAAAGTATCGGAATGGAATCACTATTCTACTTCTAC
GTAGCTGGATGTATCGCCATCAGCTTTATTACGTATTGGCGTATGGATGAATCATCGAAGACTTCGCAGATTGAGGCGGA
GCTTGGTGGCGGGGATCAATTAGTTAATAATAAGTCTAGTTAA

Upstream 100 bases:

>100_bases
TCATAATATTGAGATTTCATTCGAAAAACAGTACAATTCAACTACAATGAACACGCTTTCATATTTATCATTTTACTACT
AAGCAAGAGGAGGAATGATT

Downstream 100 bases:

>100_bases
AATTATGTATTCTATAATCTTCGTTTATCTGAACTCGATTTGCTTTATCTAAAAAAGCTTAATTGATTCATATATAATTT
AAAAACCCAAAATTCTTCCT

Product: alpha-ketoglutarate permease

Products: Proton [Cytoplasm]; 2-oxoglutarate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 440; Mature: 439

Protein sequence:

>440_residues
MAQAKSNRVAGNIFKGSVGNLIEWYDWYVYSAFAVYFSAEFFPKGDPTSQLLNTAAIFAVGFLMRPIGSLLMGRYADRHG
RRAALTLSITVMASGSLIIACTPSYESIGIMAPIILVLARLLQGLSLGGEYGTSATYLSEMASSGRRGFYSSFQYVTLVA
GQMVALGVQIVLQQLLSEPDMKAWGWRIPFIIGAMGAVAVLWLRRTMDESEQFANIKSQKRESAGTVRTLMKHPKAVLTV
VGLTLGGTVAFYTYTTYLQKFMVNTVGLPKEIVSWINFVALLIFVVLQPIAGLLSDKIGRRPLLMAFGILGTLLTAPIFF
FMEKTTEPIVAFLLMMVGLIIVTGYTSINAIVKAELFPTEIRALGVGLPYALTVAIFGGTAEFIALWLKSIGMESLFYFY
VAGCIAISFITYWRMDESSKTSQIEAELGGGDQLVNNKSS

Sequences:

>Translated_440_residues
MAQAKSNRVAGNIFKGSVGNLIEWYDWYVYSAFAVYFSAEFFPKGDPTSQLLNTAAIFAVGFLMRPIGSLLMGRYADRHG
RRAALTLSITVMASGSLIIACTPSYESIGIMAPIILVLARLLQGLSLGGEYGTSATYLSEMASSGRRGFYSSFQYVTLVA
GQMVALGVQIVLQQLLSEPDMKAWGWRIPFIIGAMGAVAVLWLRRTMDESEQFANIKSQKRESAGTVRTLMKHPKAVLTV
VGLTLGGTVAFYTYTTYLQKFMVNTVGLPKEIVSWINFVALLIFVVLQPIAGLLSDKIGRRPLLMAFGILGTLLTAPIFF
FMEKTTEPIVAFLLMMVGLIIVTGYTSINAIVKAELFPTEIRALGVGLPYALTVAIFGGTAEFIALWLKSIGMESLFYFY
VAGCIAISFITYWRMDESSKTSQIEAELGGGDQLVNNKSS
>Mature_439_residues
AQAKSNRVAGNIFKGSVGNLIEWYDWYVYSAFAVYFSAEFFPKGDPTSQLLNTAAIFAVGFLMRPIGSLLMGRYADRHGR
RAALTLSITVMASGSLIIACTPSYESIGIMAPIILVLARLLQGLSLGGEYGTSATYLSEMASSGRRGFYSSFQYVTLVAG
QMVALGVQIVLQQLLSEPDMKAWGWRIPFIIGAMGAVAVLWLRRTMDESEQFANIKSQKRESAGTVRTLMKHPKAVLTVV
GLTLGGTVAFYTYTTYLQKFMVNTVGLPKEIVSWINFVALLIFVVLQPIAGLLSDKIGRRPLLMAFGILGTLLTAPIFFF
MEKTTEPIVAFLLMMVGLIIVTGYTSINAIVKAELFPTEIRALGVGLPYALTVAIFGGTAEFIALWLKSIGMESLFYFYV
AGCIAISFITYWRMDESSKTSQIEAELGGGDQLVNNKSS

Specific function: Uptake of alpha-ketoglutarate across the boundary membrane with the concomitant import of a cation (symport system) [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family [H]

Homologues:

Organism=Escherichia coli, GI1788942, Length=420, Percent_Identity=50, Blast_Score=410, Evalue=1e-116,
Organism=Escherichia coli, GI1790550, Length=428, Percent_Identity=28.0373831775701, Blast_Score=201, Evalue=9e-53,
Organism=Escherichia coli, GI1788292, Length=427, Percent_Identity=29.5081967213115, Blast_Score=199, Evalue=3e-52,
Organism=Escherichia coli, GI1789941, Length=402, Percent_Identity=33.8308457711443, Blast_Score=182, Evalue=4e-47,
Organism=Escherichia coli, GI87082231, Length=255, Percent_Identity=27.4509803921569, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI87082404, Length=325, Percent_Identity=24.6153846153846, Blast_Score=83, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004736
- InterPro:   IPR020846
- InterPro:   IPR016196
- InterPro:   IPR005828
- InterPro:   IPR005829 [H]

Pfam domain/function: PF00083 Sugar_tr [H]

EC number: NA

Molecular weight: Translated: 48059; Mature: 47928

Theoretical pI: Translated: 9.49; Mature: 9.49

Prosite motif: PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1 ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQAKSNRVAGNIFKGSVGNLIEWYDWYVYSAFAVYFSAEFFPKGDPTSQLLNTAAIFAV
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
GFLMRPIGSLLMGRYADRHGRRAALTLSITVMASGSLIIACTPSYESIGIMAPIILVLAR
HHHHHHHHHHHHHHHHHHCCCEEEEEEEEEEEECCCEEEEECCCCCHHHHHHHHHHHHHH
LLQGLSLGGEYGTSATYLSEMASSGRRGFYSSFQYVTLVAGQMVALGVQIVLQQLLSEPD
HHHHHCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
MKAWGWRIPFIIGAMGAVAVLWLRRTMDESEQFANIKSQKRESAGTVRTLMKHPKAVLTV
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
VGLTLGGTVAFYTYTTYLQKFMVNTVGLPKEIVSWINFVALLIFVVLQPIAGLLSDKIGR
HHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
RPLLMAFGILGTLLTAPIFFFMEKTTEPIVAFLLMMVGLIIVTGYTSINAIVKAELFPTE
CHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHH
IRALGVGLPYALTVAIFGGTAEFIALWLKSIGMESLFYFYVAGCIAISFITYWRMDESSK
HHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCC
TSQIEAELGGGDQLVNNKSS
CHHEEHHCCCCHHCCCCCCC
>Mature Secondary Structure 
AQAKSNRVAGNIFKGSVGNLIEWYDWYVYSAFAVYFSAEFFPKGDPTSQLLNTAAIFAV
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
GFLMRPIGSLLMGRYADRHGRRAALTLSITVMASGSLIIACTPSYESIGIMAPIILVLAR
HHHHHHHHHHHHHHHHHHCCCEEEEEEEEEEEECCCEEEEECCCCCHHHHHHHHHHHHHH
LLQGLSLGGEYGTSATYLSEMASSGRRGFYSSFQYVTLVAGQMVALGVQIVLQQLLSEPD
HHHHHCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
MKAWGWRIPFIIGAMGAVAVLWLRRTMDESEQFANIKSQKRESAGTVRTLMKHPKAVLTV
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
VGLTLGGTVAFYTYTTYLQKFMVNTVGLPKEIVSWINFVALLIFVVLQPIAGLLSDKIGR
HHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
RPLLMAFGILGTLLTAPIFFFMEKTTEPIVAFLLMMVGLIIVTGYTSINAIVKAELFPTE
CHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHH
IRALGVGLPYALTVAIFGGTAEFIALWLKSIGMESLFYFYVAGCIAISFITYWRMDESSK
HHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCC
TSQIEAELGGGDQLVNNKSS
CHHEEHHCCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 2-oxoglutarate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 2-oxoglutarate [Periplasm] = Proton [Cytoplasm] + 2-oxoglutarate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2118499; 9205837; 9278503; 1709493; 2190187; 2053984; 8419306 [H]