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The map label for this gene is vc2606

Identifier: 45659261

GI number: 45659261

Start: 4220749

End: 4222545

Strand: Direct

Name: vc2606

Synonym: LIC13444

Alternate gene names: 45659261

Gene position: 4220749-4222545 (Clockwise)

Preceding gene: 45659260

Following gene: 45659262

Centisome position: 98.68

GC content: 35.34

Gene sequence:

>1797_bases
ATGCTAGACCATAATTTACTTATAAACCTTATCGTATTTCTTTCTGCAGCGGTAATTTCAGTACCTCTTTTCAAAAAAAT
CGGATTAGGTTCCGTAGTAGGTTATCTCGTTGGTGGAACCATAATCGGGCCTTGGGGAATAGGTTTGATTACCGACGTCG
ATAGTATTTTGCATCTTTCCGAATTCGGAGTCGTTTTACTTTTATTTTTAATAGGACTTGAGTTAAAACCTCAAAGACTT
TGGATTTTAAGAAGACCCGTTTTTGGTTTAGGAGGTCTTCAAGTTATTTTAACTTCTCTTACTTTTTTTATATTATTTTC
GCTTTTAGGTTTGGAAAAACGCCAAGCTATTGTAATTAGCATTAGTATTTCATTATCTTCTACTGCATTTGCCCTTCAAG
TTTTAGGAGAAAAAAATGAACTTAACACCACACATGGCAGAAGTGCTTTTGCAATTCTTTTGTTCCAAGATCTAGCGATA
ATTCCAATTATGGCTACACTTTCTTTTTTAACCGAATCTAGCTCCAATCCCGGATCTCATGGAAGTATAAAAGAAATCTT
ATTTCCTATCGGAACGATTATCGCTGTCATTTTAGCGGGAAGATTTTTAGCGAGACCTTTATTTAAATTAGTCGCTTCCA
GTGCAAATCATGAAATTTTCACAGCCTTGTCCCTTTTGATCGTAATCGGAGTTTCAATTCTAATGAATCAAGTAGGATTA
TCAATGGCTCTTGGATCTTTTTTAGGCGGGGTTATACTTGCAGACTCTGAGTACAGACATGAATTAGAATCTAATCTAGA
ACCATTTAAAGGATTATTCCTTGGATTATTCTTTTTAGCCGTCGGAATGTCGATTAATCTAGGAGAGGTATTAAAAGATC
CGATTCTTGTAATACTACTTGCATTTATTTTAATATTGGTCAAAACGATTATTCTCTATTTTATCGGTATAATTACCAAA
CATTCTAAGGAAGTTTCTCTCAATCTTTCCACAATTATCTCGCAAGGCGGCGAATTCGCATTTGTAATTTTAGGAGTTGG
AGTTTCTTTATCCATCCTTCCAAAAGAAAGAGCCGATTTAGTAATTGCAGTTGTAACTCTTTCCATGGGTTTAACCCCCA
TCCTTGGAATTCTCAAAGACAAAACATCTAAATGGATTCTCAAAGAAGATCAAAATATAAAAGAAGATACTATTGAAGAG
CAAAACCGAGTTATCGTGGCCGGTTTTGGAAGATTTGGTCAAATTATTGCGAGAATGCTTTTCGTTCACAAGATCGGCTT
TACCGCATTGGAACACAATCCCGACCAAGTAAATTTAGCAAGAAAATTCGGCTATAAGATCTACTACGGAGACGCGAGCA
AGTTAAGTCTTTTAAGATCCGCAGGTGCAGAACATGCAGATTTATTTATATTAGCTATTCAAGATATTGATGTTTCAGTA
AAAATTGCTGAATTGATTAAAAAAAATTTCCCGAATTTGACCATCATAGCTAGAGCAAGAAATCGGGAACACGTTTTCAA
ACTAATGGAACTGGGAATTCAAATTATTCGTAGAGATACTTTTGCTTCTGCGTTGGAATTAGCCGGAGAAACTTTGAGTC
AATTAGGTTTTATAGATTCCGAAGTAGAAAAGAAAGTTAAAAAGTTTAGGGCTCACGACGAATTGACTTTGAAAGGCCAA
TTCCAAATTCGAGGAGACGAGAAAGAGTTTATTCAATTTTCAAAAAATTCAATGCGTCAATTAGAAGACGCTTTTGAAGC
AGATCGTCAGGAAAAAGAAGGAAAGATTGCTGGATAA

Upstream 100 bases:

>100_bases
ATTACGGACGGAAATTATGTTTCTTCTCGTTGGCCAGGAGACGCACACTCTTTCACAATTTCTTTTATGAAGTTATTTTC
AGATCGTTAAATTAAAAAGA

Downstream 100 bases:

>100_bases
TTCGTTTCTAAAATTTCCAATTTGACAAAAAAATATTTATTCCGTATACGCTATTCAATAAATTATTTTAAATTTATAAC
AGCGATTTGGCGAAAAATAT

Product: glutathione-regulated potassium-efflux system protein

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: K(+)/H(+) antiporter; NEM-activatable K(+)/H(+) antiporter [H]

Number of amino acids: Translated: 598; Mature: 598

Protein sequence:

>598_residues
MLDHNLLINLIVFLSAAVISVPLFKKIGLGSVVGYLVGGTIIGPWGIGLITDVDSILHLSEFGVVLLLFLIGLELKPQRL
WILRRPVFGLGGLQVILTSLTFFILFSLLGLEKRQAIVISISISLSSTAFALQVLGEKNELNTTHGRSAFAILLFQDLAI
IPIMATLSFLTESSSNPGSHGSIKEILFPIGTIIAVILAGRFLARPLFKLVASSANHEIFTALSLLIVIGVSILMNQVGL
SMALGSFLGGVILADSEYRHELESNLEPFKGLFLGLFFLAVGMSINLGEVLKDPILVILLAFILILVKTIILYFIGIITK
HSKEVSLNLSTIISQGGEFAFVILGVGVSLSILPKERADLVIAVVTLSMGLTPILGILKDKTSKWILKEDQNIKEDTIEE
QNRVIVAGFGRFGQIIARMLFVHKIGFTALEHNPDQVNLARKFGYKIYYGDASKLSLLRSAGAEHADLFILAIQDIDVSV
KIAELIKKNFPNLTIIARARNREHVFKLMELGIQIIRRDTFASALELAGETLSQLGFIDSEVEKKVKKFRAHDELTLKGQ
FQIRGDEKEFIQFSKNSMRQLEDAFEADRQEKEGKIAG

Sequences:

>Translated_598_residues
MLDHNLLINLIVFLSAAVISVPLFKKIGLGSVVGYLVGGTIIGPWGIGLITDVDSILHLSEFGVVLLLFLIGLELKPQRL
WILRRPVFGLGGLQVILTSLTFFILFSLLGLEKRQAIVISISISLSSTAFALQVLGEKNELNTTHGRSAFAILLFQDLAI
IPIMATLSFLTESSSNPGSHGSIKEILFPIGTIIAVILAGRFLARPLFKLVASSANHEIFTALSLLIVIGVSILMNQVGL
SMALGSFLGGVILADSEYRHELESNLEPFKGLFLGLFFLAVGMSINLGEVLKDPILVILLAFILILVKTIILYFIGIITK
HSKEVSLNLSTIISQGGEFAFVILGVGVSLSILPKERADLVIAVVTLSMGLTPILGILKDKTSKWILKEDQNIKEDTIEE
QNRVIVAGFGRFGQIIARMLFVHKIGFTALEHNPDQVNLARKFGYKIYYGDASKLSLLRSAGAEHADLFILAIQDIDVSV
KIAELIKKNFPNLTIIARARNREHVFKLMELGIQIIRRDTFASALELAGETLSQLGFIDSEVEKKVKKFRAHDELTLKGQ
FQIRGDEKEFIQFSKNSMRQLEDAFEADRQEKEGKIAG
>Mature_598_residues
MLDHNLLINLIVFLSAAVISVPLFKKIGLGSVVGYLVGGTIIGPWGIGLITDVDSILHLSEFGVVLLLFLIGLELKPQRL
WILRRPVFGLGGLQVILTSLTFFILFSLLGLEKRQAIVISISISLSSTAFALQVLGEKNELNTTHGRSAFAILLFQDLAI
IPIMATLSFLTESSSNPGSHGSIKEILFPIGTIIAVILAGRFLARPLFKLVASSANHEIFTALSLLIVIGVSILMNQVGL
SMALGSFLGGVILADSEYRHELESNLEPFKGLFLGLFFLAVGMSINLGEVLKDPILVILLAFILILVKTIILYFIGIITK
HSKEVSLNLSTIISQGGEFAFVILGVGVSLSILPKERADLVIAVVTLSMGLTPILGILKDKTSKWILKEDQNIKEDTIEE
QNRVIVAGFGRFGQIIARMLFVHKIGFTALEHNPDQVNLARKFGYKIYYGDASKLSLLRSAGAEHADLFILAIQDIDVSV
KIAELIKKNFPNLTIIARARNREHVFKLMELGIQIIRRDTFASALELAGETLSQLGFIDSEVEKKVKKFRAHDELTLKGQ
FQIRGDEKEFIQFSKNSMRQLEDAFEADRQEKEGKIAG

Specific function: Transport system that facilitates potassium-efflux, possibly by potassium-proton antiport [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=402, Percent_Identity=25.1243781094527, Blast_Score=92, Evalue=1e-18,
Organism=Escherichia coli, GI1786232, Length=589, Percent_Identity=41.2563667232598, Blast_Score=469, Evalue=1e-133,
Organism=Escherichia coli, GI1789749, Length=603, Percent_Identity=40.4643449419569, Blast_Score=445, Evalue=1e-126,
Organism=Escherichia coli, GI1786685, Length=538, Percent_Identity=27.1375464684015, Blast_Score=167, Evalue=2e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR020884
- InterPro:   IPR004771
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 65697; Mature: 65697

Theoretical pI: Translated: 8.70; Mature: 8.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDHNLLINLIVFLSAAVISVPLFKKIGLGSVVGYLVGGTIIGPWGIGLITDVDSILHLS
CCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCEECCCCCHHHHHHHHHHHHH
EFGVVLLLFLIGLELKPQRLWILRRPVFGLGGLQVILTSLTFFILFSLLGLEKRQAIVIS
HHHHHHHHHHHCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEE
ISISLSSTAFALQVLGEKNELNTTHGRSAFAILLFQDLAIIPIMATLSFLTESSSNPGSH
EEEEECCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
GSIKEILFPIGTIIAVILAGRFLARPLFKLVASSANHEIFTALSLLIVIGVSILMNQVGL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
SMALGSFLGGVILADSEYRHELESNLEPFKGLFLGLFFLAVGMSINLGEVLKDPILVILL
HHHHHHHHCCEEEECCHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
AFILILVKTIILYFIGIITKHSKEVSLNLSTIISQGGEFAFVILGVGVSLSILPKERADL
HHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHCCCCEEEEEEECCCEEEECCCCHHHH
VIAVVTLSMGLTPILGILKDKTSKWILKEDQNIKEDTIEEQNRVIVAGFGRFGQIIARML
HHHHHHHHHCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHCCCEEEEECCHHHHHHHHHH
FVHKIGFTALEHNPDQVNLARKFGYKIYYGDASKLSLLRSAGAEHADLFILAIQDIDVSV
HHHHHCCHHCCCCCCHHHHHHHCCCEEEECCHHHHHHHHHCCCCCCCEEEEEEECCCCCH
KIAELIKKNFPNLTIIARARNREHVFKLMELGIQIIRRDTFASALELAGETLSQLGFIDS
HHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
EVEKKVKKFRAHDELTLKGQFQIRGDEKEFIQFSKNSMRQLEDAFEADRQEKEGKIAG
HHHHHHHHHHCCCCEEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MLDHNLLINLIVFLSAAVISVPLFKKIGLGSVVGYLVGGTIIGPWGIGLITDVDSILHLS
CCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCEECCCCCHHHHHHHHHHHHH
EFGVVLLLFLIGLELKPQRLWILRRPVFGLGGLQVILTSLTFFILFSLLGLEKRQAIVIS
HHHHHHHHHHHCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEE
ISISLSSTAFALQVLGEKNELNTTHGRSAFAILLFQDLAIIPIMATLSFLTESSSNPGSH
EEEEECCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
GSIKEILFPIGTIIAVILAGRFLARPLFKLVASSANHEIFTALSLLIVIGVSILMNQVGL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
SMALGSFLGGVILADSEYRHELESNLEPFKGLFLGLFFLAVGMSINLGEVLKDPILVILL
HHHHHHHHCCEEEECCHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
AFILILVKTIILYFIGIITKHSKEVSLNLSTIISQGGEFAFVILGVGVSLSILPKERADL
HHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHCCCCEEEEEEECCCEEEECCCCHHHH
VIAVVTLSMGLTPILGILKDKTSKWILKEDQNIKEDTIEEQNRVIVAGFGRFGQIIARML
HHHHHHHHHCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHCCCEEEEECCHHHHHHHHHH
FVHKIGFTALEHNPDQVNLARKFGYKIYYGDASKLSLLRSAGAEHADLFILAIQDIDVSV
HHHHHCCHHCCCCCCHHHHHHHCCCEEEECCHHHHHHHHHCCCCCCCEEEEEEECCCCCH
KIAELIKKNFPNLTIIARARNREHVFKLMELGIQIIRRDTFASALELAGETLSQLGFIDS
HHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
EVEKKVKKFRAHDELTLKGQFQIRGDEKEFIQFSKNSMRQLEDAFEADRQEKEGKIAG
HHHHHHHHHHCCCCEEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA