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The map label for this gene is arsAb

Identifier: 46445783

GI number: 46445783

Start: 225018

End: 226277

Strand: Direct

Name: arsAb

Synonym: pc0149

Alternate gene names: NA

Gene position: 225018-226277 (Clockwise)

Preceding gene: 46445780

Following gene: 46445785

Centisome position: 9.32

GC content: 36.11

Gene sequence:

>1260_bases
ATGATTTCTTTGGTGATCTTTGTAGCCTGCTATATTAGCTTTGTCTTAGTTCCTCAGCATAAAGCGATGTTTTCATTAAT
AGGCGTTGCTGCTTTAATTATTTTACAACAAATAGGGTTGTTAGCGGCTTTTCATGAAATTCACTGGAACGTTATGGGGC
TTTTCATGGGGACATTGATTTTGGCAGAGTTATTTCTGTATTCGCGAGTCCCAGCTGTGTTTGCGGAATGGTTAGTTGAC
CGTTCAAAAACAGTAAGAAGCGCTTTAATTAGTATTTTTCTTTTATCAAGCATTATTTCTATGTTTGTTGAAAATGTTGC
TGTTGTTTTGTTAATTGCCCCAGTTGCCTTGGCGCTTTGCGAAAAATTAAAAATTTCACCTGTAAAACCGCTGATTTTAT
TAGCCATGTTTTCCAATTTACAGGGAACAGCAACGTTGATTGGGGATCCGCCTAGTATGATTTTAGGCACTTATATGAAA
ATGACTTTTGGTGATTTTTTTGTTTATTTAGGAAAGCCTGGTATTTTTTTTATTGTGCAAGTGGGTGCTTTTTTTACACT
GTGGTTGGCTTTTTATCTTTTCAGAAATTTTAAACAACCTGCTGAATTGATCAAACTCGAAAAGGTGAAATCTTGGATTC
CTTCGTTATTGTTAGTGATTTTGATTGTAGGATTATCTATTGGCTCTCCTTTTGATCCAGATTCTTCTTGGATGGTAGGA
TCTTTTTCAATGGGTTTGGCTATAATAGGATTGATCTGGCATCATTTAGGCCCTAAATGGGTATTTACAGAACAGATTCT
CAAGACGTTAGATTGGAAGACAACTTTTTTTTTGATGGCTCTATTTATTTTAGTCGGAGCTGTTCGTTTAGAGGGGTGGA
TGGACGCTTTAGCAAAGTGGATTGTGAGTCATGTTCCTCCTAATCTATTGATGGTTTATTTTTTTTTAATTTTTATTTCT
TTAATCATATCAGCATTTGTCGACAATGTCCCTTATCTTCTCGCCATGATTCCTGTCGTGCAACAGGTAGCGGATAATAC
GGATTTTTCTTTGTCTCTCTTAATGTTTGCTTTATTTATTGGAACTTGTTTGGGAGGAAATATCACTCCTGTTGGTGCAT
CAGCAAATATAGTCGCAGTGAGTTTTTTGGAAAAGAATGGGTATTCTGTTACTTTTTCAACTTATACGTACTACGGACTT
TTATTCACAGGAATGGCTATTATTCCGGCAACCATAACTTTGTGGGTCCTATGGTCTTAA

Upstream 100 bases:

>100_bases
TGGTTATAAGAGTATTTTTAAAACATCGGATGACAATTTATGTTTTAATCAAGAAGTGATTTTGTGTATAACAAATTTTT
ATTTAATTGATTGAGGCATG

Downstream 100 bases:

>100_bases
TGATCAAGCTTGAGTGAGTTTTTATAAATTCATCCAGATTTATTATCTGCAAAATAATAAAATTTAGAGGGTCATTTCAG
GAAATACTACTCATTTTCCA

Product: putative arsenical pump membrane protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 419; Mature: 419

Protein sequence:

>419_residues
MISLVIFVACYISFVLVPQHKAMFSLIGVAALIILQQIGLLAAFHEIHWNVMGLFMGTLILAELFLYSRVPAVFAEWLVD
RSKTVRSALISIFLLSSIISMFVENVAVVLLIAPVALALCEKLKISPVKPLILLAMFSNLQGTATLIGDPPSMILGTYMK
MTFGDFFVYLGKPGIFFIVQVGAFFTLWLAFYLFRNFKQPAELIKLEKVKSWIPSLLLVILIVGLSIGSPFDPDSSWMVG
SFSMGLAIIGLIWHHLGPKWVFTEQILKTLDWKTTFFLMALFILVGAVRLEGWMDALAKWIVSHVPPNLLMVYFFLIFIS
LIISAFVDNVPYLLAMIPVVQQVADNTDFSLSLLMFALFIGTCLGGNITPVGASANIVAVSFLEKNGYSVTFSTYTYYGL
LFTGMAIIPATITLWVLWS

Sequences:

>Translated_419_residues
MISLVIFVACYISFVLVPQHKAMFSLIGVAALIILQQIGLLAAFHEIHWNVMGLFMGTLILAELFLYSRVPAVFAEWLVD
RSKTVRSALISIFLLSSIISMFVENVAVVLLIAPVALALCEKLKISPVKPLILLAMFSNLQGTATLIGDPPSMILGTYMK
MTFGDFFVYLGKPGIFFIVQVGAFFTLWLAFYLFRNFKQPAELIKLEKVKSWIPSLLLVILIVGLSIGSPFDPDSSWMVG
SFSMGLAIIGLIWHHLGPKWVFTEQILKTLDWKTTFFLMALFILVGAVRLEGWMDALAKWIVSHVPPNLLMVYFFLIFIS
LIISAFVDNVPYLLAMIPVVQQVADNTDFSLSLLMFALFIGTCLGGNITPVGASANIVAVSFLEKNGYSVTFSTYTYYGL
LFTGMAIIPATITLWVLWS
>Mature_419_residues
MISLVIFVACYISFVLVPQHKAMFSLIGVAALIILQQIGLLAAFHEIHWNVMGLFMGTLILAELFLYSRVPAVFAEWLVD
RSKTVRSALISIFLLSSIISMFVENVAVVLLIAPVALALCEKLKISPVKPLILLAMFSNLQGTATLIGDPPSMILGTYMK
MTFGDFFVYLGKPGIFFIVQVGAFFTLWLAFYLFRNFKQPAELIKLEKVKSWIPSLLLVILIVGLSIGSPFDPDSSWMVG
SFSMGLAIIGLIWHHLGPKWVFTEQILKTLDWKTTFFLMALFILVGAVRLEGWMDALAKWIVSHVPPNLLMVYFFLIFIS
LIISAFVDNVPYLLAMIPVVQQVADNTDFSLSLLMFALFIGTCLGGNITPVGASANIVAVSFLEKNGYSVTFSTYTYYGL
LFTGMAIIPATITLWVLWS

Specific function: Unknown

COG id: COG1055

COG function: function code P; Na+/H+ antiporter NhaD and related arsenite permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CitM (TC 2.A.11) transporter family [H]

Homologues:

Organism=Homo sapiens, GI157266326, Length=161, Percent_Identity=32.2981366459627, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI45550608, Length=383, Percent_Identity=27.9373368146214, Blast_Score=95, Evalue=8e-20,
Organism=Drosophila melanogaster, GI28574683, Length=136, Percent_Identity=37.5, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI28574681, Length=136, Percent_Identity=37.5, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI28574685, Length=136, Percent_Identity=37.5, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI28574678, Length=136, Percent_Identity=37.5, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24581759, Length=136, Percent_Identity=37.5, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI19920704, Length=136, Percent_Identity=37.5, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI221472711, Length=140, Percent_Identity=28.5714285714286, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24581764, Length=140, Percent_Identity=28.5714285714286, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000802
- InterPro:   IPR004680 [H]

Pfam domain/function: PF03600 CitMHS [H]

EC number: NA

Molecular weight: Translated: 46534; Mature: 46534

Theoretical pI: Translated: 8.06; Mature: 8.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISLVIFVACYISFVLVPQHKAMFSLIGVAALIILQQIGLLAAFHEIHWNVMGLFMGTLI
CHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAELFLYSRVPAVFAEWLVDRSKTVRSALISIFLLSSIISMFVENVAVVLLIAPVALALC
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EKLKISPVKPLILLAMFSNLQGTATLIGDPPSMILGTYMKMTFGDFFVYLGKPGIFFIVQ
HHCCCCCCHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHEECCCCCEEHHH
VGAFFTLWLAFYLFRNFKQPAELIKLEKVKSWIPSLLLVILIVGLSIGSPFDPDSSWMVG
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEE
SFSMGLAIIGLIWHHLGPKWVFTEQILKTLDWKTTFFLMALFILVGAVRLEGWMDALAKW
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IVSHVPPNLLMVYFFLIFISLIISAFVDNVPYLLAMIPVVQQVADNTDFSLSLLMFALFI
HHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
GTCLGGNITPVGASANIVAVSFLEKNGYSVTFSTYTYYGLLFTGMAIIPATITLWVLWS
HHHCCCCCCCCCCCCCEEEEEEEECCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHEECC
>Mature Secondary Structure
MISLVIFVACYISFVLVPQHKAMFSLIGVAALIILQQIGLLAAFHEIHWNVMGLFMGTLI
CHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAELFLYSRVPAVFAEWLVDRSKTVRSALISIFLLSSIISMFVENVAVVLLIAPVALALC
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EKLKISPVKPLILLAMFSNLQGTATLIGDPPSMILGTYMKMTFGDFFVYLGKPGIFFIVQ
HHCCCCCCHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHEECCCCCEEHHH
VGAFFTLWLAFYLFRNFKQPAELIKLEKVKSWIPSLLLVILIVGLSIGSPFDPDSSWMVG
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEE
SFSMGLAIIGLIWHHLGPKWVFTEQILKTLDWKTTFFLMALFILVGAVRLEGWMDALAKW
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IVSHVPPNLLMVYFFLIFISLIISAFVDNVPYLLAMIPVVQQVADNTDFSLSLLMFALFI
HHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
GTCLGGNITPVGASANIVAVSFLEKNGYSVTFSTYTYYGLLFTGMAIIPATITLWVLWS
HHHCCCCCCCCCCCCCEEEEEEEECCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]