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The map label for this gene is tdh

Identifier: 46446444

GI number: 46446444

Start: 991301

End: 992329

Strand: Reverse

Name: tdh

Synonym: pc0810

Alternate gene names: 46446444

Gene position: 992329-991301 (Counterclockwise)

Preceding gene: 46446445

Following gene: 46446442

Centisome position: 41.1

GC content: 38.58

Gene sequence:

>1029_bases
ATGAAAGGTTTAGTCAAGAAAATATCAGCTCCCGGTCTTTGGATGGAAAATCTGCCAATACCGTCGCATGTGAAAGATGA
TGAAGTTCTGATTAAAACAATTAAAACATCCATCTGTGGCACCGATGTTCATATTTATAAATGGGATGCTTGGGCGCAGA
AAAATGTTCCTGTGCCTTTGGTGATTGGTCATGAATTTATCGGTGAAATAGCAGAATTTGGAAAAAATGTTAAAGGATTT
AAAATTGGAGAACGAGTATGCGGGGAAGGACATATCGTTTGTAATCAATGCCCAAATTGCCGCATGGGTCGTAAGCATGT
CTGCATGCACACGAAAGGGCTAGGTTATCATATTTCTGGCTGCTTTGCTGAATATTTTGTTCTTCCTGCAGAAAATGTTT
TTTCTCTACCCCCTTCCATTTCTGATGATTTAGGCGCCATCTTCGACCCTTACGGAAATGCTGTCCATACTACGCTCGCC
TTTAATCTTATTGGTGAAGATGTTCTTATTACAGGTGCTGGCCCAATTGGAATCATGGCAGCCGCCATTGCTAAACAAGC
TGGTGCAAGACATATTGTCATCACAGATGTAAACGATTATCGTCTAGACCTTGCAAGAACTATGGGTGTCTCGCATGCTA
TTAATGTTAATCGAGAATCTTTAGATAATTTTATGCAATCTCTAGGAATCAAATATGGCTTTACAGTTGGACTTGAGATG
TCTGGCCATCCTGACGGACTAAAAACTTTAACGGAAAAAATTCGACATGGAGGAAACATCGCATTACTTGGCATTCTCCC
ACCAGCTACTTCTATTGACTGGAATTTAGTTATTTTTAAAATGTTAACTTTAAAAGGGATTTATGGAAGAGAAATTTTCT
CAACCTGGTATCAGATGGTTCACCTTCTGGAAATTGGCTTAAATTTAGCTCCTATCATTACCCATCATTTTTCAGTTGAT
AATTTTGAAAAAGGATTTGAAGTGATGTTATCAGGCCAATCAGGTAAAGTGATTCTTGATTGGGTTTAA

Upstream 100 bases:

>100_bases
GATATTTTAATTTCTGATTGCAAAGTGAAATGAATTTGTAATCATTTCGTATGCTGACTATAATGGTCCCTCCTCAAAAA
ATCACATTGAAGGTCTTTTT

Downstream 100 bases:

>100_bases
CCTTTTCCCCTGCATAAAATTTTTGATGCAGTTTACAAAATAATTATTAATAATTAAAAAATTATTGTGTCCAAAAACGG
ATGAAAAAAACATCGAATTT

Product: L-threonine 3-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 342; Mature: 342

Protein sequence:

>342_residues
MKGLVKKISAPGLWMENLPIPSHVKDDEVLIKTIKTSICGTDVHIYKWDAWAQKNVPVPLVIGHEFIGEIAEFGKNVKGF
KIGERVCGEGHIVCNQCPNCRMGRKHVCMHTKGLGYHISGCFAEYFVLPAENVFSLPPSISDDLGAIFDPYGNAVHTTLA
FNLIGEDVLITGAGPIGIMAAAIAKQAGARHIVITDVNDYRLDLARTMGVSHAINVNRESLDNFMQSLGIKYGFTVGLEM
SGHPDGLKTLTEKIRHGGNIALLGILPPATSIDWNLVIFKMLTLKGIYGREIFSTWYQMVHLLEIGLNLAPIITHHFSVD
NFEKGFEVMLSGQSGKVILDWV

Sequences:

>Translated_342_residues
MKGLVKKISAPGLWMENLPIPSHVKDDEVLIKTIKTSICGTDVHIYKWDAWAQKNVPVPLVIGHEFIGEIAEFGKNVKGF
KIGERVCGEGHIVCNQCPNCRMGRKHVCMHTKGLGYHISGCFAEYFVLPAENVFSLPPSISDDLGAIFDPYGNAVHTTLA
FNLIGEDVLITGAGPIGIMAAAIAKQAGARHIVITDVNDYRLDLARTMGVSHAINVNRESLDNFMQSLGIKYGFTVGLEM
SGHPDGLKTLTEKIRHGGNIALLGILPPATSIDWNLVIFKMLTLKGIYGREIFSTWYQMVHLLEIGLNLAPIITHHFSVD
NFEKGFEVMLSGQSGKVILDWV
>Mature_342_residues
MKGLVKKISAPGLWMENLPIPSHVKDDEVLIKTIKTSICGTDVHIYKWDAWAQKNVPVPLVIGHEFIGEIAEFGKNVKGF
KIGERVCGEGHIVCNQCPNCRMGRKHVCMHTKGLGYHISGCFAEYFVLPAENVFSLPPSISDDLGAIFDPYGNAVHTTLA
FNLIGEDVLITGAGPIGIMAAAIAKQAGARHIVITDVNDYRLDLARTMGVSHAINVNRESLDNFMQSLGIKYGFTVGLEM
SGHPDGLKTLTEKIRHGGNIALLGILPPATSIDWNLVIFKMLTLKGIYGREIFSTWYQMVHLLEIGLNLAPIITHHFSVD
NFEKGFEVMLSGQSGKVILDWV

Specific function: Threonine catabolism; first step. [C]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family

Homologues:

Organism=Homo sapiens, GI156627571, Length=343, Percent_Identity=27.1137026239067, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI71743840, Length=380, Percent_Identity=25, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI262073058, Length=378, Percent_Identity=24.8677248677249, Blast_Score=86, Evalue=7e-17,
Organism=Homo sapiens, GI4501929, Length=380, Percent_Identity=22.6315789473684, Blast_Score=73, Evalue=4e-13,
Organism=Escherichia coli, GI1790045, Length=341, Percent_Identity=60.4105571847507, Blast_Score=451, Evalue=1e-128,
Organism=Escherichia coli, GI1787863, Length=302, Percent_Identity=30.4635761589404, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1788075, Length=366, Percent_Identity=27.8688524590164, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI226510992, Length=262, Percent_Identity=31.2977099236641, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1788073, Length=331, Percent_Identity=26.5861027190332, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1788407, Length=336, Percent_Identity=30.0595238095238, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI87082125, Length=333, Percent_Identity=29.1291291291291, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1790718, Length=309, Percent_Identity=24.9190938511327, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1786825, Length=377, Percent_Identity=26.790450928382, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI1786552, Length=376, Percent_Identity=26.5957446808511, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI87081918, Length=283, Percent_Identity=25.4416961130742, Blast_Score=80, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17562876, Length=321, Percent_Identity=30.2180685358255, Blast_Score=150, Evalue=7e-37,
Organism=Caenorhabditis elegans, GI17562878, Length=332, Percent_Identity=30.421686746988, Blast_Score=138, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI17562582, Length=118, Percent_Identity=34.7457627118644, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71988145, Length=192, Percent_Identity=29.6875, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6323099, Length=329, Percent_Identity=29.7872340425532, Blast_Score=134, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6322619, Length=326, Percent_Identity=28.5276073619632, Blast_Score=132, Evalue=7e-32,
Organism=Saccharomyces cerevisiae, GI6319955, Length=326, Percent_Identity=28.2208588957055, Blast_Score=130, Evalue=4e-31,
Organism=Saccharomyces cerevisiae, GI6319258, Length=365, Percent_Identity=28.4931506849315, Blast_Score=105, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6319257, Length=262, Percent_Identity=27.8625954198473, Blast_Score=85, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6324486, Length=348, Percent_Identity=27.8735632183908, Blast_Score=73, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6323961, Length=336, Percent_Identity=26.7857142857143, Blast_Score=67, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6319621, Length=193, Percent_Identity=30.0518134715026, Blast_Score=65, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6323980, Length=210, Percent_Identity=30.952380952381, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17737897, Length=336, Percent_Identity=27.3809523809524, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI17137530, Length=347, Percent_Identity=28.2420749279539, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI17737895, Length=359, Percent_Identity=24.7910863509749, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI221457811, Length=187, Percent_Identity=29.9465240641711, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI45550770, Length=187, Percent_Identity=29.9465240641711, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI45551930, Length=187, Percent_Identity=29.9465240641711, Blast_Score=77, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TDH_PARUW (Q6MD15)

Other databases:

- EMBL:   BX908798
- RefSeq:   YP_007809.1
- ProteinModelPortal:   Q6MD15
- SMR:   Q6MD15
- STRING:   Q6MD15
- GeneID:   2781402
- GenomeReviews:   BX908798_GR
- KEGG:   pcu:pc0810
- NMPDR:   fig|264201.1.peg.810
- eggNOG:   COG1063
- HOGENOM:   HBG753318
- OMA:   VCGRCRN
- PhylomeDB:   Q6MD15
- ProtClustDB:   PRK05396
- BioCyc:   CPRO264201:PC0810-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00627
- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR004627
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR11695

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N; SSF50129 GroES_like

EC number: =1.1.1.103

Molecular weight: Translated: 37546; Mature: 37546

Theoretical pI: Translated: 7.06; Mature: 7.06

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGLVKKISAPGLWMENLPIPSHVKDDEVLIKTIKTSICGTDVHIYKWDAWAQKNVPVPL
CCCHHHHHCCCCCEEECCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEE
VIGHEFIGEIAEFGKNVKGFKIGERVCGEGHIVCNQCPNCRMGRKHVCMHTKGLGYHISG
EECHHHHHHHHHHCCCCCCEEHHHHHCCCCCEEECCCCCCCCCCCEEEEEECCCCEEHHH
CFAEYFVLPAENVFSLPPSISDDLGAIFDPYGNAVHTTLAFNLIGEDVLITGAGPIGIMA
HHHHHEECCCCHHCCCCCCCCCCHHHHCCCCCCCEEHHEEEEECCCEEEEECCCHHHHHH
AAIAKQAGARHIVITDVNDYRLDLARTMGVSHAINVNRESLDNFMQSLGIKYGFTVGLEM
HHHHHHCCCCEEEEECCCHHHHHHHHHHCCHHEECCCHHHHHHHHHHCCCCCCEEEEEEE
SGHPDGLKTLTEKIRHGGNIALLGILPPATSIDWNLVIFKMLTLKGIYGREIFSTWYQMV
CCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHH
HLLEIGLNLAPIITHHFSVDNFEKGFEVMLSGQSGKVILDWV
HHHHHCCCHHHHHHEECCCCCCCCCEEEEEECCCCCEEEEEC
>Mature Secondary Structure
MKGLVKKISAPGLWMENLPIPSHVKDDEVLIKTIKTSICGTDVHIYKWDAWAQKNVPVPL
CCCHHHHHCCCCCEEECCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEE
VIGHEFIGEIAEFGKNVKGFKIGERVCGEGHIVCNQCPNCRMGRKHVCMHTKGLGYHISG
EECHHHHHHHHHHCCCCCCEEHHHHHCCCCCEEECCCCCCCCCCCEEEEEECCCCEEHHH
CFAEYFVLPAENVFSLPPSISDDLGAIFDPYGNAVHTTLAFNLIGEDVLITGAGPIGIMA
HHHHHEECCCCHHCCCCCCCCCCHHHHCCCCCCCEEHHEEEEECCCEEEEECCCHHHHHH
AAIAKQAGARHIVITDVNDYRLDLARTMGVSHAINVNRESLDNFMQSLGIKYGFTVGLEM
HHHHHHCCCCEEEEECCCHHHHHHHHHHCCHHEECCCHHHHHHHHHHCCCCCCEEEEEEE
SGHPDGLKTLTEKIRHGGNIALLGILPPATSIDWNLVIFKMLTLKGIYGREIFSTWYQMV
CCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHH
HLLEIGLNLAPIITHHFSVDNFEKGFEVMLSGQSGKVILDWV
HHHHHCCCHHHHHHEECCCCCCCCCEEEEEECCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA