Click here to switch to the map view.

The map label for this gene is 45657733

Identifier: 45657733

GI number: 45657733

Start: 2265648

End: 2266178

Strand: Direct

Name: 45657733

Synonym: LIC11870

Alternate gene names: NA

Gene position: 2265648-2266178 (Clockwise)

Preceding gene: 45657723

Following gene: 45657735

Centisome position: 52.97

GC content: 34.65

Gene sequence:

>531_bases
TTGTGTGTAATGGAAGATTCAAATTCTACACAATGGGACGAACCTAGGAAAAATCTTTTTTCTATTCACAAACTGGATTA
TGCGAGAGGGAAAAGACCCGATGTAGATTGTATTCTTTGCGGAATTTGTAGAAAGGATCCGGAAGTTCCTAATCTTACCG
TTGCAGAAACTAATTTTACTATTGTTTCGGTAAATCTTTACCCTTATAATCCTGGACATCTAATCGTTTTTCCAAAACGC
CATATACTTTCCTACGAAGAATTAACCAAAGAAGAAGCAATGGAAATTCATGAAGGAACTGTAAAAGCAATTTCTATTTT
AAAAAAACTTTGGAACGTTCAGGGTTTCAACTTAGGTTATAATCTAGGTAAAAATTCGGGAGGTTCAATTCCTCATATTC
ACGAACACATCGTTCCTAGATTCCCAAACGAAGCCGGATTTTTAGACGTATTAGCAAATTCAAGAATTGTAATTTACGAA
CCTTATGAAATGCAAAAGGAATGGATTCGAATCTGGAAAGAATTTTCATAG

Upstream 100 bases:

>100_bases
CCTCAAATTTACTATAAAAACACATGAATAGATTTTAAAAATCTATTCATGTTTTACAAACGTACGCTAATTTTTTGACA
CAAAAGAAGATTCAAATAAT

Downstream 100 bases:

>100_bases
AAATTTTTTGAAAACGTTTCAATCATCAATAAGCTGAATTGTATCAAAAGAAATAAAAACGGAATCTGAATTGTTTTCTC
TTTATTCAAGAGCTATATAA

Product: hydrolase

Products: NA

Alternate protein names: ATP adenylyltransferase; Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase; AP,A phosphorylase [H]

Number of amino acids: Translated: 176; Mature: 176

Protein sequence:

>176_residues
MCVMEDSNSTQWDEPRKNLFSIHKLDYARGKRPDVDCILCGICRKDPEVPNLTVAETNFTIVSVNLYPYNPGHLIVFPKR
HILSYEELTKEEAMEIHEGTVKAISILKKLWNVQGFNLGYNLGKNSGGSIPHIHEHIVPRFPNEAGFLDVLANSRIVIYE
PYEMQKEWIRIWKEFS

Sequences:

>Translated_176_residues
MCVMEDSNSTQWDEPRKNLFSIHKLDYARGKRPDVDCILCGICRKDPEVPNLTVAETNFTIVSVNLYPYNPGHLIVFPKR
HILSYEELTKEEAMEIHEGTVKAISILKKLWNVQGFNLGYNLGKNSGGSIPHIHEHIVPRFPNEAGFLDVLANSRIVIYE
PYEMQKEWIRIWKEFS
>Mature_176_residues
MCVMEDSNSTQWDEPRKNLFSIHKLDYARGKRPDVDCILCGICRKDPEVPNLTVAETNFTIVSVNLYPYNPGHLIVFPKR
HILSYEELTKEEAMEIHEGTVKAISILKKLWNVQGFNLGYNLGKNSGGSIPHIHEHIVPRFPNEAGFLDVLANSRIVIYE
PYEMQKEWIRIWKEFS

Specific function: Catabolizes diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) into ADP and ATP. It does not catalyze the reverse phosphorolysis reaction. The optimum substrates are dinucleoside polyphosphates containing four or five phosphate residues [H]

COG id: COG0537

COG function: function code FGR; Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HIT domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011146
- InterPro:   IPR011151
- InterPro:   IPR001310 [H]

Pfam domain/function: PF01230 HIT [H]

EC number: =2.7.7.53 [H]

Molecular weight: Translated: 20373; Mature: 20373

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: PS51084 HIT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCVMEDSNSTQWDEPRKNLFSIHKLDYARGKRPDVDCILCGICRKDPEVPNLTVAETNFT
CEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHEEEEECCCCCCCCCCEEEEECCEE
IVSVNLYPYNPGHLIVFPKRHILSYEELTKEEAMEIHEGTVKAISILKKLWNVQGFNLGY
EEEEEEEEECCCEEEEECHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCC
NLGKNSGGSIPHIHEHIVPRFPNEAGFLDVLANSRIVIYEPYEMQKEWIRIWKEFS
CCCCCCCCCCCHHHHHHCCCCCCCCCEEEEECCCEEEEECCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MCVMEDSNSTQWDEPRKNLFSIHKLDYARGKRPDVDCILCGICRKDPEVPNLTVAETNFT
CEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHEEEEECCCCCCCCCCEEEEECCEE
IVSVNLYPYNPGHLIVFPKRHILSYEELTKEEAMEIHEGTVKAISILKKLWNVQGFNLGY
EEEEEEEEECCCEEEEECHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCC
NLGKNSGGSIPHIHEHIVPRFPNEAGFLDVLANSRIVIYEPYEMQKEWIRIWKEFS
CCCCCCCCCCCHHHHHHCCCCCCCCCEEEEECCCEEEEECCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12368430; 12218036 [H]