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The map label for this gene is alr5254

Identifier: 45658230

GI number: 45658230

Start: 2889605

End: 2890549

Strand: Direct

Name: alr5254

Synonym: LIC12384

Alternate gene names: 45658230

Gene position: 2889605-2890549 (Clockwise)

Preceding gene: 45658227

Following gene: 45658232

Centisome position: 67.56

GC content: 37.67

Gene sequence:

>945_bases
TTGAAAGAATTCAAAAATTCTGTGGACTTACTATCAAAACTACAGTACAAAGTTCGAAACAAAAATAGGTCACAAACAAT
GGAATCCAATTTGCTAACAACAGTATTTCTTCCTATCGCGTTAGGTATTATAATGCTCGGAATGGGTATGAGCCTTACGG
TAGAAGATTTCAAAAGAATTTTCGTTCTTCCTAAAGCTGTTATCACCGGGCTCATTTTACAGCTATTCCTTTTACCTCTG
ACTGGATGGTTCATTGCGAACGTCTTTAAACTTCCAAGTGAACTATCGGTAGGACTTATGATACTTGCAATTTGTCCCGG
AGGAGCCACTTCTAACCTGATCACTCACTTAGCCAAAGGAGACGTGGCGCTTTCCATAACGTTAACCGCAATCACTAGTT
GTATCACGGTTCTTTCAATTCCGTTTCTACTTAATATATCTATGCATCATTTTTTAGGATCTGGGCAAATGATCAAATTG
AATATTCCTCAAACCATATTACAAATTTTTATGATCACCGTATTACCAGTATCAATCGGAATGATTTTAAACTCTAAAAA
ACCAGAACTATCCCGCAAATTTGAAAAGACTGTAAAAGTTCTTTCCGGAATTTTTTTAGTACTGATCATCTTAGGCGCAA
TCGTTCGTGAAAGACAAAACATAATTCCATATTTTATCCAAGTTGGTCCGGCGTCTCTGGCATTGAATCTGATTACTATG
TTCTTAGGTTATCTGGGAGCGACTCTGATGAAAGTCACTCATCCACAAAGAACATCGATTACCATAGAAGTAGGAATTCA
AAACGGAACCTTAGGGATTACAATCGCAAGTGCAATTTTGAATAACCCTACAATGGCGATTCCGTCCGCGATTTACAGTT
TGATCATGTTCGCCACGGGAGCGATTTTTTCCATTTGGACAAATAAAAGTTCCAATCCAACGTAA

Upstream 100 bases:

>100_bases
ATGATTACTCGGATCCATAAAACCATAAGAATCATAGCATGTATTTTTAAAATCTGCCTTCGAAAAAGACTTTTATGGAA
TCATAATACAAGAAGTAAAA

Downstream 100 bases:

>100_bases
AACTTCCGTTGGTCTTTACGGATCTCTATAAAATTTATAGTATTCAATTTTATAGAGATCTACGATAGATAAGTGATACT
ATTTATTTTCATTAATCACT

Product: sodium bile acid symporter family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 314; Mature: 314

Protein sequence:

>314_residues
MKEFKNSVDLLSKLQYKVRNKNRSQTMESNLLTTVFLPIALGIIMLGMGMSLTVEDFKRIFVLPKAVITGLILQLFLLPL
TGWFIANVFKLPSELSVGLMILAICPGGATSNLITHLAKGDVALSITLTAITSCITVLSIPFLLNISMHHFLGSGQMIKL
NIPQTILQIFMITVLPVSIGMILNSKKPELSRKFEKTVKVLSGIFLVLIILGAIVRERQNIIPYFIQVGPASLALNLITM
FLGYLGATLMKVTHPQRTSITIEVGIQNGTLGITIASAILNNPTMAIPSAIYSLIMFATGAIFSIWTNKSSNPT

Sequences:

>Translated_314_residues
MKEFKNSVDLLSKLQYKVRNKNRSQTMESNLLTTVFLPIALGIIMLGMGMSLTVEDFKRIFVLPKAVITGLILQLFLLPL
TGWFIANVFKLPSELSVGLMILAICPGGATSNLITHLAKGDVALSITLTAITSCITVLSIPFLLNISMHHFLGSGQMIKL
NIPQTILQIFMITVLPVSIGMILNSKKPELSRKFEKTVKVLSGIFLVLIILGAIVRERQNIIPYFIQVGPASLALNLITM
FLGYLGATLMKVTHPQRTSITIEVGIQNGTLGITIASAILNNPTMAIPSAIYSLIMFATGAIFSIWTNKSSNPT
>Mature_314_residues
MKEFKNSVDLLSKLQYKVRNKNRSQTMESNLLTTVFLPIALGIIMLGMGMSLTVEDFKRIFVLPKAVITGLILQLFLLPL
TGWFIANVFKLPSELSVGLMILAICPGGATSNLITHLAKGDVALSITLTAITSCITVLSIPFLLNISMHHFLGSGQMIKL
NIPQTILQIFMITVLPVSIGMILNSKKPELSRKFEKTVKVLSGIFLVLIILGAIVRERQNIIPYFIQVGPASLALNLITM
FLGYLGATLMKVTHPQRTSITIEVGIQNGTLGITIASAILNNPTMAIPSAIYSLIMFATGAIFSIWTNKSSNPT

Specific function: Unknown

COG id: COG0385

COG function: function code R; Predicted Na+-dependent transporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:bile acid symporter family [H]

Homologues:

Organism=Homo sapiens, GI4506973, Length=288, Percent_Identity=28.4722222222222, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI215422368, Length=239, Percent_Identity=29.2887029288703, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI215422370, Length=239, Percent_Identity=29.2887029288703, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI9790143, Length=239, Percent_Identity=29.2887029288703, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI4506971, Length=263, Percent_Identity=26.9961977186312, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI37537552, Length=165, Percent_Identity=29.0909090909091, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI58219066, Length=238, Percent_Identity=26.4705882352941, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004710
- InterPro:   IPR002657 [H]

Pfam domain/function: PF01758 SBF [H]

EC number: NA

Molecular weight: Translated: 34216; Mature: 34216

Theoretical pI: Translated: 10.63; Mature: 10.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEFKNSVDLLSKLQYKVRNKNRSQTMESNLLTTVFLPIALGIIMLGMGMSLTVEDFKRI
CCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHH
FVLPKAVITGLILQLFLLPLTGWFIANVFKLPSELSVGLMILAICPGGATSNLITHLAKG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCHHEEEEEECCCCCHHHHHHHHHCC
DVALSITLTAITSCITVLSIPFLLNISMHHFLGSGQMIKLNIPQTILQIFMITVLPVSIG
CEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHHHHHH
MILNSKKPELSRKFEKTVKVLSGIFLVLIILGAIVRERQNIIPYFIQVGPASLALNLITM
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHEEECHHHHHHHHHHH
FLGYLGATLMKVTHPQRTSITIEVGIQNGTLGITIASAILNNPTMAIPSAIYSLIMFATG
HHHHHHHHHHHHCCCCCCEEEEEEEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
AIFSIWTNKSSNPT
HHHEEEECCCCCCC
>Mature Secondary Structure
MKEFKNSVDLLSKLQYKVRNKNRSQTMESNLLTTVFLPIALGIIMLGMGMSLTVEDFKRI
CCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHH
FVLPKAVITGLILQLFLLPLTGWFIANVFKLPSELSVGLMILAICPGGATSNLITHLAKG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCHHEEEEEECCCCCHHHHHHHHHCC
DVALSITLTAITSCITVLSIPFLLNISMHHFLGSGQMIKLNIPQTILQIFMITVLPVSIG
CEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHHHHHH
MILNSKKPELSRKFEKTVKVLSGIFLVLIILGAIVRERQNIIPYFIQVGPASLALNLITM
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHEEECHHHHHHHHHHH
FLGYLGATLMKVTHPQRTSITIEVGIQNGTLGITIASAILNNPTMAIPSAIYSLIMFATG
HHHHHHHHHHHHCCCCCCEEEEEEEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
AIFSIWTNKSSNPT
HHHEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]