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The map label for this gene is lysC

Identifier: 45658739

GI number: 45658739

Start: 3531712

End: 3532929

Strand: Direct

Name: lysC

Synonym: LIC12909

Alternate gene names: 45658739

Gene position: 3531712-3532929 (Clockwise)

Preceding gene: 45658737

Following gene: 45658740

Centisome position: 82.57

GC content: 41.87

Gene sequence:

>1218_bases
ATGACAAATATAATCGTTCAAAAATACGGCGGAACTTCCGTGGGTACTCCGGAAAGAATCCAGAACGTTGCAAAAAGAAT
CAAATCCTATCATGATAAAGGTCAACAAGTGGCGGTTATAGTTTCCGCAATGGGACATACCACAGACGAACTCGTTGACC
TCGCAGCGAAAATTTCTTCTAATCCGCCTAAACGTGAAATGGACATGTTACTTTCTACGGGCGAACAGATTTCCACTGCA
CTCCTCGCTATGGCTCTTTGGGAAATCGGAGTTCCGGCCACTTCTTTTACAGGTTCTCAGATCAAACTTCTTACGGACGG
AAATTTCTCCAATGCAAAGATCAAAATGATCGATCGATCCAGAATCGATTCTGCGTTGAACGAAGGTAAGGTGGTTATCA
TTGCTGGTTTTCAGGGAATAGACGCGGAAGAAAATATCACAACTTTAGGAAGAGGTGGTTCCGACACTTCTGCTGTCGCA
GTCGCTGCCATTTTAGGTGCAAAAGAATGTGAGATTTATACGGACGTAGATGGAGTTTACACCGCCGATCCAAGAGTTGT
TCCCAGCGCTAAAAAACATAAACAAATTACTTACGAAGAAATGCTCGAACTGGCGAGTTTAGGAGCGGGTGTTCTCCATT
CCAGAAGTGTGGAACTTGGGATGAATTACGACGTGGTCATTCATGTTCGTTCTAGTTTCAACGATAATATAGGAACGCTT
GTAGTGAGCGAGGATAAGATTATGGAAAAATTAAAAGTGAGCGGCGTTACTGCTAAAAACGATCAAGCAAGAATTACAAT
CGCAGGAGTTCCAGATAAACCTGGTTTAGCCGCAGGACTTTTTGGCGAACTAAGCTCTAAACATATTCTTGTAGATATGA
TCGTCCAATCTTCTCCGCATAACGGCATTAATACGATTTCCTTTACAATTCCTAAAAAAGATGTTCACGAAGCAAAACCG
ATTCTTGAAGGATTTTCAAAGTCGCATAACGCAAAGGAACCAGAGATCAACGAAAATATCGCGATCGTTTCTGCGGTCGG
AGTAGGTATGAAATCGCACGTAGGTGTTGCAGCGGGAATGTTCAAAGCACTTGCCGACAACGGAATCAACATAGAAATGA
TTTCTACTTCAGAAATCAAAATCTCTTGTGTAATTGCAGAAAGTCAGGCTAAAATCGCAGTTAATAAAATTCACGACGTA
TTTGGTCTTTCTTCTTAA

Upstream 100 bases:

>100_bases
CCTTTCTTGAAAACGAAACCTTCTTTCCAAAATATGATGAATCAAAATCGAATTCTCTTGATCCTCTACTAGTTATGAAA
ATCATGACTGCCATAAGGTT

Downstream 100 bases:

>100_bases
AGTCTGTTTCAAAATCTTCAAACGTCACTTTACAAATTTACTACGTAAATGGTGGTTCCTATATAGATCCTGATTTGTTT
AGGAATTTTTTAAACTTTGT

Product: aspartate kinase

Products: NA

Alternate protein names: Aspartate kinase [H]

Number of amino acids: Translated: 405; Mature: 404

Protein sequence:

>405_residues
MTNIIVQKYGGTSVGTPERIQNVAKRIKSYHDKGQQVAVIVSAMGHTTDELVDLAAKISSNPPKREMDMLLSTGEQISTA
LLAMALWEIGVPATSFTGSQIKLLTDGNFSNAKIKMIDRSRIDSALNEGKVVIIAGFQGIDAEENITTLGRGGSDTSAVA
VAAILGAKECEIYTDVDGVYTADPRVVPSAKKHKQITYEEMLELASLGAGVLHSRSVELGMNYDVVIHVRSSFNDNIGTL
VVSEDKIMEKLKVSGVTAKNDQARITIAGVPDKPGLAAGLFGELSSKHILVDMIVQSSPHNGINTISFTIPKKDVHEAKP
ILEGFSKSHNAKEPEINENIAIVSAVGVGMKSHVGVAAGMFKALADNGINIEMISTSEIKISCVIAESQAKIAVNKIHDV
FGLSS

Sequences:

>Translated_405_residues
MTNIIVQKYGGTSVGTPERIQNVAKRIKSYHDKGQQVAVIVSAMGHTTDELVDLAAKISSNPPKREMDMLLSTGEQISTA
LLAMALWEIGVPATSFTGSQIKLLTDGNFSNAKIKMIDRSRIDSALNEGKVVIIAGFQGIDAEENITTLGRGGSDTSAVA
VAAILGAKECEIYTDVDGVYTADPRVVPSAKKHKQITYEEMLELASLGAGVLHSRSVELGMNYDVVIHVRSSFNDNIGTL
VVSEDKIMEKLKVSGVTAKNDQARITIAGVPDKPGLAAGLFGELSSKHILVDMIVQSSPHNGINTISFTIPKKDVHEAKP
ILEGFSKSHNAKEPEINENIAIVSAVGVGMKSHVGVAAGMFKALADNGINIEMISTSEIKISCVIAESQAKIAVNKIHDV
FGLSS
>Mature_404_residues
TNIIVQKYGGTSVGTPERIQNVAKRIKSYHDKGQQVAVIVSAMGHTTDELVDLAAKISSNPPKREMDMLLSTGEQISTAL
LAMALWEIGVPATSFTGSQIKLLTDGNFSNAKIKMIDRSRIDSALNEGKVVIIAGFQGIDAEENITTLGRGGSDTSAVAV
AAILGAKECEIYTDVDGVYTADPRVVPSAKKHKQITYEEMLELASLGAGVLHSRSVELGMNYDVVIHVRSSFNDNIGTLV
VSEDKIMEKLKVSGVTAKNDQARITIAGVPDKPGLAAGLFGELSSKHILVDMIVQSSPHNGINTISFTIPKKDVHEAKPI
LEGFSKSHNAKEPEINENIAIVSAVGVGMKSHVGVAAGMFKALADNGINIEMISTSEIKISCVIAESQAKIAVNKIHDVF
GLSS

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=342, Percent_Identity=33.3333333333333, Blast_Score=159, Evalue=4e-40,
Organism=Escherichia coli, GI1790455, Length=354, Percent_Identity=28.5310734463277, Blast_Score=101, Evalue=9e-23,
Organism=Escherichia coli, GI1790376, Length=283, Percent_Identity=24.7349823321555, Blast_Score=74, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6320893, Length=379, Percent_Identity=29.023746701847, Blast_Score=129, Evalue=8e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 43060; Mature: 42929

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNIIVQKYGGTSVGTPERIQNVAKRIKSYHDKGQQVAVIVSAMGHTTDELVDLAAKISS
CCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEEHHCCCHHHHHHHHHHHCC
NPPKREMDMLLSTGEQISTALLAMALWEIGVPATSFTGSQIKLLTDGNFSNAKIKMIDRS
CCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCEEEEEEHH
RIDSALNEGKVVIIAGFQGIDAEENITTLGRGGSDTSAVAVAAILGAKECEIYTDVDGVY
HHHHHHCCCCEEEEECCCCCCCCCCEEECCCCCCCHHHHHHHHHHCCCCCEEEECCCCEE
TADPRVVPSAKKHKQITYEEMLELASLGAGVLHSRSVELGMNYDVVIHVRSSFNDNIGTL
ECCCCCCCCCHHHCCCCHHHHHHHHHCCCCHHCCCCEEECCCEEEEEEEECCCCCCCEEE
VVSEDKIMEKLKVSGVTAKNDQARITIAGVPDKPGLAAGLFGELSSKHILVDMIVQSSPH
EECHHHHHHHHHHCCCEECCCCEEEEEEECCCCCCCHHHHHHHCCCCEEEEEEEECCCCC
NGINTISFTIPKKDVHEAKPILEGFSKSHNAKEPEINENIAIVSAVGVGMKSHVGVAAGM
CCCCEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHH
FKALADNGINIEMISTSEIKISCVIAESQAKIAVNKIHDVFGLSS
HHHHHCCCCEEEEEECCCEEEEEEEECCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TNIIVQKYGGTSVGTPERIQNVAKRIKSYHDKGQQVAVIVSAMGHTTDELVDLAAKISS
CCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEEHHCCCHHHHHHHHHHHCC
NPPKREMDMLLSTGEQISTALLAMALWEIGVPATSFTGSQIKLLTDGNFSNAKIKMIDRS
CCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCEEEEEEHH
RIDSALNEGKVVIIAGFQGIDAEENITTLGRGGSDTSAVAVAAILGAKECEIYTDVDGVY
HHHHHHCCCCEEEEECCCCCCCCCCEEECCCCCCCHHHHHHHHHHCCCCCEEEECCCCEE
TADPRVVPSAKKHKQITYEEMLELASLGAGVLHSRSVELGMNYDVVIHVRSSFNDNIGTL
ECCCCCCCCCHHHCCCCHHHHHHHHHCCCCHHCCCCEEECCCEEEEEEEECCCCCCCEEE
VVSEDKIMEKLKVSGVTAKNDQARITIAGVPDKPGLAAGLFGELSSKHILVDMIVQSSPH
EECHHHHHHHHHHCCCEECCCCEEEEEEECCCCCCCHHHHHHHCCCCEEEEEEEECCCCC
NGINTISFTIPKKDVHEAKPILEGFSKSHNAKEPEINENIAIVSAVGVGMKSHVGVAAGM
CCCCEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHH
FKALADNGINIEMISTSEIKISCVIAESQAKIAVNKIHDVFGLSS
HHHHHCCCCEEEEEECCCEEEEEEEECCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]