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The map label for this gene is dld1 [H]

Identifier: 46446722

GI number: 46446722

Start: 1302350

End: 1303747

Strand: Reverse

Name: dld1 [H]

Synonym: pc1088

Alternate gene names: 46446722

Gene position: 1303747-1302350 (Counterclockwise)

Preceding gene: 46446723

Following gene: 46446714

Centisome position: 54.0

GC content: 39.63

Gene sequence:

>1398_bases
ATGGTTGAACACTATGATTTAGCAGTTGTTGGAGCTGGGCCAGGTGGGTATGTGGCAGCTATTCGAGCCGCTCAAATGGG
TTTAAAAACGATTTGTATTGATAAACGAGAAACGCTAGGAGGGACGTGTTTAAATGTGGGATGCATTCCCTCTAAAACTC
TTCTCCATTCTACAGATCTTTACTCAACATTGAAACAACATGGACTCGAACAAGCCATTGAAGTATCTGATTTAAAAGTC
AATTTTACAAAATTGATGGAACGTAAAAGAAATGTTGTCAAAGGATTGATTGAAGGGATTGCTTTACTTTTTAAAAAAAA
TGGGGTGATTTATTTAAAAGGAGAAGCGCAATTTTTGGATGCTCATACGCTTCAAGTGAAAAATGGAACTCATATAGATG
AAATTAAAGCTAATTATATTTTATTGGCAACAGGATCGGAGTCTACTTCATTACCTCATTTGCCTTTTGACGAAAAAAAT
ATTGTTTCTTCAACAGGGGCTTTAAATCTCGCTACTGTCCCTCCACGCTTACTCGTCATTGGAGGTGGAGTGATTGGGGT
AGAACTCGCTTCTGTCTACAATCGTCTGGGGTCTTCAGTGACAATTATTGAAATGTCAGATCGTCTTTGTCCTGCCATGG
ACATCGCATTATCCAAATACCTATTCCAAATTCTCAAAAAGCAGGGGATTGAAATTAAGTTGTCGACGAAAATGATGACA
GCTGTTTTGCAACCTAATGAAACGATTTTAACCATTGAACAAAACGAACAATTGCAAAATATTAGCGGGGAAGTGGTATT
AGTTGCTGTTGGTCGAAGACCCTATACCCAAGGATTAGCTTTAGATAAAGTTGGAATTCAAATAGATAAAAAAGGATTTA
TTCCCGTTGATGGATTTTTTCGTACATCTCAACCACATATCTTTGCGATTGGAGACCTTATTGAAGGTGTAATGCTTGCT
CATCGAGCTTCTCAAGAAGGAATCACTGTTGTGGAATGGCTAAAAGGGGAAAGGCAAAGTATCAATTATCTAGCTATTCC
AAATGTAGTCTATACGAATCCAGAAGTTGCTTCTGTGGGACTGACAGAGCAAGAAGCTAGCGAATCAGGACTCACTCTTT
TAACAGGAACAACCTATTTTAGAGGCAATTCTCGGGCTCGTTGCACGGATGAAATAGAAGGATTTGTGAAATTGATTGGC
GAAAAAAAATCGGGCCGTCTATTGGGAATGCATATCATAGGGGCTCATGCATCTGAGCTCATCGCAGTAGGAACTCTTGC
CATTCAAAAGCAAATCAATTTAAAAGATTTAGCCGAAACCGTGCAAGCTCATCCGACCCTCAGTGAAACTATCAAAGAGG
CTGCTCTGCAGGCTCTGGGAAAAGCCGTTCATGGGTAA

Upstream 100 bases:

>100_bases
ATGGAAAAGAGTCTGTCGCATTTTTAGTTCATATTAAAAATGCTTTAGAAGATCCTTCTCGCTTATTGTTAAATCTTTAA
AATGTAAGGAAATCACAAAT

Downstream 100 bases:

>100_bases
TATTTGAAAATTATTAAACCCTGTCTGTTGAAAAGTTAATAATCTGGGATGACGGACTTTGAAAATTAAGGTTTTTTTAA
GAAGTTTTATAGTTGTATAA

Product: dihydrolipoamide dehydrogenase precursor (E3 component of pyruvate dehydrogenase multi-enzyme complex)

Products: NA

Alternate protein names: E3 component of 2-oxoglutarate dehydrogenase complex; Glycine oxidation system L-factor; LPD-GLC [H]

Number of amino acids: Translated: 465; Mature: 465

Protein sequence:

>465_residues
MVEHYDLAVVGAGPGGYVAAIRAAQMGLKTICIDKRETLGGTCLNVGCIPSKTLLHSTDLYSTLKQHGLEQAIEVSDLKV
NFTKLMERKRNVVKGLIEGIALLFKKNGVIYLKGEAQFLDAHTLQVKNGTHIDEIKANYILLATGSESTSLPHLPFDEKN
IVSSTGALNLATVPPRLLVIGGGVIGVELASVYNRLGSSVTIIEMSDRLCPAMDIALSKYLFQILKKQGIEIKLSTKMMT
AVLQPNETILTIEQNEQLQNISGEVVLVAVGRRPYTQGLALDKVGIQIDKKGFIPVDGFFRTSQPHIFAIGDLIEGVMLA
HRASQEGITVVEWLKGERQSINYLAIPNVVYTNPEVASVGLTEQEASESGLTLLTGTTYFRGNSRARCTDEIEGFVKLIG
EKKSGRLLGMHIIGAHASELIAVGTLAIQKQINLKDLAETVQAHPTLSETIKEAALQALGKAVHG

Sequences:

>Translated_465_residues
MVEHYDLAVVGAGPGGYVAAIRAAQMGLKTICIDKRETLGGTCLNVGCIPSKTLLHSTDLYSTLKQHGLEQAIEVSDLKV
NFTKLMERKRNVVKGLIEGIALLFKKNGVIYLKGEAQFLDAHTLQVKNGTHIDEIKANYILLATGSESTSLPHLPFDEKN
IVSSTGALNLATVPPRLLVIGGGVIGVELASVYNRLGSSVTIIEMSDRLCPAMDIALSKYLFQILKKQGIEIKLSTKMMT
AVLQPNETILTIEQNEQLQNISGEVVLVAVGRRPYTQGLALDKVGIQIDKKGFIPVDGFFRTSQPHIFAIGDLIEGVMLA
HRASQEGITVVEWLKGERQSINYLAIPNVVYTNPEVASVGLTEQEASESGLTLLTGTTYFRGNSRARCTDEIEGFVKLIG
EKKSGRLLGMHIIGAHASELIAVGTLAIQKQINLKDLAETVQAHPTLSETIKEAALQALGKAVHG
>Mature_465_residues
MVEHYDLAVVGAGPGGYVAAIRAAQMGLKTICIDKRETLGGTCLNVGCIPSKTLLHSTDLYSTLKQHGLEQAIEVSDLKV
NFTKLMERKRNVVKGLIEGIALLFKKNGVIYLKGEAQFLDAHTLQVKNGTHIDEIKANYILLATGSESTSLPHLPFDEKN
IVSSTGALNLATVPPRLLVIGGGVIGVELASVYNRLGSSVTIIEMSDRLCPAMDIALSKYLFQILKKQGIEIKLSTKMMT
AVLQPNETILTIEQNEQLQNISGEVVLVAVGRRPYTQGLALDKVGIQIDKKGFIPVDGFFRTSQPHIFAIGDLIEGVMLA
HRASQEGITVVEWLKGERQSINYLAIPNVVYTNPEVASVGLTEQEASESGLTLLTGTTYFRGNSRARCTDEIEGFVKLIG
EKKSGRLLGMHIIGAHASELIAVGTLAIQKQINLKDLAETVQAHPTLSETIKEAALQALGKAVHG

Specific function: Also acts in the glycine cleavage system [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=470, Percent_Identity=44.6808510638298, Blast_Score=391, Evalue=1e-109,
Organism=Homo sapiens, GI50301238, Length=468, Percent_Identity=29.0598290598291, Blast_Score=155, Evalue=7e-38,
Organism=Homo sapiens, GI148277071, Length=467, Percent_Identity=26.9807280513919, Blast_Score=142, Evalue=1e-33,
Organism=Homo sapiens, GI33519430, Length=468, Percent_Identity=27.3504273504274, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI33519428, Length=468, Percent_Identity=27.3504273504274, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI33519426, Length=468, Percent_Identity=27.3504273504274, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI148277065, Length=467, Percent_Identity=26.9807280513919, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI22035672, Length=456, Percent_Identity=29.3859649122807, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI291045266, Length=441, Percent_Identity=25.8503401360544, Blast_Score=125, Evalue=9e-29,
Organism=Homo sapiens, GI291045268, Length=429, Percent_Identity=24.2424242424242, Blast_Score=103, Evalue=5e-22,
Organism=Escherichia coli, GI1786307, Length=450, Percent_Identity=38.6666666666667, Blast_Score=306, Evalue=2e-84,
Organism=Escherichia coli, GI87082354, Length=467, Percent_Identity=28.2655246252677, Blast_Score=195, Evalue=4e-51,
Organism=Escherichia coli, GI1789915, Length=463, Percent_Identity=30.0215982721382, Blast_Score=182, Evalue=3e-47,
Organism=Escherichia coli, GI87081717, Length=455, Percent_Identity=28.3516483516484, Blast_Score=180, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI32565766, Length=466, Percent_Identity=46.5665236051502, Blast_Score=393, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI17557007, Length=470, Percent_Identity=27.4468085106383, Blast_Score=144, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI71983429, Length=441, Percent_Identity=28.3446712018141, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI71983419, Length=441, Percent_Identity=28.3446712018141, Blast_Score=132, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI71982272, Length=485, Percent_Identity=23.5051546391753, Blast_Score=100, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6321091, Length=475, Percent_Identity=45.4736842105263, Blast_Score=395, Evalue=1e-111,
Organism=Saccharomyces cerevisiae, GI6325240, Length=479, Percent_Identity=32.9853862212944, Blast_Score=243, Evalue=7e-65,
Organism=Saccharomyces cerevisiae, GI6325166, Length=461, Percent_Identity=26.6811279826464, Blast_Score=155, Evalue=1e-38,
Organism=Drosophila melanogaster, GI21358499, Length=465, Percent_Identity=45.1612903225806, Blast_Score=388, Evalue=1e-108,
Organism=Drosophila melanogaster, GI17737741, Length=478, Percent_Identity=28.0334728033473, Blast_Score=149, Evalue=4e-36,
Organism=Drosophila melanogaster, GI24640553, Length=482, Percent_Identity=26.7634854771784, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24640549, Length=482, Percent_Identity=26.7634854771784, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24640551, Length=482, Percent_Identity=26.7634854771784, Blast_Score=140, Evalue=2e-33,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006258
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.4 [H]

Molecular weight: Translated: 50225; Mature: 50225

Theoretical pI: Translated: 7.37; Mature: 7.37

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVEHYDLAVVGAGPGGYVAAIRAAQMGLKTICIDKRETLGGTCLNVGCIPSKTLLHSTDL
CCCEEEEEEEECCCCCHHHHHHHHHHCCCEEEECCCCCCCCEEEEECCCCCCHHHHHHHH
YSTLKQHGLEQAIEVSDLKVNFTKLMERKRNVVKGLIEGIALLFKKNGVIYLKGEAQFLD
HHHHHHCCHHHHHHHHCEEEEHHHHHHHHHHHHHHHHHHHHHHEECCCEEEEECCCEEEE
AHTLQVKNGTHIDEIKANYILLATGSESTSLPHLPFDEKNIVSSTGALNLATVPPRLLVI
EEEEEECCCCCHHEECCCEEEEEECCCCCCCCCCCCCCCCHHCCCCCEEEEECCCEEEEE
GGGVIGVELASVYNRLGSSVTIIEMSDRLCPAMDIALSKYLFQILKKQGIEIKLSTKMMT
ECCHHHHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCEEEEEHHEEE
AVLQPNETILTIEQNEQLQNISGEVVLVAVGRRPYTQGLALDKVGIQIDKKGFIPVDGFF
EEECCCCEEEEEECCCHHHCCCCCEEEEEECCCCCCCCCEEEECCEEECCCCCCCCCCCE
RTSQPHIFAIGDLIEGVMLAHRASQEGITVVEWLKGERQSINYLAIPNVVYTNPEVASVG
ECCCCCEEEHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCEEEECCEEECCCCEEEEC
LTEQEASESGLTLLTGTTYFRGNSRARCTDEIEGFVKLIGEKKSGRLLGMHIIGAHASEL
CCHHHHCCCCCEEEEEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCCHHHH
IAVGTLAIQKQINLKDLAETVQAHPTLSETIKEAALQALGKAVHG
HHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVEHYDLAVVGAGPGGYVAAIRAAQMGLKTICIDKRETLGGTCLNVGCIPSKTLLHSTDL
CCCEEEEEEEECCCCCHHHHHHHHHHCCCEEEECCCCCCCCEEEEECCCCCCHHHHHHHH
YSTLKQHGLEQAIEVSDLKVNFTKLMERKRNVVKGLIEGIALLFKKNGVIYLKGEAQFLD
HHHHHHCCHHHHHHHHCEEEEHHHHHHHHHHHHHHHHHHHHHHEECCCEEEEECCCEEEE
AHTLQVKNGTHIDEIKANYILLATGSESTSLPHLPFDEKNIVSSTGALNLATVPPRLLVI
EEEEEECCCCCHHEECCCEEEEEECCCCCCCCCCCCCCCCHHCCCCCEEEEECCCEEEEE
GGGVIGVELASVYNRLGSSVTIIEMSDRLCPAMDIALSKYLFQILKKQGIEIKLSTKMMT
ECCHHHHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCEEEEEHHEEE
AVLQPNETILTIEQNEQLQNISGEVVLVAVGRRPYTQGLALDKVGIQIDKKGFIPVDGFF
EEECCCCEEEEEECCCHHHCCCCCEEEEEECCCCCCCCCEEEECCEEECCCCCCCCCCCE
RTSQPHIFAIGDLIEGVMLAHRASQEGITVVEWLKGERQSINYLAIPNVVYTNPEVASVG
ECCCCCEEEHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCEEEECCEEECCCCEEEEC
LTEQEASESGLTLLTGTTYFRGNSRARCTDEIEGFVKLIGEKKSGRLLGMHIIGAHASEL
CCHHHHCCCCCEEEEEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCCHHHH
IAVGTLAIQKQINLKDLAETVQAHPTLSETIKEAALQALGKAVHG
HHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1902462; 2914869 [H]