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The map label for this gene is lpd [H]

Identifier: 45657043

GI number: 45657043

Start: 1429100

End: 1430572

Strand: Reverse

Name: lpd [H]

Synonym: LIC11159

Alternate gene names: 45657043

Gene position: 1430572-1429100 (Counterclockwise)

Preceding gene: 45657048

Following gene: 45657041

Centisome position: 33.45

GC content: 41.28

Gene sequence:

>1473_bases
TTGCGTAAGTTCGATAAAACCCTATTTCATGAGTTCCGGAGAATTTATAAATTTATGCCAGAATCTTACGATCTCACTGT
TATTGGTGCGGGACCAGGCGGTTATGTAGCCGCAATTCGAGCCGCTCAATTGGGAATGAATGTTTGTATAATCGAAAAAG
ACAAACCAGGTGGAATTTGTTTGAACTGGGGTTGTATTCCTACCAAAGCTCTTTTAGAATCGGCCCACCTTTTAGAAAAA
CTTCATTCCGCCAAAGAATATGGAATTAATCTTTCGGATCCAAAGCCTGATTTCGCAGCGATTATACGACGTTCTAGAAA
CGTAGCAGAAGGTATGGCTTCCGGTGTGGAATTTCTTTTAAACAAAAATAAAATCACCCGCAAAAAAGGAACTGCAGTAT
TCAAAGATCCGAATACGATTTGGCTTCCAGATTCTTCCAAAGAAGAAATTACATCTAAATATTTTATTCTCGCAACTGGA
GCGAGGGCAAGAGAACTTCCTGATTTACCCTTTGACAGCCACACGGTTCTTTCCTCAAAAACTGCTATGATTCAGGACAA
AATTCCAGAATCTCTTTTGATCGTTGGGGCGGGTGCCATCGGAGTAGAGTTCGCTGACTTTTATTCTACGATGGGTACCA
AAGTAACGTTAGTCGAAATGATGGATCAAATTCTTCCTGTTGAAGATAAGGAAATTTCAACGTTCCTTGAAAAGTCCTTT
GTCAAAAGAGGAATTAGAGTTCTTACCGGAGTTGGAGTTTCCGATCCCAAAATTGTAAACGGCAAAGTAAAAGTTCTTCT
CAAAGGTAAAAATCTTCCCGAAGCAGTAGAATCTTTCGAAGCAGAAAAGATTTTGGTTTCCATTGGCCTTGTTCCTAACA
CGGATTCCATGCACTTGGAGGAAATAGGAATTTTTCTTCAAAAAGGTTTTGTAAAAACGGACACTAAATATAAAACTAGC
GTTCCTCATATCTACGCAATTGGAGATTGTAACGGCGCTCCTCTTCTTGCACACGTTGCTTCTATGGAAGGAATAAAAGC
CGTGGAGGCAATTTCAATCCACGCGGGAAACCCACATCATCTCAGTTATATTCCGATTGACTACAACGCAATTCCTGGTT
GTACATATTGTCATCCGGAAGTCGCCTCCATAGGATTTACCGAAAAAAAAGCAACTGACATGGGTTATACGATCAGCGTG
GGTAAATTTCCATTTGTTGCCAGCGGGAGAGCCAAAGCCATGGGAGATACCGGAGGTTTTACAAAAGTAATCGTAGATAA
AACTTCGGGTGAAATTTTAGGAGCCCATCTCATTGGACCTGGTGTTACGGAACTTTTACCAGCGGTCTCTCTGGGAATCA
CTCAAGAACTGACTGCAAAAGAAATTGCATCTACGATCTTTGCTCACCCAACACTTTCAGAAACCGTAATGGAGTCTTTT
GGGGCAGCGCTTGGTGAAGCGATCAATCTTTAA

Upstream 100 bases:

>100_bases
TCATTTGGTATCAATATACTTTTCCAAACCAAATTTTATAGATCGATTCCGAAAATGTGGAATCTTCTATCATTGTTAAA
AAGTTATTCTTAAAAAATTC

Downstream 100 bases:

>100_bases
GTTTCTGAAACCAGATTTCCGGTAAGTAATATATCGGTTTTGTTAACCAGAAATTCAGGTGGGAGTTTAGAACTGAGAGA
AAGTAAAGATGGATCTATAT

Product: dihydrolipoamide dehydrogenase

Products: NA

Alternate protein names: Dihydrolipoamide dehydrogenase; E3 component of pyruvate and 2-oxoglutarate dehydrogenases complexes [H]

Number of amino acids: Translated: 490; Mature: 490

Protein sequence:

>490_residues
MRKFDKTLFHEFRRIYKFMPESYDLTVIGAGPGGYVAAIRAAQLGMNVCIIEKDKPGGICLNWGCIPTKALLESAHLLEK
LHSAKEYGINLSDPKPDFAAIIRRSRNVAEGMASGVEFLLNKNKITRKKGTAVFKDPNTIWLPDSSKEEITSKYFILATG
ARARELPDLPFDSHTVLSSKTAMIQDKIPESLLIVGAGAIGVEFADFYSTMGTKVTLVEMMDQILPVEDKEISTFLEKSF
VKRGIRVLTGVGVSDPKIVNGKVKVLLKGKNLPEAVESFEAEKILVSIGLVPNTDSMHLEEIGIFLQKGFVKTDTKYKTS
VPHIYAIGDCNGAPLLAHVASMEGIKAVEAISIHAGNPHHLSYIPIDYNAIPGCTYCHPEVASIGFTEKKATDMGYTISV
GKFPFVASGRAKAMGDTGGFTKVIVDKTSGEILGAHLIGPGVTELLPAVSLGITQELTAKEIASTIFAHPTLSETVMESF
GAALGEAINL

Sequences:

>Translated_490_residues
MRKFDKTLFHEFRRIYKFMPESYDLTVIGAGPGGYVAAIRAAQLGMNVCIIEKDKPGGICLNWGCIPTKALLESAHLLEK
LHSAKEYGINLSDPKPDFAAIIRRSRNVAEGMASGVEFLLNKNKITRKKGTAVFKDPNTIWLPDSSKEEITSKYFILATG
ARARELPDLPFDSHTVLSSKTAMIQDKIPESLLIVGAGAIGVEFADFYSTMGTKVTLVEMMDQILPVEDKEISTFLEKSF
VKRGIRVLTGVGVSDPKIVNGKVKVLLKGKNLPEAVESFEAEKILVSIGLVPNTDSMHLEEIGIFLQKGFVKTDTKYKTS
VPHIYAIGDCNGAPLLAHVASMEGIKAVEAISIHAGNPHHLSYIPIDYNAIPGCTYCHPEVASIGFTEKKATDMGYTISV
GKFPFVASGRAKAMGDTGGFTKVIVDKTSGEILGAHLIGPGVTELLPAVSLGITQELTAKEIASTIFAHPTLSETVMESF
GAALGEAINL
>Mature_490_residues
MRKFDKTLFHEFRRIYKFMPESYDLTVIGAGPGGYVAAIRAAQLGMNVCIIEKDKPGGICLNWGCIPTKALLESAHLLEK
LHSAKEYGINLSDPKPDFAAIIRRSRNVAEGMASGVEFLLNKNKITRKKGTAVFKDPNTIWLPDSSKEEITSKYFILATG
ARARELPDLPFDSHTVLSSKTAMIQDKIPESLLIVGAGAIGVEFADFYSTMGTKVTLVEMMDQILPVEDKEISTFLEKSF
VKRGIRVLTGVGVSDPKIVNGKVKVLLKGKNLPEAVESFEAEKILVSIGLVPNTDSMHLEEIGIFLQKGFVKTDTKYKTS
VPHIYAIGDCNGAPLLAHVASMEGIKAVEAISIHAGNPHHLSYIPIDYNAIPGCTYCHPEVASIGFTEKKATDMGYTISV
GKFPFVASGRAKAMGDTGGFTKVIVDKTSGEILGAHLIGPGVTELLPAVSLGITQELTAKEIASTIFAHPTLSETVMESF
GAALGEAINL

Specific function: Lipoamide dehydrogenase is a component of the alpha- ketoacid dehydrogenase complexes [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=487, Percent_Identity=36.5503080082135, Blast_Score=300, Evalue=2e-81,
Organism=Homo sapiens, GI50301238, Length=469, Percent_Identity=28.7846481876333, Blast_Score=153, Evalue=3e-37,
Organism=Homo sapiens, GI22035672, Length=491, Percent_Identity=27.9022403258656, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI33519430, Length=474, Percent_Identity=25.3164556962025, Blast_Score=122, Evalue=6e-28,
Organism=Homo sapiens, GI33519428, Length=474, Percent_Identity=25.3164556962025, Blast_Score=122, Evalue=6e-28,
Organism=Homo sapiens, GI33519426, Length=474, Percent_Identity=25.3164556962025, Blast_Score=122, Evalue=6e-28,
Organism=Homo sapiens, GI148277065, Length=474, Percent_Identity=25.3164556962025, Blast_Score=122, Evalue=7e-28,
Organism=Homo sapiens, GI148277071, Length=474, Percent_Identity=25.3164556962025, Blast_Score=122, Evalue=8e-28,
Organism=Homo sapiens, GI291045266, Length=482, Percent_Identity=25.5186721991701, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI291045268, Length=476, Percent_Identity=24.1596638655462, Blast_Score=87, Evalue=3e-17,
Organism=Escherichia coli, GI1786307, Length=455, Percent_Identity=36.043956043956, Blast_Score=275, Evalue=4e-75,
Organism=Escherichia coli, GI87082354, Length=466, Percent_Identity=30.68669527897, Blast_Score=198, Evalue=8e-52,
Organism=Escherichia coli, GI87081717, Length=479, Percent_Identity=28.39248434238, Blast_Score=148, Evalue=7e-37,
Organism=Escherichia coli, GI1789915, Length=443, Percent_Identity=27.9909706546275, Blast_Score=146, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI32565766, Length=490, Percent_Identity=35.3061224489796, Blast_Score=291, Evalue=4e-79,
Organism=Caenorhabditis elegans, GI17557007, Length=487, Percent_Identity=25.2566735112936, Blast_Score=128, Evalue=7e-30,
Organism=Caenorhabditis elegans, GI71982272, Length=489, Percent_Identity=27.4028629856851, Blast_Score=102, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI71983419, Length=447, Percent_Identity=24.1610738255034, Blast_Score=99, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI71983429, Length=447, Percent_Identity=24.1610738255034, Blast_Score=99, Evalue=7e-21,
Organism=Saccharomyces cerevisiae, GI6321091, Length=489, Percent_Identity=36.8098159509202, Blast_Score=288, Evalue=1e-78,
Organism=Saccharomyces cerevisiae, GI6325240, Length=481, Percent_Identity=28.4823284823285, Blast_Score=195, Evalue=1e-50,
Organism=Saccharomyces cerevisiae, GI6325166, Length=473, Percent_Identity=26.8498942917548, Blast_Score=130, Evalue=5e-31,
Organism=Drosophila melanogaster, GI21358499, Length=485, Percent_Identity=37.5257731958763, Blast_Score=317, Evalue=1e-86,
Organism=Drosophila melanogaster, GI17737741, Length=483, Percent_Identity=28.1573498964803, Blast_Score=157, Evalue=1e-38,
Organism=Drosophila melanogaster, GI24640549, Length=477, Percent_Identity=27.6729559748428, Blast_Score=146, Evalue=3e-35,
Organism=Drosophila melanogaster, GI24640553, Length=476, Percent_Identity=27.7310924369748, Blast_Score=146, Evalue=4e-35,
Organism=Drosophila melanogaster, GI24640551, Length=476, Percent_Identity=27.7310924369748, Blast_Score=145, Evalue=5e-35,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006258
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.4 [H]

Molecular weight: Translated: 52902; Mature: 52902

Theoretical pI: Translated: 7.17; Mature: 7.17

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKFDKTLFHEFRRIYKFMPESYDLTVIGAGPGGYVAAIRAAQLGMNVCIIEKDKPGGIC
CCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHCCCEEEEEEECCCCCEE
LNWGCIPTKALLESAHLLEKLHSAKEYGINLSDPKPDFAAIIRRSRNVAEGMASGVEFLL
EECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHH
NKNKITRKKGTAVFKDPNTIWLPDSSKEEITSKYFILATGARARELPDLPFDSHTVLSSK
CCCCEECCCCCEEEECCCEEECCCCCHHHHCCEEEEEEECCCHHCCCCCCCCCCEECCCC
TAMIQDKIPESLLIVGAGAIGVEFADFYSTMGTKVTLVEMMDQILPVEDKEISTFLEKSF
HHHHHHCCCCEEEEEECCHHHHHHHHHHHHCCCEEEHHHHHHHHCCCCCHHHHHHHHHHH
VKRGIRVLTGVGVSDPKIVNGKVKVLLKGKNLPEAVESFEAEKILVSIGLVPNTDSMHLE
HHHHHHHEECCCCCCCEEECCEEEEEEECCCCHHHHHHHCCCEEEEEEECCCCCCCCHHH
EIGIFLQKGFVKTDTKYKTSVPHIYAIGDCNGAPLLAHVASMEGIKAVEAISIHAGNPHH
HHHHHHHCCEEECCCCEECCCCEEEEEECCCCCHHHHHHHHHCCCCEEEEEEEECCCCCE
LSYIPIDYNAIPGCTYCHPEVASIGFTEKKATDMGYTISVGKFPFVASGRAKAMGDTGGF
EEEEEEECCCCCCCCCCCCCHHHCCCCCHHCCCCCEEEEECCCCEEECCCCCCCCCCCCE
TKVIVDKTSGEILGAHLIGPGVTELLPAVSLGITQELTAKEIASTIFAHPTLSETVMESF
EEEEEECCCCCEEEEEECCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHH
GAALGEAINL
HHHHHHHHCC
>Mature Secondary Structure
MRKFDKTLFHEFRRIYKFMPESYDLTVIGAGPGGYVAAIRAAQLGMNVCIIEKDKPGGIC
CCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHCCCEEEEEEECCCCCEE
LNWGCIPTKALLESAHLLEKLHSAKEYGINLSDPKPDFAAIIRRSRNVAEGMASGVEFLL
EECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHH
NKNKITRKKGTAVFKDPNTIWLPDSSKEEITSKYFILATGARARELPDLPFDSHTVLSSK
CCCCEECCCCCEEEECCCEEECCCCCHHHHCCEEEEEEECCCHHCCCCCCCCCCEECCCC
TAMIQDKIPESLLIVGAGAIGVEFADFYSTMGTKVTLVEMMDQILPVEDKEISTFLEKSF
HHHHHHCCCCEEEEEECCHHHHHHHHHHHHCCCEEEHHHHHHHHCCCCCHHHHHHHHHHH
VKRGIRVLTGVGVSDPKIVNGKVKVLLKGKNLPEAVESFEAEKILVSIGLVPNTDSMHLE
HHHHHHHEECCCCCCCEEECCEEEEEEECCCCHHHHHHHCCCEEEEEEECCCCCCCCHHH
EIGIFLQKGFVKTDTKYKTSVPHIYAIGDCNGAPLLAHVASMEGIKAVEAISIHAGNPHH
HHHHHHHCCEEECCCCEECCCCEEEEEECCCCCHHHHHHHHHCCCCEEEEEEEECCCCCE
LSYIPIDYNAIPGCTYCHPEVASIGFTEKKATDMGYTISVGKFPFVASGRAKAMGDTGGF
EEEEEEECCCCCCCCCCCCCHHHCCCCCHHCCCCCEEEEECCCCEEECCCCCCCCCCCCE
TKVIVDKTSGEILGAHLIGPGVTELLPAVSLGITQELTAKEIASTIFAHPTLSETVMESF
EEEEEECCCCCEEEEEECCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHH
GAALGEAINL
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9515924 [H]