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The map label for this gene is sdcS [H]

Identifier: 45657966

GI number: 45657966

Start: 2559991

End: 2561385

Strand: Reverse

Name: sdcS [H]

Synonym: LIC12118

Alternate gene names: 45657966

Gene position: 2561385-2559991 (Counterclockwise)

Preceding gene: 45657967

Following gene: 45657965

Centisome position: 59.88

GC content: 35.48

Gene sequence:

>1395_bases
ATGAAACGTAATCTGATTTCGATGGTTTTGACTTTACTTACGGTCGGGATTCTATTTTTGATTCAGGTTCGATTTGGACT
TCCTATAAATATTGCCATTATGAATTGTATTTTCGTTTTGGCCGCAGTATTTTGGGTTCTTGAACCTATTCCTGGATACG
CCACTTCGATTCTTGTAATTTTTTTAGAAATTATTTTTTTTGCAAATCCTATCGGTGTTTCTTATTTTGAGTTTCCTCGA
AATAAAAATCCATCAACTGCGGTCTTTCTTTCTTCTTTGGCGGATTCTTCTATCGTATTATTTTTAGGAGGATTTGTATT
AGCAAAAGCTTGTGTAAAAACAGGCCTGGATCGTTTTTTTGCCAATAGAATCATTCGTAGATTTGGGGTTAAAAGTCATC
AAGTACTTTTAGGTTTTATGTTTACCACCGGATTTATATCAATGTGGATGAGTAATACTGCGACTACTTCAATGATGATC
GCTCTTTCTTTTCCTATGTTGCAGATGTTGCCGGAAAAAGAACCCTTTCGAAAAGCTTTGATATTGGGGATTCCGTTTGC
GGCGAATATAGGAGGGGTAGGAACTCCAATAGGATCTCCTCCAAATATCATAGCGATGGGAATTTTAAGACAAGAAGGTA
TTGTTGTTTCTTTTGGGACTTGGATGTTTTTTGCGGTTCCACTTGTAATCGTTTTAATTTTATTTGCTTGGTTACTTCTT
ATGAAATTGTTTCCACAAAAAGACTTACTTGAATTAGTAGTTGAGTTTCAAGAGCCAGAAGAAGGAACTAAATCTTTTTC
ATTTAGAATAACTACAGTGATTTTTTTGGGAACGGTTCTTCTTTGGTTTACAGAAAATTTACACGGAATTCCTGCGGGGG
TGGTTGCGCTTCTTCCTTTAATTTTATTTCCTGTATTTGGAATTTTAAATGAAAAAGATATTAACTCATTAGATTGGTCC
GTTTTACTTTTGATTGCTGGTGGAATCGGAATTGGGGTGGGTTTTCAACAAAGTGGGATGAAGTTTTGGTTTTCTGAATT
TTTAAAACCTATTATAAAACCAGAATATTCAGTAAGTGTATTGTTTTTACTTTGTGTTTTGGCTCTTTTGTTAAGTACAT
TTATGTCCAATACGGCGGCGACGAATCTTCTGGTCCCGTTTGCATTTCCTCTTTCCACTATTGTTCTTCCCGAGTCAAAT
GTGTATCTTTTGGAAGTGTGTTTAGGAATTGCACTTTCTGCCTCTTTGGCAATGTCTCTTCCTGTAAGTACTCCTCCCAA
TGCAATTGCATACTCGGTTGGAGGATTTGAAATTAAAGATATGATTCAAGCAGGTTTGCCGATTGGAATTTTGGGATTAA
TTTTGGTCTTAGCGGGATATTTTATATTTTTATAA

Upstream 100 bases:

>100_bases
AGACTTTTTGTCATTTCTGCAATCCGTTTTTTTATGAAATTCGGTTGGAAACTAATTTAAAACATTATAAAATTCTACTT
TTTATATATAAAATACTTGA

Downstream 100 bases:

>100_bases
TTTTTTTTTAAGAATCTATTTCAAAATCTTAGGATGGATTTTGTTTTTTTTGAATATTCAATAAAATATGTCAGTTTCTA
TAGAAAATGTCACATTGAAT

Product: divalent anion Na+ symporter

Products: NA

Alternate protein names: Na(+)/dicarboxylate symporter [H]

Number of amino acids: Translated: 464; Mature: 464

Protein sequence:

>464_residues
MKRNLISMVLTLLTVGILFLIQVRFGLPINIAIMNCIFVLAAVFWVLEPIPGYATSILVIFLEIIFFANPIGVSYFEFPR
NKNPSTAVFLSSLADSSIVLFLGGFVLAKACVKTGLDRFFANRIIRRFGVKSHQVLLGFMFTTGFISMWMSNTATTSMMI
ALSFPMLQMLPEKEPFRKALILGIPFAANIGGVGTPIGSPPNIIAMGILRQEGIVVSFGTWMFFAVPLVIVLILFAWLLL
MKLFPQKDLLELVVEFQEPEEGTKSFSFRITTVIFLGTVLLWFTENLHGIPAGVVALLPLILFPVFGILNEKDINSLDWS
VLLLIAGGIGIGVGFQQSGMKFWFSEFLKPIIKPEYSVSVLFLLCVLALLLSTFMSNTAATNLLVPFAFPLSTIVLPESN
VYLLEVCLGIALSASLAMSLPVSTPPNAIAYSVGGFEIKDMIQAGLPIGILGLILVLAGYFIFL

Sequences:

>Translated_464_residues
MKRNLISMVLTLLTVGILFLIQVRFGLPINIAIMNCIFVLAAVFWVLEPIPGYATSILVIFLEIIFFANPIGVSYFEFPR
NKNPSTAVFLSSLADSSIVLFLGGFVLAKACVKTGLDRFFANRIIRRFGVKSHQVLLGFMFTTGFISMWMSNTATTSMMI
ALSFPMLQMLPEKEPFRKALILGIPFAANIGGVGTPIGSPPNIIAMGILRQEGIVVSFGTWMFFAVPLVIVLILFAWLLL
MKLFPQKDLLELVVEFQEPEEGTKSFSFRITTVIFLGTVLLWFTENLHGIPAGVVALLPLILFPVFGILNEKDINSLDWS
VLLLIAGGIGIGVGFQQSGMKFWFSEFLKPIIKPEYSVSVLFLLCVLALLLSTFMSNTAATNLLVPFAFPLSTIVLPESN
VYLLEVCLGIALSASLAMSLPVSTPPNAIAYSVGGFEIKDMIQAGLPIGILGLILVLAGYFIFL
>Mature_464_residues
MKRNLISMVLTLLTVGILFLIQVRFGLPINIAIMNCIFVLAAVFWVLEPIPGYATSILVIFLEIIFFANPIGVSYFEFPR
NKNPSTAVFLSSLADSSIVLFLGGFVLAKACVKTGLDRFFANRIIRRFGVKSHQVLLGFMFTTGFISMWMSNTATTSMMI
ALSFPMLQMLPEKEPFRKALILGIPFAANIGGVGTPIGSPPNIIAMGILRQEGIVVSFGTWMFFAVPLVIVLILFAWLLL
MKLFPQKDLLELVVEFQEPEEGTKSFSFRITTVIFLGTVLLWFTENLHGIPAGVVALLPLILFPVFGILNEKDINSLDWS
VLLLIAGGIGIGVGFQQSGMKFWFSEFLKPIIKPEYSVSVLFLLCVLALLLSTFMSNTAATNLLVPFAFPLSTIVLPESN
VYLLEVCLGIALSASLAMSLPVSTPPNAIAYSVGGFEIKDMIQAGLPIGILGLILVLAGYFIFL

Specific function: Mediates the transport of dicarboxylates across the cytoplasmic membrane via a Na(+)-electrochemical gradient [H]

COG id: COG0471

COG function: function code P; Di- and tricarboxylate transporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SLC13A transporter (TC 2.A.47) family. NADC subfamily [H]

Homologues:

Organism=Homo sapiens, GI4506979, Length=535, Percent_Identity=26.7289719626168, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI225637549, Length=520, Percent_Identity=26.3461538461538, Blast_Score=136, Evalue=5e-32,
Organism=Homo sapiens, GI225637552, Length=485, Percent_Identity=27.0103092783505, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI29171306, Length=529, Percent_Identity=26.8431001890359, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI31795546, Length=338, Percent_Identity=27.2189349112426, Blast_Score=109, Evalue=6e-24,
Organism=Homo sapiens, GI301069349, Length=315, Percent_Identity=26.6666666666667, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI31377715, Length=333, Percent_Identity=26.7267267267267, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI58761541, Length=343, Percent_Identity=26.2390670553936, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI301069353, Length=333, Percent_Identity=26.7267267267267, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI219802232, Length=458, Percent_Identity=25.1091703056769, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI19923838, Length=340, Percent_Identity=25, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI301069346, Length=146, Percent_Identity=30.8219178082192, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI1786829, Length=496, Percent_Identity=25.4032258064516, Blast_Score=71, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71989118, Length=512, Percent_Identity=25.5859375, Blast_Score=118, Evalue=7e-27,
Organism=Caenorhabditis elegans, GI71988385, Length=483, Percent_Identity=26.7080745341615, Blast_Score=113, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI32565804, Length=419, Percent_Identity=28.1622911694511, Blast_Score=112, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI32564681, Length=549, Percent_Identity=25.6830601092896, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17551790, Length=522, Percent_Identity=22.7969348659004, Blast_Score=100, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6324340, Length=446, Percent_Identity=30.2690582959641, Blast_Score=171, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6322263, Length=444, Percent_Identity=29.2792792792793, Blast_Score=144, Evalue=4e-35,
Organism=Saccharomyces cerevisiae, GI6319885, Length=469, Percent_Identity=28.1449893390192, Blast_Score=137, Evalue=3e-33,
Organism=Drosophila melanogaster, GI281362116, Length=505, Percent_Identity=25.1485148514851, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI281362114, Length=504, Percent_Identity=25.1984126984127, Blast_Score=100, Evalue=4e-21,
Organism=Drosophila melanogaster, GI281362112, Length=504, Percent_Identity=25.1984126984127, Blast_Score=100, Evalue=4e-21,
Organism=Drosophila melanogaster, GI281366409, Length=505, Percent_Identity=24.950495049505, Blast_Score=100, Evalue=4e-21,
Organism=Drosophila melanogaster, GI17737623, Length=505, Percent_Identity=24.950495049505, Blast_Score=100, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24666468, Length=505, Percent_Identity=24.950495049505, Blast_Score=100, Evalue=4e-21,
Organism=Drosophila melanogaster, GI45551633, Length=505, Percent_Identity=24.950495049505, Blast_Score=100, Evalue=4e-21,
Organism=Drosophila melanogaster, GI78706796, Length=518, Percent_Identity=22.972972972973, Blast_Score=69, Evalue=8e-12,
Organism=Drosophila melanogaster, GI78706798, Length=518, Percent_Identity=22.972972972973, Blast_Score=69, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001898 [H]

Pfam domain/function: PF00939 Na_sulph_symp [H]

EC number: NA

Molecular weight: Translated: 50790; Mature: 50790

Theoretical pI: Translated: 7.92; Mature: 7.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRNLISMVLTLLTVGILFLIQVRFGLPINIAIMNCIFVLAAVFWVLEPIPGYATSILVI
CCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
FLEIIFFANPIGVSYFEFPRNKNPSTAVFLSSLADSSIVLFLGGFVLAKACVKTGLDRFF
HHHHHHHCCCCCCCCEECCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
ANRIIRRFGVKSHQVLLGFMFTTGFISMWMSNTATTSMMIALSFPMLQMLPEKEPFRKAL
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHH
ILGIPFAANIGGVGTPIGSPPNIIAMGILRQEGIVVSFGTWMFFAVPLVIVLILFAWLLL
HHCCCCCCCCCCCCCCCCCCCCCEEEHHHHHCCEEEEHHHHHHHHHHHHHHHHHHHHHHH
MKLFPQKDLLELVVEFQEPEEGTKSFSFRITTVIFLGTVLLWFTENLHGIPAGVVALLPL
HHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
ILFPVFGILNEKDINSLDWSVLLLIAGGIGIGVGFQQSGMKFWFSEFLKPIIKPEYSVSV
HHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHH
LFLLCVLALLLSTFMSNTAATNLLVPFAFPLSTIVLPESNVYLLEVCLGIALSASLAMSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHEEEECCCCHHHHHHHHHHHHHHHHHHCC
PVSTPPNAIAYSVGGFEIKDMIQAGLPIGILGLILVLAGYFIFL
CCCCCCCCEEEECCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MKRNLISMVLTLLTVGILFLIQVRFGLPINIAIMNCIFVLAAVFWVLEPIPGYATSILVI
CCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
FLEIIFFANPIGVSYFEFPRNKNPSTAVFLSSLADSSIVLFLGGFVLAKACVKTGLDRFF
HHHHHHHCCCCCCCCEECCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
ANRIIRRFGVKSHQVLLGFMFTTGFISMWMSNTATTSMMIALSFPMLQMLPEKEPFRKAL
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHH
ILGIPFAANIGGVGTPIGSPPNIIAMGILRQEGIVVSFGTWMFFAVPLVIVLILFAWLLL
HHCCCCCCCCCCCCCCCCCCCCCEEEHHHHHCCEEEEHHHHHHHHHHHHHHHHHHHHHHH
MKLFPQKDLLELVVEFQEPEEGTKSFSFRITTVIFLGTVLLWFTENLHGIPAGVVALLPL
HHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
ILFPVFGILNEKDINSLDWSVLLLIAGGIGIGVGFQQSGMKFWFSEFLKPIIKPEYSVSV
HHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHH
LFLLCVLALLLSTFMSNTAATNLLVPFAFPLSTIVLPESNVYLLEVCLGIALSASLAMSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHEEEECCCCHHHHHHHHHHHHHHHHHHCC
PVSTPPNAIAYSVGGFEIKDMIQAGLPIGILGLILVLAGYFIFL
CCCCCCCCEEEECCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA