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The map label for this gene is icd [H]

Identifier: 45659147

GI number: 45659147

Start: 4083538

End: 4085004

Strand: Direct

Name: icd [H]

Synonym: LIC13328

Alternate gene names: 45659147

Gene position: 4083538-4085004 (Clockwise)

Preceding gene: 45659146

Following gene: 45659148

Centisome position: 95.47

GC content: 38.45

Gene sequence:

>1467_bases
ATGTCCGAAAAAACTAAAATCGCAATTGCCTACGGTGATGGAATCGGTCCTGAGATTATGGATGCGACTCTTAAAATTTT
AAATGCTGCCGGAGCTAAAATTGAACCGATTGAAATCGAAATCGGCGAAAAAGTTTATAAGGAAGGACACTCTTCCGGAA
TTAAACCGGAAGCCTGGGATATTCTGAGACAAACTAAAGTATTTCTAAAAGCACCCATTACAACTCCTCAAGGAGGCGGT
TACAAAAGTTTAAACGTTACTGTCAGAACTACCCTAGGTCTATTTGCAAACGTTAGACCCTGTTTTTCACTGTATCCATA
CGTAGAAACCAAACACCCTTCCCTAGATATTGTAATCATCCGTGAAAATGAAGAAGATCTTTATACTGGAATAGAACACA
GACAAACCAATGACACGGTTCAATGCCTTAAATTAATTTCCCACCCAGGATCAGAAAAGATCATTCGTTACGCATTCGAA
TATGCAAGAGCTTACGGAAGAAAAAAAGTAACCGCGATGGTAAAGGACAATATTATGAAACAAACAGACGGTTTGTTTCA
TGACATTTTCAAAGAAGTAGCCAAAGAATATCCAGAATTAGAAGTAAATTCTCAAATCATAGATATAGGCGCAGCCAACC
TAGCAGACAGACCTCAAAATTTTGACGTAGTAGTTACTTTAAATTTATATGGAGATATTATTTCTGATATAGTCGCTCAG
ATCGCGGGTTCAGTAGGAATGGCAGGTTCTTCCAACATCGGAGAAATTGTTTCTATGTTCGAAGCAATCCACGGTTCTGC
TCCGGACATAGCAGGAAAAAATCTGGCAAATCCATCTGGCTTACTCAACGCCGCAGTGATGATGCTCGTTCACATTGGAC
AACCGGACATCGCTGCAAAAATTAATAACGCGTGGTTATTGACCATAGAAGAAGGAATTCATACCGGAGATATTTTTAAA
CCGGGAGTAAGCAGAATTAAAGTGGGAACCAAAGAATTTTCCGACGCGGTAATCGGAAATTTAGGTCATCTTCCTGGAAA
ATTCAAACCAGTTTCTTTTGGAAAGGCTAAGAAAATTATAATTCCTGAATATAAAAGAAACATTCAAAAGAAAGATTTAG
TAGGAGTGGATATTTTTCTGGATTGGGTAGGAAAGGATCCGAACGAACTCGGAAATAAACTCAAATCTGTTTCCGACGAA
CTGATGTTAAAAATCATCACCAACCGGGGAGTCAAAGTTTATCCTGACGGCCAACCGGAAACTTTTTTGATCGATCATTG
GAGATGTAGATTTGTAAGCAAAAATGCACTGATTAAACAAGAGGACCCTTCCTACCATCCAATTTCTCATAAACAAGTAG
CAGAACTTCTTTTAAAGTTAGACTTGGCCGGTTTTGATACAATCAAAACGGAAAATCTTTATTACTTTAACGGAAAAAGA
GCCTTTTCTTTAGGGCAAGGAGAATGA

Upstream 100 bases:

>100_bases
AAATCGAACCGTAACATTTTACACAAATTCTATTTTTTTGATGTAAGAGAATTGACCATACTCTACGTTTCAGATCTTAT
AGAAGTATTAGGAGAATAGA

Downstream 100 bases:

>100_bases
AAAAATTAGAGTTGTTGAAAAATTAATTTTCTTCTGTTTTTTTCATTAAAATAAATAGGTAAAATTGTTTGTCGATACGG
GCTTTTTTTAAACAACTCTA

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 488; Mature: 487

Protein sequence:

>488_residues
MSEKTKIAIAYGDGIGPEIMDATLKILNAAGAKIEPIEIEIGEKVYKEGHSSGIKPEAWDILRQTKVFLKAPITTPQGGG
YKSLNVTVRTTLGLFANVRPCFSLYPYVETKHPSLDIVIIRENEEDLYTGIEHRQTNDTVQCLKLISHPGSEKIIRYAFE
YARAYGRKKVTAMVKDNIMKQTDGLFHDIFKEVAKEYPELEVNSQIIDIGAANLADRPQNFDVVVTLNLYGDIISDIVAQ
IAGSVGMAGSSNIGEIVSMFEAIHGSAPDIAGKNLANPSGLLNAAVMMLVHIGQPDIAAKINNAWLLTIEEGIHTGDIFK
PGVSRIKVGTKEFSDAVIGNLGHLPGKFKPVSFGKAKKIIIPEYKRNIQKKDLVGVDIFLDWVGKDPNELGNKLKSVSDE
LMLKIITNRGVKVYPDGQPETFLIDHWRCRFVSKNALIKQEDPSYHPISHKQVAELLLKLDLAGFDTIKTENLYYFNGKR
AFSLGQGE

Sequences:

>Translated_488_residues
MSEKTKIAIAYGDGIGPEIMDATLKILNAAGAKIEPIEIEIGEKVYKEGHSSGIKPEAWDILRQTKVFLKAPITTPQGGG
YKSLNVTVRTTLGLFANVRPCFSLYPYVETKHPSLDIVIIRENEEDLYTGIEHRQTNDTVQCLKLISHPGSEKIIRYAFE
YARAYGRKKVTAMVKDNIMKQTDGLFHDIFKEVAKEYPELEVNSQIIDIGAANLADRPQNFDVVVTLNLYGDIISDIVAQ
IAGSVGMAGSSNIGEIVSMFEAIHGSAPDIAGKNLANPSGLLNAAVMMLVHIGQPDIAAKINNAWLLTIEEGIHTGDIFK
PGVSRIKVGTKEFSDAVIGNLGHLPGKFKPVSFGKAKKIIIPEYKRNIQKKDLVGVDIFLDWVGKDPNELGNKLKSVSDE
LMLKIITNRGVKVYPDGQPETFLIDHWRCRFVSKNALIKQEDPSYHPISHKQVAELLLKLDLAGFDTIKTENLYYFNGKR
AFSLGQGE
>Mature_487_residues
SEKTKIAIAYGDGIGPEIMDATLKILNAAGAKIEPIEIEIGEKVYKEGHSSGIKPEAWDILRQTKVFLKAPITTPQGGGY
KSLNVTVRTTLGLFANVRPCFSLYPYVETKHPSLDIVIIRENEEDLYTGIEHRQTNDTVQCLKLISHPGSEKIIRYAFEY
ARAYGRKKVTAMVKDNIMKQTDGLFHDIFKEVAKEYPELEVNSQIIDIGAANLADRPQNFDVVVTLNLYGDIISDIVAQI
AGSVGMAGSSNIGEIVSMFEAIHGSAPDIAGKNLANPSGLLNAAVMMLVHIGQPDIAAKINNAWLLTIEEGIHTGDIFKP
GVSRIKVGTKEFSDAVIGNLGHLPGKFKPVSFGKAKKIIIPEYKRNIQKKDLVGVDIFLDWVGKDPNELGNKLKSVSDEL
MLKIITNRGVKVYPDGQPETFLIDHWRCRFVSKNALIKQEDPSYHPISHKQVAELLLKLDLAGFDTIKTENLYYFNGKRA
FSLGQGE

Specific function: Unknown

COG id: COG0473

COG function: function code CE; Isocitrate/isopropylmalate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=302, Percent_Identity=45.0331125827815, Blast_Score=246, Evalue=5e-65,
Organism=Homo sapiens, GI4758582, Length=317, Percent_Identity=38.4858044164038, Blast_Score=202, Evalue=4e-52,
Organism=Homo sapiens, GI28178838, Length=302, Percent_Identity=38.4105960264901, Blast_Score=196, Evalue=4e-50,
Organism=Homo sapiens, GI28178821, Length=285, Percent_Identity=37.1929824561403, Blast_Score=173, Evalue=4e-43,
Organism=Homo sapiens, GI28178816, Length=285, Percent_Identity=37.1929824561403, Blast_Score=172, Evalue=5e-43,
Organism=Homo sapiens, GI28178819, Length=155, Percent_Identity=40, Blast_Score=115, Evalue=1e-25,
Organism=Escherichia coli, GI1787381, Length=386, Percent_Identity=33.9378238341969, Blast_Score=179, Evalue=3e-46,
Organism=Escherichia coli, GI1788101, Length=338, Percent_Identity=32.2485207100592, Blast_Score=151, Evalue=9e-38,
Organism=Escherichia coli, GI87081683, Length=366, Percent_Identity=31.9672131147541, Blast_Score=149, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI71986051, Length=320, Percent_Identity=42.5, Blast_Score=246, Evalue=2e-65,
Organism=Caenorhabditis elegans, GI25144293, Length=323, Percent_Identity=39.6284829721362, Blast_Score=212, Evalue=5e-55,
Organism=Caenorhabditis elegans, GI17505779, Length=313, Percent_Identity=36.741214057508, Blast_Score=195, Evalue=5e-50,
Organism=Caenorhabditis elegans, GI17550882, Length=349, Percent_Identity=34.9570200573066, Blast_Score=182, Evalue=5e-46,
Organism=Saccharomyces cerevisiae, GI6324709, Length=343, Percent_Identity=43.4402332361516, Blast_Score=255, Evalue=1e-68,
Organism=Saccharomyces cerevisiae, GI6324291, Length=309, Percent_Identity=38.8349514563107, Blast_Score=202, Evalue=1e-52,
Organism=Saccharomyces cerevisiae, GI6322097, Length=356, Percent_Identity=34.5505617977528, Blast_Score=163, Evalue=7e-41,
Organism=Saccharomyces cerevisiae, GI6319830, Length=368, Percent_Identity=26.9021739130435, Blast_Score=101, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24643268, Length=318, Percent_Identity=43.3962264150943, Blast_Score=253, Evalue=2e-67,
Organism=Drosophila melanogaster, GI24643270, Length=318, Percent_Identity=43.3962264150943, Blast_Score=253, Evalue=2e-67,
Organism=Drosophila melanogaster, GI24661184, Length=344, Percent_Identity=41.5697674418605, Blast_Score=246, Evalue=2e-65,
Organism=Drosophila melanogaster, GI161078635, Length=310, Percent_Identity=37.4193548387097, Blast_Score=183, Evalue=2e-46,
Organism=Drosophila melanogaster, GI161078637, Length=310, Percent_Identity=37.4193548387097, Blast_Score=183, Evalue=2e-46,
Organism=Drosophila melanogaster, GI161078633, Length=310, Percent_Identity=37.4193548387097, Blast_Score=183, Evalue=2e-46,
Organism=Drosophila melanogaster, GI24650122, Length=310, Percent_Identity=37.4193548387097, Blast_Score=183, Evalue=2e-46,
Organism=Drosophila melanogaster, GI161078639, Length=310, Percent_Identity=37.4193548387097, Blast_Score=183, Evalue=3e-46,
Organism=Drosophila melanogaster, GI281362242, Length=350, Percent_Identity=32.8571428571429, Blast_Score=165, Evalue=5e-41,
Organism=Drosophila melanogaster, GI24648872, Length=350, Percent_Identity=32.8571428571429, Blast_Score=165, Evalue=5e-41,
Organism=Drosophila melanogaster, GI20130355, Length=338, Percent_Identity=29.2899408284024, Blast_Score=141, Evalue=1e-33,
Organism=Drosophila melanogaster, GI45550436, Length=214, Percent_Identity=24.2990654205607, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: 8180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR014273 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 53889; Mature: 53758

Theoretical pI: Translated: 7.16; Mature: 7.16

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEKTKIAIAYGDGIGPEIMDATLKILNAAGAKIEPIEIEIGEKVYKEGHSSGIKPEAWD
CCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCEEEEEEEECCHHHHHCCCCCCCCCHHHH
ILRQTKVFLKAPITTPQGGGYKSLNVTVRTTLGLFANVRPCFSLYPYVETKHPSLDIVII
HHHHHHHHEECCCCCCCCCCEEEEEEEEEEHHHHHHCCCHHHHHCCCEECCCCCEEEEEE
RENEEDLYTGIEHRQTNDTVQCLKLISHPGSEKIIRYAFEYARAYGRKKVTAMVKDNIMK
ECCCHHHHHCCHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
QTDGLFHDIFKEVAKEYPELEVNSQIIDIGAANLADRPQNFDVVVTLNLYGDIISDIVAQ
HHCHHHHHHHHHHHHHCCCEECCCEEEEECCCCCCCCCCCCEEEEEEEHHHHHHHHHHHH
IAGSVGMAGSSNIGEIVSMFEAIHGSAPDIAGKNLANPSGLLNAAVMMLVHIGQPDIAAK
HHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEE
INNAWLLTIEEGIHTGDIFKPGVSRIKVGTKEFSDAVIGNLGHLPGKFKPVSFGKAKKII
ECCEEEEEEECCCCCCCCCCCCHHHEEECHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEE
IPEYKRNIQKKDLVGVDIFLDWVGKDPNELGNKLKSVSDELMLKIITNRGVKVYPDGQPE
CCHHHCCCCHHHCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCC
TFLIDHWRCRFVSKNALIKQEDPSYHPISHKQVAELLLKLDLAGFDTIKTENLYYFNGKR
EEEEECEEEEEECCCCEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCEEECCEEEECCCE
AFSLGQGE
EECCCCCC
>Mature Secondary Structure 
SEKTKIAIAYGDGIGPEIMDATLKILNAAGAKIEPIEIEIGEKVYKEGHSSGIKPEAWD
CCCEEEEEEECCCCCHHHHHHHHHHHHHCCCEEEEEEEECCHHHHHCCCCCCCCCHHHH
ILRQTKVFLKAPITTPQGGGYKSLNVTVRTTLGLFANVRPCFSLYPYVETKHPSLDIVII
HHHHHHHHEECCCCCCCCCCEEEEEEEEEEHHHHHHCCCHHHHHCCCEECCCCCEEEEEE
RENEEDLYTGIEHRQTNDTVQCLKLISHPGSEKIIRYAFEYARAYGRKKVTAMVKDNIMK
ECCCHHHHHCCHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
QTDGLFHDIFKEVAKEYPELEVNSQIIDIGAANLADRPQNFDVVVTLNLYGDIISDIVAQ
HHCHHHHHHHHHHHHHCCCEECCCEEEEECCCCCCCCCCCCEEEEEEEHHHHHHHHHHHH
IAGSVGMAGSSNIGEIVSMFEAIHGSAPDIAGKNLANPSGLLNAAVMMLVHIGQPDIAAK
HHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEE
INNAWLLTIEEGIHTGDIFKPGVSRIKVGTKEFSDAVIGNLGHLPGKFKPVSFGKAKKII
ECCEEEEEEECCCCCCCCCCCCHHHEEECHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEE
IPEYKRNIQKKDLVGVDIFLDWVGKDPNELGNKLKSVSDELMLKIITNRGVKVYPDGQPE
CCHHHCCCCHHHCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCC
TFLIDHWRCRFVSKNALIKQEDPSYHPISHKQVAELLLKLDLAGFDTIKTENLYYFNGKR
EEEEECEEEEEECCCCEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCEEECCEEEECCCE
AFSLGQGE
EECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA