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The map label for this gene is glyS

Identifier: 45658196

GI number: 45658196

Start: 2844717

End: 2846111

Strand: Direct

Name: glyS

Synonym: LIC12350

Alternate gene names: 45658196

Gene position: 2844717-2846111 (Clockwise)

Preceding gene: 45658191

Following gene: 45658197

Centisome position: 66.51

GC content: 38.64

Gene sequence:

>1395_bases
ATGGAAAAAAAAGAAAGTCTCGATTCTTCACTAAAGGAAATCGTATCCGTTTGTAAACGAAGAGGGTTTGTTTATCCAGG
CTCCGAAATTTACGGAGGACTTTCCAATACCTTTGACTATGGTCCTTACGGAGTCGAACTTCTTCAAAATCTAAAACAAC
TTTGGTGGAAATATTTCGTACATCTTCGAGAAGACATAGTAGGTCTTGATTCCTCAATCCTTCTCAATCCGAAAGTTTGG
GAAGCGTCCGGTCACGTTTCCAATTTCAATGATCCTTTGATCGATTGTAAAAACTGTAAGACCCGAATCCGCGCGGACAA
GTTCCTTGAAGATCAAAAGGGAGAAGGGTTCGCAACTGGTCTTACTCTTGAAAAGATGAATCAGGTAATCAAAGAAAGTA
ATTTTGCCTGTCCGAACTGTGGACAAAGAGGCACATTTACAGAAGCTCGAGACTTCAATCTTATGTTCAAAACTTCTCAT
GGAGCTAGTGCGGAAGACTCTTTAGATATTTATCTTAGACCCGAAACTGCTCAAGGTATCTTTTTGAATTTTAAGAACGT
TGTTTCCACCACTAGAAGAAAAATTCCTTTTGGAATCGCACAAATCGGAAAGTCATTTCGTAACGAAATTATGGCGCGTC
AGTTCGTATTTAGAACCAGAGAATTTGAGCAAATGGAAATGGAATTCTTTTGTGAACCAGGTACCCAAAAAGAATGGTTC
TCTCACTGGGTAAATTATTGTATGAATTGGCTTACTGAACAAGTCGGAATCAAAAAAGAAAATCTAAGAGTCAGAGAACA
CGAAAAAGAAGAATTATCTTTTTACAGCGAAGGAACCTCTGACATTGAATTTAAATATAATTTCGGTTGGGGTGAACTCT
GGGGAATCGCATCTAGAACCGACTACGATCTAAATCAGCACCAAAAATTTTCAGGCGAAGATCTTAAATACCAAGATCAA
GTTCAGAATAAAAAATACGTTCCTTTTGTCGTTGAACCTGCGTTAGGTGTAAACAGACTTTTTCTTGCAGTTGTTACAGA
CGCCTACGAAGAAGAAAAACTTCCTGACGGTGAAACTAGAACGGTTCTTCGTTTTTCTCCTAAAATCGCTCCGGTAAAAG
CTGCAGTTTTTCCTCTAATGAAAAAGGATGGACTTCCTGAAAAATCCAGAGAAATTTTTGCTGATCTTTCCAAACTCGGA
AATATTGAATACGACGACGGAGGCGCCATAGGCAAACGTTATCGTAGACAAGACGAAATCGGAACTCCTTTTTGTATTAC
AGTAGATTATGATACTCTAAAGGATAATACGGTCACGGTTCGAGAAAGAGATAGCATGTCTCAAGAAAGAATCGCCGTAA
ATCAACTTAAGAACTGGCTTTTTGAAAGGCTATAA

Upstream 100 bases:

>100_bases
AACCATTGGACCTAAACGAGGAACACAGGCAAACAAGAAATCCTTTACGGTTCAGAATTAAAATACTTTATTCCGCAGTC
CCGAACAGAATCCTGGGCTC

Downstream 100 bases:

>100_bases
ATTGTAATAGCTCCTACAATTTTTCTGTATTAGGTCTTACAATTAAGATTCTCTTTTGAAATGTAGGAACTACTGTAAAG
TTCGAGATTCTCTTTTGAAA

Product: glycyl-tRNA synthetase

Products: NA

Alternate protein names: Glycine--tRNA ligase; GlyRS [H]

Number of amino acids: Translated: 464; Mature: 464

Protein sequence:

>464_residues
MEKKESLDSSLKEIVSVCKRRGFVYPGSEIYGGLSNTFDYGPYGVELLQNLKQLWWKYFVHLREDIVGLDSSILLNPKVW
EASGHVSNFNDPLIDCKNCKTRIRADKFLEDQKGEGFATGLTLEKMNQVIKESNFACPNCGQRGTFTEARDFNLMFKTSH
GASAEDSLDIYLRPETAQGIFLNFKNVVSTTRRKIPFGIAQIGKSFRNEIMARQFVFRTREFEQMEMEFFCEPGTQKEWF
SHWVNYCMNWLTEQVGIKKENLRVREHEKEELSFYSEGTSDIEFKYNFGWGELWGIASRTDYDLNQHQKFSGEDLKYQDQ
VQNKKYVPFVVEPALGVNRLFLAVVTDAYEEEKLPDGETRTVLRFSPKIAPVKAAVFPLMKKDGLPEKSREIFADLSKLG
NIEYDDGGAIGKRYRRQDEIGTPFCITVDYDTLKDNTVTVRERDSMSQERIAVNQLKNWLFERL

Sequences:

>Translated_464_residues
MEKKESLDSSLKEIVSVCKRRGFVYPGSEIYGGLSNTFDYGPYGVELLQNLKQLWWKYFVHLREDIVGLDSSILLNPKVW
EASGHVSNFNDPLIDCKNCKTRIRADKFLEDQKGEGFATGLTLEKMNQVIKESNFACPNCGQRGTFTEARDFNLMFKTSH
GASAEDSLDIYLRPETAQGIFLNFKNVVSTTRRKIPFGIAQIGKSFRNEIMARQFVFRTREFEQMEMEFFCEPGTQKEWF
SHWVNYCMNWLTEQVGIKKENLRVREHEKEELSFYSEGTSDIEFKYNFGWGELWGIASRTDYDLNQHQKFSGEDLKYQDQ
VQNKKYVPFVVEPALGVNRLFLAVVTDAYEEEKLPDGETRTVLRFSPKIAPVKAAVFPLMKKDGLPEKSREIFADLSKLG
NIEYDDGGAIGKRYRRQDEIGTPFCITVDYDTLKDNTVTVRERDSMSQERIAVNQLKNWLFERL
>Mature_464_residues
MEKKESLDSSLKEIVSVCKRRGFVYPGSEIYGGLSNTFDYGPYGVELLQNLKQLWWKYFVHLREDIVGLDSSILLNPKVW
EASGHVSNFNDPLIDCKNCKTRIRADKFLEDQKGEGFATGLTLEKMNQVIKESNFACPNCGQRGTFTEARDFNLMFKTSH
GASAEDSLDIYLRPETAQGIFLNFKNVVSTTRRKIPFGIAQIGKSFRNEIMARQFVFRTREFEQMEMEFFCEPGTQKEWF
SHWVNYCMNWLTEQVGIKKENLRVREHEKEELSFYSEGTSDIEFKYNFGWGELWGIASRTDYDLNQHQKFSGEDLKYQDQ
VQNKKYVPFVVEPALGVNRLFLAVVTDAYEEEKLPDGETRTVLRFSPKIAPVKAAVFPLMKKDGLPEKSREIFADLSKLG
NIEYDDGGAIGKRYRRQDEIGTPFCITVDYDTLKDNTVTVRERDSMSQERIAVNQLKNWLFERL

Specific function: Catalyzes the attachment of glycine to tRNA(Gly) [H]

COG id: COG0423

COG function: function code J; Glycyl-tRNA synthetase (class II)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI116805340, Length=382, Percent_Identity=31.151832460733, Blast_Score=159, Evalue=8e-39,
Organism=Homo sapiens, GI70887790, Length=477, Percent_Identity=20.9643605870021, Blast_Score=86, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI17554996, Length=376, Percent_Identity=32.9787234042553, Blast_Score=169, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI32564541, Length=376, Percent_Identity=32.9787234042553, Blast_Score=169, Evalue=4e-42,
Organism=Saccharomyces cerevisiae, GI6325338, Length=382, Percent_Identity=32.1989528795811, Blast_Score=167, Evalue=4e-42,
Organism=Saccharomyces cerevisiae, GI6319597, Length=407, Percent_Identity=29.2383292383292, Blast_Score=157, Evalue=4e-39,
Organism=Drosophila melanogaster, GI21357965, Length=374, Percent_Identity=32.8877005347594, Blast_Score=169, Evalue=4e-42,
Organism=Drosophila melanogaster, GI24664462, Length=374, Percent_Identity=32.8877005347594, Blast_Score=169, Evalue=4e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR022961
- InterPro:   IPR002315 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.14 [H]

Molecular weight: Translated: 53771; Mature: 53771

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKKESLDSSLKEIVSVCKRRGFVYPGSEIYGGLSNTFDYGPYGVELLQNLKQLWWKYFV
CCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
HLREDIVGLDSSILLNPKVWEASGHVSNFNDPLIDCKNCKTRIRADKFLEDQKGEGFATG
HHHHHHHCCCCCEEECCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEC
LTLEKMNQVIKESNFACPNCGQRGTFTEARDFNLMFKTSHGASAEDSLDIYLRPETAQGI
CCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEECCCCCCEE
FLNFKNVVSTTRRKIPFGIAQIGKSFRNEIMARQFVFRTREFEQMEMEFFCEPGTQKEWF
EEEHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCHHHH
SHWVNYCMNWLTEQVGIKKENLRVREHEKEELSFYSEGTSDIEFKYNFGWGELWGIASRT
HHHHHHHHHHHHHHHCCCHHCCCHHHCCHHHHHHHCCCCCCEEEEEECCCHHHHCCCCCC
DYDLNQHQKFSGEDLKYQDQVQNKKYVPFVVEPALGVNRLFLAVVTDAYEEEKLPDGETR
CCCCCCCCCCCCCCCCHHHHHCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCC
TVLRFSPKIAPVKAAVFPLMKKDGLPEKSREIFADLSKLGNIEYDDGGAIGKRYRRQDEI
EEEEECCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCC
GTPFCITVDYDTLKDNTVTVRERDSMSQERIAVNQLKNWLFERL
CCCEEEEEECCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEKKESLDSSLKEIVSVCKRRGFVYPGSEIYGGLSNTFDYGPYGVELLQNLKQLWWKYFV
CCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
HLREDIVGLDSSILLNPKVWEASGHVSNFNDPLIDCKNCKTRIRADKFLEDQKGEGFATG
HHHHHHHCCCCCEEECCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEC
LTLEKMNQVIKESNFACPNCGQRGTFTEARDFNLMFKTSHGASAEDSLDIYLRPETAQGI
CCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEECCCCCCEE
FLNFKNVVSTTRRKIPFGIAQIGKSFRNEIMARQFVFRTREFEQMEMEFFCEPGTQKEWF
EEEHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCHHHH
SHWVNYCMNWLTEQVGIKKENLRVREHEKEELSFYSEGTSDIEFKYNFGWGELWGIASRT
HHHHHHHHHHHHHHHCCCHHCCCHHHCCHHHHHHHCCCCCCEEEEEECCCHHHHCCCCCC
DYDLNQHQKFSGEDLKYQDQVQNKKYVPFVVEPALGVNRLFLAVVTDAYEEEKLPDGETR
CCCCCCCCCCCCCCCCHHHHHCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCC
TVLRFSPKIAPVKAAVFPLMKKDGLPEKSREIFADLSKLGNIEYDDGGAIGKRYRRQDEI
EEEEECCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCC
GTPFCITVDYDTLKDNTVTVRERDSMSQERIAVNQLKNWLFERL
CCCEEEEEECCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA