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The map label for this gene is ygcA [C]

Identifier: 45656969

GI number: 45656969

Start: 1340307

End: 1341671

Strand: Reverse

Name: ygcA [C]

Synonym: LIC11085

Alternate gene names: 45656969

Gene position: 1341671-1340307 (Counterclockwise)

Preceding gene: 45656970

Following gene: 45656967

Centisome position: 31.37

GC content: 32.31

Gene sequence:

>1365_bases
ATGTTGGATAAAAATACAAATTTAACTCATCAAAGTAAAATCGAATTTGTAAATTCTAATCTTCGCGGAATCGGTTTTGT
AAATAATACTAAAATTGAAGTCCCATACTCATTGCCGGGTGATGTTTATAACGTAACTTTTTTTAAAAAGAAACGCCGTA
AACCTTCCGCCAAACTCGAGTTAGTTTCTCAAACCCAAAGATCTTTTATTCCTCCTTGTTCCGCTTTTACGAAGTGTGGT
GGCTGTTGTGCACAACACATTTCTTATCAAGATCAATTTCGTTATAAAACTTCCAGTTTGTTAGAAAGTTATAAAAAAGA
TTTTGAAATAGTACCAACTTTGTATCCTGCTCAAAAAACGTTTTATTATAGAAATCGAATGGACTTTGCAGTATTTCCAG
GACCGATCGTAGGTCAAAGAGAAGCGGGTTCATTTAGACATATTGTGGATTTGGAAACTTGTTTGATTCAAAGCAAAGAA
TCCAACGAAGAATTATATAGATTTAGAAATCTAATCTCGAAATTTCCAAATCTACCTTATGACAGAAAATCAGATTCAGG
ATTTCTAAAATACTTTACTCTTCGAAAAGCAAAAAATACTTCCGAATTGATGACTATTCTTACTTTTGTAGAAGAGTTTA
AAAACACGATCGAAGAAAAGGAATTTGAAAACGTATGTTTAAAAAGTCTGAAAGCGGATCATATTCTATTTTGTTTTAAT
AGAAGAAAAGGAGAAATTTCCGCGACCGGGGAAATTAAAATTCTCAAAGGTATGGATTCTTATAAGGAATTAGTTTGCGG
AAAAGAATTTAGAGTTCCTTTCGATTCTTTTTTTCAACCAAACCCAGAAGGATTCCAACCGATTTTAGATTTTATCGAAA
AAGAAATCCCGGATTCATTCGATCACTTAGTCGATTTATTTTGTGGTTCCGGTTTTTTTAGCAGAATTTTTGCGCATAAA
TTTCTGAAAATCACAGGAATAGATTCAATCGAAAGTTCTTTAGAAATAGCACGGAAACAAATGAGTCTTGATTTTCCAAA
AATAGATTCTTCATATCTGAAAGTAGATTTATTTTCAAAACATTCATCCTCCAAATTGAAAGTTTTATTTTCGTCTTCGG
ACAAGGATGTTTTAATTGCGGACCCTCCCCGTGCAGGTTTAGGCGAATTTGTTTTAGATGCGTTGAAAGATTCTAAGGTT
TCTTATTTTTTTTACGTTTCTTGTAATCCTACTTCGCAAAAATCAGATCTATGGAAGTTGAAGGATTTTTTCCAAATTCA
AAAAATCTTAATTACAGACCCATATCCTCAAACCCCTCATCTAGAATCGGTTGCTTTTTTAAAACGTAAAAATTTTACTA
CCTAA

Upstream 100 bases:

>100_bases
TGAATTTTATAGAGGTCATTAGTTCAACTGTAAAAATAAAGTACATCGTTTTAGAACAAACTAAGATTTACCCAAAATAC
AAAATCGATAGACTGGTCAT

Downstream 100 bases:

>100_bases
CCAAAATTCATCAAACACCAATAGAAGCGAGACTTCTTGTTTCTGTTTCACAAAACGATAGAGGCCTATATAATAGAGTT
GTTGAAAAATTCCCTAGTTC

Product: RNA methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 454; Mature: 454

Protein sequence:

>454_residues
MLDKNTNLTHQSKIEFVNSNLRGIGFVNNTKIEVPYSLPGDVYNVTFFKKKRRKPSAKLELVSQTQRSFIPPCSAFTKCG
GCCAQHISYQDQFRYKTSSLLESYKKDFEIVPTLYPAQKTFYYRNRMDFAVFPGPIVGQREAGSFRHIVDLETCLIQSKE
SNEELYRFRNLISKFPNLPYDRKSDSGFLKYFTLRKAKNTSELMTILTFVEEFKNTIEEKEFENVCLKSLKADHILFCFN
RRKGEISATGEIKILKGMDSYKELVCGKEFRVPFDSFFQPNPEGFQPILDFIEKEIPDSFDHLVDLFCGSGFFSRIFAHK
FLKITGIDSIESSLEIARKQMSLDFPKIDSSYLKVDLFSKHSSSKLKVLFSSSDKDVLIADPPRAGLGEFVLDALKDSKV
SYFFYVSCNPTSQKSDLWKLKDFFQIQKILITDPYPQTPHLESVAFLKRKNFTT

Sequences:

>Translated_454_residues
MLDKNTNLTHQSKIEFVNSNLRGIGFVNNTKIEVPYSLPGDVYNVTFFKKKRRKPSAKLELVSQTQRSFIPPCSAFTKCG
GCCAQHISYQDQFRYKTSSLLESYKKDFEIVPTLYPAQKTFYYRNRMDFAVFPGPIVGQREAGSFRHIVDLETCLIQSKE
SNEELYRFRNLISKFPNLPYDRKSDSGFLKYFTLRKAKNTSELMTILTFVEEFKNTIEEKEFENVCLKSLKADHILFCFN
RRKGEISATGEIKILKGMDSYKELVCGKEFRVPFDSFFQPNPEGFQPILDFIEKEIPDSFDHLVDLFCGSGFFSRIFAHK
FLKITGIDSIESSLEIARKQMSLDFPKIDSSYLKVDLFSKHSSSKLKVLFSSSDKDVLIADPPRAGLGEFVLDALKDSKV
SYFFYVSCNPTSQKSDLWKLKDFFQIQKILITDPYPQTPHLESVAFLKRKNFTT
>Mature_454_residues
MLDKNTNLTHQSKIEFVNSNLRGIGFVNNTKIEVPYSLPGDVYNVTFFKKKRRKPSAKLELVSQTQRSFIPPCSAFTKCG
GCCAQHISYQDQFRYKTSSLLESYKKDFEIVPTLYPAQKTFYYRNRMDFAVFPGPIVGQREAGSFRHIVDLETCLIQSKE
SNEELYRFRNLISKFPNLPYDRKSDSGFLKYFTLRKAKNTSELMTILTFVEEFKNTIEEKEFENVCLKSLKADHILFCFN
RRKGEISATGEIKILKGMDSYKELVCGKEFRVPFDSFFQPNPEGFQPILDFIEKEIPDSFDHLVDLFCGSGFFSRIFAHK
FLKITGIDSIESSLEIARKQMSLDFPKIDSSYLKVDLFSKHSSSKLKVLFSSSDKDVLIADPPRAGLGEFVLDALKDSKV
SYFFYVSCNPTSQKSDLWKLKDFFQIQKILITDPYPQTPHLESVAFLKRKNFTT

Specific function: Could Be A 23s rRNA (Uracil-5-)-Methyltransferase. [C]

COG id: COG2265

COG function: function code J; SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. RNA M5U methyltransferase family

Homologues:

Organism=Homo sapiens, GI34222389, Length=367, Percent_Identity=22.8882833787466, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI51173878, Length=367, Percent_Identity=22.8882833787466, Blast_Score=76, Evalue=5e-14,
Organism=Escherichia coli, GI1787083, Length=284, Percent_Identity=22.887323943662, Blast_Score=69, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24666579, Length=462, Percent_Identity=22.2943722943723, Blast_Score=82, Evalue=9e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y1085_LEPIC (Q72TD6)

Other databases:

- EMBL:   AE016823
- RefSeq:   YP_001055.1
- ProteinModelPortal:   Q72TD6
- SMR:   Q72TD6
- GeneID:   2772881
- GenomeReviews:   AE016823_GR
- KEGG:   lic:LIC11085
- NMPDR:   fig|267671.1.peg.1055
- HOGENOM:   HBG529690
- OMA:   NEACIDE
- ProtClustDB:   CLSK574675
- BioCyc:   LINT267671:LIC_11085-MONOMER
- GO:   GO:0016020
- InterPro:   IPR000072
- InterPro:   IPR010280

Pfam domain/function: PF05958 tRNA_U5-meth_tr

EC number: NA

Molecular weight: Translated: 52430; Mature: 52430

Theoretical pI: Translated: 9.09; Mature: 9.09

Prosite motif: PS01230 TRMA_1; PS01231 TRMA_2; PS50278 PDGF_2

Important sites: ACT_SITE 408-408 BINDING 279-279 BINDING 307-307 BINDING 328-328 BINDING 381-381

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDKNTNLTHQSKIEFVNSNLRGIGFVNNTKIEVPYSLPGDVYNVTFFKKKRRKPSAKLE
CCCCCCCCCHHHHHHHHCCCCCEEEEECCCEEEECCCCCCCEEEEEEHHHHCCCCCHHHH
LVSQTQRSFIPPCSAFTKCGGCCAQHISYQDQFRYKTSSLLESYKKDFEIVPTLYPAQKT
HHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCEECCCCCCCHHH
FYYRNRMDFAVFPGPIVGQREAGSFRHIVDLETCLIQSKESNEELYRFRNLISKFPNLPY
EEECCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCC
DRKSDSGFLKYFTLRKAKNTSELMTILTFVEEFKNTIEEKEFENVCLKSLKADHILFCFN
CCCCCCCCEEEEEEHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEE
RRKGEISATGEIKILKGMDSYKELVCGKEFRVPFDSFFQPNPEGFQPILDFIEKEIPDSF
CCCCCEECCCCEEEEECCCHHHHHHCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHCCCHH
DHLVDLFCGSGFFSRIFAHKFLKITGIDSIESSLEIARKQMSLDFPKIDSSYLKVDLFSK
HHHHHHHHCCHHHHHHHHHHHHEEECCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECC
HSSSKLKVLFSSSDKDVLIADPPRAGLGEFVLDALKDSKVSYFFYVSCNPTSQKSDLWKL
CCCCEEEEEEECCCCEEEEECCCCCCHHHHHHHHHCCCCEEEEEEEEECCCCCCHHHHHH
KDFFQIQKILITDPYPQTPHLESVAFLKRKNFTT
HHHHHHHHHHEECCCCCCCCHHHHHHHHHCCCCC
>Mature Secondary Structure
MLDKNTNLTHQSKIEFVNSNLRGIGFVNNTKIEVPYSLPGDVYNVTFFKKKRRKPSAKLE
CCCCCCCCCHHHHHHHHCCCCCEEEEECCCEEEECCCCCCCEEEEEEHHHHCCCCCHHHH
LVSQTQRSFIPPCSAFTKCGGCCAQHISYQDQFRYKTSSLLESYKKDFEIVPTLYPAQKT
HHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCEECCCCCCCHHH
FYYRNRMDFAVFPGPIVGQREAGSFRHIVDLETCLIQSKESNEELYRFRNLISKFPNLPY
EEECCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCC
DRKSDSGFLKYFTLRKAKNTSELMTILTFVEEFKNTIEEKEFENVCLKSLKADHILFCFN
CCCCCCCCEEEEEEHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEE
RRKGEISATGEIKILKGMDSYKELVCGKEFRVPFDSFFQPNPEGFQPILDFIEKEIPDSF
CCCCCEECCCCEEEEECCCHHHHHHCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHCCCHH
DHLVDLFCGSGFFSRIFAHKFLKITGIDSIESSLEIARKQMSLDFPKIDSSYLKVDLFSK
HHHHHHHHCCHHHHHHHHHHHHEEECCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECC
HSSSKLKVLFSSSDKDVLIADPPRAGLGEFVLDALKDSKVSYFFYVSCNPTSQKSDLWKL
CCCCEEEEEEECCCCEEEEECCCCCCHHHHHHHHHCCCCEEEEEEEEECCCCCCHHHHHH
KDFFQIQKILITDPYPQTPHLESVAFLKRKNFTT
HHHHHHHHHHEECCCCCCCCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA