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The map label for this gene is cadA [H]

Identifier: 46445921

GI number: 46445921

Start: 398281

End: 400206

Strand: Reverse

Name: cadA [H]

Synonym: pc0287

Alternate gene names: 46445921

Gene position: 400206-398281 (Counterclockwise)

Preceding gene: 46445922

Following gene: 46445919

Centisome position: 16.58

GC content: 35.83

Gene sequence:

>1926_bases
TTGCAGCTAAACAACGTTACAGAGATATCAATTATGTGGAATGAACCCAAAATTTTATGGCTAATAGCAGGTACCTTATT
TATTGCTGTCTTTGAATTTCTTTCATTAGGGGGCATTCACCTTCCTAAAGAAATTGCCTTACCTTTTTTTCTTACCTTCA
CTCTTTTTTTTGGGCGAGAAACACTTTGGCATGGTTTAAAAGCGTTATTTAATTTGAATTTTAAAAGTATTAACTTATTG
ATGTTCATCGCTGTTGTAGGAGCTTTCTATTTAGGCGAATATCCCGAAGGAACCATTGTTATTATTTTATTTACATTAGC
AGAAAGATTAGAAGATGTGGGCATTGCAAAAAGTCAGTCTGCTATCGACTCCTTTCTCAATAAAATACCAAAAACAGTCT
TCATCAAAGATCAAGAGCTCCCTATAGATATTTCTCAAGTCAAAATTGGAACAGTTGTTTTAATTAAACCGGGCCAAATG
ATCCCTCTAGATGGAATCGTTAAATCAGGAAGTTCCTTTGTAGATGAATCAGCGATTACAGGGGAGCCTTTGGCTAAAGA
TAAACGAACAGGAGATGAACTATTTGCAGGAAGTTTGAACAAACAAGGTTTTATTGAAATGGAAGTTTCTAAAACCGCAT
CGGATTCAACCATTGAAAAAATTCGAGAATTAACTTTTCATGCCACTAAGCACAAAGCTAAAACGCAACAATTTATTGAA
ATTTTTTCTCAATTTTATACCCCTTTTGTGATTTTATTAGCGACTTTTTGGACATTCTTTAACTGGCAAGTTTTGCATCA
ACCCTTTAATCAAGGGCTAGCAGATGCTTTAGCTCTTCTCGTTATCGCTTGTCCTTGTGCACTCGTCATTTCAACACCTA
TTTCTATCTTTTCTGCAATCGGCCATGCCTCTTCAAAAGGAGCTTTAATCAAAGGAGGAAAATATCTCGAAGCTATGGGG
CAAGTGAATGCCATGGCAATTGATAAAACCCGAACCCTCACAAAAGGCCAGCCTATCGTCACTCATGTGATTCCTTTTGG
AAATCATTCTAAAGAATTACTTTTAAGTTGTGCAGCTGGCATCGAAAAATTATCTGAACATCCTCTCGCTCAAAGTATAG
TCCAAGCCGCTCAAATAGAAAATCTTACCCCACATCCTGTCGAAAACTTTGAAAGTTTTATTGGGAAAGGTGCCAAAGCG
GACTGCTTGATTTGCGATGATAAACATCATTGTATCGGAAAATTGGAATTCATTTTAGAAGAACATCATTTGCCTCAAGA
CTTTATAGATCTCATCGATGCCTATCAAAAAAAAGGAAAAACGGTTGTTGCAGTCAGTACTCATAAAAAAGTCGAAGGGA
TAATTGTTCTGGAAGACGAAATCAGATCAGATAGTGCGCAATTTATTGCTGATTTAAAACAATTACAAGTTTATCCCATT
ATGTTAACTGGAGATCATTTAAATGTTGCTCATTCTATCGCTCAACAAGTGGGGATTCAAGTTGTTAAAGCAAATCTTCT
TCCTCAGGACAAATCAAAAGCTATCGAAGAATTATTAAAAGAGTATCGCACAGTTGCCATGTTTGGGGACGGAGTCAATG
ATGCACCTGCACTAGCGCTTTCAAGTGTTGGTATTTCAATGAGTTCGCTTGGCAGCGATACAGCATTAGAAGCAGCCTCT
ATCGTCATTTTAAATGATAATTTATCTCTCATCCCTTATCTGATTAAACTTGGTCGAAAAACCCTTTCTACAATTAAAAT
AAATATTACTTTTGCTTTGTCCGTGAAAATTCTTTTTATTATTCTTGCTCTTTTAAGTATATCTAACTTAGCTTTAGCTA
TTTTTGCAGATGTTGGGGTAACATTACTTGTCATTCTGAATAGCTTGAAATTAATGAACTTTAAACCAAAATCTAGTCAG
AGCTGA

Upstream 100 bases:

>100_bases
GGAGCAGAAGTGCAAAAACCTTTGGCAACTGTTGTGATTGGAGGAATCATTAGCGCTACCATTTTGACACTTTTAGTTCT
TCCAGCATTATATAAACTTT

Downstream 100 bases:

>100_bases
ATGCATTCAGTTTACTAAGCCCAGATAAGGGTAAATCAATGAAAATGCTCTGGTGCTCTTAAAAATTCATTTATTATTAA
AACGCTCTAAACAGAGTGTT

Product: putative cadmium-transporting ATPase

Products: NA

Alternate protein names: Cadmium efflux ATPase [H]

Number of amino acids: Translated: 641; Mature: 641

Protein sequence:

>641_residues
MQLNNVTEISIMWNEPKILWLIAGTLFIAVFEFLSLGGIHLPKEIALPFFLTFTLFFGRETLWHGLKALFNLNFKSINLL
MFIAVVGAFYLGEYPEGTIVIILFTLAERLEDVGIAKSQSAIDSFLNKIPKTVFIKDQELPIDISQVKIGTVVLIKPGQM
IPLDGIVKSGSSFVDESAITGEPLAKDKRTGDELFAGSLNKQGFIEMEVSKTASDSTIEKIRELTFHATKHKAKTQQFIE
IFSQFYTPFVILLATFWTFFNWQVLHQPFNQGLADALALLVIACPCALVISTPISIFSAIGHASSKGALIKGGKYLEAMG
QVNAMAIDKTRTLTKGQPIVTHVIPFGNHSKELLLSCAAGIEKLSEHPLAQSIVQAAQIENLTPHPVENFESFIGKGAKA
DCLICDDKHHCIGKLEFILEEHHLPQDFIDLIDAYQKKGKTVVAVSTHKKVEGIIVLEDEIRSDSAQFIADLKQLQVYPI
MLTGDHLNVAHSIAQQVGIQVVKANLLPQDKSKAIEELLKEYRTVAMFGDGVNDAPALALSSVGISMSSLGSDTALEAAS
IVILNDNLSLIPYLIKLGRKTLSTIKINITFALSVKILFIILALLSISNLALAIFADVGVTLLVILNSLKLMNFKPKSSQ
S

Sequences:

>Translated_641_residues
MQLNNVTEISIMWNEPKILWLIAGTLFIAVFEFLSLGGIHLPKEIALPFFLTFTLFFGRETLWHGLKALFNLNFKSINLL
MFIAVVGAFYLGEYPEGTIVIILFTLAERLEDVGIAKSQSAIDSFLNKIPKTVFIKDQELPIDISQVKIGTVVLIKPGQM
IPLDGIVKSGSSFVDESAITGEPLAKDKRTGDELFAGSLNKQGFIEMEVSKTASDSTIEKIRELTFHATKHKAKTQQFIE
IFSQFYTPFVILLATFWTFFNWQVLHQPFNQGLADALALLVIACPCALVISTPISIFSAIGHASSKGALIKGGKYLEAMG
QVNAMAIDKTRTLTKGQPIVTHVIPFGNHSKELLLSCAAGIEKLSEHPLAQSIVQAAQIENLTPHPVENFESFIGKGAKA
DCLICDDKHHCIGKLEFILEEHHLPQDFIDLIDAYQKKGKTVVAVSTHKKVEGIIVLEDEIRSDSAQFIADLKQLQVYPI
MLTGDHLNVAHSIAQQVGIQVVKANLLPQDKSKAIEELLKEYRTVAMFGDGVNDAPALALSSVGISMSSLGSDTALEAAS
IVILNDNLSLIPYLIKLGRKTLSTIKINITFALSVKILFIILALLSISNLALAIFADVGVTLLVILNSLKLMNFKPKSSQ
S
>Mature_641_residues
MQLNNVTEISIMWNEPKILWLIAGTLFIAVFEFLSLGGIHLPKEIALPFFLTFTLFFGRETLWHGLKALFNLNFKSINLL
MFIAVVGAFYLGEYPEGTIVIILFTLAERLEDVGIAKSQSAIDSFLNKIPKTVFIKDQELPIDISQVKIGTVVLIKPGQM
IPLDGIVKSGSSFVDESAITGEPLAKDKRTGDELFAGSLNKQGFIEMEVSKTASDSTIEKIRELTFHATKHKAKTQQFIE
IFSQFYTPFVILLATFWTFFNWQVLHQPFNQGLADALALLVIACPCALVISTPISIFSAIGHASSKGALIKGGKYLEAMG
QVNAMAIDKTRTLTKGQPIVTHVIPFGNHSKELLLSCAAGIEKLSEHPLAQSIVQAAQIENLTPHPVENFESFIGKGAKA
DCLICDDKHHCIGKLEFILEEHHLPQDFIDLIDAYQKKGKTVVAVSTHKKVEGIIVLEDEIRSDSAQFIADLKQLQVYPI
MLTGDHLNVAHSIAQQVGIQVVKANLLPQDKSKAIEELLKEYRTVAMFGDGVNDAPALALSSVGISMSSLGSDTALEAAS
IVILNDNLSLIPYLIKLGRKTLSTIKINITFALSVKILFIILALLSISNLALAIFADVGVTLLVILNSLKLMNFKPKSSQ
S

Specific function: This electroneutral antiporter ejects one cadmium ion while accumulating two protons by an energy-dependent efflux mechanism [H]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HMA domain [H]

Homologues:

Organism=Homo sapiens, GI55743071, Length=549, Percent_Identity=29.3260473588342, Blast_Score=228, Evalue=2e-59,
Organism=Homo sapiens, GI55743073, Length=528, Percent_Identity=28.5984848484849, Blast_Score=200, Evalue=3e-51,
Organism=Homo sapiens, GI115529486, Length=266, Percent_Identity=31.5789473684211, Blast_Score=137, Evalue=4e-32,
Organism=Homo sapiens, GI48762687, Length=575, Percent_Identity=21.9130434782609, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI48762691, Length=575, Percent_Identity=21.9130434782609, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI48762689, Length=575, Percent_Identity=21.9130434782609, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI48762685, Length=575, Percent_Identity=21.9130434782609, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI297374799, Length=252, Percent_Identity=26.5873015873016, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI83700225, Length=252, Percent_Identity=26.5873015873016, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI4502271, Length=155, Percent_Identity=30.9677419354839, Blast_Score=70, Evalue=7e-12,
Organism=Homo sapiens, GI118498343, Length=181, Percent_Identity=29.8342541436464, Blast_Score=67, Evalue=5e-11,
Organism=Homo sapiens, GI22748667, Length=155, Percent_Identity=29.0322580645161, Blast_Score=66, Evalue=8e-11,
Organism=Homo sapiens, GI237681111, Length=198, Percent_Identity=25.2525252525253, Blast_Score=66, Evalue=9e-11,
Organism=Homo sapiens, GI21361181, Length=198, Percent_Identity=25.2525252525253, Blast_Score=66, Evalue=9e-11,
Organism=Homo sapiens, GI237681109, Length=198, Percent_Identity=25.2525252525253, Blast_Score=66, Evalue=1e-10,
Organism=Homo sapiens, GI153946397, Length=212, Percent_Identity=25.9433962264151, Blast_Score=66, Evalue=1e-10,
Organism=Escherichia coli, GI1789879, Length=580, Percent_Identity=35.8620689655172, Blast_Score=342, Evalue=3e-95,
Organism=Escherichia coli, GI1786691, Length=640, Percent_Identity=30, Blast_Score=240, Evalue=3e-64,
Organism=Escherichia coli, GI1786914, Length=523, Percent_Identity=27.5334608030593, Blast_Score=155, Evalue=5e-39,
Organism=Escherichia coli, GI2367363, Length=590, Percent_Identity=21.6949152542373, Blast_Score=79, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17556548, Length=573, Percent_Identity=28.9703315881326, Blast_Score=205, Evalue=7e-53,
Organism=Caenorhabditis elegans, GI17541776, Length=211, Percent_Identity=28.436018957346, Blast_Score=79, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17557770, Length=254, Percent_Identity=24.8031496062992, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI32566766, Length=254, Percent_Identity=24.8031496062992, Blast_Score=77, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17557486, Length=189, Percent_Identity=28.5714285714286, Blast_Score=73, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17559224, Length=198, Percent_Identity=25.2525252525253, Blast_Score=69, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6320475, Length=539, Percent_Identity=30.6122448979592, Blast_Score=228, Evalue=2e-60,
Organism=Saccharomyces cerevisiae, GI6319772, Length=492, Percent_Identity=27.4390243902439, Blast_Score=166, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6321430, Length=629, Percent_Identity=24.3243243243243, Blast_Score=127, Evalue=6e-30,
Organism=Saccharomyces cerevisiae, GI6325221, Length=629, Percent_Identity=25.1192368839428, Blast_Score=125, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6321271, Length=185, Percent_Identity=34.5945945945946, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6320244, Length=171, Percent_Identity=30.9941520467836, Blast_Score=80, Evalue=9e-16,
Organism=Saccharomyces cerevisiae, GI6320243, Length=171, Percent_Identity=30.9941520467836, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6320245, Length=171, Percent_Identity=30.4093567251462, Blast_Score=79, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6321432, Length=188, Percent_Identity=30.3191489361702, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI221329854, Length=313, Percent_Identity=29.073482428115, Blast_Score=120, Evalue=3e-27,
Organism=Drosophila melanogaster, GI281366676, Length=229, Percent_Identity=26.6375545851528, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24668704, Length=198, Percent_Identity=27.2727272727273, Blast_Score=66, Evalue=9e-11,
Organism=Drosophila melanogaster, GI24668708, Length=198, Percent_Identity=27.2727272727273, Blast_Score=66, Evalue=9e-11,
Organism=Drosophila melanogaster, GI281366617, Length=198, Percent_Identity=27.2727272727273, Blast_Score=66, Evalue=9e-11,
Organism=Drosophila melanogaster, GI24668696, Length=198, Percent_Identity=27.2727272727273, Blast_Score=66, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR001366
- InterPro:   IPR006404
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR017969
- InterPro:   IPR006121 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]

EC number: =3.6.3.3 [H]

Molecular weight: Translated: 70236; Mature: 70236

Theoretical pI: Translated: 6.66; Mature: 6.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLNNVTEISIMWNEPKILWLIAGTLFIAVFEFLSLGGIHLPKEIALPFFLTFTLFFGRE
CCCCCEEEEEEEECCCCEEEEHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
TLWHGLKALFNLNFKSINLLMFIAVVGAFYLGEYPEGTIVIILFTLAERLEDVGIAKSQS
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHCCCCCHHH
AIDSFLNKIPKTVFIKDQELPIDISQVKIGTVVLIKPGQMIPLDGIVKSGSSFVDESAIT
HHHHHHHHCCCEEEEECCCCCCCHHEEEEEEEEEECCCCCCCHHHHHHCCCHHHCCCCCC
GEPLAKDKRTGDELFAGSLNKQGFIEMEVSKTASDSTIEKIRELTFHATKHKAKTQQFIE
CCCCCCCCCCCHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
IFSQFYTPFVILLATFWTFFNWQVLHQPFNQGLADALALLVIACPCALVISTPISIFSAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GHASSKGALIKGGKYLEAMGQVNAMAIDKTRTLTKGQPIVTHVIPFGNHSKELLLSCAAG
CCCCCCCCEEECCHHHHHHCCCCEEEECCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHH
IEKLSEHPLAQSIVQAAQIENLTPHPVENFESFIGKGAKADCLICDDKHHCIGKLEFILE
HHHHHCCHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHH
EHHLPQDFIDLIDAYQKKGKTVVAVSTHKKVEGIIVLEDEIRSDSAQFIADLKQLQVYPI
HCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEEEHHHCCCHHHHHHHHHHCEEEEE
MLTGDHLNVAHSIAQQVGIQVVKANLLPQDKSKAIEELLKEYRTVAMFGDGVNDAPALAL
EEECCCHHHHHHHHHHHCCEEEECCCCCCCHHHHHHHHHHHHHEEEEECCCCCCCHHHHH
SSVGISMSSLGSDTALEAASIVILNDNLSLIPYLIKLGRKTLSTIKINITFALSVKILFI
HHCCCCHHHCCCCCHHCEEEEEEECCCCHHHHHHHHHCCCEEEEEEEEEEEEHHHHHHHH
ILALLSISNLALAIFADVGVTLLVILNSLKLMNFKPKSSQS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCC
>Mature Secondary Structure
MQLNNVTEISIMWNEPKILWLIAGTLFIAVFEFLSLGGIHLPKEIALPFFLTFTLFFGRE
CCCCCEEEEEEEECCCCEEEEHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
TLWHGLKALFNLNFKSINLLMFIAVVGAFYLGEYPEGTIVIILFTLAERLEDVGIAKSQS
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHCCCCCHHH
AIDSFLNKIPKTVFIKDQELPIDISQVKIGTVVLIKPGQMIPLDGIVKSGSSFVDESAIT
HHHHHHHHCCCEEEEECCCCCCCHHEEEEEEEEEECCCCCCCHHHHHHCCCHHHCCCCCC
GEPLAKDKRTGDELFAGSLNKQGFIEMEVSKTASDSTIEKIRELTFHATKHKAKTQQFIE
CCCCCCCCCCCHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
IFSQFYTPFVILLATFWTFFNWQVLHQPFNQGLADALALLVIACPCALVISTPISIFSAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GHASSKGALIKGGKYLEAMGQVNAMAIDKTRTLTKGQPIVTHVIPFGNHSKELLLSCAAG
CCCCCCCCEEECCHHHHHHCCCCEEEECCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHH
IEKLSEHPLAQSIVQAAQIENLTPHPVENFESFIGKGAKADCLICDDKHHCIGKLEFILE
HHHHHCCHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHH
EHHLPQDFIDLIDAYQKKGKTVVAVSTHKKVEGIIVLEDEIRSDSAQFIADLKQLQVYPI
HCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEEEHHHCCCHHHHHHHHHHCEEEEE
MLTGDHLNVAHSIAQQVGIQVVKANLLPQDKSKAIEELLKEYRTVAMFGDGVNDAPALAL
EEECCCHHHHHHHHHHHCCEEEECCCCCCCHHHHHHHHHHHHHEEEEECCCCCCCHHHHH
SSVGISMSSLGSDTALEAASIVILNDNLSLIPYLIKLGRKTLSTIKINITFALSVKILFI
HHCCCCHHHCCCCCHHCEEEEEEECCCCHHHHHHHHHCCCEEEEEEEEEEEEHHHHHHHH
ILALLSISNLALAIFADVGVTLLVILNSLKLMNFKPKSSQS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1321115 [H]