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The map label for this gene is lytB

Identifier: 45657402

GI number: 45657402

Start: 1891457

End: 1892449

Strand: Reverse

Name: lytB

Synonym: LIC11529

Alternate gene names: 45657402

Gene position: 1892449-1891457 (Counterclockwise)

Preceding gene: 45657403

Following gene: 45657401

Centisome position: 44.25

GC content: 38.37

Gene sequence:

>993_bases
TTGATTCTTTACCCAAAGCAAAGAATTAGAATGGTATCGAAAATGGAGCCCAAAATGTTAGAAAAGATCTATTTAGCCAA
CCCAAGAGGGTTTTGCGCTGGCGTAAAATACGCAATTTCTTACGTAGAACAGGTACAGGCAAATTCCGAAGAACAAATTT
ATGTCCGTAAAGAGATAGTACACAATCGTCGCGTTGTGGAAGACATGAAAAAAAATGGAATCCGTTTTATCAACGATCTG
GACGAGGCGCCCAACGGGGCCACGGTCATTTTTTCAGCACACGGAGTTTCACCTTCTGTTGTGGAAGCGGCTAAACAGAG
GGGTATGAAAATTGGAGACGCAACCTGCCCTCTCGTAACGAGAGTTCATCGTAAAGCGAGAAAAATTAAAGATACACATC
AAATCATCTATATAGGGCACGAAGGACACGACGAAGCGATTGGTACTATGGGAGAAGCGGAAATGTTTCTTGTAGAATCT
CTGGAGGACATAATTTCGCTTAAAGATAAAATTGATCCAAATAAACCACTTACATATTTAATGCAAACCACACTTTCAGT
AGCAGATACTAAAAATATAATAGATCAAATATCAAAAACGTTTCCGTTCGTAGAACACCCCTCTAAGGACGATATTTGTT
ACGCTACAACGGAAAGACAAGAAGCGGTTTCTTTGATGATGGATAAAATCGATGCTATGCTTGTAATTGGAGCTGACAAC
AGCTCTAATTCATTGCGACTTTTACAACTTGCGCAAAAATCTAAGCCTCATTCATTTAAAGTTTCTACAGCGGATGATCT
TTCCAAAGAATACATTCAAAATAACGAAATTAAAATCCTAGGTTTGACCGCAGGTGCGTCAACTCCTCAGGTTCTCGTTG
ACGAAATTATTTCTAAGTTAAAGATATTTTATCCAAATGCTAATGTTGAATTATTTCCGGGTTCTAGAGATGATTCTATG
AATTTTAAACTTCCCGGAGTTTTACTCAGTTAA

Upstream 100 bases:

>100_bases
AAAAAACTCTAATTCACCAAAAAAACCGGGGAAAATTCTAAAACAAAAATGAAATATCAAAATTTTAAGAAAAGAAAAGC
CTAGGAAAACAAATAATTTT

Downstream 100 bases:

>100_bases
AAAAGTTTATTTGTATGAACTCCCACATTTTACTTTTTCCGGAAAAATAAACCTATAAAAATAACGTGAGTTCGATTTAA
AAAAAAATTTTCTAAAAGTA

Product: penicillin tolerance protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 330; Mature: 330

Protein sequence:

>330_residues
MILYPKQRIRMVSKMEPKMLEKIYLANPRGFCAGVKYAISYVEQVQANSEEQIYVRKEIVHNRRVVEDMKKNGIRFINDL
DEAPNGATVIFSAHGVSPSVVEAAKQRGMKIGDATCPLVTRVHRKARKIKDTHQIIYIGHEGHDEAIGTMGEAEMFLVES
LEDIISLKDKIDPNKPLTYLMQTTLSVADTKNIIDQISKTFPFVEHPSKDDICYATTERQEAVSLMMDKIDAMLVIGADN
SSNSLRLLQLAQKSKPHSFKVSTADDLSKEYIQNNEIKILGLTAGASTPQVLVDEIISKLKIFYPNANVELFPGSRDDSM
NFKLPGVLLS

Sequences:

>Translated_330_residues
MILYPKQRIRMVSKMEPKMLEKIYLANPRGFCAGVKYAISYVEQVQANSEEQIYVRKEIVHNRRVVEDMKKNGIRFINDL
DEAPNGATVIFSAHGVSPSVVEAAKQRGMKIGDATCPLVTRVHRKARKIKDTHQIIYIGHEGHDEAIGTMGEAEMFLVES
LEDIISLKDKIDPNKPLTYLMQTTLSVADTKNIIDQISKTFPFVEHPSKDDICYATTERQEAVSLMMDKIDAMLVIGADN
SSNSLRLLQLAQKSKPHSFKVSTADDLSKEYIQNNEIKILGLTAGASTPQVLVDEIISKLKIFYPNANVELFPGSRDDSM
NFKLPGVLLS
>Mature_330_residues
MILYPKQRIRMVSKMEPKMLEKIYLANPRGFCAGVKYAISYVEQVQANSEEQIYVRKEIVHNRRVVEDMKKNGIRFINDL
DEAPNGATVIFSAHGVSPSVVEAAKQRGMKIGDATCPLVTRVHRKARKIKDTHQIIYIGHEGHDEAIGTMGEAEMFLVES
LEDIISLKDKIDPNKPLTYLMQTTLSVADTKNIIDQISKTFPFVEHPSKDDICYATTERQEAVSLMMDKIDAMLVIGADN
SSNSLRLLQLAQKSKPHSFKVSTADDLSKEYIQNNEIKILGLTAGASTPQVLVDEIISKLKIFYPNANVELFPGSRDDSM
NFKLPGVLLS

Specific function: Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) [H]

COG id: COG0761

COG function: function code IM; Penicillin tolerance protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ispH family [H]

Homologues:

Organism=Escherichia coli, GI1786212, Length=310, Percent_Identity=45.4838709677419, Blast_Score=265, Evalue=2e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003451 [H]

Pfam domain/function: PF02401 LYTB [H]

EC number: =1.17.1.2 [H]

Molecular weight: Translated: 36971; Mature: 36971

Theoretical pI: Translated: 7.25; Mature: 7.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILYPKQRIRMVSKMEPKMLEKIYLANPRGFCAGVKYAISYVEQVQANSEEQIYVRKEIV
CCCCCHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCEEHHHHHH
HNRRVVEDMKKNGIRFINDLDEAPNGATVIFSAHGVSPSVVEAAKQRGMKIGDATCPLVT
HHHHHHHHHHHCCCEEHHHHHCCCCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCCHHHH
RVHRKARKIKDTHQIIYIGHEGHDEAIGTMGEAEMFLVESLEDIISLKDKIDPNKPLTYL
HHHHHHHHCCCCCEEEEEECCCCCHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHH
MQTTLSVADTKNIIDQISKTFPFVEHPSKDDICYATTERQEAVSLMMDKIDAMLVIGADN
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCHHHHHHHHHHCCCEEEEEECCC
SSNSLRLLQLAQKSKPHSFKVSTADDLSKEYIQNNEIKILGLTAGASTPQVLVDEIISKL
CCCCHHHHHHHHHCCCCEEEECCHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHH
KIFYPNANVELFPGSRDDSMNFKLPGVLLS
EEEECCCCEEEECCCCCCCCCEECCCEECC
>Mature Secondary Structure
MILYPKQRIRMVSKMEPKMLEKIYLANPRGFCAGVKYAISYVEQVQANSEEQIYVRKEIV
CCCCCHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCEEHHHHHH
HNRRVVEDMKKNGIRFINDLDEAPNGATVIFSAHGVSPSVVEAAKQRGMKIGDATCPLVT
HHHHHHHHHHHCCCEEHHHHHCCCCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCCHHHH
RVHRKARKIKDTHQIIYIGHEGHDEAIGTMGEAEMFLVESLEDIISLKDKIDPNKPLTYL
HHHHHHHHCCCCCEEEEEECCCCCHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHH
MQTTLSVADTKNIIDQISKTFPFVEHPSKDDICYATTERQEAVSLMMDKIDAMLVIGADN
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCHHHHHHHHHHCCCEEEEEECCC
SSNSLRLLQLAQKSKPHSFKVSTADDLSKEYIQNNEIKILGLTAGASTPQVLVDEIISKL
CCCCHHHHHHHHHCCCCEEEECCHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHH
KIFYPNANVELFPGSRDDSMNFKLPGVLLS
EEEECCCCEEEECCCCCCCCCEECCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA