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The map label for this gene is lpxD [H]

Identifier: 45658872

GI number: 45658872

Start: 3717927

End: 3718949

Strand: Reverse

Name: lpxD [H]

Synonym: LIC13046

Alternate gene names: 45658872

Gene position: 3718949-3717927 (Counterclockwise)

Preceding gene: 45658873

Following gene: 45658871

Centisome position: 86.95

GC content: 38.91

Gene sequence:

>1023_bases
ATGAAAGCCAAAAATTTAGCGGAAATATTGGGCGTAGAACTAAAGGGTGACGGAGAAATTGAAATCAGCGGAATCGGAGA
TATTGAAAATCATTCCGATATTCTACCCGATCGAATTTATTATATCGAAGCGAAAAAACACCTAATCGGTAATCCGAAAG
TAAAACAGGTTCAGTTAGCACTTACGATTCCTTCTTTGGCTGGTGAGTTTCCTACCGCCTTAGTGGTTTTAGAACAACAA
GCAAGACTTAAATTTATAGAGTTGCTTTCTCTTTTTGAAAAGAAGCCGAAACTTCCTCCTCCTTTTATTTCTGATAAAGC
AAGCATTCATAAAAATGTCCGTTTGGGCAAAAACGTTACAATTATGGATTTCGCTGTGATTCACGAAAATGTGGAAATCG
GAGATAATTGTTTTATTTATCCGAACGTTGTCATTGAAAACGGTGCGAAGATCGGTGAAGGTACCATTTTAAAATCTGGG
GTTGTTGTAGGTTATAGTTGTATTCTTGGAAAGTTCAATCTTATTCATGCGAATACGGTGATCGGTGCAGATGGGTTTGG
TTTTTATGATAAGGAAGGAGTACGTTATAAAATTCCTCAGATAGGAAACGTAGTCGTTGGAGATTATGTTGAAATGGGGG
CGTGTTGTACTGTGGATAGGGCAACGATTGAAACTACAACTGTCGGAAATCATACTAAGTTTGATGATCATGTTCACATT
GCTCACAATTGCAAAGTAGGGGATTACGTATTTATTGCCGGTGGGACCGTTCTTGCGGGTTCCGTTACTTTGGAAGATGG
AGTTATCATGGGTGGTCAAGCTGCGGTTTTACAGGGAATCACTATGAAAAAGGGTTCTATTCTTATGGGTATGTCTGCTC
TCGGTGAAGACAGCGTTGAGAAAGTTGCTTATTTTGGAATTCCTGCAAAACCTGCGATTGAAATGCATAGAATTCATTCT
TCGATGTCTAAACTTCCGGAGCTCGTGAGAGAACATAGAAATCGTTCTAAGAATTCAATTTAA

Upstream 100 bases:

>100_bases
CAATTTTAATTCTTTTATAATTCGGATTCTTTTTGTTGCAAATGAATAAAATGAAAAAAACGAGTTGAATTCCTTTTTTA
TATGATAAGAATTTGATCCG

Downstream 100 bases:

>100_bases
ATTTAAGAATTTATCATTTCTTTTCAGGTTGAATTGGATTGCCACGGTTAAATGGAGATTTCATTCGGAGACTTGATTTG
AGAATCTTCATTTTGGGATT

Product: UDP glucosamine N-acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 340; Mature: 340

Protein sequence:

>340_residues
MKAKNLAEILGVELKGDGEIEISGIGDIENHSDILPDRIYYIEAKKHLIGNPKVKQVQLALTIPSLAGEFPTALVVLEQQ
ARLKFIELLSLFEKKPKLPPPFISDKASIHKNVRLGKNVTIMDFAVIHENVEIGDNCFIYPNVVIENGAKIGEGTILKSG
VVVGYSCILGKFNLIHANTVIGADGFGFYDKEGVRYKIPQIGNVVVGDYVEMGACCTVDRATIETTTVGNHTKFDDHVHI
AHNCKVGDYVFIAGGTVLAGSVTLEDGVIMGGQAAVLQGITMKKGSILMGMSALGEDSVEKVAYFGIPAKPAIEMHRIHS
SMSKLPELVREHRNRSKNSI

Sequences:

>Translated_340_residues
MKAKNLAEILGVELKGDGEIEISGIGDIENHSDILPDRIYYIEAKKHLIGNPKVKQVQLALTIPSLAGEFPTALVVLEQQ
ARLKFIELLSLFEKKPKLPPPFISDKASIHKNVRLGKNVTIMDFAVIHENVEIGDNCFIYPNVVIENGAKIGEGTILKSG
VVVGYSCILGKFNLIHANTVIGADGFGFYDKEGVRYKIPQIGNVVVGDYVEMGACCTVDRATIETTTVGNHTKFDDHVHI
AHNCKVGDYVFIAGGTVLAGSVTLEDGVIMGGQAAVLQGITMKKGSILMGMSALGEDSVEKVAYFGIPAKPAIEMHRIHS
SMSKLPELVREHRNRSKNSI
>Mature_340_residues
MKAKNLAEILGVELKGDGEIEISGIGDIENHSDILPDRIYYIEAKKHLIGNPKVKQVQLALTIPSLAGEFPTALVVLEQQ
ARLKFIELLSLFEKKPKLPPPFISDKASIHKNVRLGKNVTIMDFAVIHENVEIGDNCFIYPNVVIENGAKIGEGTILKSG
VVVGYSCILGKFNLIHANTVIGADGFGFYDKEGVRYKIPQIGNVVVGDYVEMGACCTVDRATIETTTVGNHTKFDDHVHI
AHNCKVGDYVFIAGGTVLAGSVTLEDGVIMGGQAAVLQGITMKKGSILMGMSALGEDSVEKVAYFGIPAKPAIEMHRIHS
SMSKLPELVREHRNRSKNSI

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786376, Length=316, Percent_Identity=32.2784810126582, Blast_Score=155, Evalue=3e-39,
Organism=Escherichia coli, GI1786378, Length=199, Percent_Identity=31.1557788944724, Blast_Score=74, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573 [H]

Pfam domain/function: PF04613 LpxD [H]

EC number: 2.3.1.-

Molecular weight: Translated: 36860; Mature: 36860

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAKNLAEILGVELKGDGEIEISGIGDIENHSDILPDRIYYIEAKKHLIGNPKVKQVQLA
CCCHHHHHHHEEEECCCCEEEEEECCCCCCCCCCCCCEEEEEEECHHHCCCCCEEEEEEE
LTIPSLAGEFPTALVVLEQQARLKFIELLSLFEKKPKLPPPFISDKASIHKNVRLGKNVT
EEECHHCCCCCEEEEEECHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCEECCCCEE
IMDFAVIHENVEIGDNCFIYPNVVIENGAKIGEGTILKSGVVVGYSCILGKFNLIHANTV
EEEEEEEECCCEECCCEEECCCEEEECCCCCCCCEEEECCEEEEEHHHHCCEEEEEEEEE
IGADGFGFYDKEGVRYKIPQIGNVVVGDYVEMGACCTVDRATIETTTVGNHTKFDDHVHI
ECCCCCCCCCCCCCEEECCCCCCEEECCHHHCCCEEEECCCEEEEEECCCCCCCCCEEEE
AHNCKVGDYVFIAGGTVLAGSVTLEDGVIMGGQAAVLQGITMKKGSILMGMSALGEDSVE
EECCCCCCEEEEECCEEEEEEEEECCCEEECCCHHHHCCEEECCCCEEEEHHHCCCCCHH
KVAYFGIPAKPAIEMHRIHSSMSKLPELVREHRNRSKNSI
HEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKAKNLAEILGVELKGDGEIEISGIGDIENHSDILPDRIYYIEAKKHLIGNPKVKQVQLA
CCCHHHHHHHEEEECCCCEEEEEECCCCCCCCCCCCCEEEEEEECHHHCCCCCEEEEEEE
LTIPSLAGEFPTALVVLEQQARLKFIELLSLFEKKPKLPPPFISDKASIHKNVRLGKNVT
EEECHHCCCCCEEEEEECHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCEECCCCEE
IMDFAVIHENVEIGDNCFIYPNVVIENGAKIGEGTILKSGVVVGYSCILGKFNLIHANTV
EEEEEEEECCCEECCCEEECCCEEEECCCCCCCCEEEECCEEEEEHHHHCCEEEEEEEEE
IGADGFGFYDKEGVRYKIPQIGNVVVGDYVEMGACCTVDRATIETTTVGNHTKFDDHVHI
ECCCCCCCCCCCCCEEECCCCCCEEECCHHHCCCEEEECCCEEEEEECCCCCCCCCEEEE
AHNCKVGDYVFIAGGTVLAGSVTLEDGVIMGGQAAVLQGITMKKGSILMGMSALGEDSVE
EECCCCCCEEEEECCEEEEEEEEECCCEEECCCHHHHCCEEECCCCEEEEHHHCCCCCHH
KVAYFGIPAKPAIEMHRIHSSMSKLPELVREHRNRSKNSI
HEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA