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The map label for this gene is clpP

Identifier: 46446077

GI number: 46446077

Start: 571955

End: 572575

Strand: Reverse

Name: clpP

Synonym: pc0443

Alternate gene names: 46446077

Gene position: 572575-571955 (Counterclockwise)

Preceding gene: 46446078

Following gene: 46446076

Centisome position: 23.71

GC content: 39.13

Gene sequence:

>621_bases
TTGACTCGGGAGACTTCCATGCCCAAACATGATAAAAACAAAAGTGCCATTCCTTCTAAAATGGCAGATCGTATTGAACA
TGCTATACTAGATTCTAGAAGAATTTTTATTTCTGATGCTGTTGATAGTGGATCGGCAAGTGAAATTATTCGCAAGCTTT
GGTATCTCGAATTAACAGATCCTGGCAAACCAATTTTATTCGTCATTAATAGTCCAGGTGGCGCTGTTGATTCAGGATTT
GCGATCTGGGATCAAATCAAAATGATTACTTCCCCTGTAACAACATTGGTTACTGGATTAGCCGCTTCAATGGGTTCTAT
TTTAAGCCTTTGCGCTTCCCCTGGACGCCGATTCGCAACACCTCATTCTAGAATCATGATCCACCAACCTCTTTTATCCG
GAGTAATTAAAGGGCAAGCAACAGACTTGGAGATTCAAGCAAAAGAGATGCTAAAAACTAGAAATGGATTGATTGAAATC
TACGTACAAGCAACGGGGAAAAATTTTGCTGCCATAGAAAAAGCAATTGATCGAGATACATGGATGACAGCACAAGAAGC
CTTAGAATTTGGACTACTCGATAAAGTGATTAATAGCTTTGAAGAGATTGAATCCACTTAA

Upstream 100 bases:

>100_bases
GATTTAGAGTTTGACACAATCAAACATTTTTTCTTATTTTGCGCCTTTAGAACTTGAAAAAGGATATCAGAAATCATAAG
ATACAACTAAAAAATGAGTT

Downstream 100 bases:

>100_bases
AAAAACTTATGCAGTGGTCTTTTACTAAATATGTGGGATGTGGAAATGATTTCATTCTTTTTGATAATCGAAATGGTAAA
TTTCCATTTTCCATCCCTCT

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp 1

Number of amino acids: Translated: 206; Mature: 205

Protein sequence:

>206_residues
MTRETSMPKHDKNKSAIPSKMADRIEHAILDSRRIFISDAVDSGSASEIIRKLWYLELTDPGKPILFVINSPGGAVDSGF
AIWDQIKMITSPVTTLVTGLAASMGSILSLCASPGRRFATPHSRIMIHQPLLSGVIKGQATDLEIQAKEMLKTRNGLIEI
YVQATGKNFAAIEKAIDRDTWMTAQEALEFGLLDKVINSFEEIEST

Sequences:

>Translated_206_residues
MTRETSMPKHDKNKSAIPSKMADRIEHAILDSRRIFISDAVDSGSASEIIRKLWYLELTDPGKPILFVINSPGGAVDSGF
AIWDQIKMITSPVTTLVTGLAASMGSILSLCASPGRRFATPHSRIMIHQPLLSGVIKGQATDLEIQAKEMLKTRNGLIEI
YVQATGKNFAAIEKAIDRDTWMTAQEALEFGLLDKVINSFEEIEST
>Mature_205_residues
TRETSMPKHDKNKSAIPSKMADRIEHAILDSRRIFISDAVDSGSASEIIRKLWYLELTDPGKPILFVINSPGGAVDSGFA
IWDQIKMITSPVTTLVTGLAASMGSILSLCASPGRRFATPHSRIMIHQPLLSGVIKGQATDLEIQAKEMLKTRNGLIEIY
VQATGKNFAAIEKAIDRDTWMTAQEALEFGLLDKVINSFEEIEST

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family

Homologues:

Organism=Homo sapiens, GI5174419, Length=169, Percent_Identity=44.9704142011834, Blast_Score=150, Evalue=7e-37,
Organism=Escherichia coli, GI1786641, Length=169, Percent_Identity=40.8284023668639, Blast_Score=145, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI17538017, Length=168, Percent_Identity=45.8333333333333, Blast_Score=149, Evalue=1e-36,
Organism=Drosophila melanogaster, GI20129427, Length=169, Percent_Identity=37.8698224852071, Blast_Score=130, Evalue=8e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPP1_PARUW (Q6ME32)

Other databases:

- EMBL:   BX908798
- RefSeq:   YP_007442.1
- ProteinModelPortal:   Q6ME32
- SMR:   Q6ME32
- STRING:   Q6ME32
- MEROPS:   S14.005
- GeneID:   2780284
- GenomeReviews:   BX908798_GR
- KEGG:   pcu:pc0443
- NMPDR:   fig|264201.1.peg.443
- eggNOG:   COG0740
- HOGENOM:   HBG558421
- OMA:   FSEPVTD
- ProtClustDB:   PRK12553
- BioCyc:   CPRO264201:PC0443-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00444
- InterPro:   IPR001907
- InterPro:   IPR018215
- PANTHER:   PTHR10381
- PRINTS:   PR00127

Pfam domain/function: PF00574 CLP_protease

EC number: =3.4.21.92

Molecular weight: Translated: 22617; Mature: 22486

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS00382 CLP_PROTEASE_HIS; PS00381 CLP_PROTEASE_SER

Important sites: ACT_SITE 103-103 ACT_SITE 128-128

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRETSMPKHDKNKSAIPSKMADRIEHAILDSRRIFISDAVDSGSASEIIRKLWYLELTD
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHEEECC
PGKPILFVINSPGGAVDSGFAIWDQIKMITSPVTTLVTGLAASMGSILSLCASPGRRFAT
CCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
PHSRIMIHQPLLSGVIKGQATDLEIQAKEMLKTRNGLIEIYVQATGKNFAAIEKAIDRDT
CCHHEEEEHHHHHHHHCCCCCCHHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHH
WMTAQEALEFGLLDKVINSFEEIEST
HHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TRETSMPKHDKNKSAIPSKMADRIEHAILDSRRIFISDAVDSGSASEIIRKLWYLELTD
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHEEECC
PGKPILFVINSPGGAVDSGFAIWDQIKMITSPVTTLVTGLAASMGSILSLCASPGRRFAT
CCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
PHSRIMIHQPLLSGVIKGQATDLEIQAKEMLKTRNGLIEIYVQATGKNFAAIEKAIDRDT
CCHHEEEEHHHHHHHHCCCCCCHHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHH
WMTAQEALEFGLLDKVINSFEEIEST
HHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA