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The map label for this gene is treA [H]

Identifier: 49183624

GI number: 49183624

Start: 648351

End: 650012

Strand: Direct

Name: treA [H]

Synonym: BAS0599

Alternate gene names: 49183624

Gene position: 648351-650012 (Clockwise)

Preceding gene: 49183623

Following gene: 49183628

Centisome position: 12.4

GC content: 34.18

Gene sequence:

>1662_bases
ATGAAGGATTGGCATAAAAGTGTAGTTTATCAAATTTATCCGAAGAGCTTTAATAGCTATTACAATAAAGAAACCGGTGA
TATAAAAGGGGTTACAGAAAAACTAGATTATTTAAAAGAACTCGGAGTAGATTATATTTGGTTAACACCGATATACCAAT
CACCACAAAATGATAATGGATACGATGTAAGTGATTACTATAGTATTGATCCATCTTACGGAACGATGGAAGAGTTTGAA
GAGCTTTTAGAAGAAGCGAAAGCGCGTAACATTGAAATTATGCTCGATATCGTTGTAAATCATAGCTCGACGGAGCATAA
GTGGTTTAAAGAAGCGAAAAAAGATAAAAATAGTCCATATCGCAATTACTATATTTGGCGTGATGAAAAAAACAATTGGC
AATCTAAGTTTGGCGGGTCTGCTTGGAAATATGATGAGAAGACAAAGCAATATTTTTTACATCTATTTGATGAGACGCAA
GCGGATTTAAATTGGGAAAATGAAAAGCTTCGTGAAGAAGTATATGATATGATGCGCTTTTGGCTAGATAAAGGGGTAAC
TGGATTCCGATTAGATGTTATTAATTTAATTTCAAAAGATCAACAGTTCTTAAATGATGACGGAAGTACGGCGACAAGCG
ATGGCCGTAAATATTATACAGATGGCCCGCGCGTTCATGAATATTTACAAGAGATGAACCGAAATGTTTTTGAAGGGAAA
GATGTCCTTACAGTTGGAGAAATGTCATCTACGACAATTGATAATTGTATTAAATATTCAAACCCTGATCGTAATGAACT
AAGCATGACGTTTAGCTTTCATCATTTAAAAGTAGATTATCCGAATGGTGATAAGTGGACGAAGGCTGATTTTGATTTCA
TTAAATTAAAAGAGATTATGTCTAATTGGCAAATTGAAATGCAAAAGGGTGGAGGATGGAATGCGTTATTCTGGTGTAAT
CATGACCAGCCGCGTATTGTGTCACGCTTCGGTAATGATGAGAAGTATAGAAATGAGTCTGCAAAAATGTTAGCGACAGC
TATGCATATGTTGCAAGGAACGCCTTATATTTATCAAGGCGAAGAAATCGGTATGACGAATCCTAATTTTGAGTCTATTG
AACAATATCGTGATGTGGAATCGTTAAATATATATGATATAAAGCTGGAAGAAGGATTATCAAAAGAAGAGATTATCGGG
ATTTTAAAACAAAAATCTCGTGACAACTCCCGTACACCGATGCAGTGGAATGAAGATGTGAATAGTGGGTTTACAACAAG
TACACCTTGGATTTCGGTGGCTGAAAACTTTAAAGAAATAAACGTAGAGAAGGCATTAGAAGATAAGGAATCTGTATTTT
ATTATTATAAAAAGTTAATTGAACTTCGAAAAACGTATGATGTAATTACAGAAGGAGAATATGCTATTTTGGATGAAAAT
GATTCTGAAATTTGGGCATATACTCGTACTACAGAAAGTGAAGTGCTACTTGTTATAAATAACTTCTATGGAGAAGAAAT
AACGTATTCTGTACCAGCTCATGTTCAATTAGATGGAATGAAACAAGAAGTACTACTGTCGAATTATAAAGATTCCAGCA
AGGATATTGCAAAACTTAACTTAAGACCATACGAATCAATTGTATATCGATATACGAAATAA

Upstream 100 bases:

>100_bases
CCAATGTTTATTGTAGGAATGGTTATCGCAGTTGTCATCCCATTCACGTTAACGTGGTTATTTGCAAAAAGAGTGAAACA
GAAGTAGGAGGAAGTTAAAC

Downstream 100 bases:

>100_bases
AAGGTTGTATGCCTGCGTGGCATACAACCTTTTATTTTAAGACACCACTATACAAAATATTTACGTCTACTTCTGGTTTA
AACTTTACTTTTGCATAATC

Product: trehalose-6-phosphate hydrolase

Products: NA

Alternate protein names: Alpha,alpha-phosphotrehalase [H]

Number of amino acids: Translated: 553; Mature: 553

Protein sequence:

>553_residues
MKDWHKSVVYQIYPKSFNSYYNKETGDIKGVTEKLDYLKELGVDYIWLTPIYQSPQNDNGYDVSDYYSIDPSYGTMEEFE
ELLEEAKARNIEIMLDIVVNHSSTEHKWFKEAKKDKNSPYRNYYIWRDEKNNWQSKFGGSAWKYDEKTKQYFLHLFDETQ
ADLNWENEKLREEVYDMMRFWLDKGVTGFRLDVINLISKDQQFLNDDGSTATSDGRKYYTDGPRVHEYLQEMNRNVFEGK
DVLTVGEMSSTTIDNCIKYSNPDRNELSMTFSFHHLKVDYPNGDKWTKADFDFIKLKEIMSNWQIEMQKGGGWNALFWCN
HDQPRIVSRFGNDEKYRNESAKMLATAMHMLQGTPYIYQGEEIGMTNPNFESIEQYRDVESLNIYDIKLEEGLSKEEIIG
ILKQKSRDNSRTPMQWNEDVNSGFTTSTPWISVAENFKEINVEKALEDKESVFYYYKKLIELRKTYDVITEGEYAILDEN
DSEIWAYTRTTESEVLLVINNFYGEEITYSVPAHVQLDGMKQEVLLSNYKDSSKDIAKLNLRPYESIVYRYTK

Sequences:

>Translated_553_residues
MKDWHKSVVYQIYPKSFNSYYNKETGDIKGVTEKLDYLKELGVDYIWLTPIYQSPQNDNGYDVSDYYSIDPSYGTMEEFE
ELLEEAKARNIEIMLDIVVNHSSTEHKWFKEAKKDKNSPYRNYYIWRDEKNNWQSKFGGSAWKYDEKTKQYFLHLFDETQ
ADLNWENEKLREEVYDMMRFWLDKGVTGFRLDVINLISKDQQFLNDDGSTATSDGRKYYTDGPRVHEYLQEMNRNVFEGK
DVLTVGEMSSTTIDNCIKYSNPDRNELSMTFSFHHLKVDYPNGDKWTKADFDFIKLKEIMSNWQIEMQKGGGWNALFWCN
HDQPRIVSRFGNDEKYRNESAKMLATAMHMLQGTPYIYQGEEIGMTNPNFESIEQYRDVESLNIYDIKLEEGLSKEEIIG
ILKQKSRDNSRTPMQWNEDVNSGFTTSTPWISVAENFKEINVEKALEDKESVFYYYKKLIELRKTYDVITEGEYAILDEN
DSEIWAYTRTTESEVLLVINNFYGEEITYSVPAHVQLDGMKQEVLLSNYKDSSKDIAKLNLRPYESIVYRYTK
>Mature_553_residues
MKDWHKSVVYQIYPKSFNSYYNKETGDIKGVTEKLDYLKELGVDYIWLTPIYQSPQNDNGYDVSDYYSIDPSYGTMEEFE
ELLEEAKARNIEIMLDIVVNHSSTEHKWFKEAKKDKNSPYRNYYIWRDEKNNWQSKFGGSAWKYDEKTKQYFLHLFDETQ
ADLNWENEKLREEVYDMMRFWLDKGVTGFRLDVINLISKDQQFLNDDGSTATSDGRKYYTDGPRVHEYLQEMNRNVFEGK
DVLTVGEMSSTTIDNCIKYSNPDRNELSMTFSFHHLKVDYPNGDKWTKADFDFIKLKEIMSNWQIEMQKGGGWNALFWCN
HDQPRIVSRFGNDEKYRNESAKMLATAMHMLQGTPYIYQGEEIGMTNPNFESIEQYRDVESLNIYDIKLEEGLSKEEIIG
ILKQKSRDNSRTPMQWNEDVNSGFTTSTPWISVAENFKEINVEKALEDKESVFYYYKKLIELRKTYDVITEGEYAILDEN
DSEIWAYTRTTESEVLLVINNFYGEEITYSVPAHVQLDGMKQEVLLSNYKDSSKDIAKLNLRPYESIVYRYTK

Specific function: Unknown

COG id: COG0366

COG function: function code G; Glycosidases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyl hydrolase 13 family [H]

Homologues:

Organism=Homo sapiens, GI187423904, Length=581, Percent_Identity=28.0550774526678, Blast_Score=217, Evalue=3e-56,
Organism=Homo sapiens, GI61744479, Length=106, Percent_Identity=32.0754716981132, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI65506891, Length=106, Percent_Identity=32.0754716981132, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI61744477, Length=106, Percent_Identity=32.0754716981132, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI61744475, Length=106, Percent_Identity=32.0754716981132, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI61744481, Length=106, Percent_Identity=32.0754716981132, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI61744483, Length=106, Percent_Identity=32.0754716981132, Blast_Score=70, Evalue=5e-12,
Organism=Escherichia coli, GI1790687, Length=550, Percent_Identity=54.1818181818182, Blast_Score=622, Evalue=1e-179,
Organism=Escherichia coli, GI1786604, Length=212, Percent_Identity=27.8301886792453, Blast_Score=88, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI25147709, Length=590, Percent_Identity=23.5593220338983, Blast_Score=120, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI32565753, Length=248, Percent_Identity=25.8064516129032, Blast_Score=91, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6322245, Length=575, Percent_Identity=38.9565217391304, Blast_Score=390, Evalue=1e-109,
Organism=Saccharomyces cerevisiae, GI6321726, Length=578, Percent_Identity=36.5051903114187, Blast_Score=372, Evalue=1e-104,
Organism=Saccharomyces cerevisiae, GI6321731, Length=576, Percent_Identity=38.0208333333333, Blast_Score=372, Evalue=1e-104,
Organism=Saccharomyces cerevisiae, GI6319776, Length=576, Percent_Identity=37.8472222222222, Blast_Score=371, Evalue=1e-103,
Organism=Saccharomyces cerevisiae, GI6324416, Length=585, Percent_Identity=37.0940170940171, Blast_Score=368, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6322241, Length=585, Percent_Identity=37.0940170940171, Blast_Score=367, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6322021, Length=585, Percent_Identity=37.0940170940171, Blast_Score=367, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24583747, Length=489, Percent_Identity=34.9693251533742, Blast_Score=271, Evalue=7e-73,
Organism=Drosophila melanogaster, GI24583749, Length=489, Percent_Identity=34.9693251533742, Blast_Score=271, Evalue=8e-73,
Organism=Drosophila melanogaster, GI221330053, Length=583, Percent_Identity=31.9039451114923, Blast_Score=268, Evalue=1e-71,
Organism=Drosophila melanogaster, GI24586599, Length=590, Percent_Identity=32.5423728813559, Blast_Score=263, Evalue=2e-70,
Organism=Drosophila melanogaster, GI24583745, Length=528, Percent_Identity=32.9545454545455, Blast_Score=263, Evalue=3e-70,
Organism=Drosophila melanogaster, GI24586597, Length=586, Percent_Identity=31.2286689419795, Blast_Score=260, Evalue=2e-69,
Organism=Drosophila melanogaster, GI24586593, Length=583, Percent_Identity=31.3893653516295, Blast_Score=258, Evalue=7e-69,
Organism=Drosophila melanogaster, GI24586589, Length=490, Percent_Identity=34.8979591836735, Blast_Score=248, Evalue=9e-66,
Organism=Drosophila melanogaster, GI45549022, Length=563, Percent_Identity=31.9715808170515, Blast_Score=246, Evalue=4e-65,
Organism=Drosophila melanogaster, GI24586591, Length=590, Percent_Identity=30.1694915254237, Blast_Score=238, Evalue=6e-63,
Organism=Drosophila melanogaster, GI24586587, Length=595, Percent_Identity=29.7478991596639, Blast_Score=235, Evalue=8e-62,
Organism=Drosophila melanogaster, GI281360393, Length=526, Percent_Identity=29.8479087452471, Blast_Score=201, Evalue=1e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013780
- InterPro:   IPR006047
- InterPro:   IPR006589
- InterPro:   IPR017853
- InterPro:   IPR013781
- InterPro:   IPR012769 [H]

Pfam domain/function: PF00128 Alpha-amylase [H]

EC number: =3.2.1.93 [H]

Molecular weight: Translated: 65395; Mature: 65395

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDWHKSVVYQIYPKSFNSYYNKETGDIKGVTEKLDYLKELGVDYIWLTPIYQSPQNDNG
CCCHHHCCEEEECCHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCC
YDVSDYYSIDPSYGTMEEFEELLEEAKARNIEIMLDIVVNHSSTEHKWFKEAKKDKNSPY
CCCCCEEEECCCCCCHHHHHHHHHHHHHCCEEEEEEEEECCCCCHHHHHHHHHHCCCCCC
RNYYIWRDEKNNWQSKFGGSAWKYDEKTKQYFLHLFDETQADLNWENEKLREEVYDMMRF
CEEEEEECCCCCHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHH
WLDKGVTGFRLDVINLISKDQQFLNDDGSTATSDGRKYYTDGPRVHEYLQEMNRNVFEGK
HHHCCCCEEEHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCHHHHHHHHHHCCCCCCCC
DVLTVGEMSSTTIDNCIKYSNPDRNELSMTFSFHHLKVDYPNGDKWTKADFDFIKLKEIM
CEEEECCCCCHHHHHHHHCCCCCCCCEEEEEEEEEEEEECCCCCCCCCCCCHHHHHHHHH
SNWQIEMQKGGGWNALFWCNHDQPRIVSRFGNDEKYRNESAKMLATAMHMLQGTPYIYQG
CCCEEEEECCCCCEEEEEECCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEC
EEIGMTNPNFESIEQYRDVESLNIYDIKLEEGLSKEEIIGILKQKSRDNSRTPMQWNEDV
CCCCCCCCCHHHHHHHCCCCCCEEEEEEHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCC
NSGFTTSTPWISVAENFKEINVEKALEDKESVFYYYKKLIELRKTYDVITEGEYAILDEN
CCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECC
DSEIWAYTRTTESEVLLVINNFYGEEITYSVPAHVQLDGMKQEVLLSNYKDSSKDIAKLN
CCEEEEEEECCCCCEEEEEECCCCCCEEEECCCEEEECCCHHHHHHHCCCCCCCCCEEEC
LRPYESIVYRYTK
CCCHHHHHEEECC
>Mature Secondary Structure
MKDWHKSVVYQIYPKSFNSYYNKETGDIKGVTEKLDYLKELGVDYIWLTPIYQSPQNDNG
CCCHHHCCEEEECCHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCC
YDVSDYYSIDPSYGTMEEFEELLEEAKARNIEIMLDIVVNHSSTEHKWFKEAKKDKNSPY
CCCCCEEEECCCCCCHHHHHHHHHHHHHCCEEEEEEEEECCCCCHHHHHHHHHHCCCCCC
RNYYIWRDEKNNWQSKFGGSAWKYDEKTKQYFLHLFDETQADLNWENEKLREEVYDMMRF
CEEEEEECCCCCHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHH
WLDKGVTGFRLDVINLISKDQQFLNDDGSTATSDGRKYYTDGPRVHEYLQEMNRNVFEGK
HHHCCCCEEEHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCHHHHHHHHHHCCCCCCCC
DVLTVGEMSSTTIDNCIKYSNPDRNELSMTFSFHHLKVDYPNGDKWTKADFDFIKLKEIM
CEEEECCCCCHHHHHHHHCCCCCCCCEEEEEEEEEEEEECCCCCCCCCCCCHHHHHHHHH
SNWQIEMQKGGGWNALFWCNHDQPRIVSRFGNDEKYRNESAKMLATAMHMLQGTPYIYQG
CCCEEEEECCCCCEEEEEECCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEC
EEIGMTNPNFESIEQYRDVESLNIYDIKLEEGLSKEEIIGILKQKSRDNSRTPMQWNEDV
CCCCCCCCCHHHHHHHCCCCCCEEEEEEHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCC
NSGFTTSTPWISVAENFKEINVEKALEDKESVFYYYKKLIELRKTYDVITEGEYAILDEN
CCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECC
DSEIWAYTRTTESEVLLVINNFYGEEITYSVPAHVQLDGMKQEVLLSNYKDSSKDIAKLN
CCEEEEEEECCCCCEEEEEECCCCCCEEEECCCEEEECCCHHHHHHHCCCCCCCCCEEEC
LRPYESIVYRYTK
CCCHHHHHEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7651129; 8969503; 9384377; 7751281 [H]