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The map label for this gene is lpxB

Identifier: 45658417

GI number: 45658417

Start: 3127022

End: 3128218

Strand: Direct

Name: lpxB

Synonym: LIC12579

Alternate gene names: 45658417

Gene position: 3127022-3128218 (Clockwise)

Preceding gene: 304570500

Following gene: 45658418

Centisome position: 73.11

GC content: 36.01

Gene sequence:

>1197_bases
ATGTTGGCCGGAGAGCATTCCGGAGATCTTTTGGGTGGTGAACTCATTCGAGAACTCAAAAAGAACTTTTCCGATTTGGA
AACTTTTGGAGTAGGCGGAGAAAGAATGATCGAAGAAGGTTTTACCTCGATCGAGTCTATGGAAGAACTTTCGATCATCG
GTTTTTCCGCCATCCTTTTTAAATATAGATTTTTAAAATCCTTGATCGGAAGATTGATCAACCTCGCCGTCGAAAAAAAT
TGTTCTCACGCCATCTTAATCGACTATCCAGGTTTTAATCTTCGTCTTGCCAAAGAGTTGAAAAAACTAGGAATCACAGT
TATCTTTTATGTTTCTCCACAACTCTGGGCTTGGAAGTTCGATCGAATTTATACGATCCGAGATAACATTGATTTGATGT
TGGTTTTGTTTCCTTTTGAAAAACAAATCTACGATCGTTACGGTGTTCCTTGCGAATTTGTAGGTCATCCCCTTGCAGTT
CGTTTGAGAGAAAAAATCCGTAAAGAAGCAGTCATTCCAGAGCCAGAAGACAAAACTCAATTTCATTTTACAATCACTTT
GATGCCCGGTTCCAGAAGTGGAGAAATTAGAAGAATCTTAAATGATCTTTTACAATCCGCGGGCCAACTCGCAGATCATT
ATGAAAACAATAATAAGAAAATTCGTTTCCTTTTACCGAATATCAACCAAAAAGAAGAAGTTTTTATTTTAGAAAAAATA
GAACTCGCTAAGTCTAAATTTCCAAACTTAACAATTGAATATCTATTTGACCGTTCTCTTCGTGCAATCGAAATTTCAGA
CTTAGTTTTAGTCGCTTCTGGAACTGCTACATTAGAAGTTGCTTATTTCGAAAAACCAATGATCATACTTTATAAAGTTA
GCATGTTCACTTACGTAATCGGTTCTCTTTTTATCCAAACTCCTAATATAGGTCTTGTAAATATTCTTTCCGGTCAAGAA
ATTTGTAGAGAACTGATTCAGGCAGAATGTTCTCCGAATAACATCGTTGAGGAAACCCTGGCACTTTTAGAAAACAAAAA
GTATAGAAATAAAATAATCGAAGACGTTCGCAAAGTAAAAGAAGCCTTAGGTAGCGAAAATTCATCCAGATACGCTTCCA
GAGAAATTACAAAATTAATTAAAGGAATTGCAAAAAAAACGGGACAAGAACTCGGAAATCCAGAACAGCAAATATAA

Upstream 100 bases:

>100_bases
AGTGGCAACCTTAAAAAAATCAACTCTACAATCCAAAAAATCCGGTAACCAACCGTCTCGGGCTGTAGTTACGACCAAAA
AAGAAGATCTAAAAATTCTA

Downstream 100 bases:

>100_bases
ATTTATAATTCTAGTATATTCTAATAGTCTCATACTTAATTTCAATCTATTAACTTTACATCAATTATTTTCGTATTGTT
TACAAACTTACATTAGTTAA

Product: lipid-a-disaccharide synthase protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MLAGEHSGDLLGGELIRELKKNFSDLETFGVGGERMIEEGFTSIESMEELSIIGFSAILFKYRFLKSLIGRLINLAVEKN
CSHAILIDYPGFNLRLAKELKKLGITVIFYVSPQLWAWKFDRIYTIRDNIDLMLVLFPFEKQIYDRYGVPCEFVGHPLAV
RLREKIRKEAVIPEPEDKTQFHFTITLMPGSRSGEIRRILNDLLQSAGQLADHYENNNKKIRFLLPNINQKEEVFILEKI
ELAKSKFPNLTIEYLFDRSLRAIEISDLVLVASGTATLEVAYFEKPMIILYKVSMFTYVIGSLFIQTPNIGLVNILSGQE
ICRELIQAECSPNNIVEETLALLENKKYRNKIIEDVRKVKEALGSENSSRYASREITKLIKGIAKKTGQELGNPEQQI

Sequences:

>Translated_398_residues
MLAGEHSGDLLGGELIRELKKNFSDLETFGVGGERMIEEGFTSIESMEELSIIGFSAILFKYRFLKSLIGRLINLAVEKN
CSHAILIDYPGFNLRLAKELKKLGITVIFYVSPQLWAWKFDRIYTIRDNIDLMLVLFPFEKQIYDRYGVPCEFVGHPLAV
RLREKIRKEAVIPEPEDKTQFHFTITLMPGSRSGEIRRILNDLLQSAGQLADHYENNNKKIRFLLPNINQKEEVFILEKI
ELAKSKFPNLTIEYLFDRSLRAIEISDLVLVASGTATLEVAYFEKPMIILYKVSMFTYVIGSLFIQTPNIGLVNILSGQE
ICRELIQAECSPNNIVEETLALLENKKYRNKIIEDVRKVKEALGSENSSRYASREITKLIKGIAKKTGQELGNPEQQI
>Mature_398_residues
MLAGEHSGDLLGGELIRELKKNFSDLETFGVGGERMIEEGFTSIESMEELSIIGFSAILFKYRFLKSLIGRLINLAVEKN
CSHAILIDYPGFNLRLAKELKKLGITVIFYVSPQLWAWKFDRIYTIRDNIDLMLVLFPFEKQIYDRYGVPCEFVGHPLAV
RLREKIRKEAVIPEPEDKTQFHFTITLMPGSRSGEIRRILNDLLQSAGQLADHYENNNKKIRFLLPNINQKEEVFILEKI
ELAKSKFPNLTIEYLFDRSLRAIEISDLVLVASGTATLEVAYFEKPMIILYKVSMFTYVIGSLFIQTPNIGLVNILSGQE
ICRELIQAECSPNNIVEETLALLENKKYRNKIIEDVRKVKEALGSENSSRYASREITKLIKGIAKKTGQELGNPEQQI

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family [H]

Homologues:

Organism=Escherichia coli, GI1786379, Length=385, Percent_Identity=34.2857142857143, Blast_Score=211, Evalue=5e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003835 [H]

Pfam domain/function: PF02684 LpxB [H]

EC number: =2.4.1.182 [H]

Molecular weight: Translated: 45490; Mature: 45490

Theoretical pI: Translated: 7.04; Mature: 7.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLAGEHSGDLLGGELIRELKKNFSDLETFGVGGERMIEEGFTSIESMEELSIIGFSAILF
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KYRFLKSLIGRLINLAVEKNCSHAILIDYPGFNLRLAKELKKLGITVIFYVSPQLWAWKF
HHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHCCCEEEEEECCCCEEEEE
DRIYTIRDNIDLMLVLFPFEKQIYDRYGVPCEFVGHPLAVRLREKIRKEAVIPEPEDKTQ
CEEEEEECCCCEEEEEECCHHHHHHHHCCCHHHCCCHHHHHHHHHHHHHCCCCCCCCCCE
FHFTITLMPGSRSGEIRRILNDLLQSAGQLADHYENNNKKIRFLLPNINQKEEVFILEKI
EEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCEEEHHHH
ELAKSKFPNLTIEYLFDRSLRAIEISDLVLVASGTATLEVAYFEKPMIILYKVSMFTYVI
HHHHHCCCCCEEEEECCCCCCEEEEEEEEEEECCCCEEEEEEECCCEEEEEHHHHHHHHH
GSLFIQTPNIGLVNILSGQEICRELIQAECSPNNIVEETLALLENKKYRNKIIEDVRKVK
HHHHEECCCCCEEEECCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHH
EALGSENSSRYASREITKLIKGIAKKTGQELGNPEQQI
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MLAGEHSGDLLGGELIRELKKNFSDLETFGVGGERMIEEGFTSIESMEELSIIGFSAILF
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KYRFLKSLIGRLINLAVEKNCSHAILIDYPGFNLRLAKELKKLGITVIFYVSPQLWAWKF
HHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHCCCEEEEEECCCCEEEEE
DRIYTIRDNIDLMLVLFPFEKQIYDRYGVPCEFVGHPLAVRLREKIRKEAVIPEPEDKTQ
CEEEEEECCCCEEEEEECCHHHHHHHHCCCHHHCCCHHHHHHHHHHHHHCCCCCCCCCCE
FHFTITLMPGSRSGEIRRILNDLLQSAGQLADHYENNNKKIRFLLPNINQKEEVFILEKI
EEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCEEEHHHH
ELAKSKFPNLTIEYLFDRSLRAIEISDLVLVASGTATLEVAYFEKPMIILYKVSMFTYVI
HHHHHCCCCCEEEEECCCCCCEEEEEEEEEEECCCCEEEEEEECCCEEEEEHHHHHHHHH
GSLFIQTPNIGLVNILSGQEICRELIQAECSPNNIVEETLALLENKKYRNKIIEDVRKVK
HHHHEECCCCCEEEECCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHH
EALGSENSSRYASREITKLIKGIAKKTGQELGNPEQQI
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA