| Definition | Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130 chromosome chromosome I, complete sequence. |
|---|---|
| Accession | NC_005823 |
| Length | 4,277,185 |
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The map label for this gene is slt [H]
Identifier: 45658658
GI number: 45658658
Start: 3430449
End: 3432698
Strand: Direct
Name: slt [H]
Synonym: LIC12828
Alternate gene names: 45658658
Gene position: 3430449-3432698 (Clockwise)
Preceding gene: 45658656
Following gene: 45658659
Centisome position: 80.2
GC content: 36.04
Gene sequence:
>2250_bases ATGAAAAAATTCGCCCTGACCAGCCTACTCGTCTTCATTTTCGGCAATATTTACGCAAACGATGATCTCAAATATCTGAT CAAATCCTATAGTCTTCAAAAAATCCATCGTATTTTTCAGGAACGACATCCCGGAACTGAATCCGAAGTTTATGCATTAG TTAGATACCACGAAGAACATCCGGACGGACATCATGATAAAAAATTTTACTATCTGGTTTCTATTCTCAAAGGTAAGTTA ACTTCCCATCCAACAAGACAAGATCTTCTGGATATTTTACATTCTCCCTTACCATCTAACTCGGTAATTACGAAACTTTC CTTCTGGAAACTCTATGAAGAAGCCTCTCGCAGAAAACTTTTGAATAAAATAGAACTGATCGATTTTTTAAAAAAATTAC CGAGAGAAAACGACCCACTCAGTCAAAACGCAATTTCAGAAATTTTTAAGATCTATTACGAAACCGGAATGATTCGAGAA TGTCTGGACTTTGCCAAAACTTTTTCAGATCGAGAACGATCCGAAATTTTTTCTCCTATGATTTGGTACCGTTATGCGAA ATCTCTCTACAAATCAGGAAATACCGAAAATGCAGAATCCATTTTTTATACTGTTTTAGAAGATCCTTCCGTCCTTTCTT CTGTTAAAAAATTTATCTTGGAAGATCTACAAATCTGGAAAGGAAATTCCTTTTATTCTTCTCTTACTCCGGAAAGGGCG GCTTTGTTTCTTCCTTTTTTAAATCCCTCCGAAAAAAAACATCTGATCGCATCTAAAGATCTTGAAAAAGTTTCTTTTTC TAAAGGAGAAGCGTTTCGTAACACTGCCAGGGCCATTCTTTCTTATGAACCAGAATTACTTCCCGATTTTTTTAGAAGAA ATTCAAATCTAGCAAAATACAACCCGGATTTTACTGCGGTTATGTCGAGAGAACTTACCAATCAGAATTTTTCGGGCAAG GCTCTGGATTTGTTAAACGAATCCGGAGTCGAAAAAAACGACGAGGTTCTTTACAGTTACGCCAGGGCTTTTAAAAAACA AGGAAACAAAGATCTATATTTTAGAAATCTAATAGACTCTTTAGAAAAAAATCCGACAAATTTAATCCGACAAGACGAAT TAATCGATCTTCTGATCGGCAATCACGAAAACTTTTTAGGTGATGCTTATTGGAAAGACGCTCTTAGAAAAATTCCGGAC CTTCCAGTTAAAGGAAGATTGGTGTATTGGTATCTTAGATTCCTTAAAAAAAACGGTAGAACCGAAGAACTCAACTCTTG GCTTAAATCCTATTATAAATTCATTCCTGGTTCTTATTATACAAGAGTAATTCGAGAAGAATTCCAAGAGGAAATTTCAG CCTTCCCTCTTCCTTCTAATCCTACTTCTAATAAAGATAATTTATTTGAATATCTTTCCTTAACTGCAGGAATTCCTGAA CTTTCTGGAAAAATTTTAGGAAAAGATTTGGACTTTGCCATTCAGTCCGCAGCGTTTCAGTTAGACGGTAAAATCGATTC CGCTCATTCTAAAATTAAAGGAAATAAAATTCTACAATCTGCAAAAGAATATTTAGAAGTAGGAGAGATGGGTTATGCGC TTTCGTTAGTTCAAAAATACAAATTCCAACAAGGAATTGGAGAAAACGAAAAGGATGAAATTCTAGCTGCTCTTGGAGAA CAAACTGGAACTACTTATCTCACCGTCTTTCATACTAGAGCTCTGATGAAAAAAGAAAAAATCAGCGACGACGTGATTCT ACTTCCCTCGAAACTTGCGGCTAGAATTTATCCTAGACCACATAGAGGACTTGTAACTTCCATTTCTCAAAAACTTGGAA TCGAAGAAGACATCATATACGCAATCATGCGCCAAGAATCTTTTTTTAAAGAGAATGCTGTTTCCGTTTCGAACGCAAGG GGTTTGATGCAGATCATGGGTCCTACTGGTAAAGAAATCGCCAAAGGAATGAATCTAAATTCTTACTCACTTTTTGATCC AGAAGTTTCTATCGAAATGGGTGCGAGGTTTTTACGCTATCTTGTTGCTTCTCATGGAAACCTTCAATGGGCTTCGATCG CTTATAACGGAGGTCCTGGAAATCTGCGTAAATGGAAACGAAACCATTATCGTGGAGACTTCAATCATTTCTTAGAAGAA CTTCCTCTTAAAGAACCAAGAGACTATTGTAGAATCGTTAGTTCTAACTATTATAATTATCAGAATTTACGAAAGTATAA GAGACTTTAA
Upstream 100 bases:
>100_bases CGGGCCAAAGATCGTTCGTTTTTTCTTTTTCCAGGATTTGCATGAGAATTTCCTTTTTGCGATTGAATCCTTAGGCCGAA AAGGTAACTAAAGAATACGA
Downstream 100 bases:
>100_bases ATTTTTTAGATTGTCTCTCTGATAGAAAGAATAGGATAGGAATCTGAAACAATTGAAGCGCAATTTTTGAACGCCACCGC AAAAACGACAAACATTTATT
Product: soluble lytic transglycosylase
Products: 1,6-Anhydrobond [C]
Alternate protein names: Exomuramidase; Peptidoglycan lytic exotransglycosylase; Slt70 [H]
Number of amino acids: Translated: 749; Mature: 749
Protein sequence:
>749_residues MKKFALTSLLVFIFGNIYANDDLKYLIKSYSLQKIHRIFQERHPGTESEVYALVRYHEEHPDGHHDKKFYYLVSILKGKL TSHPTRQDLLDILHSPLPSNSVITKLSFWKLYEEASRRKLLNKIELIDFLKKLPRENDPLSQNAISEIFKIYYETGMIRE CLDFAKTFSDRERSEIFSPMIWYRYAKSLYKSGNTENAESIFYTVLEDPSVLSSVKKFILEDLQIWKGNSFYSSLTPERA ALFLPFLNPSEKKHLIASKDLEKVSFSKGEAFRNTARAILSYEPELLPDFFRRNSNLAKYNPDFTAVMSRELTNQNFSGK ALDLLNESGVEKNDEVLYSYARAFKKQGNKDLYFRNLIDSLEKNPTNLIRQDELIDLLIGNHENFLGDAYWKDALRKIPD LPVKGRLVYWYLRFLKKNGRTEELNSWLKSYYKFIPGSYYTRVIREEFQEEISAFPLPSNPTSNKDNLFEYLSLTAGIPE LSGKILGKDLDFAIQSAAFQLDGKIDSAHSKIKGNKILQSAKEYLEVGEMGYALSLVQKYKFQQGIGENEKDEILAALGE QTGTTYLTVFHTRALMKKEKISDDVILLPSKLAARIYPRPHRGLVTSISQKLGIEEDIIYAIMRQESFFKENAVSVSNAR GLMQIMGPTGKEIAKGMNLNSYSLFDPEVSIEMGARFLRYLVASHGNLQWASIAYNGGPGNLRKWKRNHYRGDFNHFLEE LPLKEPRDYCRIVSSNYYNYQNLRKYKRL
Sequences:
>Translated_749_residues MKKFALTSLLVFIFGNIYANDDLKYLIKSYSLQKIHRIFQERHPGTESEVYALVRYHEEHPDGHHDKKFYYLVSILKGKL TSHPTRQDLLDILHSPLPSNSVITKLSFWKLYEEASRRKLLNKIELIDFLKKLPRENDPLSQNAISEIFKIYYETGMIRE CLDFAKTFSDRERSEIFSPMIWYRYAKSLYKSGNTENAESIFYTVLEDPSVLSSVKKFILEDLQIWKGNSFYSSLTPERA ALFLPFLNPSEKKHLIASKDLEKVSFSKGEAFRNTARAILSYEPELLPDFFRRNSNLAKYNPDFTAVMSRELTNQNFSGK ALDLLNESGVEKNDEVLYSYARAFKKQGNKDLYFRNLIDSLEKNPTNLIRQDELIDLLIGNHENFLGDAYWKDALRKIPD LPVKGRLVYWYLRFLKKNGRTEELNSWLKSYYKFIPGSYYTRVIREEFQEEISAFPLPSNPTSNKDNLFEYLSLTAGIPE LSGKILGKDLDFAIQSAAFQLDGKIDSAHSKIKGNKILQSAKEYLEVGEMGYALSLVQKYKFQQGIGENEKDEILAALGE QTGTTYLTVFHTRALMKKEKISDDVILLPSKLAARIYPRPHRGLVTSISQKLGIEEDIIYAIMRQESFFKENAVSVSNAR GLMQIMGPTGKEIAKGMNLNSYSLFDPEVSIEMGARFLRYLVASHGNLQWASIAYNGGPGNLRKWKRNHYRGDFNHFLEE LPLKEPRDYCRIVSSNYYNYQNLRKYKRL >Mature_749_residues MKKFALTSLLVFIFGNIYANDDLKYLIKSYSLQKIHRIFQERHPGTESEVYALVRYHEEHPDGHHDKKFYYLVSILKGKL TSHPTRQDLLDILHSPLPSNSVITKLSFWKLYEEASRRKLLNKIELIDFLKKLPRENDPLSQNAISEIFKIYYETGMIRE CLDFAKTFSDRERSEIFSPMIWYRYAKSLYKSGNTENAESIFYTVLEDPSVLSSVKKFILEDLQIWKGNSFYSSLTPERA ALFLPFLNPSEKKHLIASKDLEKVSFSKGEAFRNTARAILSYEPELLPDFFRRNSNLAKYNPDFTAVMSRELTNQNFSGK ALDLLNESGVEKNDEVLYSYARAFKKQGNKDLYFRNLIDSLEKNPTNLIRQDELIDLLIGNHENFLGDAYWKDALRKIPD LPVKGRLVYWYLRFLKKNGRTEELNSWLKSYYKFIPGSYYTRVIREEFQEEISAFPLPSNPTSNKDNLFEYLSLTAGIPE LSGKILGKDLDFAIQSAAFQLDGKIDSAHSKIKGNKILQSAKEYLEVGEMGYALSLVQKYKFQQGIGENEKDEILAALGE QTGTTYLTVFHTRALMKKEKISDDVILLPSKLAARIYPRPHRGLVTSISQKLGIEEDIIYAIMRQESFFKENAVSVSNAR GLMQIMGPTGKEIAKGMNLNSYSLFDPEVSIEMGARFLRYLVASHGNLQWASIAYNGGPGNLRKWKRNHYRGDFNHFLEE LPLKEPRDYCRIVSSNYYNYQNLRKYKRL
Specific function: Murein-degrading enzyme. Catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N- acetylglucosamine residues in peptidoglycan. May play a role in recycling of muropeptides during cell elongation and/or cell division [H]
COG id: COG0741
COG function: function code M; Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains)
Gene ontology:
Cell location: Periplasm. Note=Tightly associated with the murein sacculus (By similarity) [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the transglycosylase slt family [H]
Homologues:
Organism=Escherichia coli, GI87082441, Length=135, Percent_Identity=37.7777777777778, Blast_Score=77, Evalue=3e-15,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR016026 - InterPro: IPR008258 - InterPro: IPR012289 - InterPro: IPR008939 - InterPro: IPR000189 [H]
Pfam domain/function: PF01464 SLT [H]
EC number: 3.2.1.- [C]
Molecular weight: Translated: 86759; Mature: 86759
Theoretical pI: Translated: 9.43; Mature: 9.43
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.3 %Cys (Translated Protein) 1.5 %Met (Translated Protein) 1.7 %Cys+Met (Translated Protein) 0.3 %Cys (Mature Protein) 1.5 %Met (Mature Protein) 1.7 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MKKFALTSLLVFIFGNIYANDDLKYLIKSYSLQKIHRIFQERHPGTESEVYALVRYHEEH CCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCC PDGHHDKKFYYLVSILKGKLTSHPTRQDLLDILHSPLPSNSVITKLSFWKLYEEASRRKL CCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH LNKIELIDFLKKLPRENDPLSQNAISEIFKIYYETGMIRECLDFAKTFSDRERSEIFSPM HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHH IWYRYAKSLYKSGNTENAESIFYTVLEDPSVLSSVKKFILEDLQIWKGNSFYSSLTPERA HHHHHHHHHHHCCCCCCHHHHEEEHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHCCCCHH ALFLPFLNPSEKKHLIASKDLEKVSFSKGEAFRNTARAILSYEPELLPDFFRRNSNLAKY EEEEECCCCCCHHHHHHHCCHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCC NPDFTAVMSRELTNQNFSGKALDLLNESGVEKNDEVLYSYARAFKKQGNKDLYFRNLIDS CCCHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHH LEKNPTNLIRQDELIDLLIGNHENFLGDAYWKDALRKIPDLPVKGRLVYWYLRFLKKNGR HHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCC TEELNSWLKSYYKFIPGSYYTRVIREEFQEEISAFPLPSNPTSNKDNLFEYLSLTAGIPE HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCHH LSGKILGKDLDFAIQSAAFQLDGKIDSAHSKIKGNKILQSAKEYLEVGEMGYALSLVQKY HCCHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH KFQQGIGENEKDEILAALGEQTGTTYLTVFHTRALMKKEKISDDVILLPSKLAARIYPRP HHHHCCCCCHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHCCCCEEECCHHHHHHCCCCC HRGLVTSISQKLGIEEDIIYAIMRQESFFKENAVSVSNARGLMQIMGPTGKEIAKGMNLN CCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHCCCCCC SYSLFDPEVSIEMGARFLRYLVASHGNLQWASIAYNGGPGNLRKWKRNHYRGDFNHFLEE CCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCHHHHHHHCCCCHHHHHHHH LPLKEPRDYCRIVSSNYYNYQNLRKYKRL CCCCCCHHHHHHHHCCCCCHHHHHHHHCC >Mature Secondary Structure MKKFALTSLLVFIFGNIYANDDLKYLIKSYSLQKIHRIFQERHPGTESEVYALVRYHEEH CCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCC PDGHHDKKFYYLVSILKGKLTSHPTRQDLLDILHSPLPSNSVITKLSFWKLYEEASRRKL CCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH LNKIELIDFLKKLPRENDPLSQNAISEIFKIYYETGMIRECLDFAKTFSDRERSEIFSPM HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHH IWYRYAKSLYKSGNTENAESIFYTVLEDPSVLSSVKKFILEDLQIWKGNSFYSSLTPERA HHHHHHHHHHHCCCCCCHHHHEEEHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHCCCCHH ALFLPFLNPSEKKHLIASKDLEKVSFSKGEAFRNTARAILSYEPELLPDFFRRNSNLAKY EEEEECCCCCCHHHHHHHCCHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCC NPDFTAVMSRELTNQNFSGKALDLLNESGVEKNDEVLYSYARAFKKQGNKDLYFRNLIDS CCCHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHH LEKNPTNLIRQDELIDLLIGNHENFLGDAYWKDALRKIPDLPVKGRLVYWYLRFLKKNGR HHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCC TEELNSWLKSYYKFIPGSYYTRVIREEFQEEISAFPLPSNPTSNKDNLFEYLSLTAGIPE HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCHH LSGKILGKDLDFAIQSAAFQLDGKIDSAHSKIKGNKILQSAKEYLEVGEMGYALSLVQKY HCCHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH KFQQGIGENEKDEILAALGEQTGTTYLTVFHTRALMKKEKISDDVILLPSKLAARIYPRP HHHHCCCCCHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHCCCCEEECCHHHHHHCCCCC HRGLVTSISQKLGIEEDIIYAIMRQESFFKENAVSVSNARGLMQIMGPTGKEIAKGMNLN CCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHCCCCCC SYSLFDPEVSIEMGARFLRYLVASHGNLQWASIAYNGGPGNLRKWKRNHYRGDFNHFLEE CCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCHHHHHHHCCCCHHHHHHHH LPLKEPRDYCRIVSSNYYNYQNLRKYKRL CCCCCCHHHHHHHHCCCCCHHHHHHHHCC
PDB accession: NA
Resolution: NA
Structure class: Alpha
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: Muramic Acid Residue (N-Acetylmuramic Acid And N-Acetylglucosamine Residues) [C]
Specific reaction: Cleavage Of The Beta-1,4-Glycosidic Bond Between N-Acetylmuramic Acid And N-Acetylglucosamine Residues, Thereby Conserving The Energy In A Newly Synthesized 1,6-Anhydrobond In The Muramic Acid Residue. [C]
General reaction: Cleavage Of The Beta-1,4-Glycosidic Bond [C]
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 11206551; 11258796 [H]