Click here to switch to the map view.

The map label for this gene is bioD

Identifier: 45657645

GI number: 45657645

Start: 2171259

End: 2171924

Strand: Reverse

Name: bioD

Synonym: LIC11779

Alternate gene names: 45657645

Gene position: 2171924-2171259 (Counterclockwise)

Preceding gene: 45657646

Following gene: 45657644

Centisome position: 50.78

GC content: 35.44

Gene sequence:

>666_bases
ATGGCAGTTTTTATAGGAGGTACTGGAACCGATGTAGGGAAAACTTTTTTTAGTTCTCTCATCTTAGGAAAATATGGAGA
GTCTTTAGGGCTTAAGTATTTTAAACCGGTTCAGACTGGAGATGATAGTGATCGTATCACTCTGATGCGTCTTACAGGAT
TACACGAAAGTTATGTTTTGAAAAATTACTATTCTTTGGCATTTGCAGGTTCCCCTCACTATTCTTCCGAACTGGAAGGA
ACGGAAATAGATACAGATGAACTCTCTAGACATCTTTATAGTATTCGTGATGAGAAAATCATTATAGAAGGAGCGGGTGG
CTTACTCGTACCATTGAATCGTAGAATGCTTACCTTAGAAGTAATTCGTCAAGCGGAGATACCTTTAATTTTAGTAGCAC
CTACTTCTTTGGGCGCGATCAATCAAACTCTTCTTTCAATTGAAGCAATTCAAAATAGAAATATCGATTTGAAAGGAATT
TATTTTTTAGGAATTCCAGATAAAACTACGGAAGATAATATCCGAACGATCACAGAATGGAGCGGTGTAATTTCCCTTGG
AAGTTTCTTTTTGAATTCTAATGAAAGGATTAGTTGTGAATGTTTTCAAGAGGAATGTATTCCAAAATTTGATCTAGACG
AATCTATAAAAAATATACTGGTATGA

Upstream 100 bases:

>100_bases
GGCCTCCCACTGTGAATGTTCCCAGGCTTAGAATCAGTATTCATTCCGATACGACTGAATCTATATTAGAAAAATTGATT
TCTATTTTACCGGAGTTCTA

Downstream 100 bases:

>100_bases
TCTGGTATCCTTTTACTCTACAATTTGAACCGGATTCTCCCTTAAAAATAGAAAGAGCCAAAGGCGAATTTTTATACGAT
GAATTAGGGAATTCTTATAT

Product: dethiobiotin synthetase

Products: NA

Alternate protein names: DTB synthetase; DTBS; Dethiobiotin synthase

Number of amino acids: Translated: 221; Mature: 220

Protein sequence:

>221_residues
MAVFIGGTGTDVGKTFFSSLILGKYGESLGLKYFKPVQTGDDSDRITLMRLTGLHESYVLKNYYSLAFAGSPHYSSELEG
TEIDTDELSRHLYSIRDEKIIIEGAGGLLVPLNRRMLTLEVIRQAEIPLILVAPTSLGAINQTLLSIEAIQNRNIDLKGI
YFLGIPDKTTEDNIRTITEWSGVISLGSFFLNSNERISCECFQEECIPKFDLDESIKNILV

Sequences:

>Translated_221_residues
MAVFIGGTGTDVGKTFFSSLILGKYGESLGLKYFKPVQTGDDSDRITLMRLTGLHESYVLKNYYSLAFAGSPHYSSELEG
TEIDTDELSRHLYSIRDEKIIIEGAGGLLVPLNRRMLTLEVIRQAEIPLILVAPTSLGAINQTLLSIEAIQNRNIDLKGI
YFLGIPDKTTEDNIRTITEWSGVISLGSFFLNSNERISCECFQEECIPKFDLDESIKNILV
>Mature_220_residues
AVFIGGTGTDVGKTFFSSLILGKYGESLGLKYFKPVQTGDDSDRITLMRLTGLHESYVLKNYYSLAFAGSPHYSSELEGT
EIDTDELSRHLYSIRDEKIIIEGAGGLLVPLNRRMLTLEVIRQAEIPLILVAPTSLGAINQTLLSIEAIQNRNIDLKGIY
FLGIPDKTTEDNIRTITEWSGVISLGSFFLNSNERISCECFQEECIPKFDLDESIKNILV

Specific function: Bioconversion of pimelate into dethiobiotin. [C]

COG id: COG0132

COG function: function code H; Dethiobiotin synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dethiobiotin synthetase family

Homologues:

Organism=Escherichia coli, GI1786995, Length=168, Percent_Identity=32.1428571428571, Blast_Score=85, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6324385, Length=200, Percent_Identity=30, Blast_Score=70, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): BIOD_LEPIC (Q72RG6)

Other databases:

- EMBL:   AE016823
- RefSeq:   YP_001731.1
- ProteinModelPortal:   Q72RG6
- SMR:   Q72RG6
- GeneID:   2771519
- GenomeReviews:   AE016823_GR
- KEGG:   lic:LIC11779
- HOGENOM:   HBG650065
- OMA:   WKPIQSG
- ProtClustDB:   CLSK574238
- BioCyc:   LINT267671:LIC_11779-MONOMER
- HAMAP:   MF_00336
- InterPro:   IPR004472
- PIRSF:   PIRSF006755
- TIGRFAMs:   TIGR00347

Pfam domain/function: NA

EC number: =6.3.3.3

Molecular weight: Translated: 24592; Mature: 24461

Theoretical pI: Translated: 4.55; Mature: 4.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVFIGGTGTDVGKTFFSSLILGKYGESLGLKYFKPVQTGDDSDRITLMRLTGLHESYVL
CEEEECCCCCHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCEEEEEECCCCHHHHH
KNYYSLAFAGSPHYSSELEGTEIDTDELSRHLYSIRDEKIIIEGAGGLLVPLNRRMLTLE
HHHEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCEEEECCCCEEEHH
VIRQAEIPLILVAPTSLGAINQTLLSIEAIQNRNIDLKGIYFLGIPDKTTEDNIRTITEW
HHHHCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCEEHHHH
SGVISLGSFFLNSNERISCECFQEECIPKFDLDESIKNILV
HHHHHHHHHHCCCCCEEEEEEHHHHCCCCCCHHHHHHHHCC
>Mature Secondary Structure 
AVFIGGTGTDVGKTFFSSLILGKYGESLGLKYFKPVQTGDDSDRITLMRLTGLHESYVL
EEEECCCCCHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCEEEEEECCCCHHHHH
KNYYSLAFAGSPHYSSELEGTEIDTDELSRHLYSIRDEKIIIEGAGGLLVPLNRRMLTLE
HHHEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCEEEECCCCEEEHH
VIRQAEIPLILVAPTSLGAINQTLLSIEAIQNRNIDLKGIYFLGIPDKTTEDNIRTITEW
HHHHCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCEEHHHH
SGVISLGSFFLNSNERISCECFQEECIPKFDLDESIKNILV
HHHHHHHHHHCCCCCEEEEEEHHHHCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA