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The map label for this gene is glpK2

Identifier: 45656527

GI number: 45656527

Start: 766917

End: 768464

Strand: Reverse

Name: glpK2

Synonym: LIC10629

Alternate gene names: 45656527

Gene position: 768464-766917 (Counterclockwise)

Preceding gene: 45656528

Following gene: 45656526

Centisome position: 17.97

GC content: 39.99

Gene sequence:

>1548_bases
ATGGCTAATTCACAGGGCAAATACGTCCTTTCCATCGACAGTGGGGGAAGCGGAATTCGTGCGTTTTTATTAGATCGAAA
AGGTAATATAGTCGAAAGGCAATATGAAAAAACTCCTCCTAATATTCCCGAAGCAGGTGCTTTAGAACACGATCCAGAAA
TCCTATGGAAGGCCCTTCTTTCTCTTTTAAAAAAGATCCAAAAAAATCAGCAAATTGTAAAAGAAATTATCGCATTAGGA
ATTTGTAATCAACGCGGCTCCTTTCTTCTCTGGGAAAAATCCACAGGAAAGCCATTAACTCCTTTGATCAGTTGGGCGGA
CGTTCGTTCTCATAAAATTGCAGAAGCGATGAATCGAAATCTAATCTGGACAATCATCCGTGTTGTATCTACGTTTGTAG
GAAGATTGACAAACCATCCAATGATGATCGCCACTTCCATGCTCCGATTTACGACAGATCACGCAACTTGTAGATTAAAA
TGGATTTTAGACAAAAATCCAGATCTAAAACAGAGATGCAAAAAAGGTGAAGTTCTTTTTGGTACGTTAGATACTTGGTT
CATTTATAAACTTACCGGTCAAAAACAACATCTCACCGATTCGTCAAATGCAGTTGCTACGGGAATGTTTAATCCTTTTC
AATTGATCTGGAACCAACCGATTCTTTCAATATTCGGAATTCCTTCTAATTTATTTCCGGAAGTAAAAGATAGCAACGGA
GACTTCGGTCATACTTTGCCAGAATATTTAGGAGGACATTCGATTCCAATCAGAGCTTCGATTGGAGATCAAATGGCGGC
TCTATTTGGGCATTGTTGTTTTGAAAGGGGCGAAGTAAAAATTTCTCAAGGTTCCGGGGCATTTGTGGATATTAACATAG
GGCCCAAAGCAAAACTTTCCAAACGCGGTCTTTTTCCAATGATCGCTTGGAGAATAGACGGCAATACCACATATATGTTA
GAAGGTTATGTTGCAACCGCTGGAACCCTCATAGATTGGTTAGGACAAGGAATCGGACTTTCCGACACTCCTAAAGTTTT
GAACGAACTTGCGGCCCAATCGGAAGATACAGAAGGAGTCGTTTTTATTCCAACTCCTACGGGAGCCCGTTTTCCTTATT
TCAATCCTCGTGCCAAGGCATCCGTGATCGGGCTTTCTCTAGCATCTCATAGAAGACACGTTGCAAGAGCCGTCCTAGAA
GGAATTTCTCTCAGTCTCTATGAAATTTTAGAAGGAATTCAACGAGATACAAAAGTTGAAATCAAAGACATTAAAGTGGA
CGGCGGTGTATCTCAGTCTGATATTCTTCTTCAATGTCTTTCAGATTTTTCGAATGTAAGAGTAAATCGTTCTCCCGAAC
CAGATATGACTGCAACAGGAACGGCGTATCTTGCTGGTTTGGCAGTTGGCTTTTGGAAAAATTTAGATGAATTGAAGAAT
TTACAAAAAGGTTATAAATCTTTCGAACCGAAGATGAACCCAACAAAAAGGGTTCAAAAAATTCAACGTTGGAAAAAAGC
AGTTACCGCAACTCTTTCCATCGAATGA

Upstream 100 bases:

>100_bases
TTTAAAACCTCATTCGGAAAGAAATAGACAGAAACCCACCACTTCTATTACTTAACCTTTTAATTTCTCATTCCATTATT
GAAAAAACTTCGGAGATTCA

Downstream 100 bases:

>100_bases
TTACGGTTTTAATATTTATAGAAGTTATCTCAAAAACTTTGTCTGCTTTTATGAACTTACTCGGGTATACTACCATGTGC
TTTTCAAAACTTAGAATACT

Product: glycerol kinase

Products: NA

Alternate protein names: ATP:glycerol 3-phosphotransferase; Glycerokinase; GK [H]

Number of amino acids: Translated: 515; Mature: 514

Protein sequence:

>515_residues
MANSQGKYVLSIDSGGSGIRAFLLDRKGNIVERQYEKTPPNIPEAGALEHDPEILWKALLSLLKKIQKNQQIVKEIIALG
ICNQRGSFLLWEKSTGKPLTPLISWADVRSHKIAEAMNRNLIWTIIRVVSTFVGRLTNHPMMIATSMLRFTTDHATCRLK
WILDKNPDLKQRCKKGEVLFGTLDTWFIYKLTGQKQHLTDSSNAVATGMFNPFQLIWNQPILSIFGIPSNLFPEVKDSNG
DFGHTLPEYLGGHSIPIRASIGDQMAALFGHCCFERGEVKISQGSGAFVDINIGPKAKLSKRGLFPMIAWRIDGNTTYML
EGYVATAGTLIDWLGQGIGLSDTPKVLNELAAQSEDTEGVVFIPTPTGARFPYFNPRAKASVIGLSLASHRRHVARAVLE
GISLSLYEILEGIQRDTKVEIKDIKVDGGVSQSDILLQCLSDFSNVRVNRSPEPDMTATGTAYLAGLAVGFWKNLDELKN
LQKGYKSFEPKMNPTKRVQKIQRWKKAVTATLSIE

Sequences:

>Translated_515_residues
MANSQGKYVLSIDSGGSGIRAFLLDRKGNIVERQYEKTPPNIPEAGALEHDPEILWKALLSLLKKIQKNQQIVKEIIALG
ICNQRGSFLLWEKSTGKPLTPLISWADVRSHKIAEAMNRNLIWTIIRVVSTFVGRLTNHPMMIATSMLRFTTDHATCRLK
WILDKNPDLKQRCKKGEVLFGTLDTWFIYKLTGQKQHLTDSSNAVATGMFNPFQLIWNQPILSIFGIPSNLFPEVKDSNG
DFGHTLPEYLGGHSIPIRASIGDQMAALFGHCCFERGEVKISQGSGAFVDINIGPKAKLSKRGLFPMIAWRIDGNTTYML
EGYVATAGTLIDWLGQGIGLSDTPKVLNELAAQSEDTEGVVFIPTPTGARFPYFNPRAKASVIGLSLASHRRHVARAVLE
GISLSLYEILEGIQRDTKVEIKDIKVDGGVSQSDILLQCLSDFSNVRVNRSPEPDMTATGTAYLAGLAVGFWKNLDELKN
LQKGYKSFEPKMNPTKRVQKIQRWKKAVTATLSIE
>Mature_514_residues
ANSQGKYVLSIDSGGSGIRAFLLDRKGNIVERQYEKTPPNIPEAGALEHDPEILWKALLSLLKKIQKNQQIVKEIIALGI
CNQRGSFLLWEKSTGKPLTPLISWADVRSHKIAEAMNRNLIWTIIRVVSTFVGRLTNHPMMIATSMLRFTTDHATCRLKW
ILDKNPDLKQRCKKGEVLFGTLDTWFIYKLTGQKQHLTDSSNAVATGMFNPFQLIWNQPILSIFGIPSNLFPEVKDSNGD
FGHTLPEYLGGHSIPIRASIGDQMAALFGHCCFERGEVKISQGSGAFVDINIGPKAKLSKRGLFPMIAWRIDGNTTYMLE
GYVATAGTLIDWLGQGIGLSDTPKVLNELAAQSEDTEGVVFIPTPTGARFPYFNPRAKASVIGLSLASHRRHVARAVLEG
ISLSLYEILEGIQRDTKVEIKDIKVDGGVSQSDILLQCLSDFSNVRVNRSPEPDMTATGTAYLAGLAVGFWKNLDELKNL
QKGYKSFEPKMNPTKRVQKIQRWKKAVTATLSIE

Specific function: Key enzyme in the regulation of glycerol uptake and metabolism [H]

COG id: COG0554

COG function: function code C; Glycerol kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGGY kinase family [H]

Homologues:

Organism=Homo sapiens, GI88196792, Length=507, Percent_Identity=33.7278106508876, Blast_Score=344, Evalue=1e-94,
Organism=Homo sapiens, GI4504007, Length=518, Percent_Identity=31.2741312741313, Blast_Score=249, Evalue=4e-66,
Organism=Homo sapiens, GI189409120, Length=518, Percent_Identity=31.2741312741313, Blast_Score=249, Evalue=4e-66,
Organism=Homo sapiens, GI41393575, Length=519, Percent_Identity=29.6724470134875, Blast_Score=246, Evalue=3e-65,
Organism=Homo sapiens, GI42794763, Length=524, Percent_Identity=31.1068702290076, Blast_Score=245, Evalue=6e-65,
Organism=Escherichia coli, GI1790361, Length=516, Percent_Identity=35.8527131782946, Blast_Score=330, Evalue=1e-91,
Organism=Escherichia coli, GI1789987, Length=508, Percent_Identity=25.1968503937008, Blast_Score=108, Evalue=9e-25,
Organism=Caenorhabditis elegans, GI71986140, Length=522, Percent_Identity=28.9272030651341, Blast_Score=242, Evalue=4e-64,
Organism=Caenorhabditis elegans, GI17535599, Length=510, Percent_Identity=28.8235294117647, Blast_Score=218, Evalue=6e-57,
Organism=Caenorhabditis elegans, GI71986147, Length=297, Percent_Identity=31.3131313131313, Blast_Score=155, Evalue=4e-38,
Organism=Saccharomyces cerevisiae, GI6321755, Length=488, Percent_Identity=29.9180327868852, Blast_Score=206, Evalue=9e-54,
Organism=Drosophila melanogaster, GI21357867, Length=520, Percent_Identity=30.3846153846154, Blast_Score=286, Evalue=3e-77,
Organism=Drosophila melanogaster, GI24656367, Length=520, Percent_Identity=29.8076923076923, Blast_Score=272, Evalue=3e-73,
Organism=Drosophila melanogaster, GI17864214, Length=521, Percent_Identity=29.5585412667946, Blast_Score=239, Evalue=3e-63,
Organism=Drosophila melanogaster, GI24654573, Length=448, Percent_Identity=30.5803571428571, Blast_Score=234, Evalue=1e-61,
Organism=Drosophila melanogaster, GI24656372, Length=391, Percent_Identity=32.2250639386189, Blast_Score=228, Evalue=7e-60,
Organism=Drosophila melanogaster, GI24655555, Length=481, Percent_Identity=26.8191268191268, Blast_Score=205, Evalue=8e-53,
Organism=Drosophila melanogaster, GI24655560, Length=481, Percent_Identity=26.8191268191268, Blast_Score=205, Evalue=8e-53,
Organism=Drosophila melanogaster, GI24655570, Length=481, Percent_Identity=26.8191268191268, Blast_Score=205, Evalue=8e-53,
Organism=Drosophila melanogaster, GI24655574, Length=481, Percent_Identity=26.8191268191268, Blast_Score=205, Evalue=8e-53,
Organism=Drosophila melanogaster, GI24655565, Length=481, Percent_Identity=26.8191268191268, Blast_Score=205, Evalue=8e-53,
Organism=Drosophila melanogaster, GI19922058, Length=511, Percent_Identity=25.440313111546, Blast_Score=181, Evalue=1e-45,
Organism=Drosophila melanogaster, GI24652871, Length=505, Percent_Identity=25.3465346534653, Blast_Score=177, Evalue=2e-44,
Organism=Drosophila melanogaster, GI45552909, Length=307, Percent_Identity=32.5732899022801, Blast_Score=169, Evalue=5e-42,

Paralogues:

None

Copy number: 2,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000577
- InterPro:   IPR018485
- InterPro:   IPR018483
- InterPro:   IPR018484
- InterPro:   IPR005999 [H]

Pfam domain/function: PF02782 FGGY_C; PF00370 FGGY_N [H]

EC number: =2.7.1.30 [H]

Molecular weight: Translated: 57153; Mature: 57022

Theoretical pI: Translated: 9.77; Mature: 9.77

Prosite motif: PS00445 FGGY_KINASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANSQGKYVLSIDSGGSGIRAFLLDRKGNIVERQYEKTPPNIPEAGALEHDPEILWKALL
CCCCCCCEEEEECCCCCCEEEEEEECCCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHH
SLLKKIQKNQQIVKEIIALGICNQRGSFLLWEKSTGKPLTPLISWADVRSHKIAEAMNRN
HHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCC
LIWTIIRVVSTFVGRLTNHPMMIATSMLRFTTDHATCRLKWILDKNPDLKQRCKKGEVLF
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEEEEECCCCCHHHHCCCCCEEE
GTLDTWFIYKLTGQKQHLTDSSNAVATGMFNPFQLIWNQPILSIFGIPSNLFPEVKDSNG
EECCEEEEEEECCCCCCCCCCCCCEEECCCCHHHHHHCCCHHEEECCCHHHCCCCCCCCC
DFGHTLPEYLGGHSIPIRASIGDQMAALFGHCCFERGEVKISQGSGAFVDINIGPKAKLS
CCCCCCHHHHCCCCCEEEECCCHHHHHHHHHHHHCCCCEEEECCCCCEEEEECCCCCCHH
KRGLFPMIAWRIDGNTTYMLEGYVATAGTLIDWLGQGIGLSDTPKVLNELAAQSEDTEGV
CCCCCEEEEEEECCCEEEEEECHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCE
VFIPTPTGARFPYFNPRAKASVIGLSLASHRRHVARAVLEGISLSLYEILEGIQRDTKVE
EEEECCCCCCCCCCCCCCCHHEEEHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEE
IKDIKVDGGVSQSDILLQCLSDFSNVRVNRSPEPDMTATGTAYLAGLAVGFWKNLDELKN
EEEEEECCCCCHHHHHHHHHHHHHHEEECCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHH
LQKGYKSFEPKMNPTKRVQKIQRWKKAVTATLSIE
HHHHHHHCCCCCCHHHHHHHHHHHHHHHEEEEECC
>Mature Secondary Structure 
ANSQGKYVLSIDSGGSGIRAFLLDRKGNIVERQYEKTPPNIPEAGALEHDPEILWKALL
CCCCCCEEEEECCCCCCEEEEEEECCCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHH
SLLKKIQKNQQIVKEIIALGICNQRGSFLLWEKSTGKPLTPLISWADVRSHKIAEAMNRN
HHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCC
LIWTIIRVVSTFVGRLTNHPMMIATSMLRFTTDHATCRLKWILDKNPDLKQRCKKGEVLF
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEEEEECCCCCHHHHCCCCCEEE
GTLDTWFIYKLTGQKQHLTDSSNAVATGMFNPFQLIWNQPILSIFGIPSNLFPEVKDSNG
EECCEEEEEEECCCCCCCCCCCCCEEECCCCHHHHHHCCCHHEEECCCHHHCCCCCCCCC
DFGHTLPEYLGGHSIPIRASIGDQMAALFGHCCFERGEVKISQGSGAFVDINIGPKAKLS
CCCCCCHHHHCCCCCEEEECCCHHHHHHHHHHHHCCCCEEEECCCCCEEEEECCCCCCHH
KRGLFPMIAWRIDGNTTYMLEGYVATAGTLIDWLGQGIGLSDTPKVLNELAAQSEDTEGV
CCCCCEEEEEEECCCEEEEEECHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCE
VFIPTPTGARFPYFNPRAKASVIGLSLASHRRHVARAVLEGISLSLYEILEGIQRDTKVE
EEEECCCCCCCCCCCCCCCHHEEEHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEE
IKDIKVDGGVSQSDILLQCLSDFSNVRVNRSPEPDMTATGTAYLAGLAVGFWKNLDELKN
EEEEEECCCCCHHHHHHHHHHHHHHEEECCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHH
LQKGYKSFEPKMNPTKRVQKIQRWKKAVTATLSIE
HHHHHHHCCCCCCHHHHHHHHHHHHHHHEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA