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The map label for this gene is msrA

Identifier: 45658805

GI number: 45658805

Start: 3615979

End: 3616572

Strand: Direct

Name: msrA

Synonym: LIC12978

Alternate gene names: 45658805

Gene position: 3615979-3616572 (Clockwise)

Preceding gene: 45658802

Following gene: 45658807

Centisome position: 84.54

GC content: 34.01

Gene sequence:

>594_bases
ATGTTTAATCTTAAAATTTTAATTTTTATCTATATTATATTTTTTTCTCCTAATTTAATGGCGACTCCTAAAACAGAAAA
AGCCACATTTGCCGGCGGTTGTTTTTGGTGTATGGAAGGACCATTCGAATCTCTTCCCGGAGTTATCTCGGTCGTAGCCG
GTTATTCCGGGGGAAAAGAATTCTATCCTACTTATCAGGAAGTAAGTCGAGGCAAAACGGGTCATAGAGAAAGTGTTCAA
ATAGAATTCGATTCTTCTAAAATTCGTTATGAAGAATTACTAACAGTTTTTTGGAATCAAATCGATCCAACAGACAATGG
TGGACAATTTGCAGATCGAGGAAATCAATATAGAACTGGCATTTTCTATCATAACCAAACTCAAAAAAAAGCTGCCGAAA
AATCCAAACGTGAAATTTCAGAATCCAAAAAGTTTCCCGGTTCGATCGTAGTCGAAATCATTCCTTTTACTTCTTTTTAT
CCTGCGGAAGATTATCACCAAAATTATTATAAAACCAATTCGGAACAATATAAGAAATATAAAAAATACTCAGGAAGAGA
AGATTACTTAGAAAAAATGTGTAGGCAACGTTAA

Upstream 100 bases:

>100_bases
AAATCATTCTTTTTAAATTCGATAGAAGTTCCCTTAAATTAATAGTATAAGTTCTTTTTTTAGTAACAAATTTTTCTAAA
CTTCGAATTCTTTTAGTAGG

Downstream 100 bases:

>100_bases
AACACAAGGAATCAGAATCGATTGTGTTCCACTCCAATTCCTTGTGTTTTTAAATCTGATCAGCAGAGACGAATCAAAAA
CATAGTAAGTCTTTGAAGTT

Product: peptide methionine sulfoxide reductase 2

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 197; Mature: 197

Protein sequence:

>197_residues
MFNLKILIFIYIIFFSPNLMATPKTEKATFAGGCFWCMEGPFESLPGVISVVAGYSGGKEFYPTYQEVSRGKTGHRESVQ
IEFDSSKIRYEELLTVFWNQIDPTDNGGQFADRGNQYRTGIFYHNQTQKKAAEKSKREISESKKFPGSIVVEIIPFTSFY
PAEDYHQNYYKTNSEQYKKYKKYSGREDYLEKMCRQR

Sequences:

>Translated_197_residues
MFNLKILIFIYIIFFSPNLMATPKTEKATFAGGCFWCMEGPFESLPGVISVVAGYSGGKEFYPTYQEVSRGKTGHRESVQ
IEFDSSKIRYEELLTVFWNQIDPTDNGGQFADRGNQYRTGIFYHNQTQKKAAEKSKREISESKKFPGSIVVEIIPFTSFY
PAEDYHQNYYKTNSEQYKKYKKYSGREDYLEKMCRQR
>Mature_197_residues
MFNLKILIFIYIIFFSPNLMATPKTEKATFAGGCFWCMEGPFESLPGVISVVAGYSGGKEFYPTYQEVSRGKTGHRESVQ
IEFDSSKIRYEELLTVFWNQIDPTDNGGQFADRGNQYRTGIFYHNQTQKKAAEKSKREISESKKFPGSIVVEIIPFTSFY
PAEDYHQNYYKTNSEQYKKYKKYSGREDYLEKMCRQR

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=155, Percent_Identity=41.2903225806452, Blast_Score=108, Evalue=3e-24,
Organism=Homo sapiens, GI208609995, Length=155, Percent_Identity=41.2903225806452, Blast_Score=108, Evalue=4e-24,
Organism=Homo sapiens, GI208609993, Length=109, Percent_Identity=39.4495412844037, Blast_Score=73, Evalue=2e-13,
Organism=Escherichia coli, GI1790665, Length=151, Percent_Identity=45.0331125827815, Blast_Score=118, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17533973, Length=145, Percent_Identity=37.2413793103448, Blast_Score=91, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6320881, Length=162, Percent_Identity=32.0987654320988, Blast_Score=80, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24664627, Length=142, Percent_Identity=38.0281690140845, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24664631, Length=142, Percent_Identity=37.3239436619718, Blast_Score=91, Evalue=5e-19,
Organism=Drosophila melanogaster, GI45553131, Length=137, Percent_Identity=37.2262773722628, Blast_Score=91, Evalue=5e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 22970; Mature: 22970

Theoretical pI: Translated: 8.92; Mature: 8.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFNLKILIFIYIIFFSPNLMATPKTEKATFAGGCFWCMEGPFESLPGVISVVAGYSGGKE
CCCHHHHHHHHHHHHCCCCEECCCCCCCEECCCEEEEECCCHHHHHHHHHHHHCCCCCCC
FYPTYQEVSRGKTGHRESVQIEFDSSKIRYEELLTVFWNQIDPTDNGGQFADRGNQYRTG
CCCCHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEE
IFYHNQTQKKAAEKSKREISESKKFPGSIVVEIIPFTSFYPAEDYHQNYYKTNSEQYKKY
EEEECCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHCCCHHHHHHH
KKYSGREDYLEKMCRQR
HHCCCHHHHHHHHHHCC
>Mature Secondary Structure
MFNLKILIFIYIIFFSPNLMATPKTEKATFAGGCFWCMEGPFESLPGVISVVAGYSGGKE
CCCHHHHHHHHHHHHCCCCEECCCCCCCEECCCEEEEECCCHHHHHHHHHHHHCCCCCCC
FYPTYQEVSRGKTGHRESVQIEFDSSKIRYEELLTVFWNQIDPTDNGGQFADRGNQYRTG
CCCCHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEE
IFYHNQTQKKAAEKSKREISESKKFPGSIVVEIIPFTSFYPAEDYHQNYYKTNSEQYKKY
EEEECCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHCCCHHHHHHH
KKYSGREDYLEKMCRQR
HHCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA