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The map label for this gene is ahpC [C]

Identifier: 46445658

GI number: 46445658

Start: 35903

End: 36460

Strand: Reverse

Name: ahpC [C]

Synonym: pc0024

Alternate gene names: 46445658

Gene position: 36460-35903 (Counterclockwise)

Preceding gene: 46445659

Following gene: 46445656

Centisome position: 1.51

GC content: 36.02

Gene sequence:

>558_bases
GTGAATGGTCAAATTGTAAACGATTTTTCTCTGTTACACTTCAGAGGACAAAATGTCATTTTATTTTTTTACCCTTTAGA
TTTTACTTTTGTTTGCCCAACAGAACTACATGCATTTCAAGAAAAACTTGAAGAATTTGAAAAAAGAAATGCACAAATAA
TTGGATGCTCTGTTGACAGCTGTTATAGCCATTTAGCGTGGTTGAATACCCCTAAAAGTAAAGGAGGAATTGAAGGTATC
GATTACCCTCTAATTTCCGATCTAAACAAAACCATTGCACATGATTATGATGTGTTAATTCCTCATGAAGGCATTGCTTT
CCGTGGCCTATTTTTAATTGATAAAGAAGGAATTGTCCGTCATCAAGTTATCAATGATTTACCCTTGGGACGCTCAGTTG
ATGAGGCGCTTCGTATTTTAGATGCTCTTCTTTATTTCGAAAAAAATGGAGAAGTCTGTCCAGCGAATTGGCAGCACGGC
CAAAAGGCTTTTAAACCTTCTAATGAAGGGTTAGAAGAATATTTTGCGACTGTTCCTGTTAGTCGTCCAAAAATCTAA

Upstream 100 bases:

>100_bases
AAATCGAAAATTTTGGTTAAACAAAGAGAACTCTAAAAGTGAGGTGATTATGGGATTATTAGTTGGCAAACATGCTCCAG
ATTTTAAAGCAAAAGCCGTC

Downstream 100 bases:

>100_bases
AAAATAATAACCTCTTTCTTTTACAACTCAGAAAAACCCAGCATTCGAGTTTTTCTGGGTTATTTTCAAGGAAATTGGAC
GCTTTAAAATTCAAATCTCT

Product: proteins related to alkyl hydroperoxide reductase (AhpC) and thiol specific antioxidant (TSA)

Products: NA

Alternate protein names: Thioredoxin reductase [H]

Number of amino acids: Translated: 185; Mature: 185

Protein sequence:

>185_residues
MNGQIVNDFSLLHFRGQNVILFFYPLDFTFVCPTELHAFQEKLEEFEKRNAQIIGCSVDSCYSHLAWLNTPKSKGGIEGI
DYPLISDLNKTIAHDYDVLIPHEGIAFRGLFLIDKEGIVRHQVINDLPLGRSVDEALRILDALLYFEKNGEVCPANWQHG
QKAFKPSNEGLEEYFATVPVSRPKI

Sequences:

>Translated_185_residues
MNGQIVNDFSLLHFRGQNVILFFYPLDFTFVCPTELHAFQEKLEEFEKRNAQIIGCSVDSCYSHLAWLNTPKSKGGIEGI
DYPLISDLNKTIAHDYDVLIPHEGIAFRGLFLIDKEGIVRHQVINDLPLGRSVDEALRILDALLYFEKNGEVCPANWQHG
QKAFKPSNEGLEEYFATVPVSRPKI
>Mature_185_residues
MNGQIVNDFSLLHFRGQNVILFFYPLDFTFVCPTELHAFQEKLEEFEKRNAQIIGCSVDSCYSHLAWLNTPKSKGGIEGI
DYPLISDLNKTIAHDYDVLIPHEGIAFRGLFLIDKEGIVRHQVINDLPLGRSVDEALRILDALLYFEKNGEVCPANWQHG
QKAFKPSNEGLEEYFATVPVSRPKI

Specific function: Directly Reduces Organic Hydroperoxides In Its Reduced Dithiol Form. [C]

COG id: COG0450

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI4505591, Length=175, Percent_Identity=54.8571428571429, Blast_Score=209, Evalue=1e-54,
Organism=Homo sapiens, GI32455266, Length=175, Percent_Identity=54.8571428571429, Blast_Score=209, Evalue=1e-54,
Organism=Homo sapiens, GI32455264, Length=175, Percent_Identity=54.8571428571429, Blast_Score=209, Evalue=1e-54,
Organism=Homo sapiens, GI5802974, Length=178, Percent_Identity=51.123595505618, Blast_Score=198, Evalue=2e-51,
Organism=Homo sapiens, GI32483377, Length=178, Percent_Identity=51.123595505618, Blast_Score=198, Evalue=2e-51,
Organism=Homo sapiens, GI32189392, Length=170, Percent_Identity=49.4117647058824, Blast_Score=196, Evalue=1e-50,
Organism=Homo sapiens, GI5453549, Length=169, Percent_Identity=50.2958579881657, Blast_Score=190, Evalue=6e-49,
Organism=Homo sapiens, GI33188454, Length=61, Percent_Identity=52.4590163934426, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI4758638, Length=150, Percent_Identity=31.3333333333333, Blast_Score=78, Evalue=5e-15,
Organism=Escherichia coli, GI1786822, Length=153, Percent_Identity=34.640522875817, Blast_Score=108, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI32565831, Length=175, Percent_Identity=50.8571428571429, Blast_Score=191, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI193204376, Length=175, Percent_Identity=50.8571428571429, Blast_Score=191, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI17554494, Length=165, Percent_Identity=50.3030303030303, Blast_Score=191, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI25153706, Length=154, Percent_Identity=29.2207792207792, Blast_Score=71, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6323613, Length=171, Percent_Identity=49.7076023391813, Blast_Score=188, Evalue=3e-49,
Organism=Saccharomyces cerevisiae, GI6320661, Length=171, Percent_Identity=47.3684210526316, Blast_Score=175, Evalue=4e-45,
Organism=Saccharomyces cerevisiae, GI6319407, Length=166, Percent_Identity=33.7349397590361, Blast_Score=100, Evalue=2e-22,
Organism=Drosophila melanogaster, GI17157991, Length=178, Percent_Identity=50.561797752809, Blast_Score=197, Evalue=4e-51,
Organism=Drosophila melanogaster, GI24641739, Length=178, Percent_Identity=50.561797752809, Blast_Score=197, Evalue=4e-51,
Organism=Drosophila melanogaster, GI17738015, Length=171, Percent_Identity=51.4619883040936, Blast_Score=191, Evalue=2e-49,
Organism=Drosophila melanogaster, GI24656348, Length=176, Percent_Identity=48.8636363636364, Blast_Score=188, Evalue=2e-48,
Organism=Drosophila melanogaster, GI17864676, Length=176, Percent_Identity=48.8636363636364, Blast_Score=188, Evalue=2e-48,
Organism=Drosophila melanogaster, GI21357347, Length=168, Percent_Identity=48.2142857142857, Blast_Score=184, Evalue=4e-47,
Organism=Drosophila melanogaster, GI24581278, Length=152, Percent_Identity=34.8684210526316, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI17975518, Length=155, Percent_Identity=37.4193548387097, Blast_Score=87, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24652434, Length=155, Percent_Identity=37.4193548387097, Blast_Score=87, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24652436, Length=155, Percent_Identity=37.4193548387097, Blast_Score=87, Evalue=5e-18,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2250 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 6040 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1580 Molecules/Cell In: Stationary-Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000866
- InterPro:   IPR019479
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF10417 1-cysPrx_C; PF00578 AhpC-TSA [H]

EC number: =1.11.1.15 [H]

Molecular weight: Translated: 21037; Mature: 21037

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNGQIVNDFSLLHFRGQNVILFFYPLDFTFVCPTELHAFQEKLEEFEKRNAQIIGCSVDS
CCCCEECCEEEEEECCCEEEEEEEECCEEEECCHHHHHHHHHHHHHHHCCCEEEEECHHH
CYSHLAWLNTPKSKGGIEGIDYPLISDLNKTIAHDYDVLIPHEGIAFRGLFLIDKEGIVR
HHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEECCCCCEEEEEEEECCCCHHH
HQVINDLPLGRSVDEALRILDALLYFEKNGEVCPANWQHGQKAFKPSNEGLEEYFATVPV
HHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCCCCCCHHHHHHHCCC
SRPKI
CCCCC
>Mature Secondary Structure
MNGQIVNDFSLLHFRGQNVILFFYPLDFTFVCPTELHAFQEKLEEFEKRNAQIIGCSVDS
CCCCEECCEEEEEECCCEEEEEEEECCEEEECCHHHHHHHHHHHHHHHCCCEEEEECHHH
CYSHLAWLNTPKSKGGIEGIDYPLISDLNKTIAHDYDVLIPHEGIAFRGLFLIDKEGIVR
HHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEECCCCCEEEEEEEECCCCHHH
HQVINDLPLGRSVDEALRILDALLYFEKNGEVCPANWQHGQKAFKPSNEGLEEYFATVPV
HHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCCCCCCHHHHHHHCCC
SRPKI
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12522265 [H]