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The map label for this gene is mutT

Identifier: 45658040

GI number: 45658040

Start: 2644632

End: 2645066

Strand: Reverse

Name: mutT

Synonym: LIC12191

Alternate gene names: 45658040

Gene position: 2645066-2644632 (Counterclockwise)

Preceding gene: 45658041

Following gene: 45658039

Centisome position: 61.84

GC content: 34.71

Gene sequence:

>435_bases
ATGAACTCTTCAATTGGTCATGCAGTAAAAGCTTTAATTTACAGAAATGATCAACGTATTTTATTACAGCAACGTGATTA
TACTCCAGGAATCATATTTCAGGGTTATTGGACTTTTTTTGGTGGGCAAGTGGAGTCCGGTGAAAATCTTAAAGATGCAT
TGTGTCGTGAGTTGAAAGAAGAACTTGGATGTCTTCCTGGAAGTATTGGGGAAGAATTATTTTATTGGGAATGGAGAGGT
GAACAAATTACATGTAATCACTGTTTGCCGGTTTATTTTGAAGTAAAAGAAGACGTTCTTACTTTAAATGAAGGTCTCGC
CATGAAATGGTTCTTATGGGAAGAATTGGACGAGAGACTTCCGTTAGTTCCGGGTGTTAGTGAAAATCTTTATAAAATTA
AAAGTTTCTTAGATAAAATTTTTCTCAATAGATGA

Upstream 100 bases:

>100_bases
AGTAGAAGGTTTAAAACTAAGTAATCAAGAAGAAATGGAGCGTATTGAAAATCTTTGGAAAATTAAACTTATATTACCTG
ATTGTTTGAATTATTGATTT

Downstream 100 bases:

>100_bases
TTAAGAATGGGAAAGCTTAAAAATATAGTTACACCGCTTCACAAGGCGACTCAGAGAGATTATCTGGCTCGTATGCAGGA
TCATAAAATAGAATGTATGA

Product: mutator protein

Products: CMP; diphosphate [C]

Alternate protein names: Hydrolase NUDIX Family

Number of amino acids: Translated: 144; Mature: 144

Protein sequence:

>144_residues
MNSSIGHAVKALIYRNDQRILLQQRDYTPGIIFQGYWTFFGGQVESGENLKDALCRELKEELGCLPGSIGEELFYWEWRG
EQITCNHCLPVYFEVKEDVLTLNEGLAMKWFLWEELDERLPLVPGVSENLYKIKSFLDKIFLNR

Sequences:

>Translated_144_residues
MNSSIGHAVKALIYRNDQRILLQQRDYTPGIIFQGYWTFFGGQVESGENLKDALCRELKEELGCLPGSIGEELFYWEWRG
EQITCNHCLPVYFEVKEDVLTLNEGLAMKWFLWEELDERLPLVPGVSENLYKIKSFLDKIFLNR
>Mature_144_residues
MNSSIGHAVKALIYRNDQRILLQQRDYTPGIIFQGYWTFFGGQVESGENLKDALCRELKEELGCLPGSIGEELFYWEWRG
EQITCNHCLPVYFEVKEDVLTLNEGLAMKWFLWEELDERLPLVPGVSENLYKIKSFLDKIFLNR

Specific function: Specific For Pyrimidine Substrates. Acts On 5-Methyl- Dctp, Ctp And Dctp In Decreasing Order. [C]

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 3.6.1.- [C]

Molecular weight: Translated: 16855; Mature: 16855

Theoretical pI: Translated: 4.59; Mature: 4.59

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSSIGHAVKALIYRNDQRILLQQRDYTPGIIFQGYWTFFGGQVESGENLKDALCRELKE
CCCCHHHHHHHHHHCCCCEEEEEECCCCCCEEEEHHHHHCCCCCCCCCCHHHHHHHHHHH
ELGCLPGSIGEELFYWEWRGEQITCNHCLPVYFEVKEDVLTLNEGLAMKWFLWEELDERL
HHCCCCCCCCCCEEEEEECCCEEEECCCCEEEEEECHHHHHHCCCCEEEHHHHHHHHHCC
PLVPGVSENLYKIKSFLDKIFLNR
CCCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNSSIGHAVKALIYRNDQRILLQQRDYTPGIIFQGYWTFFGGQVESGENLKDALCRELKE
CCCCHHHHHHHHHHCCCCEEEEEECCCCCCEEEEHHHHHCCCCCCCCCCHHHHHHHHHHH
ELGCLPGSIGEELFYWEWRGEQITCNHCLPVYFEVKEDVLTLNEGLAMKWFLWEELDERL
HHCCCCCCCCCCEEEEEECCCEEEECCCCEEEEEECHHHHHHCCCCEEEHHHHHHHHHCC
PLVPGVSENLYKIKSFLDKIFLNR
CCCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe; Mn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: CTP; H2O [C]

Specific reaction: CTP + H2O = CMP + diphosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA