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The map label for this gene is nhaC [H]

Identifier: 45658115

GI number: 45658115

Start: 2736180

End: 2737586

Strand: Reverse

Name: nhaC [H]

Synonym: LIC12266

Alternate gene names: 45658115

Gene position: 2737586-2736180 (Counterclockwise)

Preceding gene: 45658116

Following gene: 45658114

Centisome position: 64.0

GC content: 40.51

Gene sequence:

>1407_bases
GTGAATCCAGGATTATTCGAATCTTTTATTCCTGTGATTGTACTCGTGATGGGGCTCGGTTATGCGGGAGTTGTGTTTGG
AAATGGAACCGTGGACGGCCCCGCACAAATGCTTTTGATTCTTTCCGGAACGGTTGCGAGTTTACTCGGAATTCGTCTTG
GGGTTAAATGGGACGTTCTAGAAGAAAGAATTTTAGAATCATTGAAAAACGTATTAAAACCTGTGCTCATTCTTCTATTG
ATTGGATCTCTGATAGGAGTTTGGATTTGGTCTGGAATCGTACCTTCTATGATTGTGTGGGGATTAAAAATTTTAAAACC
TTCTTTCTTTTTAGTAACCGCTTGTGTTCTATCTTCCGTTGTTTCTTTAATTACTGGAAGTTCTTGGTCTACGGCGGGAA
CCGTAGGAGTTGCGCTGATGGGGATAGGAACCACGTTAGGCGTTCCTTCTGGGATCGCCGCAGGAGCCATCGTATCGGGG
GCGTATTTTGGAGATAAACTTTCTCCATTTTCGGAGACGACCAATCTGGCTTCTTCGATCGCTGGAACTCCACTTTTTAC
ACATATTCAACATATGTTATATACTACGATTCCTGCTTTTTGTATTGCGATTGTGTTTTTTACTTGGACCGGTTTAGATT
ATTCTGGTTCTGAAAGTGGGGATCAAAAGGTAAACGAGGTGATCGGTTTGCTCGAAAAATCTTTTCGAATTCATCCCGCT
TTGATAATCCCTCCTATTTTGACCTTTGTAATGATTTATTTTAAAATTCCAGCTATACCTTCAATTCTTGCAGGAATTCT
TTCCGGAGTGGTATCCGGAGTTTTTTTACAACATTCCGAATTAGATTTTCCGGAAATTTACAAACAGATTTTAAATGCTG
CTTCTAAAGGAAATTCGATTAAGAGTCAAAGTCCTCTTACGGATGCTTTACTTTCGAGAGGAGGAATGGCTTCTATGCTT
CCTACGGTTTGGTTGATTTTTTCGGCAATGTTTTTTGCGGGAGCGATGGAAGGGGCCGGCTTGATTCAGGAAATTACCAA
AGGAATATTAAAATATGCGAATACAGATCGATCTCTTTTAACGGGAACTATTTTTACTAGCATTTCCGCAAATCTAATTT
CTTCCGATCAATATCTTTCGATATTGGTTCCGGGAAAGATGTTTAAAAAATCTTACGAAGAGCATGGTCTTGATCCTAAA
AATCTTTCCAGGGCCTTGGAGGATTCAGGTACGATGACTTCTGCTTTGGTCCCTTGGAATACATGTGGTTCTTTTATGGC
TGCAGCACTTGGAGTTCCTGTGGTTGTATTCCTTCCGTATGCGATTTTAAATTTATGTAGTCCTATTATTTCTCTTGTCT
GCGCTTGGACTGGATGGACGATTCGAAAAAAAAGGATTGGCACGTAG

Upstream 100 bases:

>100_bases
GAATGAAAAGACAAGCTTTGCATTCGTATGCAGTTTGTTTGAATCACCCGGTCACAAATCAAAAGATGAAAATTACGGCT
CCTATTCCGGAGGATTTTTT

Downstream 100 bases:

>100_bases
AATTAAAATTTAAGAATATTATTAATTTTTGATGTTTTTTTTGAGCGACTCAAACAAGCAGAATCACTCTTTGAAAGACT
GTAATGAAACGTAGTATTAG

Product: Na+/H+ antiporter

Products: NA

Alternate protein names: Sodium/hydrogen antiporter; Sodium/proton antiporter [H]

Number of amino acids: Translated: 468; Mature: 468

Protein sequence:

>468_residues
MNPGLFESFIPVIVLVMGLGYAGVVFGNGTVDGPAQMLLILSGTVASLLGIRLGVKWDVLEERILESLKNVLKPVLILLL
IGSLIGVWIWSGIVPSMIVWGLKILKPSFFLVTACVLSSVVSLITGSSWSTAGTVGVALMGIGTTLGVPSGIAAGAIVSG
AYFGDKLSPFSETTNLASSIAGTPLFTHIQHMLYTTIPAFCIAIVFFTWTGLDYSGSESGDQKVNEVIGLLEKSFRIHPA
LIIPPILTFVMIYFKIPAIPSILAGILSGVVSGVFLQHSELDFPEIYKQILNAASKGNSIKSQSPLTDALLSRGGMASML
PTVWLIFSAMFFAGAMEGAGLIQEITKGILKYANTDRSLLTGTIFTSISANLISSDQYLSILVPGKMFKKSYEEHGLDPK
NLSRALEDSGTMTSALVPWNTCGSFMAAALGVPVVVFLPYAILNLCSPIISLVCAWTGWTIRKKRIGT

Sequences:

>Translated_468_residues
MNPGLFESFIPVIVLVMGLGYAGVVFGNGTVDGPAQMLLILSGTVASLLGIRLGVKWDVLEERILESLKNVLKPVLILLL
IGSLIGVWIWSGIVPSMIVWGLKILKPSFFLVTACVLSSVVSLITGSSWSTAGTVGVALMGIGTTLGVPSGIAAGAIVSG
AYFGDKLSPFSETTNLASSIAGTPLFTHIQHMLYTTIPAFCIAIVFFTWTGLDYSGSESGDQKVNEVIGLLEKSFRIHPA
LIIPPILTFVMIYFKIPAIPSILAGILSGVVSGVFLQHSELDFPEIYKQILNAASKGNSIKSQSPLTDALLSRGGMASML
PTVWLIFSAMFFAGAMEGAGLIQEITKGILKYANTDRSLLTGTIFTSISANLISSDQYLSILVPGKMFKKSYEEHGLDPK
NLSRALEDSGTMTSALVPWNTCGSFMAAALGVPVVVFLPYAILNLCSPIISLVCAWTGWTIRKKRIGT
>Mature_468_residues
MNPGLFESFIPVIVLVMGLGYAGVVFGNGTVDGPAQMLLILSGTVASLLGIRLGVKWDVLEERILESLKNVLKPVLILLL
IGSLIGVWIWSGIVPSMIVWGLKILKPSFFLVTACVLSSVVSLITGSSWSTAGTVGVALMGIGTTLGVPSGIAAGAIVSG
AYFGDKLSPFSETTNLASSIAGTPLFTHIQHMLYTTIPAFCIAIVFFTWTGLDYSGSESGDQKVNEVIGLLEKSFRIHPA
LIIPPILTFVMIYFKIPAIPSILAGILSGVVSGVFLQHSELDFPEIYKQILNAASKGNSIKSQSPLTDALLSRGGMASML
PTVWLIFSAMFFAGAMEGAGLIQEITKGILKYANTDRSLLTGTIFTSISANLISSDQYLSILVPGKMFKKSYEEHGLDPK
NLSRALEDSGTMTSALVPWNTCGSFMAAALGVPVVVFLPYAILNLCSPIISLVCAWTGWTIRKKRIGT

Specific function: Na(+)/H(+) antiporter. Involved in pH homeostasis and sodium extrusion [H]

COG id: COG1757

COG function: function code C; Na+/H+ antiporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaC Na(+)/H(+) antiporter family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004770
- InterPro:   IPR018461 [H]

Pfam domain/function: PF03553 Na_H_antiporter [H]

EC number: NA

Molecular weight: Translated: 49763; Mature: 49763

Theoretical pI: Translated: 8.19; Mature: 8.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCC
>Mature Secondary Structure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HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1660475; 9190799 [H]