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The map label for this gene is bioA

Identifier: 45657644

GI number: 45657644

Start: 2169961

End: 2171262

Strand: Reverse

Name: bioA

Synonym: LIC11778

Alternate gene names: 45657644

Gene position: 2171262-2169961 (Counterclockwise)

Preceding gene: 45657645

Following gene: 45657643

Centisome position: 50.76

GC content: 36.64

Gene sequence:

>1302_bases
ATGATCTGGTATCCTTTTACTCTACAATTTGAACCGGATTCTCCCTTAAAAATAGAAAGAGCCAAAGGCGAATTTTTATA
CGATGAATTAGGGAATTCTTATATAGATGGAATTTCTTCCTGGTGGGTAAGTATTCACGGACACAATCACCCTAAAATTG
TTCAAGCGGTTAAGAATCAGTTGGAAAAATTAGATCATGTTTTGCTTGCGGGTTTTACACACGATCCCGCTGAAAAACTT
GCTGCCGAACTTTTAAAAATTACAGATGGGCTGTTTCAAAAAGTTTTATATTCAGACAACGGTTCGACTGCTGTTGAAAT
TATGATTAAACTTGCTTATCAGTATTTTCAAAATATAGGAGAAGTCGATCGTAAAATATTCATAAAATGGAATTCTTCTT
ATCATGGAGATACGATCGGGACTATGAGCGTAGGCGGAAATTCTGTCTTCAATCGTGTTTTTCAGGGATTGATGTTCCCT
ACAAAGGAATTTCAAACTCCTAATTGTAACTTTTGTCCTATGGGTAAAAAACCGGAATCTTGCAAGGTAGAATGTATTGA
TCCGATAGAAGAATTTTTTCAAAAAAGTCCGAAAGCAGTTGCAGGAATTGTAATTGAACCTTTGATTTTAGGTTCTGGAG
GAATGATTTTTTATAAAGAAGAAGTCCTTCAAAGATTAGAAACCATCTCCAAAAAATACGGCAGTTTACTTTTGCTGGAC
GAGGTTTTTACTGGTTTTGGTAGAACCGGATCTGTTTTTGCTTATCAAAGAGCAAAGATACGACCCGATTTTATTGCGCT
GGCAAAAGGGCTGAGTGCTGGTGTCTCTGCGGTTGCCGTAACGTTGACAACGGATCGGATTCATTCAGCTTTTGTAACTG
CTGATCCAGAAAAAGGATTTTACCATGGACATACCATGACCGGAAATCCGATTGCTTGTTCTGCGGCGCTTGCCTCTTTA
AAAATTTTTTTTGAAGAGAATCGATTGGAACAAATTTTAAGGTTAGAATCTAAACTCAACGTAGGTTTAAAAAAGATCGC
GAAAGAATTTCCAAAAGCAGTAAAAAATTGTAGGGTTTTAGGGGCCGTAGGAGTTTTAGAATTGGAAGTAGGTAAAGCAA
GCGGTTATCATTATCCTGGAAATAAAATTCTCAAGAAGAAATTTCTAGAAAAAGGAGTTTTACTCCGTCCTTTGGGAAAC
GTAATTTATCTTACTCCTCCATACAATATAGAAAATTCTTCTTTGGAAAAAATCTTTTCCGCGATCCGAGAAACCCTCTC
TGAAATTTCTTTTGGGAATTAG

Upstream 100 bases:

>100_bases
GTTTCTTTTTGAATTCTAATGAAAGGATTAGTTGTGAATGTTTTCAAGAGGAATGTATTCCAAAATTTGATCTAGACGAA
TCTATAAAAAATATACTGGT

Downstream 100 bases:

>100_bases
ACTTTTCAAGAAAACTCATTTGCTTGAATCTGTCTGCAGAATGCTCAAGACATCCGAAAAAATATTCTCCGAAACCCCTA
GTATAATTACAAAAGAAGAA

Product: adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase [H]

Number of amino acids: Translated: 433; Mature: 433

Protein sequence:

>433_residues
MIWYPFTLQFEPDSPLKIERAKGEFLYDELGNSYIDGISSWWVSIHGHNHPKIVQAVKNQLEKLDHVLLAGFTHDPAEKL
AAELLKITDGLFQKVLYSDNGSTAVEIMIKLAYQYFQNIGEVDRKIFIKWNSSYHGDTIGTMSVGGNSVFNRVFQGLMFP
TKEFQTPNCNFCPMGKKPESCKVECIDPIEEFFQKSPKAVAGIVIEPLILGSGGMIFYKEEVLQRLETISKKYGSLLLLD
EVFTGFGRTGSVFAYQRAKIRPDFIALAKGLSAGVSAVAVTLTTDRIHSAFVTADPEKGFYHGHTMTGNPIACSAALASL
KIFFEENRLEQILRLESKLNVGLKKIAKEFPKAVKNCRVLGAVGVLELEVGKASGYHYPGNKILKKKFLEKGVLLRPLGN
VIYLTPPYNIENSSLEKIFSAIRETLSEISFGN

Sequences:

>Translated_433_residues
MIWYPFTLQFEPDSPLKIERAKGEFLYDELGNSYIDGISSWWVSIHGHNHPKIVQAVKNQLEKLDHVLLAGFTHDPAEKL
AAELLKITDGLFQKVLYSDNGSTAVEIMIKLAYQYFQNIGEVDRKIFIKWNSSYHGDTIGTMSVGGNSVFNRVFQGLMFP
TKEFQTPNCNFCPMGKKPESCKVECIDPIEEFFQKSPKAVAGIVIEPLILGSGGMIFYKEEVLQRLETISKKYGSLLLLD
EVFTGFGRTGSVFAYQRAKIRPDFIALAKGLSAGVSAVAVTLTTDRIHSAFVTADPEKGFYHGHTMTGNPIACSAALASL
KIFFEENRLEQILRLESKLNVGLKKIAKEFPKAVKNCRVLGAVGVLELEVGKASGYHYPGNKILKKKFLEKGVLLRPLGN
VIYLTPPYNIENSSLEKIFSAIRETLSEISFGN
>Mature_433_residues
MIWYPFTLQFEPDSPLKIERAKGEFLYDELGNSYIDGISSWWVSIHGHNHPKIVQAVKNQLEKLDHVLLAGFTHDPAEKL
AAELLKITDGLFQKVLYSDNGSTAVEIMIKLAYQYFQNIGEVDRKIFIKWNSSYHGDTIGTMSVGGNSVFNRVFQGLMFP
TKEFQTPNCNFCPMGKKPESCKVECIDPIEEFFQKSPKAVAGIVIEPLILGSGGMIFYKEEVLQRLETISKKYGSLLLLD
EVFTGFGRTGSVFAYQRAKIRPDFIALAKGLSAGVSAVAVTLTTDRIHSAFVTADPEKGFYHGHTMTGNPIACSAALASL
KIFFEENRLEQILRLESKLNVGLKKIAKEFPKAVKNCRVLGAVGVLELEVGKASGYHYPGNKILKKKFLEKGVLLRPLGN
VIYLTPPYNIENSSLEKIFSAIRETLSEISFGN

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=416, Percent_Identity=27.6442307692308, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI13994255, Length=389, Percent_Identity=26.4781491002571, Blast_Score=115, Evalue=9e-26,
Organism=Homo sapiens, GI37574042, Length=445, Percent_Identity=25.8426966292135, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI284507298, Length=228, Percent_Identity=28.9473684210526, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI226442705, Length=445, Percent_Identity=25.1685393258427, Blast_Score=83, Evalue=6e-16,
Organism=Homo sapiens, GI226442709, Length=403, Percent_Identity=25.0620347394541, Blast_Score=73, Evalue=6e-13,
Organism=Homo sapiens, GI188536080, Length=285, Percent_Identity=22.4561403508772, Blast_Score=69, Evalue=9e-12,
Organism=Homo sapiens, GI38679950, Length=285, Percent_Identity=22.4561403508772, Blast_Score=69, Evalue=9e-12,
Organism=Homo sapiens, GI38679946, Length=285, Percent_Identity=22.4561403508772, Blast_Score=69, Evalue=9e-12,
Organism=Escherichia coli, GI1786991, Length=434, Percent_Identity=35.7142857142857, Blast_Score=254, Evalue=1e-68,
Organism=Escherichia coli, GI145693181, Length=405, Percent_Identity=29.1358024691358, Blast_Score=172, Evalue=3e-44,
Organism=Escherichia coli, GI1789016, Length=423, Percent_Identity=30.4964539007092, Blast_Score=158, Evalue=6e-40,
Organism=Escherichia coli, GI1789759, Length=402, Percent_Identity=28.1094527363184, Blast_Score=139, Evalue=4e-34,
Organism=Escherichia coli, GI1788044, Length=425, Percent_Identity=25.4117647058824, Blast_Score=123, Evalue=3e-29,
Organism=Escherichia coli, GI1787560, Length=416, Percent_Identity=27.4038461538462, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1786349, Length=341, Percent_Identity=26.9794721407625, Blast_Score=109, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI25144271, Length=425, Percent_Identity=24.7058823529412, Blast_Score=121, Evalue=7e-28,
Organism=Caenorhabditis elegans, GI71992977, Length=449, Percent_Identity=26.7260579064588, Blast_Score=114, Evalue=8e-26,
Organism=Caenorhabditis elegans, GI25144274, Length=237, Percent_Identity=28.6919831223629, Blast_Score=96, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI32564660, Length=346, Percent_Identity=28.9017341040462, Blast_Score=93, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6324386, Length=460, Percent_Identity=30, Blast_Score=214, Evalue=2e-56,
Organism=Saccharomyces cerevisiae, GI6323470, Length=415, Percent_Identity=26.7469879518072, Blast_Score=139, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6324432, Length=423, Percent_Identity=26.241134751773, Blast_Score=120, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6321456, Length=378, Percent_Identity=23.2804232804233, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21357415, Length=415, Percent_Identity=25.5421686746988, Blast_Score=121, Evalue=9e-28,
Organism=Drosophila melanogaster, GI28574759, Length=446, Percent_Identity=27.3542600896861, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI161085790, Length=440, Percent_Identity=26.5909090909091, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI21356575, Length=453, Percent_Identity=25.8278145695364, Blast_Score=109, Evalue=4e-24,
Organism=Drosophila melanogaster, GI281366494, Length=394, Percent_Identity=25.8883248730964, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24667139, Length=394, Percent_Identity=25.8883248730964, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24667143, Length=394, Percent_Identity=25.8883248730964, Blast_Score=90, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.62 [H]

Molecular weight: Translated: 48236; Mature: 48236

Theoretical pI: Translated: 8.52; Mature: 8.52

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIWYPFTLQFEPDSPLKIERAKGEFLYDELGNSYIDGISSWWVSIHGHNHPKIVQAVKNQ
CEEEEEEEEECCCCCCEEECCCCCCHHHHHCCHHHCCHHEEEEEEECCCCHHHHHHHHHH
LEKLDHVLLAGFTHDPAEKLAAELLKITDGLFQKVLYSDNGSTAVEIMIKLAYQYFQNIG
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
EVDRKIFIKWNSSYHGDTIGTMSVGGNSVFNRVFQGLMFPTKEFQTPNCNFCPMGKKPES
HHCEEEEEEECCCCCCCCCEEEECCCHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCC
CKVECIDPIEEFFQKSPKAVAGIVIEPLILGSGGMIFYKEEVLQRLETISKKYGSLLLLD
CCEEECCHHHHHHHCCCHHHHHHHHHHEEECCCCEEEEHHHHHHHHHHHHHHHCCEEEEH
EVFTGFGRTGSVFAYQRAKIRPDFIALAKGLSAGVSAVAVTLTTDRIHSAFVTADPEKGF
HHHHCCCCCCCEEEEHHCCCCHHHHHHHHHHHCCCEEEEEEEEHHHHHHEEEECCCCCCC
YHGHTMTGNPIACSAALASLKIFFEENRLEQILRLESKLNVGLKKIAKEFPKAVKNCRVL
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEE
GAVGVLELEVGKASGYHYPGNKILKKKFLEKGVLLRPLGNVIYLTPPYNIENSSLEKIFS
ECCCEEEEEECCCCCCCCCCHHHHHHHHHHCCCEEEECCCEEEECCCCCCCCHHHHHHHH
AIRETLSEISFGN
HHHHHHHHCCCCC
>Mature Secondary Structure
MIWYPFTLQFEPDSPLKIERAKGEFLYDELGNSYIDGISSWWVSIHGHNHPKIVQAVKNQ
CEEEEEEEEECCCCCCEEECCCCCCHHHHHCCHHHCCHHEEEEEEECCCCHHHHHHHHHH
LEKLDHVLLAGFTHDPAEKLAAELLKITDGLFQKVLYSDNGSTAVEIMIKLAYQYFQNIG
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
EVDRKIFIKWNSSYHGDTIGTMSVGGNSVFNRVFQGLMFPTKEFQTPNCNFCPMGKKPES
HHCEEEEEEECCCCCCCCCEEEECCCHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCC
CKVECIDPIEEFFQKSPKAVAGIVIEPLILGSGGMIFYKEEVLQRLETISKKYGSLLLLD
CCEEECCHHHHHHHCCCHHHHHHHHHHEEECCCCEEEEHHHHHHHHHHHHHHHCCEEEEH
EVFTGFGRTGSVFAYQRAKIRPDFIALAKGLSAGVSAVAVTLTTDRIHSAFVTADPEKGF
HHHHCCCCCCCEEEEHHCCCCHHHHHHHHHHHCCCEEEEEEEEHHHHHHEEEECCCCCCC
YHGHTMTGNPIACSAALASLKIFFEENRLEQILRLESKLNVGLKKIAKEFPKAVKNCRVL
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEE
GAVGVLELEVGKASGYHYPGNKILKKKFLEKGVLLRPLGNVIYLTPPYNIENSSLEKIFS
ECCCEEEEEECCCCCCCCCCHHHHHHHHHHCCCEEEECCCEEEECCCCCCCCHHHHHHHH
AIRETLSEISFGN
HHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2110099 [H]