Click here to switch to the map view.

The map label for this gene is trxA [H]

Identifier: 46446013

GI number: 46446013

Start: 505623

End: 505943

Strand: Direct

Name: trxA [H]

Synonym: pc0379

Alternate gene names: 46446013

Gene position: 505623-505943 (Clockwise)

Preceding gene: 46446011

Following gene: 46446015

Centisome position: 20.94

GC content: 35.51

Gene sequence:

>321_bases
ATGTCAGACAAGCTTGTTCATTTAAATGATGATAATTTTCAACAAACAATTTCTCAAGGTGTCACTTTGGTTGATTTTTA
TGCCACTTGGTGTGGGCCTTGCAGAATGATAGCTCCAATTGTTGAACAATTATCTACTACGCTACAGGGGAAAGCAAAAG
TTGCTAAACTTGATATTGATCAAGCGCAAAGCACAACGGCAGATTTGCAAATTACCTCTGTACCGACGTTGATCGTTTTT
AAAGATGGAAAAGAAGTGAAAAGAGTGGTTGGAGTAAAAGATTTAGATTATCTCTTAAATCTCGTTCAATCTTTTACTTA
A

Upstream 100 bases:

>100_bases
CATTTAGCCGTTTATTTCAAGTAACACTGTTTTTAAAGAATGACAATCTTTATACCCTCTGGTATAGACTAAATTTTGTT
TATTTTAATAAGGAGTATTT

Downstream 100 bases:

>100_bases
TATTTACAATACTTGACTCAAGAGAAATTTTCTTGAGTCAAGTTCTTTTTTTTATCTCTTAACTATTTAAGTTAAGTAGA
ATTTTTTTTGTTATGGTAAT

Product: thioredoxin

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 106; Mature: 105

Protein sequence:

>106_residues
MSDKLVHLNDDNFQQTISQGVTLVDFYATWCGPCRMIAPIVEQLSTTLQGKAKVAKLDIDQAQSTTADLQITSVPTLIVF
KDGKEVKRVVGVKDLDYLLNLVQSFT

Sequences:

>Translated_106_residues
MSDKLVHLNDDNFQQTISQGVTLVDFYATWCGPCRMIAPIVEQLSTTLQGKAKVAKLDIDQAQSTTADLQITSVPTLIVF
KDGKEVKRVVGVKDLDYLLNLVQSFT
>Mature_105_residues
SDKLVHLNDDNFQQTISQGVTLVDFYATWCGPCRMIAPIVEQLSTTLQGKAKVAKLDIDQAQSTTADLQITSVPTLIVFK
DGKEVKRVVGVKDLDYLLNLVQSFT

Specific function: Component of the thioredoxin-thioredoxin reductase system. Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI224493972, Length=101, Percent_Identity=37.6237623762376, Blast_Score=77, Evalue=4e-15,
Organism=Homo sapiens, GI42794771, Length=101, Percent_Identity=37.6237623762376, Blast_Score=77, Evalue=4e-15,
Organism=Homo sapiens, GI21361403, Length=89, Percent_Identity=37.0786516853933, Blast_Score=74, Evalue=3e-14,
Organism=Homo sapiens, GI21361657, Length=96, Percent_Identity=36.4583333333333, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI87082331, Length=94, Percent_Identity=47.8723404255319, Blast_Score=100, Evalue=3e-23,
Organism=Escherichia coli, GI1788936, Length=70, Percent_Identity=35.7142857142857, Blast_Score=66, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI212646193, Length=81, Percent_Identity=35.8024691358025, Blast_Score=71, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI71980565, Length=83, Percent_Identity=37.3493975903614, Blast_Score=69, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71980562, Length=84, Percent_Identity=36.9047619047619, Blast_Score=69, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17510299, Length=101, Percent_Identity=34.6534653465347, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71998175, Length=89, Percent_Identity=33.7078651685393, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17549970, Length=85, Percent_Identity=35.2941176470588, Blast_Score=64, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6323072, Length=81, Percent_Identity=45.679012345679, Blast_Score=82, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6321648, Length=71, Percent_Identity=47.887323943662, Blast_Score=80, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6319925, Length=91, Percent_Identity=36.2637362637363, Blast_Score=65, Evalue=3e-12,
Organism=Drosophila melanogaster, GI28573567, Length=89, Percent_Identity=37.0786516853933, Blast_Score=79, Evalue=8e-16,
Organism=Drosophila melanogaster, GI18859803, Length=102, Percent_Identity=33.3333333333333, Blast_Score=72, Evalue=8e-14,
Organism=Drosophila melanogaster, GI17648013, Length=74, Percent_Identity=37.8378378378378, Blast_Score=70, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24583090, Length=74, Percent_Identity=37.8378378378378, Blast_Score=70, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24658597, Length=89, Percent_Identity=40.4494382022472, Blast_Score=69, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24664269, Length=76, Percent_Identity=39.4736842105263, Blast_Score=69, Evalue=6e-13,
Organism=Drosophila melanogaster, GI21358065, Length=85, Percent_Identity=41.1764705882353, Blast_Score=68, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24639826, Length=84, Percent_Identity=34.5238095238095, Blast_Score=66, Evalue=4e-12,
Organism=Drosophila melanogaster, GI20130317, Length=101, Percent_Identity=32.6732673267327, Blast_Score=63, Evalue=4e-11,
Organism=Drosophila melanogaster, GI19921434, Length=96, Percent_Identity=33.3333333333333, Blast_Score=63, Evalue=5e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11731; Mature: 11599

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDKLVHLNDDNFQQTISQGVTLVDFYATWCGPCRMIAPIVEQLSTTLQGKAKVAKLDID
CCCCEEEECCCHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHEEEECCC
QAQSTTADLQITSVPTLIVFKDGKEVKRVVGVKDLDYLLNLVQSFT
CCCCCCCCEEECCCCEEEEEECCHHHHHHHCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
SDKLVHLNDDNFQQTISQGVTLVDFYATWCGPCRMIAPIVEQLSTTLQGKAKVAKLDID
CCCEEEECCCHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHEEEECCC
QAQSTTADLQITSVPTLIVFKDGKEVKRVVGVKDLDYLLNLVQSFT
CCCCCCCCEEECCCCEEEEEECCHHHHHHHCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA