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The map label for this gene is ndk [H]

Identifier: 46446000

GI number: 46446000

Start: 492179

End: 492907

Strand: Reverse

Name: ndk [H]

Synonym: pc0366

Alternate gene names: 46446000

Gene position: 492907-492179 (Counterclockwise)

Preceding gene: 46446001

Following gene: 46445994

Centisome position: 20.41

GC content: 36.9

Gene sequence:

>729_bases
ATGGGGATTCAAATGAATATTTACCGCTTAATAACTTTATTTATTTTTACTTTTGCCTTACCTGGACTATCAGCAGAGGC
CACAAATCCGCAATATACTCTAGCTGAAGATAATCAACATAAAAATCAAGACGATGAAGATGATGAAGACTGGTATGATG
ACGATGAAGATGACGATAATCAATATCAAGCTCATTCTCCAACACCTAAAGAAGAGTCTCAAATAAATACTCCAAAAACT
TCTCAAGTATATCCTAAGATTACCGAAACTACTCACCCAACTTTAACTCAACAAAAACCAACGTTTGCTTCGGAACAAAC
ACTTTCTATTATCAAACCTGATGCGGTTCAAAATAACTATATTGGAGAAATTATTTCTCGTTTCGAACAAGCCGGATTAA
AAATTGCTGCCATCAAAATGACTACGTTGACAAAAGATCAAGCAAGTAAATTCTACGCTATTCATAAGGATCGACCTTTC
TACAATGATTTAGTTAATTTTATGTCCTCCGGTCCTGTTGTAGTGATGGTGCTCGAAGGCAACCAAGCAATCGCCAAAAA
TAGAGAACTCATGGGCGCTACAGATCCTAAAAAAGCTGAAAAAGGAACCCTGCGTGCTGATTTTGCAGAGTCTATGTCAC
GCAATGCTGTACATGGATCAGATAGCTCAGAAACTGCCGAAGAAGAAGTTTTATTTTTCTTTAAACCAGATGAAATAACT
CACCGTTGA

Upstream 100 bases:

>100_bases
AATCTATCATGACAGAACATGGATTTTCTCTTTTAAGAAATTTTCTTGACAAGCCATTATTGACGTTATAACCTCGAATT
AAACGATTTTTAAATTTCTA

Downstream 100 bases:

>100_bases
TTTTCAGTTCTGTAAATAAAAAATACTTGAGGTTTTACAAATTTGCCATTTTTAATACTCAAGTATTTTGACTACATCCT
AAAGTCTGATCCTAAATAAG

Product: nucleoside-diphosphate kinase

Products: NA

Alternate protein names: NDK 1; NDP kinase 1; Nucleoside-2-P kinase 1 [H]

Number of amino acids: Translated: 242; Mature: 241

Protein sequence:

>242_residues
MGIQMNIYRLITLFIFTFALPGLSAEATNPQYTLAEDNQHKNQDDEDDEDWYDDDEDDDNQYQAHSPTPKEESQINTPKT
SQVYPKITETTHPTLTQQKPTFASEQTLSIIKPDAVQNNYIGEIISRFEQAGLKIAAIKMTTLTKDQASKFYAIHKDRPF
YNDLVNFMSSGPVVVMVLEGNQAIAKNRELMGATDPKKAEKGTLRADFAESMSRNAVHGSDSSETAEEEVLFFFKPDEIT
HR

Sequences:

>Translated_242_residues
MGIQMNIYRLITLFIFTFALPGLSAEATNPQYTLAEDNQHKNQDDEDDEDWYDDDEDDDNQYQAHSPTPKEESQINTPKT
SQVYPKITETTHPTLTQQKPTFASEQTLSIIKPDAVQNNYIGEIISRFEQAGLKIAAIKMTTLTKDQASKFYAIHKDRPF
YNDLVNFMSSGPVVVMVLEGNQAIAKNRELMGATDPKKAEKGTLRADFAESMSRNAVHGSDSSETAEEEVLFFFKPDEIT
HR
>Mature_241_residues
GIQMNIYRLITLFIFTFALPGLSAEATNPQYTLAEDNQHKNQDDEDDEDWYDDDEDDDNQYQAHSPTPKEESQINTPKTS
QVYPKITETTHPTLTQQKPTFASEQTLSIIKPDAVQNNYIGEIISRFEQAGLKIAAIKMTTLTKDQASKFYAIHKDRPFY
NDLVNFMSSGPVVVMVLEGNQAIAKNRELMGATDPKKAEKGTLRADFAESMSRNAVHGSDSSETAEEEVLFFFKPDEITH
R

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate [H]

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family [H]

Homologues:

Organism=Homo sapiens, GI37693993, Length=153, Percent_Identity=40.5228758169935, Blast_Score=137, Evalue=7e-33,
Organism=Homo sapiens, GI4557797, Length=137, Percent_Identity=43.7956204379562, Blast_Score=136, Evalue=2e-32,
Organism=Homo sapiens, GI38045913, Length=137, Percent_Identity=43.7956204379562, Blast_Score=136, Evalue=2e-32,
Organism=Homo sapiens, GI66392227, Length=136, Percent_Identity=44.1176470588235, Blast_Score=136, Evalue=2e-32,
Organism=Homo sapiens, GI66392205, Length=136, Percent_Identity=44.1176470588235, Blast_Score=136, Evalue=2e-32,
Organism=Homo sapiens, GI4505409, Length=136, Percent_Identity=44.1176470588235, Blast_Score=136, Evalue=2e-32,
Organism=Homo sapiens, GI66392192, Length=136, Percent_Identity=44.1176470588235, Blast_Score=136, Evalue=2e-32,
Organism=Homo sapiens, GI66392203, Length=136, Percent_Identity=44.1176470588235, Blast_Score=136, Evalue=2e-32,
Organism=Homo sapiens, GI4826862, Length=141, Percent_Identity=39.0070921985816, Blast_Score=125, Evalue=3e-29,
Organism=Homo sapiens, GI7019465, Length=133, Percent_Identity=36.8421052631579, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI37574614, Length=133, Percent_Identity=36.8421052631579, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI4505413, Length=144, Percent_Identity=35.4166666666667, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI148839372, Length=141, Percent_Identity=35.4609929078014, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI5031951, Length=140, Percent_Identity=37.1428571428571, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI30023828, Length=135, Percent_Identity=35.5555555555556, Blast_Score=77, Evalue=1e-14,
Organism=Escherichia coli, GI1788866, Length=140, Percent_Identity=53.5714285714286, Blast_Score=160, Evalue=6e-41,
Organism=Caenorhabditis elegans, GI17506807, Length=136, Percent_Identity=41.9117647058824, Blast_Score=126, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6322783, Length=137, Percent_Identity=39.4160583941606, Blast_Score=125, Evalue=8e-30,
Organism=Drosophila melanogaster, GI45549037, Length=136, Percent_Identity=44.8529411764706, Blast_Score=136, Evalue=1e-32,
Organism=Drosophila melanogaster, GI18860097, Length=133, Percent_Identity=36.0902255639098, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24645457, Length=157, Percent_Identity=28.6624203821656, Blast_Score=68, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001564 [H]

Pfam domain/function: PF00334 NDK [H]

EC number: =2.7.4.6 [H]

Molecular weight: Translated: 27365; Mature: 27233

Theoretical pI: Translated: 4.43; Mature: 4.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGIQMNIYRLITLFIFTFALPGLSAEATNPQYTLAEDNQHKNQDDEDDEDWYDDDEDDDN
CCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCC
QYQAHSPTPKEESQINTPKTSQVYPKITETTHPTLTQQKPTFASEQTLSIIKPDAVQNNY
CEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCHHCCHH
IGEIISRFEQAGLKIAAIKMTTLTKDQASKFYAIHKDRPFYNDLVNFMSSGPVVVMVLEG
HHHHHHHHHHCCCEEEEEEEEECCHHHHHHEEEEECCCCHHHHHHHHHCCCCEEEEEECC
NQAIAKNRELMGATDPKKAEKGTLRADFAESMSRNAVHGSDSSETAEEEVLFFFKPDEIT
CHHHHHCCHHCCCCCCCHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCC
HR
CC
>Mature Secondary Structure 
GIQMNIYRLITLFIFTFALPGLSAEATNPQYTLAEDNQHKNQDDEDDEDWYDDDEDDDN
CCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCC
QYQAHSPTPKEESQINTPKTSQVYPKITETTHPTLTQQKPTFASEQTLSIIKPDAVQNNY
CEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCHHCCHH
IGEIISRFEQAGLKIAAIKMTTLTKDQASKFYAIHKDRPFYNDLVNFMSSGPVVVMVLEG
HHHHHHHHHHCCCEEEEEEEEECCHHHHHHEEEEECCCCHHHHHHHHHCCCCEEEEEECC
NQAIAKNRELMGATDPKKAEKGTLRADFAESMSRNAVHGSDSSETAEEEVLFFFKPDEIT
CHHHHHCCHHCCCCCCCHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCC
HR
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA