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The map label for this gene is map1 [H]

Identifier: 46446414

GI number: 46446414

Start: 961910

End: 962797

Strand: Reverse

Name: map1 [H]

Synonym: pc0780

Alternate gene names: 46446414

Gene position: 962797-961910 (Counterclockwise)

Preceding gene: 46446418

Following gene: 46446410

Centisome position: 39.88

GC content: 38.18

Gene sequence:

>888_bases
ATGATCGGTAGAAACGATATATGTTGGTGTGGAAGTGGTCAAAAATGGAAAAAATGTCATTATCCAAATGAAAGCTCTCC
ACAAAGAAAATCTAAAGAAAGCACCCGTGAAGAATACTTACGCCAACATCGCATCATTATTAAAGATCAAAAACAAATTG
ATGGAATCCGAGCATCTTGTCATCTAGCAAGTCGTATCTTAGAAGCAGCATGCGCTAAAGCAAAAGTGGGTGTCACAACA
CAAGAGCTCAATGATTACGCTCATAAACTGCATGATGCTGCAGGTGCGATTCCAGCTCCTTTAAATTATGGGCATCCTCC
CTTTCCCAAAAGTATTTGTACCTCTTTAAATGATGTTATTTGCCATGGCATTCCAAATGAAATTCCTCTTAAAGAGGGTG
ATATTTTAAATATTGACGTGACATGCATTTTAAATGGTTATTATGGCGACTGCAGTGCCATGGTGATGATTGGCGAAGTT
GACACAGAAAAACGACTCGTTGTTGACGTCTCTTATAATTGTTTAATGTGTGCGATAGAGATAATAAAACCAGGGATTGC
CATTTCAGCAATTGGAGAGGTAATAGAAAATTATGCTCATTCAAAGAACTGTTCAGTTGTTTATCAATTTGTTGGGCATG
GTGTCGGTATCAATTTTCATGAAGGACCTCAAATTTCTCATCATCGCAATTATAATTCTATTCTTCTCGTTCCTGGGATG
ACATTTACAATTGAACCGATGATCAATGCTGGTTCAAGAGAAGCAATTATTGATCCTATTGACCAGTGGACGGCAAGAAC
AAAAGACGGGAAAGCAAGTGCACAGTGGGAACACACGCTTTTAGTCACAGAAGATGGTCATGAAATTTTGACAAATTGGA
AAAGATAG

Upstream 100 bases:

>100_bases
TTTTGCAAACTTTGTTTAGCATATGAAGGTTGCTTAAAAGATAATTTTTTAGATATCCTTATTTTAAATAAGGATTATTG
AATGCAGAAAGGAATTTTTT

Downstream 100 bases:

>100_bases
TTTTTGTAAGTTTATTCGAATTTCAATAGTTATTTCTTGCTTTTATAGCTAAATTTTTGATTCAGTCTCAAATCAACCTC
TCACTATTTGGTGTAAAGCT

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MIGRNDICWCGSGQKWKKCHYPNESSPQRKSKESTREEYLRQHRIIIKDQKQIDGIRASCHLASRILEAACAKAKVGVTT
QELNDYAHKLHDAAGAIPAPLNYGHPPFPKSICTSLNDVICHGIPNEIPLKEGDILNIDVTCILNGYYGDCSAMVMIGEV
DTEKRLVVDVSYNCLMCAIEIIKPGIAISAIGEVIENYAHSKNCSVVYQFVGHGVGINFHEGPQISHHRNYNSILLVPGM
TFTIEPMINAGSREAIIDPIDQWTARTKDGKASAQWEHTLLVTEDGHEILTNWKR

Sequences:

>Translated_295_residues
MIGRNDICWCGSGQKWKKCHYPNESSPQRKSKESTREEYLRQHRIIIKDQKQIDGIRASCHLASRILEAACAKAKVGVTT
QELNDYAHKLHDAAGAIPAPLNYGHPPFPKSICTSLNDVICHGIPNEIPLKEGDILNIDVTCILNGYYGDCSAMVMIGEV
DTEKRLVVDVSYNCLMCAIEIIKPGIAISAIGEVIENYAHSKNCSVVYQFVGHGVGINFHEGPQISHHRNYNSILLVPGM
TFTIEPMINAGSREAIIDPIDQWTARTKDGKASAQWEHTLLVTEDGHEILTNWKR
>Mature_295_residues
MIGRNDICWCGSGQKWKKCHYPNESSPQRKSKESTREEYLRQHRIIIKDQKQIDGIRASCHLASRILEAACAKAKVGVTT
QELNDYAHKLHDAAGAIPAPLNYGHPPFPKSICTSLNDVICHGIPNEIPLKEGDILNIDVTCILNGYYGDCSAMVMIGEV
DTEKRLVVDVSYNCLMCAIEIIKPGIAISAIGEVIENYAHSKNCSVVYQFVGHGVGINFHEGPQISHHRNYNSILLVPGM
TFTIEPMINAGSREAIIDPIDQWTARTKDGKASAQWEHTLLVTEDGHEILTNWKR

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=250, Percent_Identity=44.8, Blast_Score=215, Evalue=4e-56,
Organism=Homo sapiens, GI40385867, Length=247, Percent_Identity=43.3198380566802, Blast_Score=201, Evalue=6e-52,
Organism=Escherichia coli, GI1786364, Length=256, Percent_Identity=42.1875, Blast_Score=194, Evalue=6e-51,
Organism=Caenorhabditis elegans, GI71996291, Length=267, Percent_Identity=41.1985018726592, Blast_Score=197, Evalue=5e-51,
Organism=Saccharomyces cerevisiae, GI6323273, Length=253, Percent_Identity=46.2450592885375, Blast_Score=219, Evalue=5e-58,
Organism=Drosophila melanogaster, GI24583427, Length=246, Percent_Identity=45.5284552845528, Blast_Score=216, Evalue=1e-56,
Organism=Drosophila melanogaster, GI21355531, Length=259, Percent_Identity=42.0849420849421, Blast_Score=202, Evalue=3e-52,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467
- InterPro:   IPR004027 [H]

Pfam domain/function: PF00557 Peptidase_M24; PF02810 SEC-C [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 32816; Mature: 32816

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: PS00680 MAP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.1 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
4.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGRNDICWCGSGQKWKKCHYPNESSPQRKSKESTREEYLRQHRIIIKDQKQIDGIRASC
CCCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCEEEECCHHHCHHHHHH
HLASRILEAACAKAKVGVTTQELNDYAHKLHDAAGAIPAPLNYGHPPFPKSICTSLNDVI
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHH
CHGIPNEIPLKEGDILNIDVTCILNGYYGDCSAMVMIGEVDTEKRLVVDVSYNCLMCAIE
HCCCCCCCCCCCCCEEEEEEEEEEECCCCCCEEEEEEEECCCCCEEEEEECCHHHHHHHH
IIKPGIAISAIGEVIENYAHSKNCSVVYQFVGHGVGINFHEGPQISHHRNYNSILLVPGM
HHCCCHHHHHHHHHHHHHHCCCCCHHHEEEHHCCCCCCCCCCCCCCCCCCCCEEEEECCC
TFTIEPMINAGSREAIIDPIDQWTARTKDGKASAQWEHTLLVTEDGHEILTNWKR
EEEEEECCCCCCCCCCCCCHHHHHCCCCCCCCCCCEEEEEEEECCCHHHHCCCCC
>Mature Secondary Structure
MIGRNDICWCGSGQKWKKCHYPNESSPQRKSKESTREEYLRQHRIIIKDQKQIDGIRASC
CCCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCEEEECCHHHCHHHHHH
HLASRILEAACAKAKVGVTTQELNDYAHKLHDAAGAIPAPLNYGHPPFPKSICTSLNDVI
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHH
CHGIPNEIPLKEGDILNIDVTCILNGYYGDCSAMVMIGEVDTEKRLVVDVSYNCLMCAIE
HCCCCCCCCCCCCCEEEEEEEEEEECCCCCCEEEEEEEECCCCCEEEEEECCHHHHHHHH
IIKPGIAISAIGEVIENYAHSKNCSVVYQFVGHGVGINFHEGPQISHHRNYNSILLVPGM
HHCCCHHHHHHHHHHHHHHCCCCCHHHEEEHHCCCCCCCCCCCCCCCCCCCCEEEEECCC
TFTIEPMINAGSREAIIDPIDQWTARTKDGKASAQWEHTLLVTEDGHEILTNWKR
EEEEEECCCCCCCCCCCCCHHHHHCCCCCCCCCCCEEEEEEEECCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10684935 [H]