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The map label for this gene is zraS [C]

Identifier: 45657945

GI number: 45657945

Start: 2535790

End: 2536923

Strand: Direct

Name: zraS [C]

Synonym: LIC12097

Alternate gene names: 45657945

Gene position: 2535790-2536923 (Clockwise)

Preceding gene: 45657944

Following gene: 45657946

Centisome position: 59.29

GC content: 36.77

Gene sequence:

>1134_bases
ATGTCCTCATTGCAGGAAAATCTCCTAGAAAAAACCGGCGAACTTCAAGCCATCTTAGATGGGATTACGGAACCGTTGGT
ATTGATCGATCCAGGATTTCGTATACGCAGAGTCAATCGATCCACATTGGAATTTTCCAGTCAATCCTCGTTTTTATCCA
TCATAGGTAAAAAATGTTTCGAAGTTTTATACAATCGTAATGACGTCTGTCCTTACTGCCCGATGAAAGGAATGCAATCG
AGCGAAGAAAATTTCAACAGATATTTTGAATACCCCAGATCGGACGTGAACAGAGAAATTTTTCATTCCGTCAAAGGCCA
AAAAGAAACTCTCTATCTAGACTTCTATCCTATAGAAAAAGAAGGTAACATAGGTTCCGTTCTTGAAAAGGTAAGTAACA
TTACCAGAATCAAAGAAAAAGAAGAAGAAAATCTAAGAATTCGAAATTTAGCTTCTTTGGGAATTTTTATTTCCGGTGTC
GCACACGAGCTGAACAACCCTCTTACAGGTATGAGTTTAACCCTTCAAAGTCTTTTGAACAATCTCACTTCAATCGATCC
TGATTTTTTTCGTAAACGTTTGGATATGATGAAAGAGGATCTAACAAGAGCCGCTATGATCGTCACCGATATTATCAGTT
TTGCAAAACCGGACCGATTGGTAACTACAAGCGCGGACATTTATGAAACTATCCAAAAAGCAAGAGAAAATGTGATCTGG
GTATATCCAGTACTTTCTAAAAATATTTCTTGGGAAATTTTATGTGAGCCCAGAACCACCTTTCAATTTAATCCAGTAAA
ACTAGAAAGACTATTTATCAATTTATTTAAGAACTCTTTGCAAGCATTCGATTATGGAGAAGGAAAAATTCGGGTAGAAG
TTCGTAAAACCAGAAACATGGTACATATCATCGTAGAAGATAATGCGGGAGGGATTCCGGATAATCTGATCGATAAGATA
TTTTCTCCTTTTTTTACCAAAAATAAAACCGGAATTGGAACCGGACTTGGACTTTCCATCTGTCATTCTATCGTTCGAGA
ACACAAAGGAGAACTATCCGTTAAATCCTTTGAAAAGAAAACAAGGTTTAGAGTTTCTTTACCTTTCACACAATATCAAG
AGTACATTTCCTGA

Upstream 100 bases:

>100_bases
TCAGCTCTTAAGGCTTCAAGAAATGCAAAGCCAAGAATCAGCAAAAAATAAAAAAAAGTTACTGCAAACTTTTAAAGATT
CTCTACAATATTGAATCTTC

Downstream 100 bases:

>100_bases
TGTATAATATATTGATCGTTGAAGATATCCATTCGATCCGGGAAGCGATCAAAGATTTACTCTCCGTTAAATACAATATT
TTTGACGCTGAAAATTATGA

Product: histidine kinase sensor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 377; Mature: 376

Protein sequence:

>377_residues
MSSLQENLLEKTGELQAILDGITEPLVLIDPGFRIRRVNRSTLEFSSQSSFLSIIGKKCFEVLYNRNDVCPYCPMKGMQS
SEENFNRYFEYPRSDVNREIFHSVKGQKETLYLDFYPIEKEGNIGSVLEKVSNITRIKEKEEENLRIRNLASLGIFISGV
AHELNNPLTGMSLTLQSLLNNLTSIDPDFFRKRLDMMKEDLTRAAMIVTDIISFAKPDRLVTTSADIYETIQKARENVIW
VYPVLSKNISWEILCEPRTTFQFNPVKLERLFINLFKNSLQAFDYGEGKIRVEVRKTRNMVHIIVEDNAGGIPDNLIDKI
FSPFFTKNKTGIGTGLGLSICHSIVREHKGELSVKSFEKKTRFRVSLPFTQYQEYIS

Sequences:

>Translated_377_residues
MSSLQENLLEKTGELQAILDGITEPLVLIDPGFRIRRVNRSTLEFSSQSSFLSIIGKKCFEVLYNRNDVCPYCPMKGMQS
SEENFNRYFEYPRSDVNREIFHSVKGQKETLYLDFYPIEKEGNIGSVLEKVSNITRIKEKEEENLRIRNLASLGIFISGV
AHELNNPLTGMSLTLQSLLNNLTSIDPDFFRKRLDMMKEDLTRAAMIVTDIISFAKPDRLVTTSADIYETIQKARENVIW
VYPVLSKNISWEILCEPRTTFQFNPVKLERLFINLFKNSLQAFDYGEGKIRVEVRKTRNMVHIIVEDNAGGIPDNLIDKI
FSPFFTKNKTGIGTGLGLSICHSIVREHKGELSVKSFEKKTRFRVSLPFTQYQEYIS
>Mature_376_residues
SSLQENLLEKTGELQAILDGITEPLVLIDPGFRIRRVNRSTLEFSSQSSFLSIIGKKCFEVLYNRNDVCPYCPMKGMQSS
EENFNRYFEYPRSDVNREIFHSVKGQKETLYLDFYPIEKEGNIGSVLEKVSNITRIKEKEEENLRIRNLASLGIFISGVA
HELNNPLTGMSLTLQSLLNNLTSIDPDFFRKRLDMMKEDLTRAAMIVTDIISFAKPDRLVTTSADIYETIQKARENVIWV
YPVLSKNISWEILCEPRTTFQFNPVKLERLFINLFKNSLQAFDYGEGKIRVEVRKTRNMVHIIVEDNAGGIPDNLIDKIF
SPFFTKNKTGIGTGLGLSICHSIVREHKGELSVKSFEKKTRFRVSLPFTQYQEYIS

Specific function: Member Of The Two-Component Regulatory System Zras/Zrar. May Function As A Membrane-Associated Protein Kinase That Phosphorylates Zrar In Response To High Concentrations Of Zinc Or Lead In The Medium. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=232, Percent_Identity=28.8793103448276, Blast_Score=91, Evalue=9e-20,
Organism=Escherichia coli, GI1790300, Length=257, Percent_Identity=27.2373540856031, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1788549, Length=253, Percent_Identity=28.0632411067194, Blast_Score=85, Evalue=7e-18,
Organism=Escherichia coli, GI145693157, Length=265, Percent_Identity=26.4150943396226, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1786783, Length=222, Percent_Identity=27.027027027027, Blast_Score=71, Evalue=9e-14,
Organism=Escherichia coli, GI1788393, Length=210, Percent_Identity=24.2857142857143, Blast_Score=62, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR001638
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00497 SBP_bac_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 43370; Mature: 43239

Theoretical pI: Translated: 8.18; Mature: 8.18

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSLQENLLEKTGELQAILDGITEPLVLIDPGFRIRRVNRSTLEFSSQSSFLSIIGKKCF
CCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCEEEECCCHHHHCCCCHHHHHHHHHHHH
EVLYNRNDVCPYCPMKGMQSSEENFNRYFEYPRSDVNREIFHSVKGQKETLYLDFYPIEK
HHHHCCCCCCCCCCCCCCCCCHHHHHHHHCCCCHHCCHHHHHHHCCCCEEEEEEEEEECC
EGNIGSVLEKVSNITRIKEKEEENLRIRNLASLGIFISGVAHELNNPLTGMSLTLQSLLN
CCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
NLTSIDPDFFRKRLDMMKEDLTRAAMIVTDIISFAKPDRLVTTSADIYETIQKARENVIW
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHCCEEE
VYPVLSKNISWEILCEPRTTFQFNPVKLERLFINLFKNSLQAFDYGEGKIRVEVRKTRNM
EEEECCCCCCEEEEECCCCCEEECHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCE
VHIIVEDNAGGIPDNLIDKIFSPFFTKNKTGIGTGLGLSICHSIVREHKGELSVKSFEKK
EEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHH
TRFRVSLPFTQYQEYIS
CCEEEECCHHHHHHHHC
>Mature Secondary Structure 
SSLQENLLEKTGELQAILDGITEPLVLIDPGFRIRRVNRSTLEFSSQSSFLSIIGKKCF
CHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCEEEECCCHHHHCCCCHHHHHHHHHHHH
EVLYNRNDVCPYCPMKGMQSSEENFNRYFEYPRSDVNREIFHSVKGQKETLYLDFYPIEK
HHHHCCCCCCCCCCCCCCCCCHHHHHHHHCCCCHHCCHHHHHHHCCCCEEEEEEEEEECC
EGNIGSVLEKVSNITRIKEKEEENLRIRNLASLGIFISGVAHELNNPLTGMSLTLQSLLN
CCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
NLTSIDPDFFRKRLDMMKEDLTRAAMIVTDIISFAKPDRLVTTSADIYETIQKARENVIW
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHCCEEE
VYPVLSKNISWEILCEPRTTFQFNPVKLERLFINLFKNSLQAFDYGEGKIRVEVRKTRNM
EEEECCCCCCEEEEECCCCCEEECHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCE
VHIIVEDNAGGIPDNLIDKIFSPFFTKNKTGIGTGLGLSICHSIVREHKGELSVKSFEKK
EEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHH
TRFRVSLPFTQYQEYIS
CCEEEECCHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1333793 [H]