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The map label for this gene is fbp

Identifier: 45657573

GI number: 45657573

Start: 2072824

End: 2073948

Strand: Direct

Name: fbp

Synonym: LIC11707

Alternate gene names: 45657573

Gene position: 2072824-2073948 (Clockwise)

Preceding gene: 45657571

Following gene: 304570492

Centisome position: 48.46

GC content: 38.58

Gene sequence:

>1125_bases
TTGAGTTTTCATTTTCAGACTTTTTATGGGATCTTTTCGCTTGAATTCACAGACCCACAAAAAAACTCTGTTGGAATCAT
TTTCTTAGAGGAATCTATGTCTGTTCATCCTACACAAACATTGAGTCTTTCCCAGTATTTAATCGAGGAACAGCTCAAAT
TACCCCAGGCTACTGGAGATTTTACCGCCTTGATGAGCCATTTGGTTTATGCAGCTAAAATTGTTTCCAGAGAGGTTCGA
AAAGCGGGACTTTTAGAAAATATTTTAGGTGCGACGGAAACTGTCAATGTTCAAGGGGAAACCCAAATGAAATTGGACGA
ATACGCAGATAAGGTTTTTAATCATACACTGACTCGTTCGGGTCATCTTTGTATTTTAGGAAGTGAAGAACACGAAGAAA
CCGTTCCCGTTCCAAACGGGTATAAAATCGGTAAGTATACAATCGCAATTGATCCGTTAGACGGTTCTTCTAATATAGAT
GCCAATGTTTCTATTGGGACTATTTTTTCCGTTCATTTGAGAAAAAGTCCTGCTGGAACTCCAGGAACGTTAAGCGATCT
TTTACAACAAGGTTCTGGACAAAGGGCTGCAGGTTATGTTTTATATGGGTCTTCTACAATGCTTATTCTTTGTACCGGCA
AAGGAGTTTCTGGTTTTACGTTAGATCCTTCTTGCGGTGAATTTATACTCTCGCATCCGGATATGCAGATTCCGGAAACG
GGTGGAATTTATTCTATCAACGAAGGAAATTATAACTATTGGTCCGACGAAGTAAAAAATTATATTCGTGACATCAAATC
GATTGAAGGAGGTAGAAAACCTCAATCGGGTAGATACATTGGTTCCTTAGTTGCGGATTTTCATAGAAATCTTCTAAAAG
GAGGAATCTTTCTCTATCCAAACGATACTAAGTCCACGAAATATCCGAACGGTAAATTAAGACTTCTTTATGAAGCGGCT
CCTATGGCTTTTATTGCGGAACAAGCGGGTGGTATGGCTGTGACTGTTTATGGAGAAAGAATTCTGGATCTTACTCCTAA
AGAGCTTCATGAACGTACGACTTTAGTTGTGGGAAGTAAAAAGGAAGTGGAACATTTTTTAAAGTTTGCTCCTAAAAAAT
CTTAA

Upstream 100 bases:

>100_bases
CTTGTGTGTGATCGGTTTGATTGAGGATTCCATCGGAAACTAACTCCTTTCTTCCTTACAAATATCGGATAAGAACCTTC
TAAAAAATCGTAAGATTCTT

Downstream 100 bases:

>100_bases
TCCGAAATAAAAAACATTTTCTATACGTTATATGAAATTGTTCGGGAATATTTTTTGCGAGATTCTATTATTTGTAAATT
ATATTCTGAGGATTCTCTAT

Product: fructose-1,6-bisphosphatase

Products: NA

Alternate protein names: FBPase class 1; D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 [H]

Number of amino acids: Translated: 374; Mature: 373

Protein sequence:

>374_residues
MSFHFQTFYGIFSLEFTDPQKNSVGIIFLEESMSVHPTQTLSLSQYLIEEQLKLPQATGDFTALMSHLVYAAKIVSREVR
KAGLLENILGATETVNVQGETQMKLDEYADKVFNHTLTRSGHLCILGSEEHEETVPVPNGYKIGKYTIAIDPLDGSSNID
ANVSIGTIFSVHLRKSPAGTPGTLSDLLQQGSGQRAAGYVLYGSSTMLILCTGKGVSGFTLDPSCGEFILSHPDMQIPET
GGIYSINEGNYNYWSDEVKNYIRDIKSIEGGRKPQSGRYIGSLVADFHRNLLKGGIFLYPNDTKSTKYPNGKLRLLYEAA
PMAFIAEQAGGMAVTVYGERILDLTPKELHERTTLVVGSKKEVEHFLKFAPKKS

Sequences:

>Translated_374_residues
MSFHFQTFYGIFSLEFTDPQKNSVGIIFLEESMSVHPTQTLSLSQYLIEEQLKLPQATGDFTALMSHLVYAAKIVSREVR
KAGLLENILGATETVNVQGETQMKLDEYADKVFNHTLTRSGHLCILGSEEHEETVPVPNGYKIGKYTIAIDPLDGSSNID
ANVSIGTIFSVHLRKSPAGTPGTLSDLLQQGSGQRAAGYVLYGSSTMLILCTGKGVSGFTLDPSCGEFILSHPDMQIPET
GGIYSINEGNYNYWSDEVKNYIRDIKSIEGGRKPQSGRYIGSLVADFHRNLLKGGIFLYPNDTKSTKYPNGKLRLLYEAA
PMAFIAEQAGGMAVTVYGERILDLTPKELHERTTLVVGSKKEVEHFLKFAPKKS
>Mature_373_residues
SFHFQTFYGIFSLEFTDPQKNSVGIIFLEESMSVHPTQTLSLSQYLIEEQLKLPQATGDFTALMSHLVYAAKIVSREVRK
AGLLENILGATETVNVQGETQMKLDEYADKVFNHTLTRSGHLCILGSEEHEETVPVPNGYKIGKYTIAIDPLDGSSNIDA
NVSIGTIFSVHLRKSPAGTPGTLSDLLQQGSGQRAAGYVLYGSSTMLILCTGKGVSGFTLDPSCGEFILSHPDMQIPETG
GIYSINEGNYNYWSDEVKNYIRDIKSIEGGRKPQSGRYIGSLVADFHRNLLKGGIFLYPNDTKSTKYPNGKLRLLYEAAP
MAFIAEQAGGMAVTVYGERILDLTPKELHERTTLVVGSKKEVEHFLKFAPKKS

Specific function: INVOLVED IN SEVERAL METABOLIC PATHWAYS. IN E.COLI AND YEAST IT IS NECESSARY FOR GROWTH ON SUBSTANCES SUCH AS GLYCEROL, SUCCINATE AND ACETATE. [C]

COG id: COG0158

COG function: function code G; Fructose-1,6-bisphosphatase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FBPase class 1 family [H]

Homologues:

Organism=Homo sapiens, GI22907028, Length=335, Percent_Identity=43.2835820895522, Blast_Score=251, Evalue=9e-67,
Organism=Homo sapiens, GI189083692, Length=337, Percent_Identity=44.5103857566766, Blast_Score=246, Evalue=4e-65,
Organism=Homo sapiens, GI16579888, Length=337, Percent_Identity=44.5103857566766, Blast_Score=246, Evalue=4e-65,
Organism=Escherichia coli, GI1790679, Length=334, Percent_Identity=50.5988023952096, Blast_Score=312, Evalue=2e-86,
Organism=Caenorhabditis elegans, GI17508131, Length=337, Percent_Identity=48.6646884272997, Blast_Score=308, Evalue=3e-84,
Organism=Saccharomyces cerevisiae, GI6323409, Length=332, Percent_Identity=47.289156626506, Blast_Score=303, Evalue=3e-83,
Organism=Drosophila melanogaster, GI45550998, Length=333, Percent_Identity=47.4474474474475, Blast_Score=273, Evalue=2e-73,
Organism=Drosophila melanogaster, GI19921562, Length=333, Percent_Identity=47.4474474474475, Blast_Score=272, Evalue=2e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000146
- InterPro:   IPR020548 [H]

Pfam domain/function: PF00316 FBPase [H]

EC number: =3.1.3.11 [H]

Molecular weight: Translated: 41163; Mature: 41032

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS00124 FBPASE ; PS00430 TONB_DEPENDENT_REC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFHFQTFYGIFSLEFTDPQKNSVGIIFLEESMSVHPTQTLSLSQYLIEEQLKLPQATGD
CCEEEEEEEEEEEEEECCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCH
FTALMSHLVYAAKIVSREVRKAGLLENILGATETVNVQGETQMKLDEYADKVFNHTLTRS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHCCC
GHLCILGSEEHEETVPVPNGYKIGKYTIAIDPLDGSSNIDANVSIGTIFSVHLRKSPAGT
CCEEEECCCCCCCCCCCCCCEEEEEEEEEEECCCCCCCCCCEEEEEEEEEEEEECCCCCC
PGTLSDLLQQGSGQRAAGYVLYGSSTMLILCTGKGVSGFTLDPSCGEFILSHPDMQIPET
CHHHHHHHHCCCCCCEEEEEEECCCEEEEEEECCCCCCEEECCCCCHHEECCCCCCCCCC
GGIYSINEGNYNYWSDEVKNYIRDIKSIEGGRKPQSGRYIGSLVADFHRNLLKGGIFLYP
CCEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCEEEEE
NDTKSTKYPNGKLRLLYEAAPMAFIAEQAGGMAVTVYGERILDLTPKELHERTTLVVGSK
CCCCCCCCCCCCEEEEEECCCHHHHHHCCCCEEEEEECCEEECCCHHHHHCCEEEEECCH
KEVEHFLKFAPKKS
HHHHHHHHHCCCCC
>Mature Secondary Structure 
SFHFQTFYGIFSLEFTDPQKNSVGIIFLEESMSVHPTQTLSLSQYLIEEQLKLPQATGD
CEEEEEEEEEEEEEECCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCH
FTALMSHLVYAAKIVSREVRKAGLLENILGATETVNVQGETQMKLDEYADKVFNHTLTRS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHCCC
GHLCILGSEEHEETVPVPNGYKIGKYTIAIDPLDGSSNIDANVSIGTIFSVHLRKSPAGT
CCEEEECCCCCCCCCCCCCCEEEEEEEEEEECCCCCCCCCCEEEEEEEEEEEEECCCCCC
PGTLSDLLQQGSGQRAAGYVLYGSSTMLILCTGKGVSGFTLDPSCGEFILSHPDMQIPET
CHHHHHHHHCCCCCCEEEEEEECCCEEEEEEECCCCCCEEECCCCCHHEECCCCCCCCCC
GGIYSINEGNYNYWSDEVKNYIRDIKSIEGGRKPQSGRYIGSLVADFHRNLLKGGIFLYP
CCEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCEEEEE
NDTKSTKYPNGKLRLLYEAAPMAFIAEQAGGMAVTVYGERILDLTPKELHERTTLVVGSK
CCCCCCCCCCCCEEEEEECCCHHHHHHCCCCEEEEEECCEEECCCHHHHHCCEEEEECCH
KEVEHFLKFAPKKS
HHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA