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The map label for this gene is recQ [H]

Identifier: 45658524

GI number: 45658524

Start: 3263508

End: 3264956

Strand: Direct

Name: recQ [H]

Synonym: LIC12689

Alternate gene names: 45658524

Gene position: 3263508-3264956 (Clockwise)

Preceding gene: 45658517

Following gene: 45658525

Centisome position: 76.3

GC content: 34.37

Gene sequence:

>1449_bases
ATGACCTCTCTTTCCGAACTCAAAACCCTTTTCGGAATTTCTTCTTTTAGAACCTCTCAAGAGAAAATCATTACGGATGT
TCTCTCTGGAAAAAATTGTATGGTGATCATGCCTACCGGAATGGGAAAATCGATCTGTTATCAAATTCCAGCGCTTATTT
TAGAAGGATTGACAATCGTAATTTCTCCTTTGATTGCGCTTATGCAAGATCAAGTGTTAAAACTGAAACAACTCGGAATC
GAAGCGGGCTATATCAATTCTTCTCTTTCCAAACAAGATAGACTTCAAAGTTATCAATACCTAAAAGAAGGTAAATACAA
AATCATATATGTTTCTCCGGAACGTTTTCGTAAAAATGAATTTTTAGATTGTCTTAAAAACAGAAAAATTTCTCTTCTTG
CAATCGACGAAGCCCATTGTATCAGTCAGTGGGGACACGACTTTAGACCAGATTACACTAAGATTTCTGAGTTTCGTGAA
ATTTTAGGTAAACCAATCACGATTGCGTTAACCGCAACTGCTACAACCGAAATTCAAAAAGACATGATCCTTCAGATGGG
GTTAGAAAATTCGGAAATCATAATATACAACGAAGGAATCTGTAGACCAAATCTATTTTTAGACGTAAGGACATTTGTAG
ACGAACCTTCTAAATCAAACGCAATTCTAGAACTTTTAAAAAAACAAAATGGAAGTACTATCGTTTATTTTAATCTCATT
CAGAATTTGGAAAAATTCTGTGAAAAGTTAGACATTCAAAAAATCGAATATCAAGTTTATCACGGAAAATTAACTACCGA
CCAAAGAAAAAAAGTACAGAACCAATTTTTAAAATCGAATGATAAAATTCTGCTCGCTACAAATGCGTTTGGAATGGGAG
TAGATAAACCAAATATTAGAACGATCATCCACGCGGAACTACCCTCTTCTTTAGAAAGTTATTATCAGGAAATTGGAAGA
GCGGGAAGAGACGGTAAACCTTCTGATTGTCATGTTTTCTATAACCAAGACGATCTTTCTGTATTAATGGATTTTATAGA
ATGGCAAAATCCAGACGCGGCGTTTATATCTCGCACATTTCAAACCTTGAAACGTTTGGGAGAAGAATTATCTTCGATTG
ATTACGAAGATTTACAATCTAAAATTGTTTTTAAAAATAGAGGAGACCACAGACTCCAAACCGTTCTCAATCTATTTGAT
AGATACGGAGTTACTTCTGGGGAATTAGAAAAAAATTCTTTAAAATTAATTTCTACTTTGCCCGAAGCGTTGTGTTCTGC
GGAGTTATTAGAACTTAAAAAGAAAACCAGCCTAAAACGTCTATATCAAATGCTTCTTTACTTAAAATCAGAAAAATGCA
GAAGAGAATTCGTCTACGAATACTTTGACGCCAAGTTTTCGGAATGTGGGAACTGCGATATTTGTAAAAATTCTAGTGAG
TCAAAATAG

Upstream 100 bases:

>100_bases
TTTTCTCCGGTTGAAATACGAACATCCTAAGAATTCGACCTTGTGGCAAGTAATTACATTTTATCTTGCACTCGACGATC
ATTGACAAATCCTGATCGTA

Downstream 100 bases:

>100_bases
AACTTTTTATATATGGAGAGAAATTCTTAGTTCGTTAACCTAAGTTCATTCAAAAGACAGAATGCGATTTTACTCTTTAG
AGCGTGTCTAATTGTTCCTT

Product: ATP-dependent DNA helicase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 482; Mature: 481

Protein sequence:

>482_residues
MTSLSELKTLFGISSFRTSQEKIITDVLSGKNCMVIMPTGMGKSICYQIPALILEGLTIVISPLIALMQDQVLKLKQLGI
EAGYINSSLSKQDRLQSYQYLKEGKYKIIYVSPERFRKNEFLDCLKNRKISLLAIDEAHCISQWGHDFRPDYTKISEFRE
ILGKPITIALTATATTEIQKDMILQMGLENSEIIIYNEGICRPNLFLDVRTFVDEPSKSNAILELLKKQNGSTIVYFNLI
QNLEKFCEKLDIQKIEYQVYHGKLTTDQRKKVQNQFLKSNDKILLATNAFGMGVDKPNIRTIIHAELPSSLESYYQEIGR
AGRDGKPSDCHVFYNQDDLSVLMDFIEWQNPDAAFISRTFQTLKRLGEELSSIDYEDLQSKIVFKNRGDHRLQTVLNLFD
RYGVTSGELEKNSLKLISTLPEALCSAELLELKKKTSLKRLYQMLLYLKSEKCRREFVYEYFDAKFSECGNCDICKNSSE
SK

Sequences:

>Translated_482_residues
MTSLSELKTLFGISSFRTSQEKIITDVLSGKNCMVIMPTGMGKSICYQIPALILEGLTIVISPLIALMQDQVLKLKQLGI
EAGYINSSLSKQDRLQSYQYLKEGKYKIIYVSPERFRKNEFLDCLKNRKISLLAIDEAHCISQWGHDFRPDYTKISEFRE
ILGKPITIALTATATTEIQKDMILQMGLENSEIIIYNEGICRPNLFLDVRTFVDEPSKSNAILELLKKQNGSTIVYFNLI
QNLEKFCEKLDIQKIEYQVYHGKLTTDQRKKVQNQFLKSNDKILLATNAFGMGVDKPNIRTIIHAELPSSLESYYQEIGR
AGRDGKPSDCHVFYNQDDLSVLMDFIEWQNPDAAFISRTFQTLKRLGEELSSIDYEDLQSKIVFKNRGDHRLQTVLNLFD
RYGVTSGELEKNSLKLISTLPEALCSAELLELKKKTSLKRLYQMLLYLKSEKCRREFVYEYFDAKFSECGNCDICKNSSE
SK
>Mature_481_residues
TSLSELKTLFGISSFRTSQEKIITDVLSGKNCMVIMPTGMGKSICYQIPALILEGLTIVISPLIALMQDQVLKLKQLGIE
AGYINSSLSKQDRLQSYQYLKEGKYKIIYVSPERFRKNEFLDCLKNRKISLLAIDEAHCISQWGHDFRPDYTKISEFREI
LGKPITIALTATATTEIQKDMILQMGLENSEIIIYNEGICRPNLFLDVRTFVDEPSKSNAILELLKKQNGSTIVYFNLIQ
NLEKFCEKLDIQKIEYQVYHGKLTTDQRKKVQNQFLKSNDKILLATNAFGMGVDKPNIRTIIHAELPSSLESYYQEIGRA
GRDGKPSDCHVFYNQDDLSVLMDFIEWQNPDAAFISRTFQTLKRLGEELSSIDYEDLQSKIVFKNRGDHRLQTVLNLFDR
YGVTSGELEKNSLKLISTLPEALCSAELLELKKKTSLKRLYQMLLYLKSEKCRREFVYEYFDAKFSECGNCDICKNSSES
K

Specific function: Probable DNA helicase. Required for DNA repair and intramolecular recombination; probably has overlapping function with recS (AC P50729). It probably acts to help generate ss-DNA from ds-DNA breaks [H]

COG id: COG0514

COG function: function code L; Superfamily II DNA helicase

Gene ontology:

Cell location: Cytoplasm, nucleoid. Note=Localized throughout the nucleoid in the presence or absence of DNA double- strand breaks [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Homo sapiens, GI51242947, Length=351, Percent_Identity=41.025641025641, Blast_Score=263, Evalue=4e-70,
Organism=Homo sapiens, GI51242943, Length=351, Percent_Identity=41.025641025641, Blast_Score=262, Evalue=5e-70,
Organism=Homo sapiens, GI148612816, Length=351, Percent_Identity=41.025641025641, Blast_Score=260, Evalue=2e-69,
Organism=Homo sapiens, GI14591902, Length=357, Percent_Identity=36.6946778711485, Blast_Score=234, Evalue=1e-61,
Organism=Homo sapiens, GI14591904, Length=357, Percent_Identity=36.6946778711485, Blast_Score=234, Evalue=1e-61,
Organism=Homo sapiens, GI4557365, Length=347, Percent_Identity=38.6167146974063, Blast_Score=234, Evalue=2e-61,
Organism=Homo sapiens, GI110735439, Length=348, Percent_Identity=38.5057471264368, Blast_Score=232, Evalue=5e-61,
Organism=Homo sapiens, GI169218196, Length=348, Percent_Identity=38.5057471264368, Blast_Score=232, Evalue=6e-61,
Organism=Homo sapiens, GI284005309, Length=377, Percent_Identity=32.8912466843501, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI21071032, Length=368, Percent_Identity=24.4565217391304, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI45446747, Length=346, Percent_Identity=22.8323699421965, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI45446743, Length=346, Percent_Identity=22.8323699421965, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI41327771, Length=379, Percent_Identity=22.9551451187335, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI48994977, Length=343, Percent_Identity=41.6909620991254, Blast_Score=287, Evalue=1e-78,
Organism=Escherichia coli, GI1787016, Length=351, Percent_Identity=22.5071225071225, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI25145561, Length=358, Percent_Identity=40.2234636871508, Blast_Score=251, Evalue=5e-67,
Organism=Caenorhabditis elegans, GI32564293, Length=349, Percent_Identity=39.2550143266476, Blast_Score=246, Evalue=2e-65,
Organism=Caenorhabditis elegans, GI71987993, Length=347, Percent_Identity=38.0403458213257, Blast_Score=241, Evalue=9e-64,
Organism=Caenorhabditis elegans, GI71987997, Length=347, Percent_Identity=38.0403458213257, Blast_Score=240, Evalue=1e-63,
Organism=Caenorhabditis elegans, GI17552866, Length=330, Percent_Identity=37.8787878787879, Blast_Score=227, Evalue=1e-59,
Organism=Caenorhabditis elegans, GI32565321, Length=375, Percent_Identity=23.4666666666667, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71995724, Length=359, Percent_Identity=22.8412256267409, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17507121, Length=359, Percent_Identity=22.5626740947075, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI115533224, Length=354, Percent_Identity=24.8587570621469, Blast_Score=69, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI71995718, Length=223, Percent_Identity=28.2511210762332, Blast_Score=69, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6323844, Length=361, Percent_Identity=36.5650969529086, Blast_Score=227, Evalue=4e-60,
Organism=Saccharomyces cerevisiae, GI6321360, Length=342, Percent_Identity=25.4385964912281, Blast_Score=91, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6325138, Length=137, Percent_Identity=27.7372262773723, Blast_Score=71, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6324778, Length=232, Percent_Identity=26.2931034482759, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6320224, Length=343, Percent_Identity=21.865889212828, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6321856, Length=343, Percent_Identity=23.0320699708455, Blast_Score=65, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6320400, Length=390, Percent_Identity=24.8717948717949, Blast_Score=63, Evalue=1e-10,
Organism=Drosophila melanogaster, GI24646066, Length=342, Percent_Identity=40.3508771929825, Blast_Score=243, Evalue=2e-64,
Organism=Drosophila melanogaster, GI24664226, Length=359, Percent_Identity=37.0473537604457, Blast_Score=233, Evalue=2e-61,
Organism=Drosophila melanogaster, GI62472181, Length=359, Percent_Identity=37.0473537604457, Blast_Score=233, Evalue=2e-61,
Organism=Drosophila melanogaster, GI24664230, Length=359, Percent_Identity=37.0473537604457, Blast_Score=233, Evalue=2e-61,
Organism=Drosophila melanogaster, GI21358123, Length=358, Percent_Identity=35.195530726257, Blast_Score=209, Evalue=5e-54,
Organism=Drosophila melanogaster, GI24666101, Length=395, Percent_Identity=21.5189873417722, Blast_Score=72, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR011545
- InterPro:   IPR004589
- InterPro:   IPR006293
- InterPro:   IPR002121
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR010997
- InterPro:   IPR018982 [H]

Pfam domain/function: PF00270 DEAD; PF00271 Helicase_C; PF00570 HRDC; PF09382 RQC [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 55312; Mature: 55180

Theoretical pI: Translated: 7.80; Mature: 7.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSLSELKTLFGISSFRTSQEKIITDVLSGKNCMVIMPTGMGKSICYQIPALILEGLTIV
CCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHH
ISPLIALMQDQVLKLKQLGIEAGYINSSLSKQDRLQSYQYLKEGKYKIIYVSPERFRKNE
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECHHHHHHHH
FLDCLKNRKISLLAIDEAHCISQWGHDFRPDYTKISEFREILGKPITIALTATATTEIQK
HHHHHHCCCEEEEEECHHHHHHHCCCCCCCCHHHHHHHHHHHCCCEEEEEEECHHHHHHH
DMILQMGLENSEIIIYNEGICRPNLFLDVRTFVDEPSKSNAILELLKKQNGSTIVYFNLI
HHHHHHCCCCCEEEEEECCCCCCCCEEEHHHHHCCCCCCHHHHHHHHHCCCCEEEEHHHH
QNLEKFCEKLDIQKIEYQVYHGKLTTDQRKKVQNQFLKSNDKILLATNAFGMGVDKPNIR
HHHHHHHHHHCCHHEEEEEEECCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCE
TIIHAELPSSLESYYQEIGRAGRDGKPSDCHVFYNQDDLSVLMDFIEWQNPDAAFISRTF
EEEEECCCHHHHHHHHHHHCCCCCCCCCCEEEEECCCHHHHHHHHHHCCCCCHHHHHHHH
QTLKRLGEELSSIDYEDLQSKIVFKNRGDHRLQTVLNLFDRYGVTSGELEKNSLKLISTL
HHHHHHHHHHHCCCHHHHHHHEEECCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
PEALCSAELLELKKKTSLKRLYQMLLYLKSEKCRREFVYEYFDAKFSECGNCDICKNSSE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
SK
CC
>Mature Secondary Structure 
TSLSELKTLFGISSFRTSQEKIITDVLSGKNCMVIMPTGMGKSICYQIPALILEGLTIV
CCHHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHH
ISPLIALMQDQVLKLKQLGIEAGYINSSLSKQDRLQSYQYLKEGKYKIIYVSPERFRKNE
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECHHHHHHHH
FLDCLKNRKISLLAIDEAHCISQWGHDFRPDYTKISEFREILGKPITIALTATATTEIQK
HHHHHHCCCEEEEEECHHHHHHHCCCCCCCCHHHHHHHHHHHCCCEEEEEEECHHHHHHH
DMILQMGLENSEIIIYNEGICRPNLFLDVRTFVDEPSKSNAILELLKKQNGSTIVYFNLI
HHHHHHCCCCCEEEEEECCCCCCCCEEEHHHHHCCCCCCHHHHHHHHHCCCCEEEEHHHH
QNLEKFCEKLDIQKIEYQVYHGKLTTDQRKKVQNQFLKSNDKILLATNAFGMGVDKPNIR
HHHHHHHHHHCCHHEEEEEEECCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCE
TIIHAELPSSLESYYQEIGRAGRDGKPSDCHVFYNQDDLSVLMDFIEWQNPDAAFISRTF
EEEEECCCHHHHHHHHHHHCCCCCCCCCCEEEEECCCHHHHHHHHHHCCCCCHHHHHHHH
QTLKRLGEELSSIDYEDLQSKIVFKNRGDHRLQTVLNLFDRYGVTSGELEKNSLKLISTL
HHHHHHHHHHHCCCHHHHHHHEEECCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
PEALCSAELLELKKKTSLKRLYQMLLYLKSEKCRREFVYEYFDAKFSECGNCDICKNSSE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
SK
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9642195 [H]