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The map label for this gene is lysA

Identifier: 45658455

GI number: 45658455

Start: 3167254

End: 3168522

Strand: Reverse

Name: lysA

Synonym: LIC12618

Alternate gene names: 45658455

Gene position: 3168522-3167254 (Counterclockwise)

Preceding gene: 45658463

Following gene: 45658454

Centisome position: 74.08

GC content: 40.98

Gene sequence:

>1269_bases
ATGCAATCAATAGAAAAATTAAAATTTTTAACAGAATCACAGGTGAGATCCATTGCTGGACAATTTGGAACTCCAGTTTT
CGTTTATTCCAGAGAACGAATCGAAAAAAGTTGTGAGGTCGCTCTTGCGTTTCCGAACGCTTATGGTTTGACCGTTCGAT
ACGCTATGAAAGCCAATCCCAATCGTACCGTTTTAGAAATTATGAAACGAAAGGGAATCCAAATTGACGCAAGTTCAGAA
TACGAAGTTTTGAGAGCGATCCATTACGGATTTAAACCGGAACAGATCATGTTGACTTCTCAAGAACTCGCCAAGGGTCT
TAAAGAATTGGTAGAAAAGGGTGTGGTTTTTAACGCTTGTTCCCTTCGTCAGTTAGAAACCTTTGGAAATTTATTTCCAG
GGAAAGAAGTTAGTGTTCGGTTTAATCCGGGGCTTGGTTCCGGTCAGACTAAAAAGACGGACGTGGGCGGAAAAACTTCT
TCCTTTGGAATTTGGTACGAGGATATAAATCAGGTTAAAGAGATTGCGTCTAAGTTTGATCTGAAAATTTTTAAGGTTCA
TACCCATATCGGATCCGGGAGTGATCCGGAAGTTTGGAAAGTGGTCGCTCAAGTTTCGCTCGATATTGCCGCTCAGTTTT
CTGAGTGTAAGATCTTAAATTTAGGCGGTGGTTTTAAGGTAGGTAGAATGGAAGATGAAAAAACTACTGATTTTCAAAAG
ATTGGTCCGCCAGTGGTTGAACTCTTTCAGGAGTTTGCAAAAAAACACGGGACTGAACTTCGTTTAGAGATAGAACCTGG
CTCGTTTTTAATGGTAAATAACGGTTCTATACTTACTACCGTGGACGACGTGGTTTCTACCGGTCCGGGCGGTTATACTT
TTGTTAAATTGGACGCGGGTATGGACGTAAACACTAGGCCTTCTTTGTATGCCGCCAAACATCCGTTAGTTGTTGTTTCC
AAAGAAGGAGTTCATTCCGGTAAAACGGCGGACTATGTTTATGTTGGTCATTGTTGCGAAAGCGGGGATTTATTTACTCA
AGCAGAAGGTGGCGGTCCAATTACAAGAATAACAGGAGAAGCTAAATTAGGAGATTATGTTGTTATGGAAGGAGCTGGTG
CATATTGTTCTTCTATGTCCACGAAAAATTACAACTCTTTTCCTGAAACGGCAGAGGTTTTGGTTGATTCGGATGGAAGT
TTTCAACTAATTCGAAGACGTCAGAATTGGGAACAGATCTTTCAGAATGAAGTCACTGTTTCTCTCTGA

Upstream 100 bases:

>100_bases
CTAGATGAGTGATTTTACCAGCCATGACTGAAAATGCCTTTTAAAAAACGGAACTCTTTAGGAGCGTGTTCTAAAACCAT
TTAGAATTGTACGTTTCACT

Downstream 100 bases:

>100_bases
AAAAATTTACGTTTTAATTTTAGCTGGTGGAACCGGTTCTAGAATGGGTTCTAAAATTCCAAAACAGTTTTTGGAATTAA
ATGGTGAGCCTATTCTTATT

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 422; Mature: 422

Protein sequence:

>422_residues
MQSIEKLKFLTESQVRSIAGQFGTPVFVYSRERIEKSCEVALAFPNAYGLTVRYAMKANPNRTVLEIMKRKGIQIDASSE
YEVLRAIHYGFKPEQIMLTSQELAKGLKELVEKGVVFNACSLRQLETFGNLFPGKEVSVRFNPGLGSGQTKKTDVGGKTS
SFGIWYEDINQVKEIASKFDLKIFKVHTHIGSGSDPEVWKVVAQVSLDIAAQFSECKILNLGGGFKVGRMEDEKTTDFQK
IGPPVVELFQEFAKKHGTELRLEIEPGSFLMVNNGSILTTVDDVVSTGPGGYTFVKLDAGMDVNTRPSLYAAKHPLVVVS
KEGVHSGKTADYVYVGHCCESGDLFTQAEGGGPITRITGEAKLGDYVVMEGAGAYCSSMSTKNYNSFPETAEVLVDSDGS
FQLIRRRQNWEQIFQNEVTVSL

Sequences:

>Translated_422_residues
MQSIEKLKFLTESQVRSIAGQFGTPVFVYSRERIEKSCEVALAFPNAYGLTVRYAMKANPNRTVLEIMKRKGIQIDASSE
YEVLRAIHYGFKPEQIMLTSQELAKGLKELVEKGVVFNACSLRQLETFGNLFPGKEVSVRFNPGLGSGQTKKTDVGGKTS
SFGIWYEDINQVKEIASKFDLKIFKVHTHIGSGSDPEVWKVVAQVSLDIAAQFSECKILNLGGGFKVGRMEDEKTTDFQK
IGPPVVELFQEFAKKHGTELRLEIEPGSFLMVNNGSILTTVDDVVSTGPGGYTFVKLDAGMDVNTRPSLYAAKHPLVVVS
KEGVHSGKTADYVYVGHCCESGDLFTQAEGGGPITRITGEAKLGDYVVMEGAGAYCSSMSTKNYNSFPETAEVLVDSDGS
FQLIRRRQNWEQIFQNEVTVSL
>Mature_422_residues
MQSIEKLKFLTESQVRSIAGQFGTPVFVYSRERIEKSCEVALAFPNAYGLTVRYAMKANPNRTVLEIMKRKGIQIDASSE
YEVLRAIHYGFKPEQIMLTSQELAKGLKELVEKGVVFNACSLRQLETFGNLFPGKEVSVRFNPGLGSGQTKKTDVGGKTS
SFGIWYEDINQVKEIASKFDLKIFKVHTHIGSGSDPEVWKVVAQVSLDIAAQFSECKILNLGGGFKVGRMEDEKTTDFQK
IGPPVVELFQEFAKKHGTELRLEIEPGSFLMVNNGSILTTVDDVVSTGPGGYTFVKLDAGMDVNTRPSLYAAKHPLVVVS
KEGVHSGKTADYVYVGHCCESGDLFTQAEGGGPITRITGEAKLGDYVVMEGAGAYCSSMSTKNYNSFPETAEVLVDSDGS
FQLIRRRQNWEQIFQNEVTVSL

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Escherichia coli, GI1789203, Length=407, Percent_Identity=34.1523341523341, Blast_Score=228, Evalue=5e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 46458; Mature: 46458

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS00878 ODR_DC_2_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSIEKLKFLTESQVRSIAGQFGTPVFVYSRERIEKSCEVALAFPNAYGLTVRYAMKANP
CCHHHHHHHHHHHHHHHHHHHCCCEEEEEEHHHHCCCCEEEEECCCCCCEEEEEEEECCC
NRTVLEIMKRKGIQIDASSEYEVLRAIHYGFKPEQIMLTSQELAKGLKELVEKGVVFNAC
CHHHHHHHHHCCCEEECCCHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHCCEEEECH
SLRQLETFGNLFPGKEVSVRFNPGLGSGQTKKTDVGGKTSSFGIWYEDINQVKEIASKFD
HHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHC
LKIFKVHTHIGSGSDPEVWKVVAQVSLDIAAQFSECKILNLGGGFKVGRMEDEKTTDFQK
EEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEECCCCCCCCCCHHH
IGPPVVELFQEFAKKHGTELRLEIEPGSFLMVNNGSILTTVDDVVSTGPGGYTFVKLDAG
CCCHHHHHHHHHHHHCCCEEEEEECCCCEEEEECCCEEEEHHHHHHCCCCCEEEEEEECC
MDVNTRPSLYAAKHPLVVVSKEGVHSGKTADYVYVGHCCESGDLFTQAEGGGPITRITGE
CCCCCCCCEEECCCCEEEEECCCCCCCCCCCEEEEEEEECCCCEEEECCCCCCEEEEECC
AKLGDYVVMEGAGAYCSSMSTKNYNSFPETAEVLVDSDGSFQLIRRRQNWEQIFQNEVTV
CCCCCEEEEECCCHHHHCCCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHCCCEE
SL
EC
>Mature Secondary Structure
MQSIEKLKFLTESQVRSIAGQFGTPVFVYSRERIEKSCEVALAFPNAYGLTVRYAMKANP
CCHHHHHHHHHHHHHHHHHHHCCCEEEEEEHHHHCCCCEEEEECCCCCCEEEEEEEECCC
NRTVLEIMKRKGIQIDASSEYEVLRAIHYGFKPEQIMLTSQELAKGLKELVEKGVVFNAC
CHHHHHHHHHCCCEEECCCHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHCCEEEECH
SLRQLETFGNLFPGKEVSVRFNPGLGSGQTKKTDVGGKTSSFGIWYEDINQVKEIASKFD
HHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHC
LKIFKVHTHIGSGSDPEVWKVVAQVSLDIAAQFSECKILNLGGGFKVGRMEDEKTTDFQK
EEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEECCCCCCCCCCHHH
IGPPVVELFQEFAKKHGTELRLEIEPGSFLMVNNGSILTTVDDVVSTGPGGYTFVKLDAG
CCCHHHHHHHHHHHHCCCEEEEEECCCCEEEEECCCEEEEHHHHHHCCCCCEEEEEEECC
MDVNTRPSLYAAKHPLVVVSKEGVHSGKTADYVYVGHCCESGDLFTQAEGGGPITRITGE
CCCCCCCCEEECCCCEEEEECCCCCCCCCCCEEEEEEEECCCCEEEECCCCCCEEEEECC
AKLGDYVVMEGAGAYCSSMSTKNYNSFPETAEVLVDSDGSFQLIRRRQNWEQIFQNEVTV
CCCCCEEEEECCCHHHHCCCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHCCCEE
SL
EC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12089438 [H]