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The map label for this gene is groEL

Identifier: 46446814

GI number: 46446814

Start: 1406392

End: 1408014

Strand: Direct

Name: groEL

Synonym: pc1180

Alternate gene names: 46446814

Gene position: 1406392-1408014 (Clockwise)

Preceding gene: 46446813

Following gene: 46446815

Centisome position: 58.25

GC content: 40.54

Gene sequence:

>1623_bases
ATGGCCGCTAAAATTATTAAATTTAAAGAAGATGCCAGACAAAAAATTTTAAAAGGTGTCCGTACTTTAGCTGACGCTGT
TAAAGTTACCCTCGGTCCTAAAGGACGTAATGTCGTTATTGACAAATCTTATGGAACTCCCCATATCACAAAAGACGGAG
TCACTGTTGCTAAAGAAATCGAACTGGAAGATAAGTTCGAAAATATGGGCGCACAAATGGTTAAAGAAGTTGCTAGTAAA
ACAGCTGATAAAGCTGGCGATGGAACTACGACTGCAACCGTATTAGCTGAAGCAATCTACTCTGAAGGACTTAGAAATGT
AGCAGCAGGTGCTAATCCTCTTGATCTAAAACGTGGAATGGAAAAAGCTGTTAAAGTTATTGTTCAAGAACTCAAAAAAA
GAAGCAAAACAGTTGATGATCGCAATGAAATCGCACAAGTAGCCACTATTTCTGCTAATAACGATGCTGAAATCGGAGAA
ATGATTGCTCAAGCGATTGAAAAAGTTGGCCGTGATGGAACAATCACTGTTGAAGAAGGCAAAGGATTTGAAACTGAACT
TGATGTCGTCAAAGGAATGAAATTTGATCGAGGTTATTTATCCGCTTATTTCATGACAAATTCGGAATCTCAAGAATGTA
TCTTAGAAGATGCTTATGTCTTAATTTATGAGAAAAAAATCAGTGCGATTAAAGAAATTATTCCGCTTCTACAAGCCGTT
GTGGAAACAGGTCGCCCTCTTCTTATTATCGCTGAAGATGTTGAAGGTGAAGCTCTTGCAACGCTTGTTGTCAATCGCCT
ACGTGCAGGTTTAAAAGTTTGTGCTGTTAAAGCACCCGGCTTTGGTGATCGTCGTAAAGCCATGTTACAAGATATTGCCA
TTCTTACTGGTGGAGAACTCATAAGTGAAGAAATTGGTTTAAAATTGGAAACAACAACAATCGAACAATTAGGTCGTGTT
AAAAAAGCTGTTTTAACAAAAGATGAAACAACCCTTGTTGAAGGGGCTGGAACTAAAGCGGCTATTCTTGATCGCGCTTC
ACAAATCAAACGTCAAATTGAAGAAAGCACTTCGGACTATGATAAAGAGAAACTTCAAGAACGACTTGCTAAGCTCGTCG
GTGGAGTTGCTGTGATTCATGTCGGAGCTGCTACAGAAATTGAAATGAAAGAAAAGAAAGACCGTGTAGATGATGCACAA
AGAGCTACCGCTGCAGCCGTAGAAGAAGGGATTCTTCCTGGCGGTGGAACAGCCTTTATTCGTTGCATTCCAGCTGTTAA
TAGTTTAGCTGACAGTTTAGAAGGCGATGAAAAAACAGGTGCTAAAATCATGGCGCGCTCGTTAAGTGCTCCCCTTCGTC
AAATTGCTGAAAATGCAGGACAAGAAGGTGCCATCATTTTGCAAGCTGTAGAAAAAATGAAAGAAAAAGAAGGATATAAC
GCATTAACAGGCGAATATGTAGACATGATCACAGCCGGTATCTTAGATCCTACTAAAGTTGTTCGCTGCGCGTTAGAGAA
CGCCGTTTCTGTTGCTGCTATGTTACTAACAACAGAGGCTATTGTTGCGGACATCCCAGAAGAGAAACCGGCTCCTGCGG
CGCCTGTCGGCATGGATTATTAA

Upstream 100 bases:

>100_bases
AATAACTCTAAATGATGAGGAGTTAGTGATTCTTCGTGCCGATGATATCATTGCCATTGTAGAAAAATAATTAATTATTC
ACATTCACAGGAGATTTCAA

Downstream 100 bases:

>100_bases
TCCATTCTTGCTTTTCTTAAGAGTAAAGGGAAGAACATGTTGTTCTTCCCTTTTTTATTTTGATCGGATTTTAAAATCTC
TCAAAATATCCTTAAATTTA

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein 2; Protein Cpn60 2

Number of amino acids: Translated: 540; Mature: 539

Protein sequence:

>540_residues
MAAKIIKFKEDARQKILKGVRTLADAVKVTLGPKGRNVVIDKSYGTPHITKDGVTVAKEIELEDKFENMGAQMVKEVASK
TADKAGDGTTTATVLAEAIYSEGLRNVAAGANPLDLKRGMEKAVKVIVQELKKRSKTVDDRNEIAQVATISANNDAEIGE
MIAQAIEKVGRDGTITVEEGKGFETELDVVKGMKFDRGYLSAYFMTNSESQECILEDAYVLIYEKKISAIKEIIPLLQAV
VETGRPLLIIAEDVEGEALATLVVNRLRAGLKVCAVKAPGFGDRRKAMLQDIAILTGGELISEEIGLKLETTTIEQLGRV
KKAVLTKDETTLVEGAGTKAAILDRASQIKRQIEESTSDYDKEKLQERLAKLVGGVAVIHVGAATEIEMKEKKDRVDDAQ
RATAAAVEEGILPGGGTAFIRCIPAVNSLADSLEGDEKTGAKIMARSLSAPLRQIAENAGQEGAIILQAVEKMKEKEGYN
ALTGEYVDMITAGILDPTKVVRCALENAVSVAAMLLTTEAIVADIPEEKPAPAAPVGMDY

Sequences:

>Translated_540_residues
MAAKIIKFKEDARQKILKGVRTLADAVKVTLGPKGRNVVIDKSYGTPHITKDGVTVAKEIELEDKFENMGAQMVKEVASK
TADKAGDGTTTATVLAEAIYSEGLRNVAAGANPLDLKRGMEKAVKVIVQELKKRSKTVDDRNEIAQVATISANNDAEIGE
MIAQAIEKVGRDGTITVEEGKGFETELDVVKGMKFDRGYLSAYFMTNSESQECILEDAYVLIYEKKISAIKEIIPLLQAV
VETGRPLLIIAEDVEGEALATLVVNRLRAGLKVCAVKAPGFGDRRKAMLQDIAILTGGELISEEIGLKLETTTIEQLGRV
KKAVLTKDETTLVEGAGTKAAILDRASQIKRQIEESTSDYDKEKLQERLAKLVGGVAVIHVGAATEIEMKEKKDRVDDAQ
RATAAAVEEGILPGGGTAFIRCIPAVNSLADSLEGDEKTGAKIMARSLSAPLRQIAENAGQEGAIILQAVEKMKEKEGYN
ALTGEYVDMITAGILDPTKVVRCALENAVSVAAMLLTTEAIVADIPEEKPAPAAPVGMDY
>Mature_539_residues
AAKIIKFKEDARQKILKGVRTLADAVKVTLGPKGRNVVIDKSYGTPHITKDGVTVAKEIELEDKFENMGAQMVKEVASKT
ADKAGDGTTTATVLAEAIYSEGLRNVAAGANPLDLKRGMEKAVKVIVQELKKRSKTVDDRNEIAQVATISANNDAEIGEM
IAQAIEKVGRDGTITVEEGKGFETELDVVKGMKFDRGYLSAYFMTNSESQECILEDAYVLIYEKKISAIKEIIPLLQAVV
ETGRPLLIIAEDVEGEALATLVVNRLRAGLKVCAVKAPGFGDRRKAMLQDIAILTGGELISEEIGLKLETTTIEQLGRVK
KAVLTKDETTLVEGAGTKAAILDRASQIKRQIEESTSDYDKEKLQERLAKLVGGVAVIHVGAATEIEMKEKKDRVDDAQR
ATAAAVEEGILPGGGTAFIRCIPAVNSLADSLEGDEKTGAKIMARSLSAPLRQIAENAGQEGAIILQAVEKMKEKEGYNA
LTGEYVDMITAGILDPTKVVRCALENAVSVAAMLLTTEAIVADIPEEKPAPAAPVGMDY

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family

Homologues:

Organism=Homo sapiens, GI41399285, Length=531, Percent_Identity=53.6723163841808, Blast_Score=561, Evalue=1e-160,
Organism=Homo sapiens, GI31542947, Length=531, Percent_Identity=53.6723163841808, Blast_Score=561, Evalue=1e-160,
Organism=Escherichia coli, GI1790586, Length=531, Percent_Identity=62.3352165725047, Blast_Score=644, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=529, Percent_Identity=51.6068052930057, Blast_Score=521, Evalue=1e-148,
Organism=Caenorhabditis elegans, GI193210679, Length=209, Percent_Identity=49.7607655502392, Blast_Score=192, Evalue=5e-49,
Organism=Saccharomyces cerevisiae, GI6323288, Length=528, Percent_Identity=52.6515151515151, Blast_Score=539, Evalue=1e-154,
Organism=Saccharomyces cerevisiae, GI6322524, Length=155, Percent_Identity=27.741935483871, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24641193, Length=527, Percent_Identity=54.0796963946869, Blast_Score=557, Evalue=1e-159,
Organism=Drosophila melanogaster, GI24641191, Length=527, Percent_Identity=54.0796963946869, Blast_Score=557, Evalue=1e-159,
Organism=Drosophila melanogaster, GI45550936, Length=528, Percent_Identity=51.5151515151515, Blast_Score=534, Evalue=1e-152,
Organism=Drosophila melanogaster, GI45550132, Length=528, Percent_Identity=51.5151515151515, Blast_Score=534, Evalue=1e-152,
Organism=Drosophila melanogaster, GI45550935, Length=528, Percent_Identity=51.5151515151515, Blast_Score=534, Evalue=1e-152,
Organism=Drosophila melanogaster, GI17864606, Length=526, Percent_Identity=45.0570342205323, Blast_Score=467, Evalue=1e-131,
Organism=Drosophila melanogaster, GI24584129, Length=539, Percent_Identity=35.8070500927644, Blast_Score=326, Evalue=3e-89,
Organism=Drosophila melanogaster, GI19921262, Length=539, Percent_Identity=35.8070500927644, Blast_Score=326, Evalue=3e-89,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): CH602_PARUW (Q6MBZ5)

Other databases:

- EMBL:   BX908798
- RefSeq:   YP_008179.1
- ProteinModelPortal:   Q6MBZ5
- SMR:   Q6MBZ5
- STRING:   Q6MBZ5
- GeneID:   2780167
- GenomeReviews:   BX908798_GR
- KEGG:   pcu:pc1180
- NMPDR:   fig|264201.1.peg.1180
- eggNOG:   COG0459
- HOGENOM:   HBG625289
- OMA:   ENTTLAM
- PhylomeDB:   Q6MBZ5
- ProtClustDB:   PRK00013
- BioCyc:   CPRO264201:PC1180-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00600
- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423
- PANTHER:   PTHR11353
- PRINTS:   PR00298
- TIGRFAMs:   TIGR02348

Pfam domain/function: PF00118 Cpn60_TCP1; SSF48592 GroEL-ATPase

EC number: NA

Molecular weight: Translated: 57893; Mature: 57762

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAKIIKFKEDARQKILKGVRTLADAVKVTLGPKGRNVVIDKSYGTPHITKDGVTVAKEI
CCCCHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCEEEEECCCCCCCCCCCCCCHHHHC
ELEDKFENMGAQMVKEVASKTADKAGDGTTTATVLAEAIYSEGLRNVAAGANPLDLKRGM
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
EKAVKVIVQELKKRSKTVDDRNEIAQVATISANNDAEIGEMIAQAIEKVGRDGTITVEEG
HHHHHHHHHHHHHHHCCCCCHHHHHHHEEECCCCCHHHHHHHHHHHHHHCCCCEEEEECC
KGFETELDVVKGMKFDRGYLSAYFMTNSESQECILEDAYVLIYEKKISAIKEIIPLLQAV
CCCCHHHHHHHCCCCCCCCEEEEEEECCCCHHHHHHCCEEEEEHHHHHHHHHHHHHHHHH
VETGRPLLIIAEDVEGEALATLVVNRLRAGLKVCAVKAPGFGDRRKAMLQDIAILTGGEL
HHCCCCEEEEEECCCCHHHHHHHHHHHHCCHHEEEEECCCCCHHHHHHHHHHHHHCCCHH
ISEEIGLKLETTTIEQLGRVKKAVLTKDETTLVEGAGTKAAILDRASQIKRQIEESTSDY
HHHHHCCEEEHHHHHHHHHHHHHHHCCCCHHEEECCCCHHHHHHHHHHHHHHHHHHHCCC
DKEKLQERLAKLVGGVAVIHVGAATEIEMKEKKDRVDDAQRATAAAVEEGILPGGGTAFI
CHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
RCIPAVNSLADSLEGDEKTGAKIMARSLSAPLRQIAENAGQEGAIILQAVEKMKEKEGYN
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCC
ALTGEYVDMITAGILDPTKVVRCALENAVSVAAMLLTTEAIVADIPEEKPAPAAPVGMDY
CHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AAKIIKFKEDARQKILKGVRTLADAVKVTLGPKGRNVVIDKSYGTPHITKDGVTVAKEI
CCCHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCEEEEECCCCCCCCCCCCCCHHHHC
ELEDKFENMGAQMVKEVASKTADKAGDGTTTATVLAEAIYSEGLRNVAAGANPLDLKRGM
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
EKAVKVIVQELKKRSKTVDDRNEIAQVATISANNDAEIGEMIAQAIEKVGRDGTITVEEG
HHHHHHHHHHHHHHHCCCCCHHHHHHHEEECCCCCHHHHHHHHHHHHHHCCCCEEEEECC
KGFETELDVVKGMKFDRGYLSAYFMTNSESQECILEDAYVLIYEKKISAIKEIIPLLQAV
CCCCHHHHHHHCCCCCCCCEEEEEEECCCCHHHHHHCCEEEEEHHHHHHHHHHHHHHHHH
VETGRPLLIIAEDVEGEALATLVVNRLRAGLKVCAVKAPGFGDRRKAMLQDIAILTGGEL
HHCCCCEEEEEECCCCHHHHHHHHHHHHCCHHEEEEECCCCCHHHHHHHHHHHHHCCCHH
ISEEIGLKLETTTIEQLGRVKKAVLTKDETTLVEGAGTKAAILDRASQIKRQIEESTSDY
HHHHHCCEEEHHHHHHHHHHHHHHHCCCCHHEEECCCCHHHHHHHHHHHHHHHHHHHCCC
DKEKLQERLAKLVGGVAVIHVGAATEIEMKEKKDRVDDAQRATAAAVEEGILPGGGTAFI
CHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
RCIPAVNSLADSLEGDEKTGAKIMARSLSAPLRQIAENAGQEGAIILQAVEKMKEKEGYN
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCC
ALTGEYVDMITAGILDPTKVVRCALENAVSVAAMLLTTEAIVADIPEEKPAPAAPVGMDY
CHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA