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The map label for this gene is nuoE

Identifier: 45658579

GI number: 45658579

Start: 3341224

End: 3341709

Strand: Direct

Name: nuoE

Synonym: LIC12745

Alternate gene names: 45658579

Gene position: 3341224-3341709 (Clockwise)

Preceding gene: 45658578

Following gene: 45658580

Centisome position: 78.12

GC content: 40.95

Gene sequence:

>486_bases
TTGCTGATGGGTTATAAGTTCAGCGAAACTTCCGAAAAAAGATTTCAAAAAATGCTGGAAGCGTTTCCGGACAAACGTTC
CCTGATTCTTCCTTGTTTGTATATTCTACAAAGAGAAAACGGATTTGTGGATCAAGAAGGAATGAACTACATTGCAGAAC
GTATAGGAGATCCGATTTCTCTGGCGCAAGTCTACGGGGTCGCCACGTTTTATACCCTCTACAATAAAAAACCGGTCGGT
AAATATCATATACAGATTTGCGGAACGTCTAGCTGTTATCTGCGTGGAAGCGACGAAATCGAAGAACATATTTGTAAACG
TCTCGGAATTCATACCGGACAAACTACGTCTGATCAAAAATTCACCTTAGAAGAAGTAGAATGTTTAGGCGCCTGTGGAT
ACGCTCCTATGGTGCAAATTAACGACGACTTTTACGAACATCTGACTCCCGAAAAAGTAGATCAGATTTTAGACGATCTG
AACTGA

Upstream 100 bases:

>100_bases
TTTGGTATTATCAATCTTTTGCAGAACTGGTCCGTGGCGGACTTTTAGCGGATTCGGTCGCGACCATGAGTTCCTTAAAT
GTGATCGCAGGGGAGTTGGA

Downstream 100 bases:

>100_bases
CAAAAGGAAATCCTTATGGCAGAAATGAAACTTCTTACGAAATACATCGACAATCCTCAGTCCACCAAACTGGAGTTTTA
CGAATCCGTACACGGATACG

Product: NADH dehydrogenase subunit I E

Products: NA

Alternate protein names: NADH dehydrogenase I subunit E; NDH-1 subunit E [H]

Number of amino acids: Translated: 161; Mature: 161

Protein sequence:

>161_residues
MLMGYKFSETSEKRFQKMLEAFPDKRSLILPCLYILQRENGFVDQEGMNYIAERIGDPISLAQVYGVATFYTLYNKKPVG
KYHIQICGTSSCYLRGSDEIEEHICKRLGIHTGQTTSDQKFTLEEVECLGACGYAPMVQINDDFYEHLTPEKVDQILDDL
N

Sequences:

>Translated_161_residues
MLMGYKFSETSEKRFQKMLEAFPDKRSLILPCLYILQRENGFVDQEGMNYIAERIGDPISLAQVYGVATFYTLYNKKPVG
KYHIQICGTSSCYLRGSDEIEEHICKRLGIHTGQTTSDQKFTLEEVECLGACGYAPMVQINDDFYEHLTPEKVDQILDDL
N
>Mature_161_residues
MLMGYKFSETSEKRFQKMLEAFPDKRSLILPCLYILQRENGFVDQEGMNYIAERIGDPISLAQVYGVATFYTLYNKKPVG
KYHIQICGTSSCYLRGSDEIEEHICKRLGIHTGQTTSDQKFTLEEVECLGACGYAPMVQINDDFYEHLTPEKVDQILDDL
N

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cyto

COG id: COG1905

COG function: function code C; NADH:ubiquinone oxidoreductase 24 kD subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 24 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI222080062, Length=158, Percent_Identity=50.6329113924051, Blast_Score=164, Evalue=3e-41,
Organism=Escherichia coli, GI1788621, Length=155, Percent_Identity=33.5483870967742, Blast_Score=102, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17561328, Length=158, Percent_Identity=46.8354430379747, Blast_Score=161, Evalue=2e-40,
Organism=Drosophila melanogaster, GI18859877, Length=158, Percent_Identity=48.7341772151899, Blast_Score=156, Evalue=5e-39,
Organism=Drosophila melanogaster, GI21355353, Length=161, Percent_Identity=38.5093167701863, Blast_Score=121, Evalue=3e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002023
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF01257 Complex1_24kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 18454; Mature: 18454

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: PS01099 COMPLEX1_24K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
3.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
6.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLMGYKFSETSEKRFQKMLEAFPDKRSLILPCLYILQRENGFVDQEGMNYIAERIGDPIS
CCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHH
LAQVYGVATFYTLYNKKPVGKYHIQICGTSSCYLRGSDEIEEHICKRLGIHTGQTTSDQK
HHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEECCCHHHHHHHHHHHCCCCCCCCCCCC
FTLEEVECLGACGYAPMVQINDDFYEHLTPEKVDQILDDLN
HHHHHHHHHHCCCCCCEEEECCHHHHHCCHHHHHHHHHCCC
>Mature Secondary Structure
MLMGYKFSETSEKRFQKMLEAFPDKRSLILPCLYILQRENGFVDQEGMNYIAERIGDPIS
CCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHH
LAQVYGVATFYTLYNKKPVGKYHIQICGTSSCYLRGSDEIEEHICKRLGIHTGQTTSDQK
HHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEECCCHHHHHHHHHHHCCCCCCCCCCCC
FTLEEVECLGACGYAPMVQINDDFYEHLTPEKVDQILDDLN
HHHHHHHHHHCCCCCCEEEECCHHHHHCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA