Click here to switch to the map view.

The map label for this gene is qacA [H]

Identifier: 45656556

GI number: 45656556

Start: 804145

End: 805668

Strand: Reverse

Name: qacA [H]

Synonym: LIC10658

Alternate gene names: 45656556

Gene position: 805668-804145 (Counterclockwise)

Preceding gene: 45656557

Following gene: 45656544

Centisome position: 18.84

GC content: 41.93

Gene sequence:

>1524_bases
ATGAATCCCACAAACACAAATCTCGCTACTAAAAAAGAATGGATCGGCCTTGCAGTAATTGCACTTCCTTGTCTACTTTA
TGCTATGGACCTGACCGTATTGTATTTAGCCGTACCTCATCTTACGGAAGATCTAAAACCTACCGGTTCCCAACTTTTAT
GGATCGTAGACATCTACGGCTTTTTAGTGGCTGGTTTTTTAGTCACCATGGGTACGTTAGGTGATCGTATCGGAAGAAGA
AAACTTCTCATGATAGGCGCAGCATCATTTGGAGTTGCGTCCGTTTTGGCGGCATTTTCCAAAAATGCGGAAATGTTAAT
CGCAACCAGAGCCTTATTAGGTATTACGGCCGCAACCCTAGCTCCATCTACTCTATCATTAATTCGTAATATGTTTTTAG
ACGCAAACCAAAGAACGGTCGCAATTGGAATCTGGGGGACTAGCTTTTCCATCGGTGGAGCAATCGGTCCTTTAATTGGT
GGATTACTTTTGGAACATTTTTGGTGGGGTTCCGTTTTTCTATTAAGTGTTCCAGTTATGATTCTTCTTTTAATTGCAGG
GCCTAAACTTCTTCCCGAATTCAAAGATCCAAACGCGGGAAGTTTAGACATTCCCAGCGTAATCCTATCTTTGAGTTCCG
TTTTGAGTATCATATACGGATTTAAACGAGTCGCTGAGGATGGCTGGGAAGTTCTTTCATTCCTTTTCATCGTTAGTGGT
TTTTTAATCGGAACACTTTTTATCCGAAGACAACAAAATCTCAAAGATCCTTTAATCGATCTTCAGTTGTTTAAAGTTCC
TGCCTTTAGCGCCGCCCTGATCGCCAACTCATTGACCATTTTCGTCGGGTTGGGTAGTTTTTTATTTCTAGCTCAATACT
TACAATTAGTTCTCGGCTTATCACCGTTAGTTGCAGGATTTTGGACTCTTCCTTCTGCTGCCGGAAACGTCGTGGGTTCT
CTCGCGGTTCCTATGTTAGTTAGAAAAATTCGTCCAATCATTGTAGTATCTGGAGGTCTCGTTTTAAACATCGTTGGACT
CGCCTTTTATGCGTTAGTTGATGCGAATTCTGGACTTGTTTATGTTGTAATAGGCTCTGTAATCATATCTTTGGGAATCT
GTTCGGTTGTAATTTTAGGCACAGATTTAATCGTAGGTTCCGCTCCTCCAGAAAGAGCCGGAGCCGCTGCCTCTATTTCA
GAAACCGGCGTCGAATTTGGTGGAGTTTTAGGAATAGCCGTTTTAGGAAGTATCGGAACCGCGGTTTATAAAAATCGTAT
GGACGGCTTAAACTTCAATGGAATCTCGCCGGAATCGATGGAATCCGCAAAAGGCACATTAGGTGCAGCTGTCTCAGTCG
CTAAAGAACTACCAGAAGATATTGCACTTTCTCTGTTGCATTCCGCCAAACACGCATTTACCGATTCGTTTCAATTAGTT
TCTATCATTTGTGCGGTGATCTCTTTTGTATTAGCGATAACAATTTTTATCATGCGTAAGAGTCTGGAAAAAGAAGAAAG
CTGA

Upstream 100 bases:

>100_bases
AAGGAATTCAAAATCGAATAAGTTTGAAGTTAATTCAAACAAAAACATTCCAATCCGGCAACGTATTACTCTATTATCAA
CCTCTATAAGAAGAAACAAA

Downstream 100 bases:

>100_bases
TAGACATAGTTAGGTAATCTATCAATGAATTAGAATATTAATATAACTACTGATAACTATATAATAGAGTACCGAGCATT
TTGCATCGAAATAGGATTTG

Product: proton antiporter efflux pump

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 507; Mature: 507

Protein sequence:

>507_residues
MNPTNTNLATKKEWIGLAVIALPCLLYAMDLTVLYLAVPHLTEDLKPTGSQLLWIVDIYGFLVAGFLVTMGTLGDRIGRR
KLLMIGAASFGVASVLAAFSKNAEMLIATRALLGITAATLAPSTLSLIRNMFLDANQRTVAIGIWGTSFSIGGAIGPLIG
GLLLEHFWWGSVFLLSVPVMILLLIAGPKLLPEFKDPNAGSLDIPSVILSLSSVLSIIYGFKRVAEDGWEVLSFLFIVSG
FLIGTLFIRRQQNLKDPLIDLQLFKVPAFSAALIANSLTIFVGLGSFLFLAQYLQLVLGLSPLVAGFWTLPSAAGNVVGS
LAVPMLVRKIRPIIVVSGGLVLNIVGLAFYALVDANSGLVYVVIGSVIISLGICSVVILGTDLIVGSAPPERAGAAASIS
ETGVEFGGVLGIAVLGSIGTAVYKNRMDGLNFNGISPESMESAKGTLGAAVSVAKELPEDIALSLLHSAKHAFTDSFQLV
SIICAVISFVLAITIFIMRKSLEKEES

Sequences:

>Translated_507_residues
MNPTNTNLATKKEWIGLAVIALPCLLYAMDLTVLYLAVPHLTEDLKPTGSQLLWIVDIYGFLVAGFLVTMGTLGDRIGRR
KLLMIGAASFGVASVLAAFSKNAEMLIATRALLGITAATLAPSTLSLIRNMFLDANQRTVAIGIWGTSFSIGGAIGPLIG
GLLLEHFWWGSVFLLSVPVMILLLIAGPKLLPEFKDPNAGSLDIPSVILSLSSVLSIIYGFKRVAEDGWEVLSFLFIVSG
FLIGTLFIRRQQNLKDPLIDLQLFKVPAFSAALIANSLTIFVGLGSFLFLAQYLQLVLGLSPLVAGFWTLPSAAGNVVGS
LAVPMLVRKIRPIIVVSGGLVLNIVGLAFYALVDANSGLVYVVIGSVIISLGICSVVILGTDLIVGSAPPERAGAAASIS
ETGVEFGGVLGIAVLGSIGTAVYKNRMDGLNFNGISPESMESAKGTLGAAVSVAKELPEDIALSLLHSAKHAFTDSFQLV
SIICAVISFVLAITIFIMRKSLEKEES
>Mature_507_residues
MNPTNTNLATKKEWIGLAVIALPCLLYAMDLTVLYLAVPHLTEDLKPTGSQLLWIVDIYGFLVAGFLVTMGTLGDRIGRR
KLLMIGAASFGVASVLAAFSKNAEMLIATRALLGITAATLAPSTLSLIRNMFLDANQRTVAIGIWGTSFSIGGAIGPLIG
GLLLEHFWWGSVFLLSVPVMILLLIAGPKLLPEFKDPNAGSLDIPSVILSLSSVLSIIYGFKRVAEDGWEVLSFLFIVSG
FLIGTLFIRRQQNLKDPLIDLQLFKVPAFSAALIANSLTIFVGLGSFLFLAQYLQLVLGLSPLVAGFWTLPSAAGNVVGS
LAVPMLVRKIRPIIVVSGGLVLNIVGLAFYALVDANSGLVYVVIGSVIISLGICSVVILGTDLIVGSAPPERAGAAASIS
ETGVEFGGVLGIAVLGSIGTAVYKNRMDGLNFNGISPESMESAKGTLGAAVSVAKELPEDIALSLLHSAKHAFTDSFQLV
SIICAVISFVLAITIFIMRKSLEKEES

Specific function: Confers export-mediated resistance against antiseptic and disinfectant compounds such as intercalating dyes, quaternary ammonium salts and diamidines [H]

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily [H]

Homologues:

Organism=Escherichia coli, GI87081983, Length=394, Percent_Identity=25.6345177664975, Blast_Score=105, Evalue=6e-24,
Organism=Escherichia coli, GI1789042, Length=436, Percent_Identity=23.8532110091743, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI1790195, Length=328, Percent_Identity=28.0487804878049, Blast_Score=90, Evalue=4e-19,
Organism=Escherichia coli, GI1788710, Length=298, Percent_Identity=24.8322147651007, Blast_Score=85, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6324954, Length=386, Percent_Identity=22.020725388601, Blast_Score=68, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 53474; Mature: 53474

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPTNTNLATKKEWIGLAVIALPCLLYAMDLTVLYLAVPHLTEDLKPTGSQLLWIVDIYG
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
FLVAGFLVTMGTLGDRIGRRKLLMIGAASFGVASVLAAFSKNAEMLIATRALLGITAATL
HHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
APSTLSLIRNMFLDANQRTVAIGIWGTSFSIGGAIGPLIGGLLLEHFWWGSVFLLSVPVM
CHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILLLIAGPKLLPEFKDPNAGSLDIPSVILSLSSVLSIIYGFKRVAEDGWEVLSFLFIVSG
HHHHHHCCHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLIGTLFIRRQQNLKDPLIDLQLFKVPAFSAALIANSLTIFVGLGSFLFLAQYLQLVLGL
HHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH
SPLVAGFWTLPSAAGNVVGSLAVPMLVRKIRPIIVVSGGLVLNIVGLAFYALVDANSGLV
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHCCCCCEE
YVVIGSVIISLGICSVVILGTDLIVGSAPPERAGAAASISETGVEFGGVLGIAVLGSIGT
EHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCHHHHCHHHHHHHHHHHHHHHHH
AVYKNRMDGLNFNGISPESMESAKGTLGAAVSVAKELPEDIALSLLHSAKHAFTDSFQLV
HHHHHCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCHHHHH
SIICAVISFVLAITIFIMRKSLEKEES
HHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNPTNTNLATKKEWIGLAVIALPCLLYAMDLTVLYLAVPHLTEDLKPTGSQLLWIVDIYG
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
FLVAGFLVTMGTLGDRIGRRKLLMIGAASFGVASVLAAFSKNAEMLIATRALLGITAATL
HHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
APSTLSLIRNMFLDANQRTVAIGIWGTSFSIGGAIGPLIGGLLLEHFWWGSVFLLSVPVM
CHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILLLIAGPKLLPEFKDPNAGSLDIPSVILSLSSVLSIIYGFKRVAEDGWEVLSFLFIVSG
HHHHHHCCHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLIGTLFIRRQQNLKDPLIDLQLFKVPAFSAALIANSLTIFVGLGSFLFLAQYLQLVLGL
HHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH
SPLVAGFWTLPSAAGNVVGSLAVPMLVRKIRPIIVVSGGLVLNIVGLAFYALVDANSGLV
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHCCCCCEE
YVVIGSVIISLGICSVVILGTDLIVGSAPPERAGAAASISETGVEFGGVLGIAVLGSIGT
EHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCHHHHCHHHHHHHHHHHHHHHHH
AVYKNRMDGLNFNGISPESMESAKGTLGAAVSVAKELPEDIALSLLHSAKHAFTDSFQLV
HHHHHCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCHHHHH
SIICAVISFVLAITIFIMRKSLEKEES
HHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11418146 [H]