| Definition | Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130 chromosome chromosome I, complete sequence. |
|---|---|
| Accession | NC_005823 |
| Length | 4,277,185 |
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The map label for this gene is trpC
Identifier: 45658617
GI number: 45658617
Start: 3391956
End: 3392714
Strand: Reverse
Name: trpC
Synonym: LIC12786
Alternate gene names: 45658617
Gene position: 3392714-3391956 (Counterclockwise)
Preceding gene: 45658618
Following gene: 45658616
Centisome position: 79.32
GC content: 39.26
Gene sequence:
>759_bases ATGTCTTCTTCTCAACCTCACCGGGTTCTCCGGGAAATCATTTCTACAAAACAAAATGAAATCAAAAAAATTTCAGCCTG GGACCCTCTTCCACATCGTGGTCTCAGTCTTCGTGATTCTTTAAAAAGTAGAACCTTTTCCATTATTGCAGAGTGTAAAC GAAAGAGTCCATCGGCCGGTGAACTTCGTGCGGATTATCGTCCGGTTCAAATCGCTAAAACATACGAAGAGTTAGGCGCT TCTGCTATTTCTGTACTTACGGATCAGAATTACTTTGGAGGTTCTTTGGAAGATCTGAAGGACGTCTCTTCAGAATTGAA AATTCCAGTTTTAAGAAAAGATTTTATTCTGGATGAAATTCAGATTCGGGAAGCAAGGGCTTTCGGTGCATCCGCAATTT TATTGATCGTCAGAATTTTGACTCCGGAACAGATTAAGTCTTTTTTAAAGTTAGCTTCTTCTTTGGGAATGGATTGTTTG GTTGAAGTTCATACTTCGGATGAGGCGAAACTTGCTCTGGATTGTGGTGCGGAAATTATTGGAATCAATACGAGAGATTT AGATACGTTTCAAATTCATCAGAATCTGGTAGAAGAAGTATCCGCCTTCTTACCACCTAACATAGTAAAAGTAGGTGAAT CCGGTATAAAAAAACGTTCCGACTTGGACACTTTTCGTAAATTAGTGGACGCGGCTTTGATCGGGACCTATTTTATGGAA AAACAAGATATTCGAAAAGCCTGGTTGAATTTATTTTAG
Upstream 100 bases:
>100_bases TAAACCTGCAGTCAAAAGAATCTTTGATGTAATCGAGTTAACTTCTCTTTTCGATATTTGCGAAACCGAAGACGAGGCTT TAAAGTCCTTTTAAAACTGA
Downstream 100 bases:
>100_bases AATATTCTTATATTATAATTCTCTTTTTGGGAATTTTTTTGTATATAAATCAAAGCAAAGTTTCTTATATAAAAGTAATG GATTTTTATGTAATATTTCT
Product: indole-3-glycerol-phosphate synthase
Products: NA
Alternate protein names: IGPS
Number of amino acids: Translated: 252; Mature: 251
Protein sequence:
>252_residues MSSSQPHRVLREIISTKQNEIKKISAWDPLPHRGLSLRDSLKSRTFSIIAECKRKSPSAGELRADYRPVQIAKTYEELGA SAISVLTDQNYFGGSLEDLKDVSSELKIPVLRKDFILDEIQIREARAFGASAILLIVRILTPEQIKSFLKLASSLGMDCL VEVHTSDEAKLALDCGAEIIGINTRDLDTFQIHQNLVEEVSAFLPPNIVKVGESGIKKRSDLDTFRKLVDAALIGTYFME KQDIRKAWLNLF
Sequences:
>Translated_252_residues MSSSQPHRVLREIISTKQNEIKKISAWDPLPHRGLSLRDSLKSRTFSIIAECKRKSPSAGELRADYRPVQIAKTYEELGA SAISVLTDQNYFGGSLEDLKDVSSELKIPVLRKDFILDEIQIREARAFGASAILLIVRILTPEQIKSFLKLASSLGMDCL VEVHTSDEAKLALDCGAEIIGINTRDLDTFQIHQNLVEEVSAFLPPNIVKVGESGIKKRSDLDTFRKLVDAALIGTYFME KQDIRKAWLNLF >Mature_251_residues SSSQPHRVLREIISTKQNEIKKISAWDPLPHRGLSLRDSLKSRTFSIIAECKRKSPSAGELRADYRPVQIAKTYEELGAS AISVLTDQNYFGGSLEDLKDVSSELKIPVLRKDFILDEIQIREARAFGASAILLIVRILTPEQIKSFLKLASSLGMDCLV EVHTSDEAKLALDCGAEIIGINTRDLDTFQIHQNLVEEVSAFLPPNIVKVGESGIKKRSDLDTFRKLVDAALIGTYFMEK QDIRKAWLNLF
Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]
COG id: COG0134
COG function: function code E; Indole-3-glycerol phosphate synthase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the trpC family
Homologues:
Organism=Escherichia coli, GI87081863, Length=209, Percent_Identity=38.755980861244, Blast_Score=139, Evalue=1e-34, Organism=Saccharomyces cerevisiae, GI6322638, Length=208, Percent_Identity=38.4615384615385, Blast_Score=138, Evalue=1e-33,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): TRPC_LEPIC (Q72NP6)
Other databases:
- EMBL: AE016823 - RefSeq: YP_002703.1 - ProteinModelPortal: Q72NP6 - SMR: Q72NP6 - GeneID: 2770882 - GenomeReviews: AE016823_GR - KEGG: lic:LIC12786 - HOGENOM: HBG540956 - OMA: LRKDFMF - ProtClustDB: PRK13957 - BioCyc: LINT267671:LIC_12786-MONOMER - HAMAP: MF_00134_B - InterPro: IPR013785 - InterPro: IPR013798 - InterPro: IPR001468 - InterPro: IPR011060 - Gene3D: G3DSA:3.20.20.70
Pfam domain/function: PF00218 IGPS; SSF51366 RibP_bind_barrel
EC number: =4.1.1.48
Molecular weight: Translated: 28229; Mature: 28098
Theoretical pI: Translated: 7.51; Mature: 7.51
Prosite motif: PS00614 IGPS
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.2 %Cys (Translated Protein) 1.2 %Met (Translated Protein) 2.4 %Cys+Met (Translated Protein) 1.2 %Cys (Mature Protein) 0.8 %Met (Mature Protein) 2.0 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MSSSQPHRVLREIISTKQNEIKKISAWDPLPHRGLSLRDSLKSRTFSIIAECKRKSPSAG CCCCCHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCC ELRADYRPVQIAKTYEELGASAISVLTDQNYFGGSLEDLKDVSSELKIPVLRKDFILDEI CCCCCCCHHHHHHHHHHHCHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHH QIREARAFGASAILLIVRILTPEQIKSFLKLASSLGMDCLVEVHTSDEAKLALDCGAEII HHHHHHHHCHHHHHHHHHHCCHHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEECCCEEE GINTRDLDTFQIHQNLVEEVSAFLPPNIVKVGESGIKKRSDLDTFRKLVDAALIGTYFME ECCCCCCHHHHHHHHHHHHHHHHCCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHH KQDIRKAWLNLF HHHHHHHHHHCC >Mature Secondary Structure SSSQPHRVLREIISTKQNEIKKISAWDPLPHRGLSLRDSLKSRTFSIIAECKRKSPSAG CCCCHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCC ELRADYRPVQIAKTYEELGASAISVLTDQNYFGGSLEDLKDVSSELKIPVLRKDFILDEI CCCCCCCHHHHHHHHHHHCHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHH QIREARAFGASAILLIVRILTPEQIKSFLKLASSLGMDCLVEVHTSDEAKLALDCGAEII HHHHHHHHCHHHHHHHHHHCCHHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEECCCEEE GINTRDLDTFQIHQNLVEEVSAFLPPNIVKVGESGIKKRSDLDTFRKLVDAALIGTYFME ECCCCCCHHHHHHHHHHHHHHHHCCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHH KQDIRKAWLNLF HHHHHHHHHHCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: NA