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The map label for this gene is ciaH [H]

Identifier: 49183567

GI number: 49183567

Start: 579337

End: 580587

Strand: Direct

Name: ciaH [H]

Synonym: BAS0541

Alternate gene names: 49183567

Gene position: 579337-580587 (Clockwise)

Preceding gene: 49183566

Following gene: 49183568

Centisome position: 11.08

GC content: 34.85

Gene sequence:

>1251_bases
ATGAAAAAGGGAAGTATGTTTCAGAAGACGCGTATTCGATTGACTATATTGAATTCATTAGTATTTATCATTTTGATAGG
CGTATTAGGTAGTATCATTTATTCTTACACATATAAGCGTATTTATAGTGGAGTAAATGAATCGATAGAAAAAGCCGTTC
AACATAGAAAGAATGCAGATGATAAAAAACTACCTAAAAAAATTAGAGGATATCCTCCAATTGGGGATCCAAGGATAATG
GAGTTAACTTGGCTTGGAAACACGGTGGAGATAGATATTGAAAACGGCAAACGTCGTTTTATTTTTGAAGACAATTTGGA
AAAGTTTTCTCCAAAGAAATTAGGAACTTTGCAAGATATAGAAGTACAAGGACGATATTTTAGAATATTTGCATTTCAGA
AAGATGCAAAAATAGTTCAAATTGCAAGGGATATAACGGCTGAAAAAGAAATGTTACATACTTTATTTTTAATTCTTGTG
ATAGGGTGTAGCATAGGAAGTCTATGTGCAATAGGAATCGGATTTTTCTTAGCTGGCAGGGCACTCGTACCTATTCAAAA
TTCATGGGAAAAACAGCAACAATTTGTGTCGGACGCATCACATGAATTAAGGACACCGCTTGCGGTTATTCAATCCAAAA
CAGATATATTATTTCAGTCACCATCTGCGACAATAGAAGAAAAAGCGATGGATATTTCTACGATTTCAAAGGAGTGTAGA
CGATTATCTAAGCTTGTAGCTAATTTATTATTGTTAGCACGTTCAGATTCTAATCAAATTGAGATGGATAAGAAAATATT
TGAATTGGATAAATTGTTAGAAGAAATAGTAGAGCCATATAAGGAAATTGCTTCCTACCAAGAAAAAGAGATGATATTGA
AAGTAGAGTATGACATATCATTTATGGGTGATAGGGAGAGAATTCATCAAATGATGGTCATATTGTTAGATAATGCGATG
AAGTATACAAATGAGGGAGGACATATACAAATCGATTGTACGCAAACGAACAGTTCGATTCGTATACGAGTGAAAGATGA
TGGGATAGGAGTGAAAGGTGAGGACATTCCGAAACTATTTGATCGTTTTTATCAAGGAGATAAAGCGAGAAGTGCGTCAG
AGGGAGCGGGATTAGGCCTTTCAATCGCGAACTGGATTGTAGAAAAGCATTATGGGAAAATATCAGTAGAGAGCCAATGG
GGAGAGGGCACTTGCTTTGAAGTGATTCTTCCTAAAAATCAAAGAATATAA

Upstream 100 bases:

>100_bases
TAGAAGTGTATGTACATCATTTACGTAAAAAATTAGAGCCATTCGGTTATCAGAAAGATATTCAAACCGTTCGTGGTATT
GGATATATATTAAAAGAACA

Downstream 100 bases:

>100_bases
GTGAGAAGACGACCTTGTTTTTACAAGGGCGTCTTTTTTTAAGGGAAAGTTAAGAAACTATTTATAACATGTATTATATA
CAGAAAGTTTGTCCCCTAAA

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 416; Mature: 416

Protein sequence:

>416_residues
MKKGSMFQKTRIRLTILNSLVFIILIGVLGSIIYSYTYKRIYSGVNESIEKAVQHRKNADDKKLPKKIRGYPPIGDPRIM
ELTWLGNTVEIDIENGKRRFIFEDNLEKFSPKKLGTLQDIEVQGRYFRIFAFQKDAKIVQIARDITAEKEMLHTLFLILV
IGCSIGSLCAIGIGFFLAGRALVPIQNSWEKQQQFVSDASHELRTPLAVIQSKTDILFQSPSATIEEKAMDISTISKECR
RLSKLVANLLLLARSDSNQIEMDKKIFELDKLLEEIVEPYKEIASYQEKEMILKVEYDISFMGDRERIHQMMVILLDNAM
KYTNEGGHIQIDCTQTNSSIRIRVKDDGIGVKGEDIPKLFDRFYQGDKARSASEGAGLGLSIANWIVEKHYGKISVESQW
GEGTCFEVILPKNQRI

Sequences:

>Translated_416_residues
MKKGSMFQKTRIRLTILNSLVFIILIGVLGSIIYSYTYKRIYSGVNESIEKAVQHRKNADDKKLPKKIRGYPPIGDPRIM
ELTWLGNTVEIDIENGKRRFIFEDNLEKFSPKKLGTLQDIEVQGRYFRIFAFQKDAKIVQIARDITAEKEMLHTLFLILV
IGCSIGSLCAIGIGFFLAGRALVPIQNSWEKQQQFVSDASHELRTPLAVIQSKTDILFQSPSATIEEKAMDISTISKECR
RLSKLVANLLLLARSDSNQIEMDKKIFELDKLLEEIVEPYKEIASYQEKEMILKVEYDISFMGDRERIHQMMVILLDNAM
KYTNEGGHIQIDCTQTNSSIRIRVKDDGIGVKGEDIPKLFDRFYQGDKARSASEGAGLGLSIANWIVEKHYGKISVESQW
GEGTCFEVILPKNQRI
>Mature_416_residues
MKKGSMFQKTRIRLTILNSLVFIILIGVLGSIIYSYTYKRIYSGVNESIEKAVQHRKNADDKKLPKKIRGYPPIGDPRIM
ELTWLGNTVEIDIENGKRRFIFEDNLEKFSPKKLGTLQDIEVQGRYFRIFAFQKDAKIVQIARDITAEKEMLHTLFLILV
IGCSIGSLCAIGIGFFLAGRALVPIQNSWEKQQQFVSDASHELRTPLAVIQSKTDILFQSPSATIEEKAMDISTISKECR
RLSKLVANLLLLARSDSNQIEMDKKIFELDKLLEEIVEPYKEIASYQEKEMILKVEYDISFMGDRERIHQMMVILLDNAM
KYTNEGGHIQIDCTQTNSSIRIRVKDDGIGVKGEDIPKLFDRFYQGDKARSASEGAGLGLSIANWIVEKHYGKISVESQW
GEGTCFEVILPKNQRI

Specific function: Member of the two-component regulatory system CiaH/CiaR. Involved in early steps of competence regulation and in penicillin susceptibility. Probably phosphorylates CiaR [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=233, Percent_Identity=33.9055793991416, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1786600, Length=223, Percent_Identity=29.5964125560538, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI1786783, Length=228, Percent_Identity=30.2631578947368, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1788279, Length=225, Percent_Identity=32, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI145693157, Length=231, Percent_Identity=29.004329004329, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1786912, Length=220, Percent_Identity=31.3636363636364, Blast_Score=92, Evalue=9e-20,
Organism=Escherichia coli, GI1789149, Length=229, Percent_Identity=27.5109170305677, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1790436, Length=284, Percent_Identity=24.2957746478873, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1788549, Length=222, Percent_Identity=28.3783783783784, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1790346, Length=251, Percent_Identity=27.4900398406374, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI87082128, Length=238, Percent_Identity=27.3109243697479, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1788713, Length=230, Percent_Identity=25.6521739130435, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1790551, Length=238, Percent_Identity=26.890756302521, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1787374, Length=223, Percent_Identity=28.2511210762332, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1790861, Length=207, Percent_Identity=25.6038647342995, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI87081816, Length=221, Percent_Identity=25.7918552036199, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI48994928, Length=224, Percent_Identity=22.7678571428571, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1789403, Length=219, Percent_Identity=27.8538812785388, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1789808, Length=220, Percent_Identity=26.3636363636364, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 47427; Mature: 47427

Theoretical pI: Translated: 8.63; Mature: 8.63

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKGSMFQKTRIRLTILNSLVFIILIGVLGSIIYSYTYKRIYSGVNESIEKAVQHRKNAD
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DKKLPKKIRGYPPIGDPRIMELTWLGNTVEIDIENGKRRFIFEDNLEKFSPKKLGTLQDI
HHHHHHHHCCCCCCCCCCEEEEEECCCEEEEEECCCCEEEEEECCHHHCCCHHCCCCCCE
EVQGRYFRIFAFQKDAKIVQIARDITAEKEMLHTLFLILVIGCSIGSLCAIGIGFFLAGR
EECCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCC
ALVPIQNSWEKQQQFVSDASHELRTPLAVIQSKTDILFQSPSATIEEKAMDISTISKECR
EEECCCCCHHHHHHHHHHHHHHHHCHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHH
RLSKLVANLLLLARSDSNQIEMDKKIFELDKLLEEIVEPYKEIASYQEKEMILKVEYDIS
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECEE
FMGDRERIHQMMVILLDNAMKYTNEGGHIQIDCTQTNSSIRIRVKDDGIGVKGEDIPKLF
ECCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCEEEEEEECCCCCCCCCCHHHHH
DRFYQGDKARSASEGAGLGLSIANWIVEKHYGKISVESQWGEGTCFEVILPKNQRI
HHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCEEEEEECCCCCC
>Mature Secondary Structure
MKKGSMFQKTRIRLTILNSLVFIILIGVLGSIIYSYTYKRIYSGVNESIEKAVQHRKNAD
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DKKLPKKIRGYPPIGDPRIMELTWLGNTVEIDIENGKRRFIFEDNLEKFSPKKLGTLQDI
HHHHHHHHCCCCCCCCCCEEEEEECCCEEEEEECCCCEEEEEECCHHHCCCHHCCCCCCE
EVQGRYFRIFAFQKDAKIVQIARDITAEKEMLHTLFLILVIGCSIGSLCAIGIGFFLAGR
EECCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCC
ALVPIQNSWEKQQQFVSDASHELRTPLAVIQSKTDILFQSPSATIEEKAMDISTISKECR
EEECCCCCHHHHHHHHHHHHHHHHCHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHH
RLSKLVANLLLLARSDSNQIEMDKKIFELDKLLEEIVEPYKEIASYQEKEMILKVEYDIS
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECEE
FMGDRERIHQMMVILLDNAMKYTNEGGHIQIDCTQTNSSIRIRVKDDGIGVKGEDIPKLF
ECCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCEEEEEEECCCCCCCCCCHHHHH
DRFYQGDKARSASEGAGLGLSIANWIVEKHYGKISVESQWGEGTCFEVILPKNQRI
HHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11463916 [H]