Click here to switch to the map view.

The map label for this gene is tetA

Identifier: 45657827

GI number: 45657827

Start: 2377490

End: 2378827

Strand: Direct

Name: tetA

Synonym: LIC11973

Alternate gene names: 45657827

Gene position: 2377490-2378827 (Clockwise)

Preceding gene: 45657826

Following gene: 45657833

Centisome position: 55.59

GC content: 35.8

Gene sequence:

>1338_bases
TTGAAAGACCATTGTCTTCAGGCCTTTCAACTTCGTATGAATAAAATTTCTTTCGTACTTTTTTTTACCGTATTCATAGA
CATGATGGGATTTTCTGTAATCTTTCCCATCTTTCCAGAAACTCTTAAGATATTTCTTTCTCAATCTGGTGATCCGGTTT
TAGATCAATTTGCTGACTGGACTCGAATTTTACTGGAAGCTTCTTCCGGAGATCGTTCTTTATTTGTAGCTCTTTTTGGT
GGAATCGTAGCAAGTCTCTATTCTATTTTACAATTTATATTTGCACCGATCTGGGGAAGGATCTCGGATCATGTAGGCCG
CAAACCGGTATTAGTTCTCACTAGCTTTGGAAGTTTTTTAGGTTATGTAATTTGGTTGTTTTCGGGAAGTTTTTCTTTCT
TCGTTTTATCCAGAGTGATCACCGGAACGATGGGAGGAAACATATCCGTAGCGTCTGCAGCGATGGCAGACATTACAAAC
GAAAAAGATCGGGCCAAAGGAATGGGAATGATAGGTGCCGGTGTGGGTTTAGGTTTTATCGCAGGCCCTCCAACGGGAGG
ATTGTTCGCCAAAATCAATTTAGACTTTTTGAAACTTGTGTTTCCAGATTTAACGTTTACAGTGTTTCCTGCATCCGCTC
TTGCCGCTACAATCATCGCGTTAATCAATCTGCTTATGATTCTTTTTTGGTTTCGGGAAACATTCGATCAAAAAGATTTG
TTAGAAAAGAAAAAAATTCATCCGATTTTAGGAGTTTTCACTTCTAAAAATAAAGAAGTCGTTTTATATTCTATTTTTTA
CTTCGTTTTCGTATTTGCGTTTTCTGGCTTCGAATTTTCAATCAATTTTTATCTCAGTCAATTTTTGAACTACAAACCTA
TTGAAATCGGTTTTACTTTCGTTTATATAGGAATGATCATCGTGCTGATTCAAGGAGGAGTTTTTAGAAGACTGTCCGGA
AAAGTTGACGAAACAAAATTAATTCGTATAGGAACCTTCTCTTTGTTAGTAGGTTTTTTTATTTTATACTTCGTTTCTAA
TTCTTATCAACTTTTTATTTCACTTACTTTTTTAGCTTCTGGAAGCGCCCTACTTCATCCTTCCTTATCTACGTTAGTCT
CTCTTGTATCTGGAAAAGAAGAACAAGGAACCAACCTCGGAATGTTTAGAAGTCTCGCTTCTTTAGGAAGAGGAATGGCC
CCTTTTGTATTTTGTCTGATTTACTTTAGTAAAGGTCCAGCAATTTCATTTTTAACTTCTGGACTTGTTAGTTTTTTATT
TTTGCTTTTTATATGGAAATTGAAACAACCAAAACTAGTAGAATCTAAAAACTACTGA

Upstream 100 bases:

>100_bases
CAAAGCGGCTGCAAAAAATACCTTAGATGAATTAAAACATCTCTTAAGTAAAAAATAATAACCCTACTTTTTCTGAAAAT
GTTAAGACAAGGTAAACGGC

Downstream 100 bases:

>100_bases
TCTTTATAAAATTGAGTACCATAAATTTTAACCGCAAAATCATGTCTCAGTTCAAAATATTTAGTATTTTATTATATAGC
CATGAATAAACAATAAAATA

Product: tetracycline resistance protein

Products: NA

Alternate protein names: TetA(B); Metal-tetracycline/H(+) antiporter [H]

Number of amino acids: Translated: 445; Mature: 445

Protein sequence:

>445_residues
MKDHCLQAFQLRMNKISFVLFFTVFIDMMGFSVIFPIFPETLKIFLSQSGDPVLDQFADWTRILLEASSGDRSLFVALFG
GIVASLYSILQFIFAPIWGRISDHVGRKPVLVLTSFGSFLGYVIWLFSGSFSFFVLSRVITGTMGGNISVASAAMADITN
EKDRAKGMGMIGAGVGLGFIAGPPTGGLFAKINLDFLKLVFPDLTFTVFPASALAATIIALINLLMILFWFRETFDQKDL
LEKKKIHPILGVFTSKNKEVVLYSIFYFVFVFAFSGFEFSINFYLSQFLNYKPIEIGFTFVYIGMIIVLIQGGVFRRLSG
KVDETKLIRIGTFSLLVGFFILYFVSNSYQLFISLTFLASGSALLHPSLSTLVSLVSGKEEQGTNLGMFRSLASLGRGMA
PFVFCLIYFSKGPAISFLTSGLVSFLFLLFIWKLKQPKLVESKNY

Sequences:

>Translated_445_residues
MKDHCLQAFQLRMNKISFVLFFTVFIDMMGFSVIFPIFPETLKIFLSQSGDPVLDQFADWTRILLEASSGDRSLFVALFG
GIVASLYSILQFIFAPIWGRISDHVGRKPVLVLTSFGSFLGYVIWLFSGSFSFFVLSRVITGTMGGNISVASAAMADITN
EKDRAKGMGMIGAGVGLGFIAGPPTGGLFAKINLDFLKLVFPDLTFTVFPASALAATIIALINLLMILFWFRETFDQKDL
LEKKKIHPILGVFTSKNKEVVLYSIFYFVFVFAFSGFEFSINFYLSQFLNYKPIEIGFTFVYIGMIIVLIQGGVFRRLSG
KVDETKLIRIGTFSLLVGFFILYFVSNSYQLFISLTFLASGSALLHPSLSTLVSLVSGKEEQGTNLGMFRSLASLGRGMA
PFVFCLIYFSKGPAISFLTSGLVSFLFLLFIWKLKQPKLVESKNY
>Mature_445_residues
MKDHCLQAFQLRMNKISFVLFFTVFIDMMGFSVIFPIFPETLKIFLSQSGDPVLDQFADWTRILLEASSGDRSLFVALFG
GIVASLYSILQFIFAPIWGRISDHVGRKPVLVLTSFGSFLGYVIWLFSGSFSFFVLSRVITGTMGGNISVASAAMADITN
EKDRAKGMGMIGAGVGLGFIAGPPTGGLFAKINLDFLKLVFPDLTFTVFPASALAATIIALINLLMILFWFRETFDQKDL
LEKKKIHPILGVFTSKNKEVVLYSIFYFVFVFAFSGFEFSINFYLSQFLNYKPIEIGFTFVYIGMIIVLIQGGVFRRLSG
KVDETKLIRIGTFSLLVGFFILYFVSNSYQLFISLTFLASGSALLHPSLSTLVSLVSGKEEQGTNLGMFRSLASLGRGMA
PFVFCLIYFSKGPAISFLTSGLVSFLFLLFIWKLKQPKLVESKNY

Specific function: Resistance to tetracycline by an active tetracycline efflux. This is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. This protein functions as a metal-tetracycline/H(+) antiporter [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Homo sapiens, GI225703104, Length=364, Percent_Identity=29.1208791208791, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI225703102, Length=364, Percent_Identity=29.1208791208791, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI39753965, Length=345, Percent_Identity=24.3478260869565, Blast_Score=80, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17551570, Length=432, Percent_Identity=29.1666666666667, Blast_Score=154, Evalue=7e-38,
Organism=Caenorhabditis elegans, GI71996331, Length=351, Percent_Identity=24.7863247863248, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17567337, Length=174, Percent_Identity=26.4367816091954, Blast_Score=65, Evalue=8e-11,
Organism=Drosophila melanogaster, GI17738085, Length=436, Percent_Identity=31.4220183486239, Blast_Score=183, Evalue=3e-46,
Organism=Drosophila melanogaster, GI221513297, Length=340, Percent_Identity=24.7058823529412, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21357569, Length=342, Percent_Identity=24.5614035087719, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24656463, Length=342, Percent_Identity=24.5614035087719, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24656468, Length=342, Percent_Identity=24.5614035087719, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI161080926, Length=342, Percent_Identity=24.5614035087719, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI161080924, Length=342, Percent_Identity=24.5614035087719, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829
- InterPro:   IPR001958 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 49519; Mature: 49519

Theoretical pI: Translated: 9.92; Mature: 9.92

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDHCLQAFQLRMNKISFVLFFTVFIDMMGFSVIFPIFPETLKIFLSQSGDPVLDQFADW
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
TRILLEASSGDRSLFVALFGGIVASLYSILQFIFAPIWGRISDHVGRKPVLVLTSFGSFL
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHH
GYVIWLFSGSFSFFVLSRVITGTMGGNISVASAAMADITNEKDRAKGMGMIGAGVGLGFI
HHHHHHHCCCHHHHHHHHHHHHCCCCCEEHHHHHHHHHCCCHHHHCCCCEEECCCCCCCC
AGPPTGGLFAKINLDFLKLVFPDLTFTVFPASALAATIIALINLLMILFWFRETFDQKDL
CCCCCCCEEEEECHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
LEKKKIHPILGVFTSKNKEVVLYSIFYFVFVFAFSGFEFSINFYLSQFLNYKPIEIGFTF
HHHHCCCHHHHHEECCCCCEEHHHHHHHHHHHHHCCCEEEHHHHHHHHCCCCCHHHHHHH
VYIGMIIVLIQGGVFRRLSGKVDETKLIRIGTFSLLVGFFILYFVSNSYQLFISLTFLAS
HHHHHHHHHHCCCHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHCCCEEEEEEEEEHHC
GSALLHPSLSTLVSLVSGKEEQGTNLGMFRSLASLGRGMAPFVFCLIYFSKGPAISFLTS
CCCEECCCHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHH
GLVSFLFLLFIWKLKQPKLVESKNY
HHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MKDHCLQAFQLRMNKISFVLFFTVFIDMMGFSVIFPIFPETLKIFLSQSGDPVLDQFADW
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
TRILLEASSGDRSLFVALFGGIVASLYSILQFIFAPIWGRISDHVGRKPVLVLTSFGSFL
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHH
GYVIWLFSGSFSFFVLSRVITGTMGGNISVASAAMADITNEKDRAKGMGMIGAGVGLGFI
HHHHHHHCCCHHHHHHHHHHHHCCCCCEEHHHHHHHHHCCCHHHHCCCCEEECCCCCCCC
AGPPTGGLFAKINLDFLKLVFPDLTFTVFPASALAATIIALINLLMILFWFRETFDQKDL
CCCCCCCEEEEECHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
LEKKKIHPILGVFTSKNKEVVLYSIFYFVFVFAFSGFEFSINFYLSQFLNYKPIEIGFTF
HHHHCCCHHHHHEECCCCCEEHHHHHHHHHHHHHCCCEEEHHHHHHHHCCCCCHHHHHHH
VYIGMIIVLIQGGVFRRLSGKVDETKLIRIGTFSLLVGFFILYFVSNSYQLFISLTFLAS
HHHHHHHHHHCCCHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHCCCEEEEEEEEEHHC
GSALLHPSLSTLVSLVSGKEEQGTNLGMFRSLASLGRGMAPFVFCLIYFSKGPAISFLTS
CCCEECCCHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHH
GLVSFLFLLFIWKLKQPKLVESKNY
HHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6319234; 6298728; 1848846; 2168416; 8995300 [H]