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The map label for this gene is tlpB [H]

Identifier: 45656583

GI number: 45656583

Start: 828048

End: 829760

Strand: Direct

Name: tlpB [H]

Synonym: LIC10685

Alternate gene names: 45656583

Gene position: 828048-829760 (Clockwise)

Preceding gene: 45656582

Following gene: 45656585

Centisome position: 19.36

GC content: 36.78

Gene sequence:

>1713_bases
GTGAATTTACTCGGCAATATTAGGATTAAAACAAGATTACGTCTCAGTTTTGGCGCTATCATAGGAGTGTTTATTCTTTC
TTCGGCTCTGATCGTCTACAATACTTTTGTGTATCGTAAAACGATTCGATCGATGATAGAAAATTCTCAACCTAAATTCC
AACTGATGAATTTGACATTGGAAAAGTTGATTCTTGCGGAGCTGACGATTTCGTCTAAAGTGTCCACGATTGACTCTCTT
CTTTCCGAAGAGGAATACGAAAAAGTAAAAACTCTTTTAGAAGAAATAAAGAAGAGTAACGTCACATTTCGGGAATTTCC
TTTGGAAGAGAACGAACTTGAAAATTTAAAAATTCTTGAAGACGGTATCAAAAATTTTGCTCAATATGCAGAAACGATTC
ATATATTAGGTAAAGATAATAGAAGACAAGAAGCTCAGATTCTTTACGTTCGTGGAGTGAATCCTCTGAGTGCTTCTCTT
CGTCAAACGGTCAAAACCTTGATTGAGTTTGAAGCGTCTAATTCCCGTAAAAACGAAGACGCGGCGGAATCTCAACTTAC
CTTTTCCTTGTATATGATTTGTGTACTTTCTCTTCTTTCTTTGGTGGCGGGTATTTTATTTTCGAGATCCATTATACGAT
CCGTAATGTTTCCTTTAAGAAAGGCGATTCATTTTGCGTCCGAAATTCAAAATGGAAATTTGAACAATCGGATTCAAATT
GATCGTTTGGATGAGATGGGAGAACTTTTGGAATTCTTAAAGAAAATGGAAGTTTCACTTCGTGAGATCATTGTAGAGGC
GAGGATTTCTGTCGAAAACTCTGAAAAGGCTAGTAAAGAATTTTATAAAGTTTCGAAAGAATTTATTTCCACTTCAGAAA
CTCAGGCAAATGATTCTCAAAAAGTAGCCGATCATATAGATCGTTTAAGTACTTTAGTAGAAGCGAATACTTCTGTTATT
CTTACTTCTGCGGAGCATCTTAGAAATTTGGAAAAGGAAATTCAAAAAAATCTTTCTTCATTAATCGACGTAACGGAGTC
CTTAAACTCTTTGGCCTTACAGGCGAAGGAATCTTCCGATACTGCATTAAAAGGACAAGAAAAGGTAGATGGGATCCAAA
AATCTTTTTTAGAAGTAAAGAGGACCGTTCACAAAATCAACGAATCTCTTGTTAAGATTGGAGATATTTCCACTCGCACG
AATATGCTCGCTCTTAACGCGGCGATCGAGGCGGCAAGAGCGGGAGATCATGGAAGAGGTTTTTCGGTTGTTGCCGATGA
AATTTCACAACTGGCTGAACATACAATGAAAAACACCAGAGAGATTACGGATTTGATCGAATTTACAAGATCCAGTATTG
AATCCGGAGACGGAGAGATGAATCAGTTCTCCGACTTTTTTACGATTATCCAAGAAAATGCGTCTAATATGGCTCGTTTT
AGTATGCATTTATTGGAAGATATGAGGACTCAAGAATCTGGTTTAAATATTTGTTCTCGTAAGATGTACGAGATCGCTTC
GAATATTACGGATTTGGAACATTCTTCTTTAGAAAATAAAAGCGCATACAGTTCCATCAAACAGTCGATTCAGGATCTTT
CTCAGGGAGCAAATTTGATTTCTGCGGGTTCTCAAGAAATCAGTTCTGGCGCAAAACGAATTGATGAACAATCTGATAAA
GTAAAACGTCTGATGGAAAAATTTTCGATTTAA

Upstream 100 bases:

>100_bases
TGAATTGTCTGAAGAACAAATTAAGGACGTGATTTCTTACATCAATTTCCTTTCGAAATCGAAATGATCGGAAAAAAGTT
TCCGCAACAATTTTTAAACA

Downstream 100 bases:

>100_bases
AATTTGTTTTTAATAAATGTTTTTATTTCTTTAACGTGAATTTTGTATAAGAAAATTTAGGCGAATCTGGTTGCTGAACT
GTTCTTTCTACTCTGATCAA

Product: methyl-accepting chemotaxis transducer transmembrane protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 570; Mature: 570

Protein sequence:

>570_residues
MNLLGNIRIKTRLRLSFGAIIGVFILSSALIVYNTFVYRKTIRSMIENSQPKFQLMNLTLEKLILAELTISSKVSTIDSL
LSEEEYEKVKTLLEEIKKSNVTFREFPLEENELENLKILEDGIKNFAQYAETIHILGKDNRRQEAQILYVRGVNPLSASL
RQTVKTLIEFEASNSRKNEDAAESQLTFSLYMICVLSLLSLVAGILFSRSIIRSVMFPLRKAIHFASEIQNGNLNNRIQI
DRLDEMGELLEFLKKMEVSLREIIVEARISVENSEKASKEFYKVSKEFISTSETQANDSQKVADHIDRLSTLVEANTSVI
LTSAEHLRNLEKEIQKNLSSLIDVTESLNSLALQAKESSDTALKGQEKVDGIQKSFLEVKRTVHKINESLVKIGDISTRT
NMLALNAAIEAARAGDHGRGFSVVADEISQLAEHTMKNTREITDLIEFTRSSIESGDGEMNQFSDFFTIIQENASNMARF
SMHLLEDMRTQESGLNICSRKMYEIASNITDLEHSSLENKSAYSSIKQSIQDLSQGANLISAGSQEISSGAKRIDEQSDK
VKRLMEKFSI

Sequences:

>Translated_570_residues
MNLLGNIRIKTRLRLSFGAIIGVFILSSALIVYNTFVYRKTIRSMIENSQPKFQLMNLTLEKLILAELTISSKVSTIDSL
LSEEEYEKVKTLLEEIKKSNVTFREFPLEENELENLKILEDGIKNFAQYAETIHILGKDNRRQEAQILYVRGVNPLSASL
RQTVKTLIEFEASNSRKNEDAAESQLTFSLYMICVLSLLSLVAGILFSRSIIRSVMFPLRKAIHFASEIQNGNLNNRIQI
DRLDEMGELLEFLKKMEVSLREIIVEARISVENSEKASKEFYKVSKEFISTSETQANDSQKVADHIDRLSTLVEANTSVI
LTSAEHLRNLEKEIQKNLSSLIDVTESLNSLALQAKESSDTALKGQEKVDGIQKSFLEVKRTVHKINESLVKIGDISTRT
NMLALNAAIEAARAGDHGRGFSVVADEISQLAEHTMKNTREITDLIEFTRSSIESGDGEMNQFSDFFTIIQENASNMARF
SMHLLEDMRTQESGLNICSRKMYEIASNITDLEHSSLENKSAYSSIKQSIQDLSQGANLISAGSQEISSGAKRIDEQSDK
VKRLMEKFSI
>Mature_570_residues
MNLLGNIRIKTRLRLSFGAIIGVFILSSALIVYNTFVYRKTIRSMIENSQPKFQLMNLTLEKLILAELTISSKVSTIDSL
LSEEEYEKVKTLLEEIKKSNVTFREFPLEENELENLKILEDGIKNFAQYAETIHILGKDNRRQEAQILYVRGVNPLSASL
RQTVKTLIEFEASNSRKNEDAAESQLTFSLYMICVLSLLSLVAGILFSRSIIRSVMFPLRKAIHFASEIQNGNLNNRIQI
DRLDEMGELLEFLKKMEVSLREIIVEARISVENSEKASKEFYKVSKEFISTSETQANDSQKVADHIDRLSTLVEANTSVI
LTSAEHLRNLEKEIQKNLSSLIDVTESLNSLALQAKESSDTALKGQEKVDGIQKSFLEVKRTVHKINESLVKIGDISTRT
NMLALNAAIEAARAGDHGRGFSVVADEISQLAEHTMKNTREITDLIEFTRSSIESGDGEMNQFSDFFTIIQENASNMARF
SMHLLEDMRTQESGLNICSRKMYEIASNITDLEHSSLENKSAYSSIKQSIQDLSQGANLISAGSQEISSGAKRIDEQSDK
VKRLMEKFSI

Specific function: Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of

COG id: COG0840

COG function: function code NT; Methyl-accepting chemotaxis protein

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 methyl-accepting transducer domain [H]

Homologues:

Organism=Escherichia coli, GI1788195, Length=246, Percent_Identity=32.1138211382114, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI2367378, Length=295, Percent_Identity=28.135593220339, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1787690, Length=540, Percent_Identity=22.4074074074074, Blast_Score=96, Evalue=7e-21,
Organism=Escherichia coli, GI1789453, Length=315, Percent_Identity=23.1746031746032, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI1788194, Length=289, Percent_Identity=28.3737024221453, Blast_Score=91, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004010
- InterPro:   IPR003122
- InterPro:   IPR004089
- InterPro:   IPR003660
- InterPro:   IPR022094 [H]

Pfam domain/function: PF02743 Cache_1; PF00672 HAMP; PF12332 McpA_N; PF00015 MCPsignal; PF02203 TarH [H]

EC number: NA

Molecular weight: Translated: 64224; Mature: 64224

Theoretical pI: Translated: 5.50; Mature: 5.50

Prosite motif: PS50885 HAMP ; PS50111 CHEMOTAXIS_TRANSDUC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLLGNIRIKTRLRLSFGAIIGVFILSSALIVYNTFVYRKTIRSMIENSQPKFQLMNLTL
CCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
EKLILAELTISSKVSTIDSLLSEEEYEKVKTLLEEIKKSNVTFREFPLEENELENLKILE
HHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHH
DGIKNFAQYAETIHILGKDNRRQEAQILYVRGVNPLSASLRQTVKTLIEFEASNSRKNED
HHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCH
AAESQLTFSLYMICVLSLLSLVAGILFSRSIIRSVMFPLRKAIHFASEIQNGNLNNRIQI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEH
DRLDEMGELLEFLKKMEVSLREIIVEARISVENSEKASKEFYKVSKEFISTSETQANDSQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHH
KVADHIDRLSTLVEANTSVILTSAEHLRNLEKEIQKNLSSLIDVTESLNSLALQAKESSD
HHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
TALKGQEKVDGIQKSFLEVKRTVHKINESLVKIGDISTRTNMLALNAAIEAARAGDHGRG
CHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCC
FSVVADEISQLAEHTMKNTREITDLIEFTRSSIESGDGEMNQFSDFFTIIQENASNMARF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
SMHLLEDMRTQESGLNICSRKMYEIASNITDLEHSSLENKSAYSSIKQSIQDLSQGANLI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHH
SAGSQEISSGAKRIDEQSDKVKRLMEKFSI
HCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNLLGNIRIKTRLRLSFGAIIGVFILSSALIVYNTFVYRKTIRSMIENSQPKFQLMNLTL
CCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
EKLILAELTISSKVSTIDSLLSEEEYEKVKTLLEEIKKSNVTFREFPLEENELENLKILE
HHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHH
DGIKNFAQYAETIHILGKDNRRQEAQILYVRGVNPLSASLRQTVKTLIEFEASNSRKNED
HHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCH
AAESQLTFSLYMICVLSLLSLVAGILFSRSIIRSVMFPLRKAIHFASEIQNGNLNNRIQI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEH
DRLDEMGELLEFLKKMEVSLREIIVEARISVENSEKASKEFYKVSKEFISTSETQANDSQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHH
KVADHIDRLSTLVEANTSVILTSAEHLRNLEKEIQKNLSSLIDVTESLNSLALQAKESSD
HHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
TALKGQEKVDGIQKSFLEVKRTVHKINESLVKIGDISTRTNMLALNAAIEAARAGDHGRG
CHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCC
FSVVADEISQLAEHTMKNTREITDLIEFTRSSIESGDGEMNQFSDFFTIIQENASNMARF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
SMHLLEDMRTQESGLNICSRKMYEIASNITDLEHSSLENKSAYSSIKQSIQDLSQGANLI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHH
SAGSQEISSGAKRIDEQSDKVKRLMEKFSI
HCCHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8188684; 9384377 [H]