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The map label for this gene is uvsE [H]

Identifier: 46446815

GI number: 46446815

Start: 1408863

End: 1409825

Strand: Direct

Name: uvsE [H]

Synonym: pc1181

Alternate gene names: 46446815

Gene position: 1408863-1409825 (Clockwise)

Preceding gene: 46446814

Following gene: 46446816

Centisome position: 58.35

GC content: 35.62

Gene sequence:

>963_bases
ATGTTCATGACAAGGGAATATCCAATGCATAAAATTAGATGGGGACTGTGTTGTATTTTTAAAGAAGCTCCAATTAAGTT
TCGCAAGACAACTGTGGCGTATATTGCAAGATTAAATAATCGAGGCGAACCTTATTTAAATTTTTTAAGTACATTAATCT
TAAGTAATTTAAATACGTTGATAGCTGCTATTGAATATTGTAAACAATTTAATATTGGGAGTTTTCGAATTCAAAGTGAA
TTTCTTCCTTTATTTAAACATTCTCAATATGGTTACCAACTTGAGCAATTACCAGAAGCTGCGCTTATTTTCCAAAAATT
TGAATACTGCAAAAAATTAGCTCAAACAAATGCTGTTCGGCTAACCTTTCATCCTGATCAATTTGTCGTTCTTAACTCCC
CTCACGAGCATGTCGTCAAAAATTCTATTCAAGAACTAGAATACCATGGAGAAATAGCAGAATTATTAGGAGCAGATGTA
ATCAACATTCATGCGGGAGGAACATACGGAAATAAAGCAAAGGCTCTAACTAATTTTGCAGAGCGATTTGAACGTTTATC
AAAACGCGTTCGCACACGTTTAACAATAGAAAATGATGATCGGTGTTTTACTCCCCAAGATCTGCTTTCCCTTTGTCAAC
AACTCAAAATCCCCCTAGTTTATGATGTTCATCACCATCGTTGTTTACCCGATGAATTGTCCCTAGAACAAGCAAGCATT
CAGGCTTATAAAACATGGGATCGAGAACCCCTTTTCCATATATCTTCTCCTTTAGAGGGCTGGAATGGACCAAAACGAGA
AAGGCATCATGACTATATTGATATTCAAGATTTCCCTACCTGTTGGTTCGATTTTCCGGCAATGACAATTGAAATTGAGG
CTAAAGCGAAAGAGCTAGCCATTTTCAAACTACAAGCTGAGCTTGATCTTATATTAAAAAAAATTAAACATGGGTTCGAT
TGA

Upstream 100 bases:

>100_bases
CAAAACTTGATATTTAAATCTTTATCTCCGGGCAAAAACAAACTAGATCTCTAGTCTAGCCAATTTTTTTATGATAGTAT
TGTACATGTATAAACAATAG

Downstream 100 bases:

>100_bases
CTTATAATTTTTTTAGTTTATTTCTTAAAAAAAATTATATAGCCATACATTAAAAATACTAGCTTTAAAAAATAAACTAG
CCTTGCTTAAGATTAGACTC

Product: putative UV damage endonuclease

Products: NA

Alternate protein names: UV-endonuclease; UVED [H]

Number of amino acids: Translated: 320; Mature: 320

Protein sequence:

>320_residues
MFMTREYPMHKIRWGLCCIFKEAPIKFRKTTVAYIARLNNRGEPYLNFLSTLILSNLNTLIAAIEYCKQFNIGSFRIQSE
FLPLFKHSQYGYQLEQLPEAALIFQKFEYCKKLAQTNAVRLTFHPDQFVVLNSPHEHVVKNSIQELEYHGEIAELLGADV
INIHAGGTYGNKAKALTNFAERFERLSKRVRTRLTIENDDRCFTPQDLLSLCQQLKIPLVYDVHHHRCLPDELSLEQASI
QAYKTWDREPLFHISSPLEGWNGPKRERHHDYIDIQDFPTCWFDFPAMTIEIEAKAKELAIFKLQAELDLILKKIKHGFD

Sequences:

>Translated_320_residues
MFMTREYPMHKIRWGLCCIFKEAPIKFRKTTVAYIARLNNRGEPYLNFLSTLILSNLNTLIAAIEYCKQFNIGSFRIQSE
FLPLFKHSQYGYQLEQLPEAALIFQKFEYCKKLAQTNAVRLTFHPDQFVVLNSPHEHVVKNSIQELEYHGEIAELLGADV
INIHAGGTYGNKAKALTNFAERFERLSKRVRTRLTIENDDRCFTPQDLLSLCQQLKIPLVYDVHHHRCLPDELSLEQASI
QAYKTWDREPLFHISSPLEGWNGPKRERHHDYIDIQDFPTCWFDFPAMTIEIEAKAKELAIFKLQAELDLILKKIKHGFD
>Mature_320_residues
MFMTREYPMHKIRWGLCCIFKEAPIKFRKTTVAYIARLNNRGEPYLNFLSTLILSNLNTLIAAIEYCKQFNIGSFRIQSE
FLPLFKHSQYGYQLEQLPEAALIFQKFEYCKKLAQTNAVRLTFHPDQFVVLNSPHEHVVKNSIQELEYHGEIAELLGADV
INIHAGGTYGNKAKALTNFAERFERLSKRVRTRLTIENDDRCFTPQDLLSLCQQLKIPLVYDVHHHRCLPDELSLEQASI
QAYKTWDREPLFHISSPLEGWNGPKRERHHDYIDIQDFPTCWFDFPAMTIEIEAKAKELAIFKLQAELDLILKKIKHGFD

Specific function: Component in a DNA repair pathway. Removal of UV-light damaged nucleotides. Recognizes pyrimidine dimers and cleave a phosphodiester bond immediately 5' to the lesion [H]

COG id: COG4294

COG function: function code L; UV damage repair endonuclease

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uve1/uvsE family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004601
- InterPro:   IPR013022 [H]

Pfam domain/function: PF03851 UvdE [H]

EC number: NA

Molecular weight: Translated: 37405; Mature: 37405

Theoretical pI: Translated: 7.60; Mature: 7.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFMTREYPMHKIRWGLCCIFKEAPIKFRKTTVAYIARLNNRGEPYLNFLSTLILSNLNTL
CCCCCCCCHHHHHHHHEEEEECCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
IAAIEYCKQFNIGSFRIQSEFLPLFKHSQYGYQLEQLPEAALIFQKFEYCKKLAQTNAVR
HHHHHHHHHCCCCCEEEHHHHHHHHHCCCCCCCHHHCCHHHHHHHHHHHHHHHHHCCCEE
LTFHPDQFVVLNSPHEHVVKNSIQELEYHGEIAELLGADVINIHAGGTYGNKAKALTNFA
EEECCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHH
ERFERLSKRVRTRLTIENDDRCFTPQDLLSLCQQLKIPLVYDVHHHRCLPDELSLEQASI
HHHHHHHHHHHHEEEEECCCCCCCHHHHHHHHHHCCCCEEEECHHCCCCCHHHCHHHHHH
QAYKTWDREPLFHISSPLEGWNGPKRERHHDYIDIQDFPTCWFDFPAMTIEIEAKAKELA
HHHHCCCCCCCEEECCCCCCCCCCCCCCCCCEECCCCCCCCEECCCEEEEEEECCCCEEE
IFKLQAELDLILKKIKHGFD
EEEEHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MFMTREYPMHKIRWGLCCIFKEAPIKFRKTTVAYIARLNNRGEPYLNFLSTLILSNLNTL
CCCCCCCCHHHHHHHHEEEEECCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
IAAIEYCKQFNIGSFRIQSEFLPLFKHSQYGYQLEQLPEAALIFQKFEYCKKLAQTNAVR
HHHHHHHHHCCCCCEEEHHHHHHHHHCCCCCCCHHHCCHHHHHHHHHHHHHHHHHCCCEE
LTFHPDQFVVLNSPHEHVVKNSIQELEYHGEIAELLGADVINIHAGGTYGNKAKALTNFA
EEECCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHH
ERFERLSKRVRTRLTIENDDRCFTPQDLLSLCQQLKIPLVYDVHHHRCLPDELSLEQASI
HHHHHHHHHHHHEEEEECCCCCCCHHHHHHHHHHCCCCEEEECHHCCCCCHHHCHHHHHH
QAYKTWDREPLFHISSPLEGWNGPKRERHHDYIDIQDFPTCWFDFPAMTIEIEAKAKELA
HHHHCCCCCCCEEECCCCCCCCCCCCCCCCCEECCCCCCCCEECCCEEEEEEECCCCEEE
IFKLQAELDLILKKIKHGFD
EEEEHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377; 8614629 [H]