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The map label for this gene is trpF

Identifier: 45657639

GI number: 45657639

Start: 2163491

End: 2164147

Strand: Direct

Name: trpF

Synonym: LIC11773

Alternate gene names: 45657639

Gene position: 2163491-2164147 (Clockwise)

Preceding gene: 45657635

Following gene: 45657640

Centisome position: 50.58

GC content: 35.16

Gene sequence:

>657_bases
TTGGAAGATTGGATCATGATAACGAATTCTTTGCAAAAAACAAAGGTCAAGATCTGTGGAATTAAAGACCTAGAAATTGC
AAAAATTTGCAAAGAAGAAGGAGCCGATTACATCGGATTCAATTTCGTATCGAGTAGTCCTAGAAAGATCGAACTTTCAA
ACGCTCAAAAAATCGTGGAATATTATAAATCGGAAAAAAATTCTCCCGAAATTGTACTTTTGTTTTATCAAAATTCATTC
GAAGAAATTGAGTCCATTACATCGGTATTAGATCACGATTTAGTTCAATGGGTTTGGGACGACCCCTTAATCAATCGGAA
AAAACTTTTATACAAACGACAAATTTGTTCTTATAGAGTCCAAACTCAGATTCATGATCAGGATTTAAAAGACATTGAAG
CGGAGTTTTTAATCTTAGATAGTTATTCTAAAGGTGTGGGGGGCGGAACTGGCGAAACATTCAATTGGGAATTGATTTCC
AAAGTTAAAAGAAAGTTTCTTTTAGCTGGAGGTTTAGATCCGTCTAACGTAGTCAATGCGATTGAAATCGTAAAACCGTT
CGGAGTAGACGTTGCCAGTGGAGTAGAATCTTCTCCAGGAATCAAAGATCCACAAAAAGTAATTCAATTTATCAGGAACG
TAAAATCTACATCATGA

Upstream 100 bases:

>100_bases
ATAAAGAGGAGCCAATCAATCGTATTTCATAAAACTTATAGATAAAGTTTATGAATCCACCTGCATTCCCGTTTAAAGTA
CGTGATCTAAAGAAACCCCT

Downstream 100 bases:

>100_bases
ATTTGGAAAGTACAGCAACTTCGGCAGAATATTGGAGCGATTTAGCGGATGCTCTCAATACACCTATGATGAAACAATTC
CTGGCGATCAAAAAGGATTT

Product: N-(5'-phosphoribosyl)anthranilate isomerase

Products: NA

Alternate protein names: PRAI [H]

Number of amino acids: Translated: 218; Mature: 218

Protein sequence:

>218_residues
MEDWIMITNSLQKTKVKICGIKDLEIAKICKEEGADYIGFNFVSSSPRKIELSNAQKIVEYYKSEKNSPEIVLLFYQNSF
EEIESITSVLDHDLVQWVWDDPLINRKKLLYKRQICSYRVQTQIHDQDLKDIEAEFLILDSYSKGVGGGTGETFNWELIS
KVKRKFLLAGGLDPSNVVNAIEIVKPFGVDVASGVESSPGIKDPQKVIQFIRNVKSTS

Sequences:

>Translated_218_residues
MEDWIMITNSLQKTKVKICGIKDLEIAKICKEEGADYIGFNFVSSSPRKIELSNAQKIVEYYKSEKNSPEIVLLFYQNSF
EEIESITSVLDHDLVQWVWDDPLINRKKLLYKRQICSYRVQTQIHDQDLKDIEAEFLILDSYSKGVGGGTGETFNWELIS
KVKRKFLLAGGLDPSNVVNAIEIVKPFGVDVASGVESSPGIKDPQKVIQFIRNVKSTS
>Mature_218_residues
MEDWIMITNSLQKTKVKICGIKDLEIAKICKEEGADYIGFNFVSSSPRKIELSNAQKIVEYYKSEKNSPEIVLLFYQNSF
EEIESITSVLDHDLVQWVWDDPLINRKKLLYKRQICSYRVQTQIHDQDLKDIEAEFLILDSYSKGVGGGTGETFNWELIS
KVKRKFLLAGGLDPSNVVNAIEIVKPFGVDVASGVESSPGIKDPQKVIQFIRNVKSTS

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0135

COG function: function code E; Phosphoribosylanthranilate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpF family [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6320210, Length=226, Percent_Identity=30.9734513274336, Blast_Score=79, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR001240
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00697 PRAI [H]

EC number: =5.3.1.24 [H]

Molecular weight: Translated: 24741; Mature: 24741

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEDWIMITNSLQKTKVKICGIKDLEIAKICKEEGADYIGFNFVSSSPRKIELSNAQKIVE
CCCEEEEECCCCHHEEEECCCCCHHHHHHHHHCCCCEEEEEEECCCCCEEEHHHHHHHHH
YYKSEKNSPEIVLLFYQNSFEEIESITSVLDHDLVQWVWDDPLINRKKLLYKRQICSYRV
HHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
QTQIHDQDLKDIEAEFLILDSYSKGVGGGTGETFNWELISKVKRKFLLAGGLDPSNVVNA
HHHHCCCHHHHCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHH
IEIVKPFGVDVASGVESSPGIKDPQKVIQFIRNVKSTS
HHHHHHCCCHHHCCCCCCCCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MEDWIMITNSLQKTKVKICGIKDLEIAKICKEEGADYIGFNFVSSSPRKIELSNAQKIVE
CCCEEEEECCCCHHEEEECCCCCHHHHHHHHHCCCCEEEEEEECCCCCEEEHHHHHHHHH
YYKSEKNSPEIVLLFYQNSFEEIESITSVLDHDLVQWVWDDPLINRKKLLYKRQICSYRV
HHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
QTQIHDQDLKDIEAEFLILDSYSKGVGGGTGETFNWELISKVKRKFLLAGGLDPSNVVNA
HHHHCCCHHHHCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHH
IEIVKPFGVDVASGVESSPGIKDPQKVIQFIRNVKSTS
HHHHHHCCCHHHCCCCCCCCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA