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The map label for this gene is hisC

Identifier: 45658350

GI number: 45658350

Start: 3036789

End: 3037901

Strand: Direct

Name: hisC

Synonym: LIC12508

Alternate gene names: 45658350

Gene position: 3036789-3037901 (Clockwise)

Preceding gene: 45658348

Following gene: 45658351

Centisome position: 71.0

GC content: 36.75

Gene sequence:

>1113_bases
ATGGGAGTGATGATTCCATTTCGATCTATATTGAACTCTCTCAAAAGTTACGAAGCCGGAAAACCAATCGAACTTGTGGT
TCGAGAATTCGGAATTGATCCAAATCGTATAATCAAATTAGGTTCGAACGAAAATCCTTTCGGTTGCGCAGAATCCGTTA
TGGAAGTTGTTCGACAAGCGATTTCCAAAATGTCTTTTTATCCGGACGATTCTTATCTAGATTTAAAAACTGCGATCGCT
TCCAAGTTTGATCTTACCACTGATCGTATCATTCCGGGAAATGGAAGCGACCAGGTTTTAGATTTTGTTTGCAGATGTGT
TTTAGATCAGGGAGATTCCGTTCTGATCAATCGAATTACTTTTGCGATGTATAAAATTTACGCTTTGCAATGTGGAGCAA
AAATTCATTCCACAGACAGCGTTACTCATGATTTAAACGCGTTTTTGGATCTGGCAAAATTGATTCGTCCTAAGATTATT
TTTTTGTGCACTCCTTCCAATCCCGCAGGAGATGCACTTTCTAAATCTGACGTTTATGAATTTTTAAGTAAAATCTCTTT
AGATACGTTAGTCGTAATTGATGCGGCTTATATGGAATTTGGAAAAAAAAAGGATCCGAATAAATTTATCCCTGCGAAAG
AAGTTACCGATCTTTTTCCGAATGTTTTTTATACTGGTACCTTTTCTAAAGTTTACGGACTGGGCGGAATGAGAATCGGG
TACGGGATCGGAAATCAAGAATTGATCTCCAATTTATATAAGATGCGCCCTCCTTTTAGTGTTACCAATCTTTCTGCTCT
GGCCGCCACGGAAGCTCTCAAAAATGAATCTTATGTGGAATCATATCTAGAAAATAATTGGAATGAAATGAAACGATATG
AAAAATTTGCCGCCGAACAAAGTATAGAGTTTATTGATTCTTACGCAAACTTTATTACATTTTTTGCAAGAAAGCGCGGT
AAATCTTCTTCCGAAATTGCCCATTCCCTTTTAAAACAGGGAATTATTCTACGAGACTTAAAAAATTATGACCTAAATGC
ACTTAGAATCACAATCGGTAGGCCGGAGCAAAACGATCTAGTTTTAGAAGCTTTAGAAAAAGAATTTCATTAA

Upstream 100 bases:

>100_bases
AAAAAAAATTTCGGAATATAACGAACGAAAATATTTTTTTCCGGAGTTTGATACAAATGGATTCTTAAATCGATTTCCAA
AATTTTTCCCATCCAAAAGC

Downstream 100 bases:

>100_bases
TAGGGACAGACGTTTTATAATTCAAATGTATTAAAATAGCTCCAAAAATCAAAGATGATCTTATAAAGAAAAGATGCAAA
AATTCTTAAAAATTAATTAT

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase

Number of amino acids: Translated: 370; Mature: 369

Protein sequence:

>370_residues
MGVMIPFRSILNSLKSYEAGKPIELVVREFGIDPNRIIKLGSNENPFGCAESVMEVVRQAISKMSFYPDDSYLDLKTAIA
SKFDLTTDRIIPGNGSDQVLDFVCRCVLDQGDSVLINRITFAMYKIYALQCGAKIHSTDSVTHDLNAFLDLAKLIRPKII
FLCTPSNPAGDALSKSDVYEFLSKISLDTLVVIDAAYMEFGKKKDPNKFIPAKEVTDLFPNVFYTGTFSKVYGLGGMRIG
YGIGNQELISNLYKMRPPFSVTNLSALAATEALKNESYVESYLENNWNEMKRYEKFAAEQSIEFIDSYANFITFFARKRG
KSSSEIAHSLLKQGIILRDLKNYDLNALRITIGRPEQNDLVLEALEKEFH

Sequences:

>Translated_370_residues
MGVMIPFRSILNSLKSYEAGKPIELVVREFGIDPNRIIKLGSNENPFGCAESVMEVVRQAISKMSFYPDDSYLDLKTAIA
SKFDLTTDRIIPGNGSDQVLDFVCRCVLDQGDSVLINRITFAMYKIYALQCGAKIHSTDSVTHDLNAFLDLAKLIRPKII
FLCTPSNPAGDALSKSDVYEFLSKISLDTLVVIDAAYMEFGKKKDPNKFIPAKEVTDLFPNVFYTGTFSKVYGLGGMRIG
YGIGNQELISNLYKMRPPFSVTNLSALAATEALKNESYVESYLENNWNEMKRYEKFAAEQSIEFIDSYANFITFFARKRG
KSSSEIAHSLLKQGIILRDLKNYDLNALRITIGRPEQNDLVLEALEKEFH
>Mature_369_residues
GVMIPFRSILNSLKSYEAGKPIELVVREFGIDPNRIIKLGSNENPFGCAESVMEVVRQAISKMSFYPDDSYLDLKTAIAS
KFDLTTDRIIPGNGSDQVLDFVCRCVLDQGDSVLINRITFAMYKIYALQCGAKIHSTDSVTHDLNAFLDLAKLIRPKIIF
LCTPSNPAGDALSKSDVYEFLSKISLDTLVVIDAAYMEFGKKKDPNKFIPAKEVTDLFPNVFYTGTFSKVYGLGGMRIGY
GIGNQELISNLYKMRPPFSVTNLSALAATEALKNESYVESYLENNWNEMKRYEKFAAEQSIEFIDSYANFITFFARKRGK
SSSEIAHSLLKQGIILRDLKNYDLNALRITIGRPEQNDLVLEALEKEFH

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788332, Length=337, Percent_Identity=26.4094955489614, Blast_Score=108, Evalue=4e-25,
Organism=Escherichia coli, GI1788722, Length=196, Percent_Identity=29.0816326530612, Blast_Score=67, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6322075, Length=379, Percent_Identity=26.1213720316623, Blast_Score=90, Evalue=7e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS8_LEPIC (Q72PG3)

Other databases:

- EMBL:   AE016823
- RefSeq:   YP_002436.1
- ProteinModelPortal:   Q72PG3
- GeneID:   2770752
- GenomeReviews:   AE016823_GR
- KEGG:   lic:LIC12508
- HOGENOM:   HBG646350
- OMA:   KLIYIAN
- ProtClustDB:   PRK02731
- BioCyc:   LINT267671:LIC_12508-MONOMER
- HAMAP:   MF_01023
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 41605; Mature: 41474

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGVMIPFRSILNSLKSYEAGKPIELVVREFGIDPNRIIKLGSNENPFGCAESVMEVVRQA
CCCCCCHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHEEEECCCCCCCHHHHHHHHHHHHH
ISKMSFYPDDSYLDLKTAIASKFDLTTDRIIPGNGSDQVLDFVCRCVLDQGDSVLINRIT
HHHCCCCCCCCCHHHHHHHHHHCCCCCCCEECCCCCHHHHHHHHHHHHCCCCHHHHHHHH
FAMYKIYALQCGAKIHSTDSVTHDLNAFLDLAKLIRPKIIFLCTPSNPAGDALSKSDVYE
HHHHHHHHHHHCCEECCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHH
FLSKISLDTLVVIDAAYMEFGKKKDPNKFIPAKEVTDLFPNVFYTGTFSKVYGLGGMRIG
HHHHHCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCEECCCHHHHHCCCCCEEE
YGIGNQELISNLYKMRPPFSVTNLSALAATEALKNESYVESYLENNWNEMKRYEKFAAEQ
CCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHH
SIEFIDSYANFITFFARKRGKSSSEIAHSLLKQGIILRDLKNYDLNALRITIGRPEQNDL
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHCCCCCEEEEEEECCCCCHHH
VLEALEKEFH
HHHHHHHHCC
>Mature Secondary Structure 
GVMIPFRSILNSLKSYEAGKPIELVVREFGIDPNRIIKLGSNENPFGCAESVMEVVRQA
CCCCCHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHEEEECCCCCCCHHHHHHHHHHHHH
ISKMSFYPDDSYLDLKTAIASKFDLTTDRIIPGNGSDQVLDFVCRCVLDQGDSVLINRIT
HHHCCCCCCCCCHHHHHHHHHHCCCCCCCEECCCCCHHHHHHHHHHHHCCCCHHHHHHHH
FAMYKIYALQCGAKIHSTDSVTHDLNAFLDLAKLIRPKIIFLCTPSNPAGDALSKSDVYE
HHHHHHHHHHHCCEECCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHH
FLSKISLDTLVVIDAAYMEFGKKKDPNKFIPAKEVTDLFPNVFYTGTFSKVYGLGGMRIG
HHHHHCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCEECCCHHHHHCCCCCEEE
YGIGNQELISNLYKMRPPFSVTNLSALAATEALKNESYVESYLENNWNEMKRYEKFAAEQ
CCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHH
SIEFIDSYANFITFFARKRGKSSSEIAHSLLKQGIILRDLKNYDLNALRITIGRPEQNDL
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHCCCCCEEEEEEECCCCCHHH
VLEALEKEFH
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA