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The map label for this gene is hemF [H]

Identifier: 46447609

GI number: 46447609

Start: 2354640

End: 2355440

Strand: Reverse

Name: hemF [H]

Synonym: pc1975

Alternate gene names: 46447609

Gene position: 2355440-2354640 (Counterclockwise)

Preceding gene: 46447610

Following gene: 46447608

Centisome position: 97.56

GC content: 37.7

Gene sequence:

>801_bases
ATGGTTTTTCCCCACCCTTCCCGTTTAGAACTCATTGATTTTTTAAAATCTTTGCGTGAAAAAATAATCACTTCTTTTGA
ACAGATAGAAAAAACCCATCACTTTGAACGTAAAAGTTGGGCACATCATGAAGAAGGTGGAGGAGAAATTGCCGTTTTAA
GAGGAAATATTTTTGAGAAAGCGGCTGTTAATTGGTCTGGAGTTGGAGGTACTCGTTTTCCTTTAGGCGAAGCAGAGGGA
CCTTTTTTTGCGACAGGAGTAAGCTTAATTACCCATATGAGCAATCCTCATGTACCTACCTCGCATTTTAATATTCGATT
TATTGAGACAAAAGATCGTTATTGGTTTGGAGGGGGTTACGATTTGACTCCTATGGGATTTCCTTATTTAGAAGATACAA
CTCATTTTCACACTATTGCAGAGCAAGCCTTACTTCCTTTTGGTTCTCACTTATATCCTCAATTTTCTCAGCAAGCTAAA
GAGTATTTTTATATTCCTCATCGCCAAAAAGAACGTGGGGTGGGAGGAATTTTTTTTGATCATTACAACACCGGAGATTT
TGAAAAAGACAAACAATTATGGGAATCGGTTGGCCATTCATTTATTCAAGCGATTATGCCTATTTATCAGCGTCGAATCT
CACAACCGTTCAATCAAGAAGAACGAGAGATTCAATTGAAGCATAGAGCTCACTATGCAGAATTTAACTTAGTTTATGAT
CGAGGAACGAGATTTGGATTTCAGTCAGGAGGAAATACTGAAGCAATTCTTTGTTCAATGCCCCCATTAGCAAAATGGTA
A

Upstream 100 bases:

>100_bases
TGAAAAGTTTTATCCTTGTTTTTCAAAGGAATAACTATTTAAACGCAAACAAATGTAAATATAAAGTTAGGCATTAACCT
TCGTTCAAAAAAGATAAGTT

Downstream 100 bases:

>100_bases
ACGATTAGTCTTTTGTAAATTTGTAATCATAGGACAGTTATGAAGATTCTTTCTTATTTTCGCTTTTTAAGCTTTTGCCT
CTTGAGTTTTTTTAGTTCTT

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 266; Mature: 266

Protein sequence:

>266_residues
MVFPHPSRLELIDFLKSLREKIITSFEQIEKTHHFERKSWAHHEEGGGEIAVLRGNIFEKAAVNWSGVGGTRFPLGEAEG
PFFATGVSLITHMSNPHVPTSHFNIRFIETKDRYWFGGGYDLTPMGFPYLEDTTHFHTIAEQALLPFGSHLYPQFSQQAK
EYFYIPHRQKERGVGGIFFDHYNTGDFEKDKQLWESVGHSFIQAIMPIYQRRISQPFNQEEREIQLKHRAHYAEFNLVYD
RGTRFGFQSGGNTEAILCSMPPLAKW

Sequences:

>Translated_266_residues
MVFPHPSRLELIDFLKSLREKIITSFEQIEKTHHFERKSWAHHEEGGGEIAVLRGNIFEKAAVNWSGVGGTRFPLGEAEG
PFFATGVSLITHMSNPHVPTSHFNIRFIETKDRYWFGGGYDLTPMGFPYLEDTTHFHTIAEQALLPFGSHLYPQFSQQAK
EYFYIPHRQKERGVGGIFFDHYNTGDFEKDKQLWESVGHSFIQAIMPIYQRRISQPFNQEEREIQLKHRAHYAEFNLVYD
RGTRFGFQSGGNTEAILCSMPPLAKW
>Mature_266_residues
MVFPHPSRLELIDFLKSLREKIITSFEQIEKTHHFERKSWAHHEEGGGEIAVLRGNIFEKAAVNWSGVGGTRFPLGEAEG
PFFATGVSLITHMSNPHVPTSHFNIRFIETKDRYWFGGGYDLTPMGFPYLEDTTHFHTIAEQALLPFGSHLYPQFSQQAK
EYFYIPHRQKERGVGGIFFDHYNTGDFEKDKQLWESVGHSFIQAIMPIYQRRISQPFNQEEREIQLKHRAHYAEFNLVYD
RGTRFGFQSGGNTEAILCSMPPLAKW

Specific function: Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III [H]

COG id: COG0408

COG function: function code H; Coproporphyrinogen III oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI41393599, Length=281, Percent_Identity=34.8754448398576, Blast_Score=173, Evalue=2e-43,
Organism=Escherichia coli, GI1788777, Length=274, Percent_Identity=42.3357664233577, Blast_Score=219, Evalue=1e-58,
Organism=Saccharomyces cerevisiae, GI6320249, Length=293, Percent_Identity=36.518771331058, Blast_Score=179, Evalue=3e-46,
Organism=Drosophila melanogaster, GI17864388, Length=280, Percent_Identity=36.7857142857143, Blast_Score=172, Evalue=2e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001260
- InterPro:   IPR018375 [H]

Pfam domain/function: PF01218 Coprogen_oxidas [H]

EC number: =1.3.3.3 [H]

Molecular weight: Translated: 30812; Mature: 30812

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVFPHPSRLELIDFLKSLREKIITSFEQIEKTHHFERKSWAHHEEGGGEIAVLRGNIFEK
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCHHH
AAVNWSGVGGTRFPLGEAEGPFFATGVSLITHMSNPHVPTSHFNIRFIETKDRYWFGGGY
HCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCEEECCCC
DLTPMGFPYLEDTTHFHTIAEQALLPFGSHLYPQFSQQAKEYFYIPHRQKERGVGGIFFD
CCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHEEECCCCCCCCCCCCEEEE
HYNTGDFEKDKQLWESVGHSFIQAIMPIYQRRISQPFNQEEREIQLKHRAHYAEFNLVYD
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCEEEEEEEEE
RGTRFGFQSGGNTEAILCSMPPLAKW
CCCCCCCCCCCCCCEEEECCCCCCCC
>Mature Secondary Structure
MVFPHPSRLELIDFLKSLREKIITSFEQIEKTHHFERKSWAHHEEGGGEIAVLRGNIFEK
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCHHH
AAVNWSGVGGTRFPLGEAEGPFFATGVSLITHMSNPHVPTSHFNIRFIETKDRYWFGGGY
HCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCEEECCCC
DLTPMGFPYLEDTTHFHTIAEQALLPFGSHLYPQFSQQAKEYFYIPHRQKERGVGGIFFD
CCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHEEECCCCCCCCCCCCEEEE
HYNTGDFEKDKQLWESVGHSFIQAIMPIYQRRISQPFNQEEREIQLKHRAHYAEFNLVYD
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCEEEEEEEEE
RGTRFGFQSGGNTEAILCSMPPLAKW
CCCCCCCCCCCCCCEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA