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The map label for this gene is echA8 [H]

Identifier: 45656690

GI number: 45656690

Start: 967220

End: 967966

Strand: Reverse

Name: echA8 [H]

Synonym: LIC10799

Alternate gene names: 45656690

Gene position: 967966-967220 (Counterclockwise)

Preceding gene: 45656691

Following gene: 45656683

Centisome position: 22.63

GC content: 35.88

Gene sequence:

>747_bases
ATGAAATATCAGTGCTTGCTTACCGAAAACAGGAATCAAATTTTAATCGTAACTCTCAATCGACCCGAAAAATCCAACTC
ACTAAACTTACAAATTAGAGACGAACTTGAAAACGTATTTAATGTAAACGCAAACAATGAATCTGTAAAAGCGATCCTAC
TCAATTCTTCAGGCAAACACTTTTCAAGTGGATACGATTTAGAAGAAGTAGTTCGAACAAAACTAGAATCCTTTCGACAT
AGAATATTAGAGTATCATTATGCACTTTACAGTTTTCCCAAACCAGTGGTTACGATATTAAAAGGATTTGCATCCGCTGG
AGGTTTTGATCTTGCTCTTTGTGGAGACTACATCATTTCTGAAAAAAAGGCGATTCTTTTCAGACCAGAAATTCGATTCG
GAGGACCTCCTCTAATCACTACACTCGCAAGAAAAGTTGGGCCGAACAAATCTTTGAGTCTAACCTTAAAAGGAGATCCG
ATTCGATCTTCTCAGGCTTTGAGTTTGGGAATTATAGACGAGATCTATGAAGGAGACGACATATTACAACATTCGGTCCA
AGTCGCTTCTAAACTTTCACAATGGAATTTAAATATGTTATCCACATTAAAAGGAATATCAAATAATTATTTCATAGGAA
ACTTATACGAAAACTTAAAAAACGAGTTCGACGCGTTCGCTTCCGTATTAGAAGATCCTAAATTTTTCCAGAAAGTTCAA
GAATATGCGGGAACGATACAACAATGA

Upstream 100 bases:

>100_bases
TTTCCCAAAAAAGATATATGCCACTTTAAATTTTTCTTGCGCAAAGTGTATTCAAAATTAAGATCATGCGCGTTTAATCC
GAGTTCAAAAGGATCGAAAA

Downstream 100 bases:

>100_bases
ACGCCCTTTATGGAAATTTCATACGCTCGTTATTTAGGATTTAGTTCCTATAGAATTTTCATCAAATACCGCGAAATAAA
AACGTCAAAATTTTGTTTAA

Product: enoyl-CoA hydratase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 248; Mature: 248

Protein sequence:

>248_residues
MKYQCLLTENRNQILIVTLNRPEKSNSLNLQIRDELENVFNVNANNESVKAILLNSSGKHFSSGYDLEEVVRTKLESFRH
RILEYHYALYSFPKPVVTILKGFASAGGFDLALCGDYIISEKKAILFRPEIRFGGPPLITTLARKVGPNKSLSLTLKGDP
IRSSQALSLGIIDEIYEGDDILQHSVQVASKLSQWNLNMLSTLKGISNNYFIGNLYENLKNEFDAFASVLEDPKFFQKVQ
EYAGTIQQ

Sequences:

>Translated_248_residues
MKYQCLLTENRNQILIVTLNRPEKSNSLNLQIRDELENVFNVNANNESVKAILLNSSGKHFSSGYDLEEVVRTKLESFRH
RILEYHYALYSFPKPVVTILKGFASAGGFDLALCGDYIISEKKAILFRPEIRFGGPPLITTLARKVGPNKSLSLTLKGDP
IRSSQALSLGIIDEIYEGDDILQHSVQVASKLSQWNLNMLSTLKGISNNYFIGNLYENLKNEFDAFASVLEDPKFFQKVQ
EYAGTIQQ
>Mature_248_residues
MKYQCLLTENRNQILIVTLNRPEKSNSLNLQIRDELENVFNVNANNESVKAILLNSSGKHFSSGYDLEEVVRTKLESFRH
RILEYHYALYSFPKPVVTILKGFASAGGFDLALCGDYIISEKKAILFRPEIRFGGPPLITTLARKVGPNKSLSLTLKGDP
IRSSQALSLGIIDEIYEGDDILQHSVQVASKLSQWNLNMLSTLKGISNNYFIGNLYENLKNEFDAFASVLEDPKFFQKVQ
EYAGTIQQ

Specific function: Could possibly oxidize fatty acids using specific components [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=235, Percent_Identity=27.2340425531915, Blast_Score=93, Evalue=2e-19,
Organism=Homo sapiens, GI31542718, Length=192, Percent_Identity=23.4375, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI20127408, Length=183, Percent_Identity=28.4153005464481, Blast_Score=66, Evalue=2e-11,
Organism=Escherichia coli, GI1787659, Length=193, Percent_Identity=27.979274611399, Blast_Score=95, Evalue=4e-21,
Organism=Escherichia coli, GI221142681, Length=212, Percent_Identity=25.9433962264151, Blast_Score=70, Evalue=9e-14,
Organism=Escherichia coli, GI87082183, Length=201, Percent_Identity=23.8805970149254, Blast_Score=70, Evalue=9e-14,
Organism=Escherichia coli, GI1788682, Length=191, Percent_Identity=24.0837696335079, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17554946, Length=213, Percent_Identity=27.2300469483568, Blast_Score=95, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI25145438, Length=222, Percent_Identity=26.5765765765766, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17560910, Length=254, Percent_Identity=24.8031496062992, Blast_Score=76, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17534483, Length=194, Percent_Identity=26.8041237113402, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17540714, Length=193, Percent_Identity=27.4611398963731, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17549921, Length=179, Percent_Identity=27.9329608938547, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI20129971, Length=222, Percent_Identity=28.3783783783784, Blast_Score=94, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24653477, Length=222, Percent_Identity=28.3783783783784, Blast_Score=94, Evalue=6e-20,
Organism=Drosophila melanogaster, GI21357171, Length=199, Percent_Identity=28.1407035175879, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI19920382, Length=208, Percent_Identity=26.9230769230769, Blast_Score=67, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24650670, Length=205, Percent_Identity=26.3414634146341, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.17 [H]

Molecular weight: Translated: 27970; Mature: 27970

Theoretical pI: Translated: 7.56; Mature: 7.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYQCLLTENRNQILIVTLNRPEKSNSLNLQIRDELENVFNVNANNESVKAILLNSSGKH
CCEEEEEECCCCEEEEEEECCCCCCCCEEEEEHHHHHHHEECCCCCCCEEEEEEECCCCC
FSSGYDLEEVVRTKLESFRHRILEYHYALYSFPKPVVTILKGFASAGGFDLALCGDYIIS
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEEHHHHHHC
EKKAILFRPEIRFGGPPLITTLARKVGPNKSLSLTLKGDPIRSSQALSLGIIDEIYEGDD
CCCEEEECCCCCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCCCCCEEHHHHHHHHCCHH
ILQHSVQVASKLSQWNLNMLSTLKGISNNYFIGNLYENLKNEFDAFASVLEDPKFFQKVQ
HHHHHHHHHHHHHHCCHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHCCHHHHHHHH
EYAGTIQQ
HHHHCCCC
>Mature Secondary Structure
MKYQCLLTENRNQILIVTLNRPEKSNSLNLQIRDELENVFNVNANNESVKAILLNSSGKH
CCEEEEEECCCCEEEEEEECCCCCCCCEEEEEHHHHHHHEECCCCCCCEEEEEEECCCCC
FSSGYDLEEVVRTKLESFRHRILEYHYALYSFPKPVVTILKGFASAGGFDLALCGDYIIS
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEEHHHHHHC
EKKAILFRPEIRFGGPPLITTLARKVGPNKSLSLTLKGDPIRSSQALSLGIIDEIYEGDD
CCCEEEECCCCCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCCCCCEEHHHHHHHHCCHH
ILQHSVQVASKLSQWNLNMLSTLKGISNNYFIGNLYENLKNEFDAFASVLEDPKFFQKVQ
HHHHHHHHHHHHHHCCHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHCCHHHHHHHH
EYAGTIQQ
HHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]