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The map label for this gene is tmk

Identifier: 45658645

GI number: 45658645

Start: 3419353

End: 3419967

Strand: Direct

Name: tmk

Synonym: LIC12814

Alternate gene names: 45658645

Gene position: 3419353-3419967 (Clockwise)

Preceding gene: 45658639

Following gene: 45658646

Centisome position: 79.94

GC content: 34.15

Gene sequence:

>615_bases
ATGAAGAATAAAAAACCAATCTTTGTAGTTTTTGAAGGAATTGATGGAAGTGGCAAATCTACACTTTGCAAATCGTTAAC
CGAAAAACTCATTGAACTTGGAATTCCCTCTGCAGCTTTTACCGAACCTACAAATCTGGAAACCGGAAAATATCTTAGAA
AGTTTCTCAGAGGAGAAATCGAACTTGGAAAAGAAGAACAAATCGAGGCCTTTTTAAACGATAGAGAAGAATCTTTAAAA
CAAAATATTCTTCCCGCTTTGAACTCAGACAAAAACGTTTTACTCGATCGTTATATGTATTCTACAGCCGCCTATCAAAG
TGGAGACGATTTGTCTCCTGAAATGATTCTTAAAAAAAATCTAAATCGAAATTTCAAAATCCCGGATCTTTTATTTTATT
TAGATTTAAGTCCTTCTATAGCCCTTGAAAGACTAAACCGAAGAAAGGAAGGTAAAGAAAGATTTGAAACGTTAGCTCAG
CTTGAAAAAATCCGTTCAGCTTACGAGAAAATTCTCCCCAAAGATACGATCCGAATCGACGGCAATAAAAACCAAAATCA
AATCGTTCAAGAATGTTTGGAAATTTTTCTCACAAACATCAAAAGTAAATCTTAG

Upstream 100 bases:

>100_bases
TTCATTGGATTCCTAATTTCTAAAAAATCCAATGTCTGTAGATATAAGAATGATTTTATACGAATCCATCTTTGTCAAGA
ATTGAATCGGAACCGTTAGA

Downstream 100 bases:

>100_bases
AGTCTTTGAGTAACCATAAAACAAGAGGCTAAGCTCCTGCATAAATTCAAAAAATGGAATATTAAAAATTTTCAAATTAT
TCAATGCAACGTTTTTTGTG

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase

Number of amino acids: Translated: 204; Mature: 204

Protein sequence:

>204_residues
MKNKKPIFVVFEGIDGSGKSTLCKSLTEKLIELGIPSAAFTEPTNLETGKYLRKFLRGEIELGKEEQIEAFLNDREESLK
QNILPALNSDKNVLLDRYMYSTAAYQSGDDLSPEMILKKNLNRNFKIPDLLFYLDLSPSIALERLNRRKEGKERFETLAQ
LEKIRSAYEKILPKDTIRIDGNKNQNQIVQECLEIFLTNIKSKS

Sequences:

>Translated_204_residues
MKNKKPIFVVFEGIDGSGKSTLCKSLTEKLIELGIPSAAFTEPTNLETGKYLRKFLRGEIELGKEEQIEAFLNDREESLK
QNILPALNSDKNVLLDRYMYSTAAYQSGDDLSPEMILKKNLNRNFKIPDLLFYLDLSPSIALERLNRRKEGKERFETLAQ
LEKIRSAYEKILPKDTIRIDGNKNQNQIVQECLEIFLTNIKSKS
>Mature_204_residues
MKNKKPIFVVFEGIDGSGKSTLCKSLTEKLIELGIPSAAFTEPTNLETGKYLRKFLRGEIELGKEEQIEAFLNDREESLK
QNILPALNSDKNVLLDRYMYSTAAYQSGDDLSPEMILKKNLNRNFKIPDLLFYLDLSPSIALERLNRRKEGKERFETLAQ
LEKIRSAYEKILPKDTIRIDGNKNQNQIVQECLEIFLTNIKSKS

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family

Homologues:

Organism=Escherichia coli, GI1787340, Length=159, Percent_Identity=32.0754716981132, Blast_Score=70, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17535647, Length=192, Percent_Identity=31.7708333333333, Blast_Score=68, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KTHY_LEPIC (Q72NL9)

Other databases:

- EMBL:   AE016823
- RefSeq:   YP_002731.1
- ProteinModelPortal:   Q72NL9
- SMR:   Q72NL9
- GeneID:   2770099
- GenomeReviews:   AE016823_GR
- KEGG:   lic:LIC12814
- NMPDR:   fig|267671.1.peg.2731
- HOGENOM:   HBG626009
- OMA:   SSLAYQW
- ProtClustDB:   CLSK573646
- BioCyc:   LINT267671:LIC_12814-MONOMER
- HAMAP:   MF_00165
- InterPro:   IPR018095
- InterPro:   IPR018094
- PANTHER:   PTHR10344
- TIGRFAMs:   TIGR00041

Pfam domain/function: PF02223 Thymidylate_kin

EC number: =2.7.4.9

Molecular weight: Translated: 23421; Mature: 23421

Theoretical pI: Translated: 8.62; Mature: 8.62

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNKKPIFVVFEGIDGSGKSTLCKSLTEKLIELGIPSAAFTEPTNLETGKYLRKFLRGEI
CCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHH
ELGKEEQIEAFLNDREESLKQNILPALNSDKNVLLDRYMYSTAAYQSGDDLSPEMILKKN
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
LNRNFKIPDLLFYLDLSPSIALERLNRRKEGKERFETLAQLEKIRSAYEKILPKDTIRID
CCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEC
GNKNQNQIVQECLEIFLTNIKSKS
CCCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKNKKPIFVVFEGIDGSGKSTLCKSLTEKLIELGIPSAAFTEPTNLETGKYLRKFLRGEI
CCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHH
ELGKEEQIEAFLNDREESLKQNILPALNSDKNVLLDRYMYSTAAYQSGDDLSPEMILKKN
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
LNRNFKIPDLLFYLDLSPSIALERLNRRKEGKERFETLAQLEKIRSAYEKILPKDTIRID
CCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEC
GNKNQNQIVQECLEIFLTNIKSKS
CCCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA