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The map label for this gene is pgmA

Identifier: 46445795

GI number: 46445795

Start: 240480

End: 241160

Strand: Direct

Name: pgmA

Synonym: pc0161

Alternate gene names: 46445795

Gene position: 240480-241160 (Clockwise)

Preceding gene: 46445791

Following gene: 46445796

Centisome position: 9.96

GC content: 38.33

Gene sequence:

>681_bases
ATGGTTAAATTAATTTTGATGCGTCACGGCCAATCTCAGTGGAATTTAGCAAATTTGTTTACTGGTTGGGTAGACATTCC
CCTGTCTTTTAAAGGAATTGAAGAGGCTATAGAGGCAGGAAAACAAATCAAAAATTACCCTATTGATTTAATTTTTACTT
CTTCCTTAATTCGTGCTCAAATGACAGCAATGTTGGCAATGTCTGTTCATACATCTGGTAAAGTCCCTGTGATTCTTCAC
ACAGGTGAGGGGCGACTAGAAGAATGGGCAAGTATTTATAGTTCCGAATCTCAATCTCAGACAATACCTGTCATTCGTGC
TTGGGAATTGAATGAGCGGATGTATGGAGAATTACAAGGAATAAATAAAGAAGAAATGGCTAAAAAATATGGAGCTGAGC
AGGTGCATATTTGGCGACGAAGTTTTGATGTTCCCCCTCCAAATGGAGAAAGTTTACAAATGACAGCAGCTCGGACCATA
CCTTATTTTGAAAACACCATTGTCCCTCATTTGAAAGAGAAGAAAAATATTTTTATTGCTGCACACGGAAATTCCCTGCG
TTCGATTATCATGAAATTAGATGGGCTGACAACAGATCAAGTCGTTAAGTTGGAACTGGCAACAGGGGTGCCTGTGATCT
ATGATTTCAATCACGATGAATATATTAAACAACAAAAGTAG

Upstream 100 bases:

>100_bases
TTCTTCCTTTTTACGAAAGAACTATTAATAATAGTTCTTAAAAAATTAAAAATCAATAAAATGGGGAAGAAAATTTCTTG
ATTAGATGGAGTAAAGGTAA

Downstream 100 bases:

>100_bases
AATAGCATGGTTAAATTGCCTATTTATTTAGATAACAGTACAACTAGTCGTCCATCTGATTTATCAATTAGCCAAATGAT
GCCTTATTTAACAGATCGTT

Product: phosphoglyceromutase

Products: NA

Alternate protein names: BPG-dependent PGAM; PGAM; Phosphoglyceromutase; dPGM

Number of amino acids: Translated: 226; Mature: 226

Protein sequence:

>226_residues
MVKLILMRHGQSQWNLANLFTGWVDIPLSFKGIEEAIEAGKQIKNYPIDLIFTSSLIRAQMTAMLAMSVHTSGKVPVILH
TGEGRLEEWASIYSSESQSQTIPVIRAWELNERMYGELQGINKEEMAKKYGAEQVHIWRRSFDVPPPNGESLQMTAARTI
PYFENTIVPHLKEKKNIFIAAHGNSLRSIIMKLDGLTTDQVVKLELATGVPVIYDFNHDEYIKQQK

Sequences:

>Translated_226_residues
MVKLILMRHGQSQWNLANLFTGWVDIPLSFKGIEEAIEAGKQIKNYPIDLIFTSSLIRAQMTAMLAMSVHTSGKVPVILH
TGEGRLEEWASIYSSESQSQTIPVIRAWELNERMYGELQGINKEEMAKKYGAEQVHIWRRSFDVPPPNGESLQMTAARTI
PYFENTIVPHLKEKKNIFIAAHGNSLRSIIMKLDGLTTDQVVKLELATGVPVIYDFNHDEYIKQQK
>Mature_226_residues
MVKLILMRHGQSQWNLANLFTGWVDIPLSFKGIEEAIEAGKQIKNYPIDLIFTSSLIRAQMTAMLAMSVHTSGKVPVILH
TGEGRLEEWASIYSSESQSQTIPVIRAWELNERMYGELQGINKEEMAKKYGAEQVHIWRRSFDVPPPNGESLQMTAARTI
PYFENTIVPHLKEKKNIFIAAHGNSLRSIIMKLDGLTTDQVVKLELATGVPVIYDFNHDEYIKQQK

Specific function: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate

COG id: COG0588

COG function: function code G; Phosphoglycerate mutase 1

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily

Homologues:

Organism=Homo sapiens, GI50593010, Length=246, Percent_Identity=37.8048780487805, Blast_Score=169, Evalue=2e-42,
Organism=Homo sapiens, GI4505753, Length=246, Percent_Identity=37.3983739837398, Blast_Score=161, Evalue=5e-40,
Organism=Homo sapiens, GI4502445, Length=248, Percent_Identity=34.6774193548387, Blast_Score=150, Evalue=6e-37,
Organism=Homo sapiens, GI40353764, Length=248, Percent_Identity=34.6774193548387, Blast_Score=150, Evalue=6e-37,
Organism=Homo sapiens, GI71274132, Length=249, Percent_Identity=35.7429718875502, Blast_Score=147, Evalue=6e-36,
Organism=Homo sapiens, GI310129614, Length=188, Percent_Identity=35.6382978723404, Blast_Score=102, Evalue=2e-22,
Organism=Escherichia coli, GI1786970, Length=246, Percent_Identity=39.0243902439024, Blast_Score=172, Evalue=2e-44,
Organism=Escherichia coli, GI1786857, Length=217, Percent_Identity=25.3456221198157, Blast_Score=68, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6322697, Length=254, Percent_Identity=38.5826771653543, Blast_Score=168, Evalue=5e-43,
Organism=Saccharomyces cerevisiae, GI6320183, Length=278, Percent_Identity=24.8201438848921, Blast_Score=104, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6324516, Length=271, Percent_Identity=25.4612546125461, Blast_Score=102, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24646216, Length=251, Percent_Identity=37.8486055776892, Blast_Score=174, Evalue=5e-44,
Organism=Drosophila melanogaster, GI85725270, Length=247, Percent_Identity=40.080971659919, Blast_Score=171, Evalue=3e-43,
Organism=Drosophila melanogaster, GI85725272, Length=247, Percent_Identity=40.080971659919, Blast_Score=171, Evalue=3e-43,
Organism=Drosophila melanogaster, GI24650981, Length=247, Percent_Identity=40.080971659919, Blast_Score=171, Evalue=3e-43,
Organism=Drosophila melanogaster, GI24648979, Length=245, Percent_Identity=26.1224489795918, Blast_Score=106, Evalue=1e-23,
Organism=Drosophila melanogaster, GI28571817, Length=245, Percent_Identity=26.1224489795918, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI28571815, Length=245, Percent_Identity=26.1224489795918, Blast_Score=105, Evalue=2e-23,

Paralogues:

None

Copy number: 960 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): GPMA_PARUW (Q6MEW4)

Other databases:

- EMBL:   BX908798
- RefSeq:   YP_007160.1
- ProteinModelPortal:   Q6MEW4
- SMR:   Q6MEW4
- STRING:   Q6MEW4
- GeneID:   2780459
- GenomeReviews:   BX908798_GR
- KEGG:   pcu:pc0161
- NMPDR:   fig|264201.1.peg.161
- eggNOG:   COG0588
- HOGENOM:   HBG658938
- OMA:   IRTLWFV
- PhylomeDB:   Q6MEW4
- ProtClustDB:   PRK01112
- BioCyc:   CPRO264201:PC0161-MONOMER
- BioCyc:   PCHL-E25-01:PCHL-E25-01-000161-MONOMER
- GO:   GO:0006096
- HAMAP:   MF_01039
- InterPro:   IPR013078
- InterPro:   IPR001345
- InterPro:   IPR005952
- PANTHER:   PTHR11931
- SMART:   SM00855
- TIGRFAMs:   TIGR01258

Pfam domain/function: PF00300 PGAM

EC number: =5.4.2.1

Molecular weight: Translated: 25683; Mature: 25683

Theoretical pI: Translated: 7.26; Mature: 7.26

Prosite motif: PS00175 PG_MUTASE

Important sites: ACT_SITE 9-9 ACT_SITE 182-182

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKLILMRHGQSQWNLANLFTGWVDIPLSFKGIEEAIEAGKQIKNYPIDLIFTSSLIRAQ
CEEEEEEECCCCCCCHHHHHHCEEECCCCHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHH
MTAMLAMSVHTSGKVPVILHTGEGRLEEWASIYSSESQSQTIPVIRAWELNERMYGELQG
HHHHHHHEECCCCCEEEEEECCCCCHHHHHHHHCCCCCCCCCCEEEEEECCHHHHHHHCC
INKEEMAKKYGAEQVHIWRRSFDVPPPNGESLQMTAARTIPYFENTIVPHLKEKKNIFIA
CCHHHHHHHHCCCEEEEEHHHCCCCCCCCCEEEEEEEECCCCHHCCCCCCCCCCCCEEEE
AHGNSLRSIIMKLDGLTTDQVVKLELATGVPVIYDFNHDEYIKQQK
ECCCHHHHHHHHHCCCCCCCEEEEEECCCCEEEEECCCHHHHHCCC
>Mature Secondary Structure
MVKLILMRHGQSQWNLANLFTGWVDIPLSFKGIEEAIEAGKQIKNYPIDLIFTSSLIRAQ
CEEEEEEECCCCCCCHHHHHHCEEECCCCHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHH
MTAMLAMSVHTSGKVPVILHTGEGRLEEWASIYSSESQSQTIPVIRAWELNERMYGELQG
HHHHHHHEECCCCCEEEEEECCCCCHHHHHHHHCCCCCCCCCCEEEEEECCHHHHHHHCC
INKEEMAKKYGAEQVHIWRRSFDVPPPNGESLQMTAARTIPYFENTIVPHLKEKKNIFIA
CCHHHHHHHHCCCEEEEEHHHCCCCCCCCCEEEEEEEECCCCHHCCCCCCCCCCCCEEEE
AHGNSLRSIIMKLDGLTTDQVVKLELATGVPVIYDFNHDEYIKQQK
ECCCHHHHHHHHHCCCCCCCEEEEEECCCCEEEEECCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA