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The map label for this gene is hisI

Identifier: 45658843

GI number: 45658843

Start: 3671749

End: 3672312

Strand: Reverse

Name: hisI

Synonym: LIC13016

Alternate gene names: 45658843

Gene position: 3672312-3671749 (Counterclockwise)

Preceding gene: 45658844

Following gene: 45658842

Centisome position: 85.86

GC content: 37.06

Gene sequence:

>564_bases
ATGAGTTCTAGAGAAATTACAATTCTAAAAATACAAGAACCAACTAGATCGATTGCTTCTCTAACTCGAATTATGGAAGA
AGAATTATCACAGTATAGAAAGACACTTCCTAAAGGTTTTAGAGAAGAAGTGGATTGCGACGAGGACACGGTTTTATTTT
TACATGTCGATTTTTTACCGTTAGATTTTCAAAAAACGACGGAACTACTTTTGACTGGAAAAAAAGATTTGGTTCCAGTT
GTGGCGATCGATCTTCAAGGCCAGATTCTTATGCAAGCGTTTGGGAATGAAGAAAGTCAAACTTTGTCTTTAAAAACCGG
ATATGCGCATTACTTTAGCCGGTCCAGAAATCAACTTTGGAAAAAAGGAGATACTTCGGGACATACTCAAAAAATTCTCC
AAATTCTATCTCCTACGGATCGTTCTTTTTTAGTCTATCAAGTGGAACAAGAAGTAGCTGCTTGCCATGAAGGTTACTAC
AGTTGTTTTTTTAGGGAGAGAATGGAAGGAGTCACTTGGAAACTACTTCCGGTTCCGAGAAATTTTCTTCCAGAAAAGAG
CTAA

Upstream 100 bases:

>100_bases
AAAATATAGATTTGTGAGAGTTCCCACAGGTTAAGTCGCATTACAAATTTTAAAACATTCTTACAATTTAGAAAAGTTCA
AGTGAGTCTAAAAAACGAAA

Downstream 100 bases:

>100_bases
AATTGTATTCTGCCTTTTGGAAACTTGTCGAAGGATATAAATGGATTTATGAATATTAAAAAGTTTTTGATTTTCTCCGG
ATTTGTTATTGGAGTTCTGT

Product: phosphoribosyl-AMP cyclohydrolase protein

Products: NA

Alternate protein names: PRA-CH

Number of amino acids: Translated: 187; Mature: 186

Protein sequence:

>187_residues
MSSREITILKIQEPTRSIASLTRIMEEELSQYRKTLPKGFREEVDCDEDTVLFLHVDFLPLDFQKTTELLLTGKKDLVPV
VAIDLQGQILMQAFGNEESQTLSLKTGYAHYFSRSRNQLWKKGDTSGHTQKILQILSPTDRSFLVYQVEQEVAACHEGYY
SCFFRERMEGVTWKLLPVPRNFLPEKS

Sequences:

>Translated_187_residues
MSSREITILKIQEPTRSIASLTRIMEEELSQYRKTLPKGFREEVDCDEDTVLFLHVDFLPLDFQKTTELLLTGKKDLVPV
VAIDLQGQILMQAFGNEESQTLSLKTGYAHYFSRSRNQLWKKGDTSGHTQKILQILSPTDRSFLVYQVEQEVAACHEGYY
SCFFRERMEGVTWKLLPVPRNFLPEKS
>Mature_186_residues
SSREITILKIQEPTRSIASLTRIMEEELSQYRKTLPKGFREEVDCDEDTVLFLHVDFLPLDFQKTTELLLTGKKDLVPVV
AIDLQGQILMQAFGNEESQTLSLKTGYAHYFSRSRNQLWKKGDTSGHTQKILQILSPTDRSFLVYQVEQEVAACHEGYYS
CFFRERMEGVTWKLLPVPRNFLPEKS

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-CH family

Homologues:

Organism=Saccharomyces cerevisiae, GI6319819, Length=98, Percent_Identity=36.734693877551, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS3_LEPIC (P62392)

Other databases:

- EMBL:   AE016823
- RefSeq:   YP_002929.1
- ProteinModelPortal:   P62392
- SMR:   P62392
- GeneID:   2770807
- GenomeReviews:   AE016823_GR
- KEGG:   lic:LIC13016
- NMPDR:   fig|267671.1.peg.2929
- HOGENOM:   HBG294308
- OMA:   FRERMEG
- ProtClustDB:   CLSK573553
- BioCyc:   LINT-130-01:LINT-130-01-002929-MONOMER
- BioCyc:   LINT267671:LIC_13016-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01021
- InterPro:   IPR002496
- ProDom:   PD002610

Pfam domain/function: PF01502 PRA-CH

EC number: =3.5.4.19

Molecular weight: Translated: 21654; Mature: 21523

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSREITILKIQEPTRSIASLTRIMEEELSQYRKTLPKGFREEVDCDEDTVLFLHVDFLP
CCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCEEEEEEEECEE
LDFQKTTELLLTGKKDLVPVVAIDLQGQILMQAFGNEESQTLSLKTGYAHYFSRSRNQLW
CCHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHH
KKGDTSGHTQKILQILSPTDRSFLVYQVEQEVAACHEGYYSCFFRERMEGVTWKLLPVPR
HCCCCCHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCC
NFLPEKS
CCCCCCC
>Mature Secondary Structure 
SSREITILKIQEPTRSIASLTRIMEEELSQYRKTLPKGFREEVDCDEDTVLFLHVDFLP
CCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCEEEEEEEECEE
LDFQKTTELLLTGKKDLVPVVAIDLQGQILMQAFGNEESQTLSLKTGYAHYFSRSRNQLW
CCHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHH
KKGDTSGHTQKILQILSPTDRSFLVYQVEQEVAACHEGYYSCFFRERMEGVTWKLLPVPR
HCCCCCHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCC
NFLPEKS
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA